O R F Mook
Affiliation: Academic Medical Center
Country: The Netherlands
- Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivoOlaf R Mook
Department of Neurogenetics, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Mol Cancer Ther 6:833-43. 2007..Therefore, LNA-modified siRNA should be preferred over unmodified siRNA...
- Targeted sequence capture and GS-FLX Titanium sequencing of 23 hypertrophic and dilated cardiomyopathy genes: implementation into diagnosticsOlaf R F Mook
Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands
J Med Genet 50:614-26. 2013..Recent developments in sequencing have increased the throughput, enabling simultaneous screening of multiple genes for multiple patients in a single sequencing run...
- Allele-specific cancer cell killing in vitro and in vivo targeting a single-nucleotide polymorphism in POLR2AO R F Mook
Department of Neurogenetics, Academic Medical Center, Amsterdam, The Netherlands
Cancer Gene Ther 16:532-8. 2009..Furthermore, cancer cell proliferation and tumor growth inhibition in nude mice was genotype dependent. We conclude that siRNA can be used for genotype-specific inhibition of tumor growth targeting an SNP in POLR2A in vivo...
- Interactions between colon cancer cells and hepatocytes in rats in relation to metastasisO R F Mook
Department of Cell Biology and Histology, University of Amsterdam, Amsterdam, The Netherlands
J Cell Mol Med 12:2052-61. 2008....