J J Molenaar

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi request reprint LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
    Jan J Molenaar
    Department of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands
    Nat Genet 44:1199-206. 2012
  2. pmc Identification of BIRC6 as a novel intervention target for neuroblastoma therapy
    Fieke Lamers
    Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, Amsterdam, AZ 1105, The Netherlands
    BMC Cancer 12:285. 2012
  3. doi request reprint Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
    Jan J Molenaar
    Department of Oncogenomics, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Nature 483:589-93. 2012
  4. pmc A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients
    Paolo Fardin
    Laboratory of Molecular Biology, Gaslini Institute, Genoa, Italy
    Mol Cancer 9:185. 2010
  5. doi request reprint Cyclin D1 is a direct transcriptional target of GATA3 in neuroblastoma tumor cells
    J J Molenaar
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Oncogene 29:2739-45. 2010
  6. pmc Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells
    Jan J Molenaar
    Department of Human Genetics, Academic Medical Center, Department of Pediatric Oncology, Emma Kinderziekenhuis, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 106:12968-73. 2009
  7. doi request reprint Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis
    Jan J Molenaar
    Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, The Netherlands
    Genes Chromosomes Cancer 51:10-9. 2012
  8. doi request reprint Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma
    Jan J Molenaar
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cancer Res 68:2599-609. 2008
  9. doi request reprint Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastoma
    E E Santo
    Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Oncogene 31:1571-81. 2012
  10. ncbi request reprint Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma
    Jan J Molenaar
    Department of Human Genetics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Genes Chromosomes Cancer 36:242-9. 2003

Collaborators

Detail Information

Publications11

  1. doi request reprint LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
    Jan J Molenaar
    Department of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands
    Nat Genet 44:1199-206. 2012
    ..Interference with this pathway might offer therapeutic perspectives...
  2. pmc Identification of BIRC6 as a novel intervention target for neuroblastoma therapy
    Fieke Lamers
    Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, Amsterdam, AZ 1105, The Netherlands
    BMC Cancer 12:285. 2012
    ..Neuroblastoma are pediatric tumors of the sympathetic nervous system with a poor prognosis. Apoptosis is often deregulated in cancer cells, but only a few defects in apoptotic routes have been identified in neuroblastoma...
  3. doi request reprint Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
    Jan J Molenaar
    Department of Oncogenomics, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Nature 483:589-93. 2012
    ..The genomic landscape of neuroblastoma therefore reveals two novel molecular defects, chromothripsis and neuritogenesis gene alterations, which frequently occur in high-risk tumours...
  4. pmc A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients
    Paolo Fardin
    Laboratory of Molecular Biology, Gaslini Institute, Genoa, Italy
    Mol Cancer 9:185. 2010
    ..To examine the relationship between hypoxia and neuroblastoma, we generated and tested an in vitro derived hypoxia gene signature for its ability to predict patients' outcome...
  5. doi request reprint Cyclin D1 is a direct transcriptional target of GATA3 in neuroblastoma tumor cells
    J J Molenaar
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Oncogene 29:2739-45. 2010
    ..Moreover, GATA3 silencing caused differentiation that was similar to that caused by Cyclin D1 inhibition. These finding implicate GATA3 in Cyclin D1 overexpression in neuroblastoma...
  6. pmc Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells
    Jan J Molenaar
    Department of Human Genetics, Academic Medical Center, Department of Pediatric Oncology, Emma Kinderziekenhuis, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 106:12968-73. 2009
    ..The synthetically lethal relationship between CDK2 and MYCN indicates CDK2 inhibitors as potential MYCN-selective cancer therapeutics...
  7. doi request reprint Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis
    Jan J Molenaar
    Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, The Netherlands
    Genes Chromosomes Cancer 51:10-9. 2012
    ..These tumors have a poor prognosis. Our findings suggest that pharmacological inhibition of cell cycle genes might bear therapeutic promises for patients with high risk neuroblastoma...
  8. doi request reprint Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma
    Jan J Molenaar
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cancer Res 68:2599-609. 2008
    ..Several new potential downstream players are identified. We conclude that neuroblastoma functionally depend on overexpression of G(1)-regulating genes to maintain their undifferentiated phenotype...
  9. doi request reprint Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastoma
    E E Santo
    Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Oncogene 31:1571-81. 2012
    ..Forkhead-box transcription factors have not been previously implicated in neuroblastoma pathogenesis. Furthermore, this is the first identification of intrachromosomal fusion genes in neuroblastoma...
  10. ncbi request reprint Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma
    Jan J Molenaar
    Department of Human Genetics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Genes Chromosomes Cancer 36:242-9. 2003
    ..Analysis of the 3'-UTR of CCND1 showed a rearrangement in 1 of 96 tumors. These clonal aberrations of CCND1 together with the high expression suggest a role for deregulated CCND1 activity in neuroblastoma tumorigenesis...
  11. ncbi request reprint ArrayCGH-based classification of neuroblastoma into genomic subgroups
    Evi Michels
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Genes Chromosomes Cancer 46:1098-108. 2007
    ..Further multicentric studies on large tumor series are warranted in order to improve therapeutic stratification in conjunction with other features such as age at diagnosis, tumor stage, and gene expression signatures...