S Middeldorp

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Elevated levels of FVIII:C within families are associated with an increased risk for venous and arterial thrombosis
    I Bank
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 3:79-84. 2005
  2. pmc AQUILA: assessment of quality in lower limb arthroplasty. An expert Delphi consensus for total knee and total hip arthroplasty
    Bart G Pijls
    Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands, Albinusdreef 2, Leiden, The Netherlands
    BMC Musculoskelet Disord 12:173. 2011
  3. pmc Incidence of postpartum haemorrhage in women receiving therapeutic doses of low-molecular-weight heparin: results of a retrospective cohort study
    Sara Roshani
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    BMJ Open 1:e000257. 2011
  4. doi request reprint Thrombosis in women: what are the knowledge gaps in 2013?
    S Middeldorp
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Thromb Haemost 11:180-91. 2013
  5. ncbi request reprint Antithrombotic prophylaxis for women with thrombophilia and pregnancy complications--No
    S Middeldorp
    Academic Medical Center, Department of Vascular Medicine, F4 277, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Thromb Haemost 1:2073-4. 2003
  6. ncbi request reprint [Recurrent miscarriage and thrombophilia]
    S Middeldorp
    Academisch Medisch Centrum Universiteit van Amsterdam, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 150:189-93. 2006
  7. ncbi request reprint Unselected women with elevated levels of factor VIII:C or homocysteine are not at increased risk for obstetric complications
    Saskia Middeldorp
    Academic Medical Center, Department of Vascular Medicine, F4 276, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Thromb Haemost 92:787-90. 2004
  8. pmc Evidence-based approach to thrombophilia testing
    Saskia Middeldorp
    Academic Medical Centre, Department of Vascular Medicine, F4 276, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands
    J Thromb Thrombolysis 31:275-81. 2011
  9. ncbi request reprint [Adverse cardiovascular effects of postmenopausal hormone replacement therapy]
    S Middeldorp
    Academisch Medisch Centrum, afd Vasculaire Geneeskunde, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 146:2123-7. 2002
  10. doi request reprint Is thrombophilia testing useful?
    Saskia Middeldorp
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Hematology Am Soc Hematol Educ Program 2011:150-5. 2011

Detail Information

Publications74

  1. ncbi request reprint Elevated levels of FVIII:C within families are associated with an increased risk for venous and arterial thrombosis
    I Bank
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 3:79-84. 2005
    ....
  2. pmc AQUILA: assessment of quality in lower limb arthroplasty. An expert Delphi consensus for total knee and total hip arthroplasty
    Bart G Pijls
    Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands, Albinusdreef 2, Leiden, The Netherlands
    BMC Musculoskelet Disord 12:173. 2011
    ..A Delphi approach was used to develop a checklist for reporting quality, methodological quality and generalizability of case series and cohorts in total hip and total knee arthroplasty with a focus on aseptic loosening...
  3. pmc Incidence of postpartum haemorrhage in women receiving therapeutic doses of low-molecular-weight heparin: results of a retrospective cohort study
    Sara Roshani
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    BMJ Open 1:e000257. 2011
    ..A randomised controlled trial is necessary to provide a definite answer about the optimal dose of LMWH in pregnancy...
  4. doi request reprint Thrombosis in women: what are the knowledge gaps in 2013?
    S Middeldorp
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Thromb Haemost 11:180-91. 2013
    ..However, whether antithrombotic therapy prevents recurrent miscarriage in thrombophilic women, or in women with severe pregnancy complications, remains unknown and urgently requires future research. ..
  5. ncbi request reprint Antithrombotic prophylaxis for women with thrombophilia and pregnancy complications--No
    S Middeldorp
    Academic Medical Center, Department of Vascular Medicine, F4 277, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Thromb Haemost 1:2073-4. 2003
  6. ncbi request reprint [Recurrent miscarriage and thrombophilia]
    S Middeldorp
    Academisch Medisch Centrum Universiteit van Amsterdam, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 150:189-93. 2006
    ..However, it is unknown whether anticoagulant treatment of women with recurrent miscarriage and hereditary risk factors for thrombophilia improves the outcome of a subsequent pregnancy...
  7. ncbi request reprint Unselected women with elevated levels of factor VIII:C or homocysteine are not at increased risk for obstetric complications
    Saskia Middeldorp
    Academic Medical Center, Department of Vascular Medicine, F4 276, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Thromb Haemost 92:787-90. 2004
    ..Unselected women with elevated plasma levels of FVIII:C or hyperhomocysteinemia are not at increased risk for obstetric complications as compared to their relatives with normal levels...
  8. pmc Evidence-based approach to thrombophilia testing
    Saskia Middeldorp
    Academic Medical Centre, Department of Vascular Medicine, F4 276, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands
    J Thromb Thrombolysis 31:275-81. 2011
    ..Because testing for thrombophilia only serves limited purpose this should not be performed on a routine basis...
  9. ncbi request reprint [Adverse cardiovascular effects of postmenopausal hormone replacement therapy]
    S Middeldorp
    Academisch Medisch Centrum, afd Vasculaire Geneeskunde, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 146:2123-7. 2002
    ..These results demonstrate that bias and confounding can play an important role in observational research and underscore the importance of randomised, placebo-controlled trials when studying the efficacy of drugs...
  10. doi request reprint Is thrombophilia testing useful?
    Saskia Middeldorp
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Hematology Am Soc Hematol Educ Program 2011:150-5. 2011
    ..Because testing for thrombophilia serves a limited purpose, this test should not be performed on a routine basis...
  11. ncbi request reprint [No indication for thrombophilia screening in patients with idiopathic venous thromboembolism and their relatives]
    S Middeldorp
    afd Vasculaire Geneeskunde, Academisch Medisch Centrum, Postbus 22 600, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 145:1047-51. 2001
    ..In conclusion, a conservative approach towards thrombophilia screening in idiopathic venous thromboembolism is warranted...
  12. ncbi request reprint The risk of pregnancy-related venous thromboembolism in women who are homozygous for factor V Leiden
    S Middeldorp
    Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Br J Haematol 113:553-5. 2001
    ..7-37.4). Anticoagulant prophylaxis during the post-partum period appears to be indicated in asymptomatic homozygous women from symptomatic kindred, whereas this could be decided on an individual basis during pregnancy...
  13. ncbi request reprint [Effects of second and third generation oral contraceptives on hemostasis]
    S Middeldorp
    Academisch Medisch Centrum, afd Vasculaire Geneeskunde, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 145:252-6. 2001
    ..In view of the epidemiological backgrounds of the difference in risk of thrombosis between second and third generation contraceptives, the second generation pill is recommended as the first choice for oral contraception...
  14. ncbi request reprint Effects on coagulation of levonorgestrel- and desogestrel-containing low dose oral contraceptives: a cross-over study
    S Middeldorp
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Thromb Haemost 84:4-8. 2000
    ..The real challenge now becomes to define a pattern of changes in the various systems which, if affected simultaneously, may tip the hemostatic balance towards a prethrombotic state and may lead to overt clinical venous thromboembolism...
  15. ncbi request reprint Oral contraceptives and the risk of venous thromboembolism
    Saskia Middeldorp
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gend Med 2:S3-9. 2005
    ..In response, the amount of estrogen used in these contraceptives was decreased. Later, the concept that reducing the dose of estrogen would eliminate the risk of venous thrombosis was strongly challenged...
  16. doi request reprint How I treat pregnancy-related venous thromboembolism
    Saskia Middeldorp
    Academic Medical Center, Department of Vascular Medicine, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood 118:5394-400. 2011
    ..Management of delivery, including the type of anesthesia if deemed necessary, requires a multidisciplinary approach, and several options are possible, depending on local preferences and patient-specific conditions...
  17. ncbi request reprint A prospective study of asymptomatic carriers of the factor V Leiden mutation to determine the incidence of venous thromboembolism
    S Middeldorp
    Department of Vascular Medicine, Academic Medical Center F4 277, 1100 DE Amsterdam, The Netherlands
    Ann Intern Med 135:322-7. 2001
    ..The clinical implications for asymptomatic carriers of this mutation and, consequently, the usefulness of screening families in which a proband has both the mutation and venous thromboembolism are unclear...
  18. ncbi request reprint Outcome of the subsequent pregnancy after a first loss in women with the factor V Leiden or prothrombin 20210A mutations
    M Coppens
    Academic Medical Center, Department of Vascular Medicine, Amsterdam, The Netherlands
    J Thromb Haemost 5:1444-8. 2007
    ..The factor V Leiden (FVL) and prothrombin 20210A (PTm) mutations are associated with single late pregnancy loss and recurrent early pregnancy loss. The prognosis after an initial loss in women with thrombophilia is uncertain...
  19. ncbi request reprint [Early termination of the multicentre randomised clinical trial to evaluate the benefit of testing for thrombophilia following a first venous thromboembolism: the NOSTRADAMUS study]
    D M Cohn
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Vasculaire Geneeskunde, Meibergdreef 9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 152:2093-4. 2008
    ..We advise restraint with respect to testing for thrombophilia in patients with a first deep vein thrombosis or pulmonary embolism, as the benefit of this procedure has yet to be demonstrated...
  20. ncbi request reprint Activation of coagulation system during air travel: a crossover study
    A J M Schreijer
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands
    Lancet 367:832-8. 2006
    ..There is an increased risk of venous thrombosis after air travel, but the underlying mechanism is unclear. Our aim was to ascertain whether flying leads to a hypercoagulable state...
  21. ncbi request reprint [From the Cochrane Library: postmenopausal hormone replacement therapy (HRT) does not protect women against cardiovascular disease but does lead to an increased risk of venous thromboembolism]
    J V Th H Hamerlynck
    Academisch Medisch Centrum Universiteit van Amsterdam, Dutch Cochrane Centre, J1B 108, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 150:546-8. 2006
    ..Further, in the case of other risk factors for venous thromboembolic events, the use of HRT for preventive purposes should be discouraged...
  22. ncbi request reprint Risk factors of arterial cardiovascular complications in patients with prior venous thromboembolism
    S Roshani
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Neth J Med 69:27-30. 2011
    ..The effect of cardiovascular risk factors (CVRs) and thrombophilic defects on the risk of arterial cardiovascular complications in patients with prior venous thromboembolism (VTE) is unclear...
  23. ncbi request reprint Treatment of venous thromboembolism
    H R Buller
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Thromb Haemost 3:1554-60. 2005
    ..This section describes the current recommendations about how to treat patients with VTE initially and long term. Finally, in the third section the challenges for the treatment of patients beyond 2005 are discussed...
  24. ncbi request reprint [From the Cochrane Library: wearing compression stockings during long-distance flights reduces the risk of asymptomatic deep-vein thrombosis]
    J V Th H Hamerlynck
    Academisch Medisch Centrum Universiteit van Amsterdam, Dutch Cochrane Centre, J1B 108, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 150:2486-8. 2006
    ..10; 95% CI: 0.04-0.25). No deaths, pulmonary emboli or symptomatic DVTs were reported. Wearing stockings had a significant impact in reducing oedema of the lower legs. No significant adverse effects of wearing stockings were reported...
  25. doi request reprint Testing for inherited thrombophilia does not reduce the recurrence of venous thrombosis
    M Coppens
    Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    J Thromb Haemost 6:1474-7. 2008
    ..In spite of this, thrombophilia testing is often performed in these patients. Positive results may influence patient management such as prolonged anticoagulant treatment or intensified prophylaxis in high-risk situations...
  26. ncbi request reprint [A multicentre randomised clinical trial to evaluate the benefit of testing for thrombophilia following a first venous thromboembolism: the NOSTRADAMUS study]
    D M Cohn
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Vasculaire Geneeskunde, Meibergdreef 9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 151:371-3. 2007
    ..Other outcomes include overall quality of life and costs associated with outcome measures 18 months after the initial episode of VTE...
  27. doi request reprint Increased sperm count may account for high population frequency of factor V Leiden
    D M Cohn
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
    J Thromb Haemost 8:513-6. 2010
    ..Men with FVL have previously been found to have higher fecundity (the time between marriage and first pregnancy). Whether this is caused by increased sperm counts in men with FVL is unknown...
  28. ncbi request reprint A prospective cohort study on the absolute incidence of venous thromboembolism and arterial cardiovascular disease in asymptomatic carriers of the prothrombin 20210A mutation
    Michiel Coppens
    Department of Vascular Medicine F4 276, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood 108:2604-7. 2006
    ....
  29. ncbi request reprint Thrombophilia and venous thromboembolism: implications for testing
    Danny M Cohn
    Academic Medical Center, Department of Vascular Medicine, Amsterdam, The Netherlands
    Semin Thromb Hemost 33:573-81. 2007
    ..This article reviews the currently established thrombophilic abnormalities and discusses the potential usefulness and implications of testing for thrombophilia...
  30. ncbi request reprint Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study
    H Buller
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 6:1313-8. 2008
    ..We conducted a dose-ranging study in patients with deep vein thrombosis...
  31. ncbi request reprint Skin reactions due to low molecular weight heparin in pregnancy: a strategic dilemma
    A E M Verdonkschot
    Department of Obstetrics and Gynaecology, Academic Medical Centre H4 249, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Arch Gynecol Obstet 271:163-5. 2005
    ..Heparin-induced allergic reactions may cause problems if heparin administration is needed for thrombo-embolic disease in pregnancy...
  32. ncbi request reprint Factor XIII Val34Leu and the risk of venous thromboembolism in factor V Leiden carriers
    R F Franco
    Laboratory for Experimental Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Br J Haematol 111:118-21. 2000
    ..5 (95% CI 0.06-4.5) in relatives older than 60 years. In conclusion, the impact of FXIII Val34Leu on the venous thromboembolic risk is modest, suggesting that screening for this mutation in factor V Leiden carriers is not justified...
  33. ncbi request reprint Acute myocardial infarction with large bilateral intracoronary thrombi in a young patient with the prothrombin 20210 G-->A mutation
    R J de Winter
    Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Cathet Cardiovasc Diagn 44:427-30. 1998
    ..We describe a case of a young patient carrying the mutation, with an AMI caused by large bilateral intracoronary thrombi, that underwent direct PTCA...
  34. pmc Recurrent miscarriage and antiphospholipid antibodies: prognosis of subsequent pregnancy
    D M Cohn
    Department of Internal Medicine, Academic Medical Center Center, University of Amsterdam, The Netherlands
    J Thromb Haemost 8:2208-13. 2010
    ..Although women with antiphospholipid antibodies (APLAs) are at increased risk of recurrent miscarriage, the outcome of a subsequent pregnancy is not clearly elucidated...
  35. ncbi request reprint Increased fibrinolytic activity during use of oral contraceptives is counteracted by an enhanced factor XI-independent down regulation of fibrinolysis: a randomized cross-over study of two low-dose oral contraceptives
    J C Meijers
    Department of Haematology, University Medical Center Utrecht, The Netherlands
    Thromb Haemost 84:9-14. 2000
    ..These data indicate that the OC-induced inhibition of endogenous fibrinolysis takes place in a factor XI-independent way and is more pronounced on desogestrel than on levonorgestrel-containing OC...
  36. ncbi request reprint Absolute annual incidences of first events of venous thromboembolism and arterial vascular events in individuals with elevated FVIII:c. A prospective family cohort study
    Ivan Bank
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thromb Haemost 98:1040-4. 2007
    ..Elevated FVIII:c may be a common risk factor for both clinical entities...
  37. ncbi request reprint Assessment of coagulation and fibrinolysis in families with unexplained thrombophilia
    Iris M Wichers
    Dept of Vascular Medicine, F4 276, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Thromb Haemost 101:465-70. 2009
    ..We found that an increased ETP may serve as an intermediate phenotype for VTE and may be used to discover novel inherited risk factors by genetic linkage analysis...
  38. ncbi request reprint Acquired and inherited thrombophilic factors and the risk for residual venous thrombosis
    Ivan Bank
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Pathophysiol Haemost Thromb 33:192-6. 2003
    ..7, 95% CI 1.2-2.2). Although these results should be confirmed in a larger study, they might help us form hypotheses concerning why patients with thrombophilia are more prone to recurrent venous thromboembolic disease...
  39. ncbi request reprint Social aspects of genetic testing for factor V Leiden mutation in healthy individuals and their importance for daily practice
    Ivan Bank
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, F4 277, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Thromb Res 113:7-12. 2004
    ..Any guideline to be developed for the screening for FVL should take this into account too...
  40. ncbi request reprint Prothrombin 20210A mutation: a mild risk factor for venous thromboembolism but not for arterial thrombotic disease and pregnancy-related complications in a family study
    Ivan Bank
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arch Intern Med 164:1932-7. 2004
    ..The aim of this study was to estimate the incidences of first venous and arterial thrombotic events and pregnancy-related complications in relatives of patients with the mutation...
  41. ncbi request reprint Treatment of venous thromboembolism with vitamin K antagonists: patients' health state valuations and treatment preferences
    Mirjam Locadia
    Department of Medical Psychology J3 219, Academic Medical Centre, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Thromb Haemost 92:1336-41. 2004
    ..Due to the substantial and unpredictable variability in valuations and treatment preferences, recommendations regarding treatment duration should be tailored to patients' specific values and concerns...
  42. ncbi request reprint Direct thrombin inhibitors
    Marcello Di Nisio
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    N Engl J Med 353:1028-40. 2005
  43. ncbi request reprint Treatment of superficial vein thrombosis to prevent deep vein thrombosis and pulmonary embolism: a systematic review
    Iris M Wichers
    Dept of Vascular Medicine, F4 276, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Haematologica 90:672-7. 2005
    ....
  44. ncbi request reprint Monitoring of unfractionated heparin in critically ill patients
    R Aarab
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Neth J Med 71:466-71. 2013
    ..We evaluated the quality of UFH therapy in critically ill patients in terms of activated partial thromboplastin time (APTT) test values and time to therapeutic range...
  45. doi request reprint Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin transporter polymorphism
    N Abdelmalik
    Program for Mood Disorders, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 6:2168-74. 2008
    ..Selective serotonin reuptake inhibitors (SSRIs) have been associated with an increased bleeding tendency...
  46. ncbi request reprint Development in anticoagulant therapy
    F F van Doormaal
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Crit Rev Oncol Hematol 66:145-54. 2008
    ..Several novel anticoagulants are being developed and are undergoing clinical evaluation. New anticoagulants should also be evaluated on the effect on progression of cancer and cancer-related survival...
  47. ncbi request reprint A retrospective analysis of patients treated for superficial vein thrombosis
    I M Wichers
    Department of Vascular Medicine F4 276, Academic Medical Center, Amsterdam, The Netherlands
    Neth J Med 66:423-7. 2008
    ..We retrospectively evaluated therapeutic management, thrombophilic risk factors and clinical outcome of SVT...
  48. ncbi request reprint [From the Cochrane Library: Improvement of photodamaged skin with retinoid creams and not with other local treatments]
    J V Th H Hamerlynck
    Academisch Medisch Centrum Universiteit van Amsterdam, Dutch Cochrane Centre, Amsterdam
    Ned Tijdschr Geneeskd 150:140-2. 2006
    ..Adverse effects were pain and redness. Both the efficacy and adverse effects were dose-dependent. Other treatments, such as polysaccharides, hydroxy acids, surgical procedures and laser, cannot be recommended...
  49. doi request reprint The psychological impact of testing for thrombophilia: a systematic review
    D M Cohn
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Thromb Haemost 6:1099-104. 2008
    ..A potential disadvantage of this predominantly genetic testing is the psychological impact, including fear, depression and worry...
  50. ncbi request reprint Time to conception and time to live birth in women with unexplained recurrent miscarriage
    S P Kaandorp
    Department of Obstetrics and Gynaecology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Hum Reprod 29:1146-52. 2014
    ..What is the time to conception in a cohort of women with unexplained recurrent miscarriage (RM)...
  51. doi request reprint The tropics and the crime they did not commit
    A Goorhuis
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Infection 41:275-7. 2013
    ..This case illustrates that broad differential diagnostic thinking is paramount in the assessment of returned travellers...
  52. doi request reprint Evolution of Factor V Leiden
    Thijs E van Mens
    Department of Vascular Medicine, F4 276, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Thromb Haemost 110:23-30. 2013
    ..Elevated APC levels possibly mediate anti-inflammatory effects. Higher sperm counts and more successful embryo implantation seem to play a role in the increased fecundity. ..
  53. doi request reprint Venous thromboembolism in adults treated for acute lymphoblastic leukaemia: Effect of fresh frozen plasma supplementation
    Mandy N Lauw
    Department of Haematology, F4 224, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Thromb Haemost 109:633-42. 2013
    ..17; 95% CI 0.04-0.65). Our study suggests that prophylactic FFP supplementation effectively reduces symptomatic VTE incidence during ALL treatment in adults. This should be confirmed in a randomised controlled trial...
  54. ncbi request reprint [From the Cochrane Library: Routine use of nasogastric tubes after abdominal surgery is not effective]
    J V Th H Hamerlynck
    Academisch Medisch Centrum Universiteit van Amsterdam, Dutch Cochrane Centre, Postbus 22 660, iioO DD Amsterdam
    Ned Tijdschr Geneeskd 149:2279-80. 2005
    ..Routine nasogastric decompression should be abandoned in favour of temporary use of the nasogastric tube...
  55. ncbi request reprint Hormone replacement therapy and arterial thrombotic disease
    S Middeldorp
    Academic Medical Center, Department of Vascular Medicine, Amsterdam, The Netherlands
    Thromb Res 115:68-71. 2005
  56. ncbi request reprint [From the Cochrane Library: brushing the teeth with an electric toothbrush with an oscllating rotating movement more effective against plaque and gingivitis than brushing with a conventional toothbrush]
    J V T Hamerlynck
    Academisch Medisch Centrum Universiteitvan Amsterdam, Dutch Cochrane Centre J 1B 108, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 149:2673-5. 2005
    ..The long-term clinical relevance of the differences is unclear. Electric toothbrushes that did not have an oscillating rotating movement were not consistently better than manual toothbrushes...
  57. ncbi request reprint [From the Cochrane Library: Phosphodiesterase inhibitors are effective in treating erectile dysfunction in diabetic men]
    J V Th H Hamerlynck
    Academisch Medisch Centrum Universiteit van Amsterdam, Dutch Cochrane Centre, J1B 108, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 151:2101-4. 2007
    ..8 in the PDE-5 inhibitors arm as compared to the control arm. It was concluded that sufficient evidence exists that treatment with PDE-5 inhibitors can improve erectile dysfunction in diabetic men...
  58. ncbi request reprint [From the Cochrane Library: effective measures are available to prevent falls in the elderly]
    J V T H Hamerlynck
    Universiteit van Amsterdam, Dutch Cochrane Centre, J 1B 108, Postbus 22 660, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 150:374-6. 2006
    ..Some potential interventions were of unknown effectiveness or unlikely to be beneficial. Examples of these are physical exercises, the use of dietary supplements and the correction of impaired vision...
  59. ncbi request reprint [From the Cochrane Library: routine membrane sweeping ('stripping') for induction of labor in full-term pregnancies effective, but not always useful]
    J V Th H Hamerlynck
    Academisch Medisch Centrum Universiteit van Amsterdam, Dutch Cochrane Centre, Postbus 22 660, J 1B 108, 1100 DD Amsterdam
    Ned Tijdschr Geneeskd 149:2508-10. 2005
    ..When used as a means of inducing labour, the reduction in the use of more formal methods of induction must be balanced against the resulting discomfort and other adverse effects...
  60. ncbi request reprint Inherited thrombophilias
    Michiel Coppens
    Academic Medical Center, F4 276, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Obstet Gynecol Clin North Am 33:357-74. 2006
    ..For this group, well-designed placebo-controlled trials to assess the harm-benefit ratio are urgently needed...
  61. doi request reprint Aspirin plus heparin or aspirin alone in women with recurrent miscarriage
    Stef P Kaandorp
    Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    N Engl J Med 362:1586-96. 2010
    ....
  62. ncbi request reprint Thrombophilia: an update
    Saskia Middeldorp
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Semin Thromb Hemost 33:563-72. 2007
  63. ncbi request reprint Pregnancy failure and heritable thrombophilia
    Saskia Middeldorp
    Department of Clinical Epidemiology, and Vascular Medicine Unit, Leiden University Medical Center, Leiden, The Netherlands
    Semin Hematol 44:93-7. 2007
    ..The role of heritable thrombophilia in pregnancy failure is reviewed, with a focus on recurrent miscarriage, in terms of epidemiology, etiology, and potential therapeutic implications...
  64. ncbi request reprint The incidence of recurrent venous thromboembolism in carriers of factor V Leiden is related to concomitant thrombophilic disorders
    Johan R Meinardi
    Division of Haemostasis, Thrombosis and Rheology, University Hospital, Groningen, The Netherlands
    Br J Haematol 116:625-31. 2002
    ....
  65. doi request reprint Absolute risk of venous and arterial thromboembolism in thrombophilic families is not increased by high thrombin-activatable fibrinolysis inhibitor (TAFI) levels
    Nienke Folkeringa
    Division of Haemostasis, Thrombosis and Rheology, Department of Haematology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Thromb Haemost 100:38-44. 2008
    ..None of these concomitant defects showed interaction with high TAFI levels. High TAFI levels were not associated with an increased risk of venous and arterial thromboembolism in thrombophilic families...
  66. doi request reprint Inherited thrombophilia and pregnancy complications revisited
    Marc A Rodger
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Obstet Gynecol 112:320-4. 2008
    ....
  67. ncbi request reprint Co-segregation of thrombophilic disorders in factor V Leiden carriers; the contributions of factor VIII, factor XI, thrombin activatable fibrinolysis inhibitor and lipoprotein(a) to the absolute risk of venous thromboembolism
    Eduard J Libourel
    Division of Hemostasis, Thrombosis and Rheology, University Hospital Groningen, The Netherlands
    Haematologica 87:1068-73. 2002
    ..Our aim was to assess the contributions of high levels of factor VIII:C, factor XI:C, thrombin activatable fibrinolysis inhibitor (TAFI) and lipoprotein (a) (Lp(a)) to the risk of venous thromboembolism in factor V Leiden carriers...
  68. ncbi request reprint High factor VIII plasma levels as a risk factor for venous thrombosis: no evidence of inheritance from a family cohort study
    Eduard J Libourel
    Haematologica 89:118-20. 2004
  69. ncbi request reprint The risk of venous and arterial thrombosis in hyperhomocysteinaemia is low and mainly depends on concomitant thrombophilic defects
    Willem M Lijfering
    Division of Haemostasis, Thrombosis and Rheology, Department of Hematology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Thromb Haemost 98:457-63. 2007
    ..Concomitant thrombophilic defects are probably main determinants on the risk of venous thrombosis, rather than hyperhomocysteinaemia itself...
  70. ncbi request reprint Protein S type III deficiency is no risk factor for venous and arterial thromboembolism in 168 thrombophilic families: a retrospective study
    Eduard J Libourel
    Department of Hematology, Division of Hemostasis, Thrombosis and Rheology, University Hospital, Groningen, The Netherlands
    Blood Coagul Fibrinolysis 16:135-40. 2005
    ..10 per 100 person-years (95% CI, 0.05-0.19) [hazard ratio, 1.5 (95% CI, 0.3-6.0)]. These results suggest that protein S deficiency type III is not associated with an increased risk of either venous or arterial thromboembolism...
  71. ncbi request reprint A rebuttal: Counseling pregnant women with factor V Leiden homozygosity: use absolute instead of relative risks
    Saskia Middeldorp
    Thromb Haemost 87:360-1; author reply 361. 2002
  72. ncbi request reprint Molecular screening for familial hypercholesterolaemia: consequences for life and disability insurance
    Sietske J M Homsma
    General Medical Affairs, Dutch Association of Insurers, The Hague, The Netherlands
    Eur J Hum Genet 16:14-7. 2008
    ..0 mmol/l, in the absence of additional risk factors. After implementation of these guidelines, the number of complaints about insurance contracts has decreased markedly...
  73. pmc The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations
    Saskia Kuipers
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Med 4:e290. 2007
    ..The risk of venous thrombosis is approximately 2- to 4-fold increased after air travel, but the absolute risk is unknown. The objective of this study was to assess the absolute risk of venous thrombosis after air travel...
  74. pmc Parenteral anticoagulation may prolong the survival of patients with limited small cell lung cancer: a Cochrane systematic review
    Elie A Akl
    Department of Medicine, State University of New York at Buffalo, NY, USA
    J Exp Clin Cancer Res 27:4. 2008
    ..To determine the efficacy and safety of heparin (unfractionated heparin (UFH) or low-molecular-weight-heparin (LMWH)) and fondaparinux in improving the survival of patients with cancer...