J C Meijers

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc High-density lipoprotein proteome dynamics in human endotoxemia
    Johannes Hm Levels
    Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Proteome Sci 9:34. 2011
  2. pmc SELDI-TOF mass spectrometry of High-Density Lipoprotein
    Johannes Hm Levels
    Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Proteome Sci 5:15. 2007
  3. pmc Expression patterns of protein C inhibitor in mouse development
    Gerry T M Wagenaar
    Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, The Netherlands
    J Mol Histol 41:27-37. 2010
  4. pmc Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study
    Pieter R Tuinman
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Meibergdreef 9, Amsterdam NL 1105 AZ, The Netherlands
    Crit Care 15:R59. 2011
  5. pmc Pharmacokinetics and pharmacodynamics of danaparoid during continuous venovenous hemofiltration: a pilot study
    Anne Cornelie J M de Pont
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Crit Care 11:R102. 2007
  6. pmc Recombinant human activated protein C resets thrombin generation in patients with severe sepsis - a case control study
    Anne Cornelie J M de Pont
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, The Netherlands
    Crit Care 9:R490-7. 2005
  7. pmc The effects of continuous venovenous hemofiltration on coagulation activation
    Catherine S C Bouman
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, PO 22660, 1100 DD Amsterdam, The Netherlands
    Crit Care 10:R150. 2006
  8. pmc Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir
    Eefje Jong
    Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
    AIDS Res Ther 7:9. 2010
  9. doi request reprint Protein C inhibitor
    Joost C M Meijers
    Departments of Vascular Medicine and Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Semin Thromb Hemost 37:349-54. 2011
  10. ncbi request reprint Protein C inhibitor (plasminogen activator inhibitor-3) and the risk of venous thrombosis
    Joost C M Meijers
    Department of Vascular Medicine G1 143, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Br J Haematol 118:604-9. 2002

Detail Information

Publications85

  1. pmc High-density lipoprotein proteome dynamics in human endotoxemia
    Johannes Hm Levels
    Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Proteome Sci 9:34. 2011
    ..abstract:..
  2. pmc SELDI-TOF mass spectrometry of High-Density Lipoprotein
    Johannes Hm Levels
    Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Proteome Sci 5:15. 2007
    ..High-Density Lipoprotein (HDL), one of the main plasma lipoproteins, serves as a docking station for proteins involved in inflammation, coagulation, and lipid metabolism...
  3. pmc Expression patterns of protein C inhibitor in mouse development
    Gerry T M Wagenaar
    Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, The Netherlands
    J Mol Histol 41:27-37. 2010
    ..In general, embryonic PCI expression indicates multifunctional roles of PCI during mouse development. The expression pattern of PCI during lung development suggests its possible involvement in lung morphogenesis and angiogenesis...
  4. pmc Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study
    Pieter R Tuinman
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Meibergdreef 9, Amsterdam NL 1105 AZ, The Netherlands
    Crit Care 15:R59. 2011
    ..We hypothesized that blood transfusion is associated with changes in pulmonary and systemic inflammation and coagulation occurring in patients who do not meet the clinical diagnosis of transfusion-related acute lung injury (TRALI)...
  5. pmc Pharmacokinetics and pharmacodynamics of danaparoid during continuous venovenous hemofiltration: a pilot study
    Anne Cornelie J M de Pont
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Crit Care 11:R102. 2007
    ..In the present study, we analyzed the pharmacokinetics and pharmacodynamics of danaparoid during CVVH in patients with suspected HIT...
  6. pmc Recombinant human activated protein C resets thrombin generation in patients with severe sepsis - a case control study
    Anne Cornelie J M de Pont
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, The Netherlands
    Crit Care 9:R490-7. 2005
    ..The aim of the present study was to evaluate the dynamics of the anticoagulant, anti-inflammatory and pro-fibrinolytic action of rhAPC in patients with severe sepsis, by comparing rhAPC-treated patients with case controls...
  7. pmc The effects of continuous venovenous hemofiltration on coagulation activation
    Catherine S C Bouman
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, PO 22660, 1100 DD Amsterdam, The Netherlands
    Crit Care 10:R150. 2006
    ..In contrast to previous studies, CVVH was performed without anticoagulation...
  8. pmc Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir
    Eefje Jong
    Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
    AIDS Res Ther 7:9. 2010
    ..Thirty-three percent of patients with long-term use of antiretroviral treatment had hsCRP levels above 3 mg/L, which is strongly associated with cardiovascular disease in HIV-uninfected individuals...
  9. doi request reprint Protein C inhibitor
    Joost C M Meijers
    Departments of Vascular Medicine and Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Semin Thromb Hemost 37:349-54. 2011
    ....
  10. ncbi request reprint Protein C inhibitor (plasminogen activator inhibitor-3) and the risk of venous thrombosis
    Joost C M Meijers
    Department of Vascular Medicine G1 143, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Br J Haematol 118:604-9. 2002
    ..However, it is unclear whether adjustment for such factors in the risk models is justified. These results indicate that high levels of PCI may constitute a mild risk factor for venous thrombosis...
  11. ncbi request reprint High levels of coagulation factor XI as a risk factor for venous thrombosis
    J C Meijers
    Department of Hematology, University Medical Center, and Institute of Biomembranes, Utrecht University, The Netherlands
    N Engl J Med 342:696-701. 2000
    ..A deficiency of factor XI is associated with bleeding, but a role of high factor XI levels in thrombosis has not been investigated...
  12. doi request reprint Evolutionary conservation of the lipopolysaccharide binding site of β₂-glycoprotein I
    Cetin Agar
    Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thromb Haemost 106:1069-75. 2011
    ..GPI is highly conserved across the animal kingdom, which suggests that the function of β₂GPI may be more important than anticipated...
  13. ncbi request reprint Increased fibrinolytic activity during use of oral contraceptives is counteracted by an enhanced factor XI-independent down regulation of fibrinolysis: a randomized cross-over study of two low-dose oral contraceptives
    J C Meijers
    Department of Haematology, University Medical Center Utrecht, The Netherlands
    Thromb Haemost 84:9-14. 2000
    ..These data indicate that the OC-induced inhibition of endogenous fibrinolysis takes place in a factor XI-independent way and is more pronounced on desogestrel than on levonorgestrel-containing OC...
  14. ncbi request reprint Effects on coagulation of levonorgestrel- and desogestrel-containing low dose oral contraceptives: a cross-over study
    S Middeldorp
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Thromb Haemost 84:4-8. 2000
    ..The real challenge now becomes to define a pattern of changes in the various systems which, if affected simultaneously, may tip the hemostatic balance towards a prethrombotic state and may lead to overt clinical venous thromboembolism...
  15. ncbi request reprint Protein C inhibitor regulates the thrombin-thrombomodulin complex in the up- and down regulation of TAFI activation
    L O Mosnier
    Dept Haematology, University Medical Center, Utrecht, The Netherlands
    Thromb Haemost 86:1057-64. 2001
    ..The local TM concentration plays an important role in the outcome of this process...
  16. ncbi request reprint The role of protein S in the activation of thrombin activatable fibrinolysis inhibitor (TAFI) and regulation of fibrinolysis
    L O Mosnier
    Dept of Haematology, University Medical Center Utrecht, The Netherlands
    Thromb Haemost 86:1040-6. 2001
    ..The effect of the APC-independent anticoagulant activity of protein S on the activation of TAFI provides a new mechanism for the regulation of fibrinolysis in the early stages of clot formation...
  17. ncbi request reprint Regulation of fibrinolysis in plasma by TAFI and protein C is dependent on the concentration of thrombomodulin
    L O Mosnier
    Dept of Haematology, University Medical Center, Utrecht, The Netherlands
    Thromb Haemost 85:5-11. 2001
    ..These results suggest that fibrinolysis might be differentially regulated by TM in different parts of the body depending on the local TM concentration in the vasculature...
  18. ncbi request reprint The defective down regulation of fibrinolysis in haemophilia A can be restored by increasing the TAFI plasma concentration
    L O Mosnier
    Dept of Haematology, University Medical Center, Utrecht, The Netherlands
    Thromb Haemost 86:1035-9. 2001
    ....
  19. ncbi request reprint Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage
    P F Marx
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Biol Chem 275:12410-5. 2000
    ..Studies of a mutant R302Q-TAFI confirmed identification of this thrombin cleavage site and, furthermore, suggested that inactivation of TAFIa is based on its conformational instability rather than proteolytic cleavage at Arg(302)...
  20. ncbi request reprint Thrombin-activatable fibrinolysis inhibitor deficiency in cirrhosis is not associated with increased plasma fibrinolysis
    T Lisman
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center, 3508 GA Utrecht, The Netherlands
    Gastroenterology 121:131-9. 2001
    ..In this study, the role of the recently discovered inhibitor of fibrinolysis, thrombin-activatable fibrinolysis inhibitor (TAFI) in cirrhosis was examined...
  21. ncbi request reprint Thrombin-activatable fibrinolysis inhibitor (TAFI, plasma procarboxypeptidase B, procarboxypeptidase R, procarboxypeptidase U)
    B N Bouma
    Thrombosis and Hemostasis Laboratory, Department of Haematology, University Medical Center, Utrecht, The Netherlands
    Thromb Res 101:329-54. 2001
    ..In this review, we will describe the properties of basic carboxypeptidases with the emphasis on the role of TAFI in coagulation and fibrinolysis. It cannot be ruled out, however, that TAFI has other, yet undefined, functions in biology...
  22. ncbi request reprint Characterization of mouse thrombin-activatable fibrinolysis inhibitor
    P F Marx
    Department of Haematology, University Medical Center, Utrecht, The Netherlands
    Thromb Haemost 83:297-303. 2000
    ..We conclude that mice have functional TAFI in plasma, which is highly similar to human TAFI. Therefore, genetically modified mice may provide useful models to study the role of TAFI in vivo...
  23. ncbi request reprint C4b-binding protein inhibits the factor V-dependent but not the factor V-independent cofactor activity of protein S in the activated protein C-mediated inactivation of factor VIIIa
    R H van de Poel
    Department of Haematology, University Medical Center, Utrecht, The Netherlands
    Thromb Haemost 85:761-5. 2001
    ..We conclude that C4BP-bound protein S retains its cofactor activity to APC in the factor VIIIa inactivation...
  24. ncbi request reprint Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor
    J C Meijers
    Department of Haematology, University Hospital Utrecht, The Netherlands
    Biochemistry 27:4231-7. 1988
    ..APC and kallikrein formed 1:1 molar complexes with PCI.(ABSTRACT TRUNCATED AT 250 WORDS)..
  25. ncbi request reprint Activation of coagulation factor XI, without detectable contact activation in dengue haemorrhagic fever
    E C van Gorp
    Department of Internal Medicine Slotervaart Hospital, Amsterdam, The Netherlands
    Br J Haematol 113:94-9. 2001
    ..These findings in a human viral infection model are in accordance with earlier findings in bacterial sepsis...
  26. ncbi request reprint Interaction between protein S and complement C4b-binding protein (C4BP). Affinity studies using chimeras containing c4bp beta-chain short consensus repeats
    R H van de Poel
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    J Biol Chem 274:15144-50. 1999
    ..SCR-1+2 inhibited more potently than SCR-1 and SCR-1+3. SCR-3 had no additional effect on SCR-1, and therefore the effect of SCR-2 was specific. In conclusion, beta-chain SCR-2 contributes to the interaction of C4BP with protein S...
  27. ncbi request reprint Complexes of anti-prothrombin antibodies and prothrombin cause lupus anticoagulant activity by competing with the binding of clotting factors for catalytic phospholipid surfaces
    M J Simmelink
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Centre, Utrecht, The Netherlands
    Br J Haematol 113:621-9. 2001
    ....
  28. ncbi request reprint Protein C inhibitor may modulate human sperm-oocyte interactions
    M G Elisen
    Department of Haematology, University Hospital, Utrecht, The Netherlands
    Biol Reprod 58:670-7. 1998
    ....
  29. ncbi request reprint Dimers of beta 2-glycoprotein I mimic the in vitro effects of beta 2-glycoprotein I-anti-beta 2-glycoprotein I antibody complexes
    B C Lutters
    Department of Haematology, University Medical Center, 3508 GA Utrecht, Utrecht University, 3508 TB Utrecht, The Netherlands
    J Biol Chem 276:3060-7. 2001
    ..In conclusion, dimerization of beta(2)GPI explains the in vitro observed effects of beta(2)GPI-anti-beta(2)GPI antibody complexes...
  30. ncbi request reprint Role of blood coagulation factor XI in downregulation of fibrinolysis
    B N Bouma
    Department of Haematology, University Medical Center, Utrecht, The Netherlands
    Curr Opin Hematol 7:266-72. 2000
    ..The new insights in the role of factor XI in coagulation and fibrinolysis may lead to new strategies for the treatment of thrombotic disorders...
  31. ncbi request reprint Characterization of transgenic mice that secrete functional human protein C inhibitor into the circulation
    G T Wagenaar
    Department of Haematology, University Medical Center, Utrecht, The Netherlands
    Thromb Haemost 83:93-101. 2000
    ..These results demonstrate that the human PCI transgenic mice are a suitable model for studying the in vivo role of PCI in blood coagulation...
  32. ncbi request reprint Protein C inhibitor acts as a procoagulant by inhibiting the thrombomodulin-induced activation of protein C in human plasma
    M G Elisen
    Department of Haematology, University Hospital and Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands
    Blood 91:1542-7. 1998
    ..We conclude that TM alters PCI from an anticoagulant into a procoagulant during tissue factor-induced coagulation...
  33. ncbi request reprint C4b-binding protein (C4BP) beta-chain Short Consensus Repeat-2 specifically contributes to the interaction of C4BP with protein S
    R H van de Poel
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Blood Cells Mol Dis 25:279-86. 1999
    ..In conclusion, Beta-chain SCR-2 specifically contributes to the interaction of SCR-1 with protein S...
  34. doi request reprint Binding characteristics of thrombin-activatable fibrinolysis inhibitor to streptococcal surface collagen-like proteins A and B
    Mercedes Valls Seron
    Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Thromb Haemost 106:609-16. 2011
    ..In conclusion, the bacterial proteins SclA and SclB bind to a TAFI fragment encompassing residues G205-D232. Binding of TAFI to the bacteria may allow activation of TAFI, whereafter the enzyme easily dissociates...
  35. ncbi request reprint Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo
    Max Nieuwdorp
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands
    Diabetes 55:480-6. 2006
    ..4 +/- 0.1 to 1.1 +/- 0.2 nmol/l; d-dimer: from 0.27 +/- 0.1 to 0.55 +/- 0.2 g/l; P < 0.05). Taken together, these data indicate a potential role for glycocalyx perturbation in mediating vascular dysfunction during hyperglycemia...
  36. ncbi request reprint Effect of hypobaric hypoxia, simulating conditions during long-haul air travel, on coagulation, fibrinolysis, platelet function, and endothelial activation
    William D Toff
    Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, England
    JAMA 295:2251-61. 2006
    ..It remains unclear whether the reduced cabin pressure and oxygen tension in the airplane cabin create an increased risk compared with seated immobility at ground level...
  37. ncbi request reprint Endotoxaemia induces resistance to activated protein C in healthy humans
    Anne Cornelie J M de Pont
    Department of Intensive Care, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Br J Haematol 134:213-9. 2006
    ..In vitro tests confirmed that an increase in factor VIII induced APC resistance, as measured by both tests. This finding suggests that APC resistance might play a role in the procoagulant state occurring during human endotoxemia...
  38. ncbi request reprint Predilution versus postdilution during continuous venovenous hemofiltration: a comparison of circuit thrombogenesis
    Anne Cornelie J M de Pont
    Departments of Intensive Care, Academic Medical Center, University of Amsterdam, The Netherlands
    ASAIO J 52:416-22. 2006
    ..In summary, predilution and postdilution did not differ with respect to extracorporeal circuit thrombogenesis. During postdilution, baseline platelet count and maximal prefilter pressure were inversely related with circuit survival time...
  39. ncbi request reprint Effects on coagulation and fibrinolysis induced by influenza in mice with a reduced capacity to generate activated protein C and a deficiency in plasminogen activator inhibitor type 1
    Tymen T Keller
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 99:1261-9. 2006
    ..These findings suggest that influenza leads to a prothrombotic state by coagulation activation. Heparin treatment reduces the influenza induced prothrombotic state...
  40. ncbi request reprint High-density lipoprotein attenuates inflammation and coagulation response on endotoxin challenge in humans
    Rakesh S Birjmohun
    Academic Medical Center of Amsterdam, Department of Vascular Medicine, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 27:1153-8. 2007
    ..In the present study, we evaluated whether there is a relation between HDL and sensitivity toward a low-dose endotoxin challenge...
  41. ncbi request reprint Prednisolone dose-dependently influences inflammation and coagulation during human endotoxemia
    Martijn D de Kruif
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 178:1845-51. 2007
    ..These data indicate that prednisolone dose-dependently and differentially influences the systemic activation of different host response pathways during human endotoxemia...
  42. ncbi request reprint Effects of CRP infusion on endothelial function and coagulation in normocholesterolemic and hypercholesterolemic subjects
    Radjesh J Bisoendial
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Lipid Res 48:952-60. 2007
    ..These findings suggest that particularly in hypercholesterolemia, CRP-lowering strategies should be considered in addition to LDL reduction...
  43. doi request reprint Association between thrombotic microangiopathy and reduced ADAMTS13 activity in malignant hypertension
    Bert Jan H van den Born
    Department of Internal and Vascular Medicine, Academic Medical Centre, Meibergdreef 9, Room F4 222, PO Box 22660, 1100 DD, Amsterdam, The Netherlands
    Hypertension 51:862-6. 2008
    ..A severe deficiency could not be demonstrated. More studies are needed to identify the role of ADAMTS13 in the thrombotic microangiopathy and ischemic complications of malignant hypertension...
  44. ncbi request reprint Effects of intra-abdominal administration of recombinant tissue plasminogen activator on coagulation, fibrinolysis and inflammatory responses in experimental polymicrobial peritonitis
    Suzanne Q van Veen
    Department of Surgery, Surgical Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Shock 27:534-41. 2007
    ..Survival rate was unaffected likely due to adverse changes in IL-12 and IL-10 levels...
  45. ncbi request reprint Thrombin-activatable fibrinolysis inhibitor binds to Streptococcus pyogenes by interacting with collagen-like proteins A and B
    Lisa I Påhlman
    Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, SE 22184 Lund, Sweden
    J Biol Chem 282:24873-81. 2007
    ..These findings suggest an important role for TAFI in the modulation of host responses by streptococci...
  46. doi request reprint Fluid loss does not explain coagulation activation during air travel
    Anja J M Schreijer
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Thromb Haemost 99:1053-9. 2008
    ..These findings do not support the hypothesis that fluid loss contributes to thrombus formation during air travel...
  47. doi request reprint Endogenous beta-adrenergic receptors inhibit lipopolysaccharide-induced pulmonary cytokine release and coagulation
    Ida A J Giebelen
    Center for Infection and Immunity Amsterdam CINIMA, University of Amsterdam, Amsterdam, The Netherlands
    Am J Respir Cell Mol Biol 39:373-9. 2008
    ..This study suggests that beta-adrenergic receptors, which are widely expressed in the lungs, serve as negative regulators of pulmonary cytokine release and coagulation induced by LPS and less so during LTA-induced pulmonary inflammation...
  48. ncbi request reprint Alterations in lipoprotein homeostasis during human experimental endotoxemia and clinical sepsis
    Johannes H M Levels
    Department of Experimental Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Biochim Biophys Acta 1771:1429-38. 2007
    ..This may be explained, at least in part, by the fact that PLTP as a positive acute phase protein, can accelerate the alterations in (phospho)lipid homeostasis thereby playing a role in the attenuation of the acute phase response...
  49. ncbi request reprint The antibacterial activity of peptides derived from human beta-2 glycoprotein I is inhibited by protein H and M1 protein from Streptococcus pyogenes
    Maria Nilsson
    Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden
    Mol Microbiol 67:482-92. 2008
    ..Taken together, the data suggest that the interaction between the streptococcal proteins and beta(2)GPI or beta(2)GPI-derived peptides presents a novel mechanism to resist an antibacterial attack by beta(2)GPI-cleavage products...
  50. ncbi request reprint Platelet-activating factor receptor contributes to host defense against Pseudomonas aeruginosa pneumonia but is not essential for the accompanying inflammatory and procoagulant response
    Marieke A D van Zoelen
    Center for Infection and Immunity Amsterdam, Department for Pathology, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 180:3357-65. 2008
    ..Additionally, our results indicate that PAFR signaling is not essential for the induction of a local and systemic inflammatory and procoagulant response to Pseudomonas pneumonia...
  51. pmc Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia
    Michiel E Stegenga
    Center for Infection and Immunity Amsterdam, Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 112:82-9. 2008
    ..These data suggest that type 2 diabetes patients may be especially vulnerable to prothrombotic events during inflammatory states...
  52. ncbi request reprint Proteomic analysis of high-density lipoprotein
    Farhad Rezaee
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Proteomics 6:721-30. 2006
    ..Our approach thus resulted in the identification of a large number of proteins associated with HDL. The combination of proteomic technologies proved to be a powerful and comprehensive tool for the identification of proteins on HDL...
  53. pmc Distribution and kinetics of lipoprotein-bound lipoteichoic acid
    Johannes H M Levels
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Infect Immun 71:3280-4. 2003
    ..H. M. Levels, P. R. Abraham, A. van den Ende, and S. J. H. van Deventer, Infect. Immun. 68:2821-2828, 2001)...
  54. ncbi request reprint Absence of thrombin-activatable fibrinolysis inhibitor protects against sepsis-induced liver injury in mice
    Rosemarijn Renckens
    Laboratory of Experimental Internal Medicine, Amsterdam, The Netherlands
    J Immunol 175:6764-71. 2005
    ..These data argue against an important part for TAFI in the regulation of the procoagulant-fibrinolytic balance in sepsis and reveals a thus far unknown role of TAFI in the occurrence of hepatic necrosis...
  55. ncbi request reprint Generation and characterization of a highly stable form of activated thrombin-activable fibrinolysis inhibitor
    Pauline F Marx
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands
    J Biol Chem 279:6620-8. 2004
    ..In conclusion, by replacing a region in TAFI with the corresponding region in pancreatic CPB, we were able to generate a TAFIa form with a highly stable activity...
  56. ncbi request reprint Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide
    Anita W Rijneveld
    Academic Medical Center, University of Amsterdam, The Netherlands
    Blood 103:1702-9. 2004
    ..These data suggest that the capacity of TM to generate APC does not play a role of importance in the pulmonary response to respiratory pathogens or LPS...
  57. ncbi request reprint Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial
    Jeanet M Kemmeren
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room D 01 335, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Blood 103:927-33. 2004
    ....
  58. ncbi request reprint The impact on coagulation of an intravenous loading dose in addition to a subcutaneous regimen of low-molecular-weight heparin in the initial treatment of acute coronary syndromes
    Nick R Bijsterveld
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 42:424-7. 2003
    ..We sought to quantify the impact of adding an intravenous loading dose to a subcutaneous regimen of enoxaparin in patients with an acute coronary syndrome (ACS)...
  59. ncbi request reprint Amyloid endostatin induces endothelial cell detachment by stimulation of the plasminogen activation system
    Arie Reijerkerk
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Cancer Res 1:561-8. 2003
    ..Our results suggest that amyloid endostatin may inhibit angiogenesis and tumor growth by stimulating the fibrinolytic system...
  60. ncbi request reprint Identification of thrombin activatable fibrinolysis inhibitor (TAFI) in human platelets
    Laurent O Mosnier
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Center Utrecht, The Netherlands
    Blood 101:4844-6. 2003
    ..These results establish the presence of TAFI in platelets and suggest a role for platelet-derived TAFI in the protection of the clot against fibrinolysis...
  61. ncbi request reprint Effects of IC14, an anti-CD14 antibody, on coagulation and fibrinolysis during low-grade endotoxemia in humans
    Annelies Verbon
    Department of Infectious Diseases, Tropical Medicine, and AIDS, Academic Medical Center, University of Amsterdam, The Netherlands
    J Infect Dis 187:55-61. 2003
    ..These results suggest that different hemostatic responses during endotoxemia may proceed via CD14-dependent and -independent pathways...
  62. ncbi request reprint Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers
    Nick R Bijsterveld
    Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circulation 106:2550-4. 2002
    ..The aim of this study was to investigate whether recombinant factor VIIa (rFVIIa) could neutralize the anticoagulant effects of subcutaneously administered fondaparinux...
  63. ncbi request reprint Enhanced coagulation activation in preeclampsia: the role of APC resistance, microparticles and other plasma constituents
    Marja J VanWijk
    Department of Obstetrics, Academic Medical Center, Amsterdam, The Netherlands
    Thromb Haemost 88:415-20. 2002
    ..In contrast, APC resistance can explain coagulation activation in pregnancy, while enhanced coagulation activation in preeclampsia results, in part, from an increased thrombin generating capacity of plasma independent of APC resistance...
  64. ncbi request reprint Plasmin-mediated activation and inactivation of thrombin-activatable fibrinolysis inhibitor
    Pauline F Marx
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Centre, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Biochemistry 41:6688-96. 2002
    ..The 44.3-kDa fragment is no longer activatable since it lacks part of the catalytic center. We concluded that plasmin can cleave at several sites in TAFI and that this contributes to the regulation of TAFI and TAFIa...
  65. ncbi request reprint Rebound thrombin generation after heparin therapy in unstable angina. A randomized comparison between unfractionated and low-molecular-weight heparin
    Nick R Bijsterveld
    Department of Cardiology, Academic Medical Center, Amsterdam, Netherlands
    J Am Coll Cardiol 39:811-7. 2002
    ..This study compared rebound coagulation in patients with acute coronary syndrome patients after discontinuation of unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH)...
  66. ncbi request reprint Role of zinc ions in activation and inactivation of thrombin-activatable fibrinolysis inhibitor
    Pauline F Marx
    Thrombosis and Haemostasis Laboratory, Department of Haematology, University Medical Centre, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Biochemistry 41:1211-6. 2002
    ....
  67. ncbi request reprint Inhibition of fibrinolysis by recombinant factor VIIa in plasma from patients with severe hemophilia A
    Ton Lisman
    Thrombosis and Haemostasis Laboratory, Department of Haematology, Institute of Biomembranes, Van Creveldkliniek, University Medical Centre, Utrecht University, The Netherlands
    Blood 99:175-9. 2002
    ..However, a large variability in antifibrinolytic potential of rFVIIa exists between patients...
  68. ncbi request reprint Anti-inflammatory and anticoagulant effects of pravastatin in patients with type 2 diabetes
    Dirkje W Sommeijer
    Laboratory for Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, and Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
    Diabetes Care 27:468-73. 2004
    ..Our objective was to evaluate the effect of pravastatin (40 mg/day) on coagulation and inflammation markers in type 2 diabetic patients...
  69. ncbi request reprint Recombinant factor VIIa reverses the anticoagulant effect of the long-acting pentasaccharide idraparinux in healthy volunteers
    Nick R Bijsterveld
    Department of Cardiology, Room F3 241, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Br J Haematol 124:653-8. 2004
    ..We conclude that rFVIIa has significant effects on the idraparinux-inhibited thrombin generation and clotting parameters. These results suggest that rFVIIa may be useful in serious bleeding complications in idraparinux treated patients...
  70. ncbi request reprint Effects of clopidogrel on the rebound hypercoagulable state after heparin discontinuation in patients with acute coronary syndromes
    Marcello Di Nisio
    J Am Coll Cardiol 46:1582-3. 2005
  71. ncbi request reprint Hypercoagulability in the metabolic syndrome
    Max Nieuwdorp
    Department of Vascular Medicine, AMC, Meibergdreef 9 room F4 159 2, 1100 DD Amsterdam, The Netherlands
    Curr Opin Pharmacol 5:155-9. 2005
    ..In view of the rising incidence of metabolic syndrome even at a young age, both the incidence of venous thromboembolism and the effect of intervention on markers of hypercoagulability in metabolic syndrome call for further studies...
  72. ncbi request reprint Activation of inflammation and coagulation after infusion of C-reactive protein in humans
    Radjesh J Bisoendial
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 96:714-6. 2005
    ..1) mg/L, and subsequently both inflammation and coagulation were activated. This sequence of events suggests that CRP is not only a well known marker of cardiovascular disease, but is also probably a mediator of atherothrombotic disease...
  73. ncbi request reprint Alveolar fibrinolytic capacity suppressed by injurious mechanical ventilation
    Peter Dahlem
    Pediatric Intensive Care Unit, Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1100 DD Amsterdam, The Netherlands
    Intensive Care Med 31:724-32. 2005
    ..To investigate the effect of mechanical ventilation on alveolar fibrinolytic capacity...
  74. ncbi request reprint Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation
    Kamran Bakhtiari
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Crit Care Med 32:2416-21. 2004
    ..The aim of this study was to prospectively validate this scoring system and assess its feasibility, sensitivity, and specificity in a consecutive series of intensive care patients...
  75. ncbi request reprint Absence of mutations in the PCI gene in subfertile men
    Judith Gianotten
    Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Mol Hum Reprod 10:807-13. 2004
    ....
  76. ncbi request reprint Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein
    Thomas Renne
    Institute for Biochemistry II, Johann Wolfgang Goethe University of Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    J Biol Chem 277:4892-9. 2002
    ..Our data show that HK binding to FXI involves multiple apple domains, with F2 being most important. The findings demonstrate a similarity in mechanism for FXI and prekallikrein binding to HK...
  77. ncbi request reprint New insights into factors affecting clot stability: A role for thrombin activatable fibrinolysis inhibitor (TAFI; plasma procarboxypeptidase B, plasma procarboxypeptidase U, procarboxypeptidase R)
    Bonno N Bouma
    Thrombosis and Hemostasis Laboratory, Department of Hematology, University Medical Center, Utrecht, The Netherlands
    Semin Hematol 41:13-9. 2004
    ..In addition, the importance of TAFI in the coagulation process and how changes in its availability may contribute to bleeding or thrombotic disorders are discussed...
  78. ncbi request reprint The role of the fibrinolytic system in corneal angiogenesis
    J Mathijs Vogten
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Angiogenesis 6:311-6. 2003
    ..Our results corroborate earlier findings that angiogenesis in the mouse cornea is dependent on PAI-1 and plasminogen. The absence of tPA, uPA or TAFI did not affect the formation of new vessels in the cornea...
  79. ncbi request reprint KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium
    Rob J Dekker
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Blood 107:4354-63. 2006
    ..These results establish that KLF2 acts as a central transcriptional switch point between the quiescent and activated states of the adult endothelial cell...
  80. ncbi request reprint Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity
    Thijs W H Pols
    Medical Biochemistry, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Biochem Biophys Res Commun 366:910-6. 2008
    ..Taken together, our study demonstrates that Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity...
  81. ncbi request reprint Dominant factor XI deficiency caused by mutations in the factor XI catalytic domain
    Dmitri V Kravtsov
    Department of Pathology, Vanderbilt University, Nashville, TN 37232, USA
    Blood 104:128-34. 2004
    ....
  82. ncbi request reprint Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: Opposite and synergistic effects of factors XI and XII
    Carine J M Doggen
    Department of Clinical Epidemiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Blood 108:4045-51. 2006
    ..2 (ORadj, 3.2; 95% CI, 2.0-5.1). Thus, factors XIc and XIIc have opposite and synergistic effects on the risk of myocardial infarction in men; factor VIIIc and factor IXc increase the risk...
  83. doi request reprint Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation
    Pauline F Marx
    Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 112:2803-9. 2008
    ..This represents a novel mechanism of enzyme control that enables TAFI to regulate its activity in plasma in the absence of specific inhibitors...
  84. ncbi request reprint Pentoxifylline reduces fibrin deposition and prolongs survival in neonatal hyperoxic lung injury
    Simone A J ter Horst
    Department of Pediatrics, Division of Neonatology, Leiden Univ Medical Center, P3 25, PO Box 9600, 2300 RC, Leiden, The Netherlands
    J Appl Physiol 97:2014-9. 2004
    ..029) in the pentoxifylline group. Pentoxifylline treatment attenuates alveolar fibrin deposition and prolongs survival in preterm rat pups with neonatal hyperoxic lung injury, probably by reducing capillary-alveolar protein leakage...
  85. ncbi request reprint Reduced plasma fibrinolytic potential is a risk factor for venous thrombosis
    Ton Lisman
    Thrombosis and Haemostasis Laboratory, Department of Haematology G 03 647, University Medical Centre, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Blood 105:1102-5. 2005
    ..6 for 90th percentile). Taken together, these results indicate that plasma hypofibrinolysis constitutes a risk factor for venous thrombosis, with a doubling of the risk at clot lysis times that are present in 10% of the population...