A J Meijer

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy
    Séverine Lorin
    EA4530, Faculty of Pharmacy, University Paris Sud, Chatenay Malabry, France
    Autophagy 9:850-60. 2013
  2. ncbi request reprint Amino acid-dependent signal transduction and insulin sensitivity
    A J Meijer
    Department of Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands
    Curr Opin Clin Nutr Metab Care 2:207-11. 1999
  3. ncbi request reprint Signalling and autophagy regulation in health, aging and disease
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Mol Aspects Med 27:411-25. 2006
  4. ncbi request reprint AMP-activated protein kinase and autophagy
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands
    Autophagy 3:238-40. 2007
  5. ncbi request reprint Macroautophagy: protector in the diabetes drama?
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands
    Autophagy 3:523-6. 2007
  6. doi request reprint Autophagy: a sweet process in diabetes
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands
    Cell Metab 8:275-6. 2008
  7. ncbi request reprint Autophagy research: lessons from metabolism
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Autophagy 5:3-5. 2009
  8. doi request reprint Autophagy: regulation and role in disease
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands
    Crit Rev Clin Lab Sci 46:210-40. 2009
  9. doi request reprint Autophagy: regulation by energy sensing
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands
    Curr Biol 21:R227-9. 2011
  10. ncbi request reprint Amino acid signalling and the integration of metabolism
    Alfred J Meijer
    Department of Biochemistry, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Biochem Biophys Res Commun 313:397-403. 2004

Collaborators

Detail Information

Publications33

  1. pmc Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy
    Séverine Lorin
    EA4530, Faculty of Pharmacy, University Paris Sud, Chatenay Malabry, France
    Autophagy 9:850-60. 2013
    ..The data suggest a dual mechanism by which glutamate dehydrogenase activity modulates autophagy, i.e., by activating MTORC1 and by limiting the formation of reactive oxygen species...
  2. ncbi request reprint Amino acid-dependent signal transduction and insulin sensitivity
    A J Meijer
    Department of Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands
    Curr Opin Clin Nutr Metab Care 2:207-11. 1999
    ..Amino acid-dependent signal transduction is present in all insulin-sensitive tissues and in pancreatic beta cells. A defect in amino acid-dependent signal transduction may result in phenomena similar to those found in diabetes mellitus...
  3. ncbi request reprint Signalling and autophagy regulation in health, aging and disease
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Mol Aspects Med 27:411-25. 2006
    ..Autophagy is controlled by complex signalling pathways, including that used by insulin. In these pathways, phosphatidylinositol 3-kinases and the protein kinase mTOR play important roles...
  4. ncbi request reprint AMP-activated protein kinase and autophagy
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands
    Autophagy 3:238-40. 2007
    ..The data suggest that in mammalian cells, as in yeast, AMPK is required for autophagy...
  5. ncbi request reprint Macroautophagy: protector in the diabetes drama?
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands
    Autophagy 3:523-6. 2007
    ..We discuss the possibility that this may be a useful mechanism for eliminating damaged mitochondria and other cell structures to prevent cell death...
  6. doi request reprint Autophagy: a sweet process in diabetes
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands
    Cell Metab 8:275-6. 2008
    ..2008) provide evidence that basal autophagy is necessary to maintain the architecture and function of pancreatic beta cells and that its induction in diabetic mice protects beta cells against damage by oxidative stress...
  7. ncbi request reprint Autophagy research: lessons from metabolism
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Autophagy 5:3-5. 2009
    ..Unfortunately, unawareness of possible metabolic complications may sometimes lead to misinterpretation of the data obtained...
  8. doi request reprint Autophagy: regulation and role in disease
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands
    Crit Rev Clin Lab Sci 46:210-40. 2009
    ....
  9. doi request reprint Autophagy: regulation by energy sensing
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands
    Curr Biol 21:R227-9. 2011
    ..Two recent studies have shed light on the molecular mechanism by which AMPK controls autophagic flux...
  10. ncbi request reprint Amino acid signalling and the integration of metabolism
    Alfred J Meijer
    Department of Biochemistry, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Biochem Biophys Res Commun 313:397-403. 2004
    ..Finally, amino acid-dependent signalling controls the production of leptin by adipocytes, and thus contributes to the regulation of appetite...
  11. ncbi request reprint Amino acids as regulators and components of nonproteinogenic pathways
    Alfred J Meijer
    Department of Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Nutr 133:2057S-2062S. 2003
    ..Amino acid-dependent signaling also promotes insulin production by beta-cells. This further adds to the anabolic properties of amino acids. It is concluded that amino acids are important regulators of major metabolic pathways...
  12. ncbi request reprint The effects of carbohydrate variation in isocaloric diets on glycogenolysis and gluconeogenesis in healthy men
    P H Bisschop
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    J Clin Endocrinol Metab 85:1963-7. 2000
    ..In contrast, dietary carbohydrate content affects the postabsorptive rate of gluconeogenesis minimally, as evidenced by only a slight increase in gluconeogenesis during severe carbohydrate restriction...
  13. ncbi request reprint Dietary fat content alters insulin-mediated glucose metabolism in healthy men
    P H Bisschop
    Departments of Endocrinology and Metabolism, Clinical Chemistry Laboratory of Endocrinology, and Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Clin Nutr 73:554-9. 2001
    ..A high dietary fat intake is involved in the pathogenesis of insulin resistance...
  14. pmc Fatty acid and amino acid modulation of glucose cycling in isolated rat hepatocytes
    L A Gustafson
    Department of Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Biochem J 358:665-71. 2001
    ..Variation in glucose 6-phosphate does not always result in activity changes of GSa. Activation of glucose 6-phosphatase flux by fatty acids may contribute to the increased hepatic glucose production as seen in Type 2 diabetes...
  15. ncbi request reprint Dietary carbohydrate deprivation increases 24-hour nitrogen excretion without affecting postabsorptive hepatic or whole body protein metabolism in healthy men
    P H Bisschop
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    J Clin Endocrinol Metab 88:3801-5. 2003
    ..By deduction, dietary carbohydrate is required for an optimal regulation of absorptive, rather than postabsorptive, protein metabolism...
  16. ncbi request reprint Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects
    M J Serlie
    Department of Endocrinology and Metabolism, Laboratory of Endocrinology, Academic Medical Center F5 169, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Clin Endocrinol Metab 92:1524-9. 2007
    ..Increased plasma free fatty acid (FFA) concentrations may be in part responsible for the increased levels of ceramide in skeletal muscle of obese subjects...
  17. pmc Inhibition of autophagic proteolysis by inhibitors of phosphoinositide 3-kinase can interfere with the regulation of glycogen synthesis in isolated hepatocytes
    Peter F Dubbelhuis
    Department of Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Biochem J 368:827-33. 2002
    ....
  18. ncbi request reprint Clofibrate improves glucose tolerance in fat-fed rats but decreases hepatic glucose consumption capacity
    Lori A Gustafson
    Department of Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Hepatol 37:425-31. 2002
    ..High-fat (HF) diets cause glucose intolerance. Fibrates improve glucose tolerance. We have tried to obtain information on possible hepatic mechanisms contributing to this effect...
  19. ncbi request reprint Free fatty acids increase hepatic glycogen content in obese males
    G Allick
    Metabolism Research Unit, Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands
    Metabolism 53:886-93. 2004
    ....
  20. ncbi request reprint The effect of carbohydrate and fat variation in euenergetic diets on postabsorptive free fatty acid release
    Peter H Bisschop
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Br J Nutr 87:555-9. 2002
    ..01 compared with the other diets). A euenergetic high-fat diet results in increased postabsorptive FFA release and fat oxidation, whereas a euenergetic high-carbohydrate diet does not affect these variables of fat metabolism...
  21. ncbi request reprint Chronic treatment with pioglitazone does not protect obese patients with diabetes mellitus type II from free fatty acid-induced insulin resistance
    Mireille J Serlie
    Department of Endocrinology and Metabolism, Academic Medical Center, F5 169, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Clin Endocrinol Metab 92:166-71. 2007
    ..Thiazolidinediones increase peripheral insulin sensitivity and decrease plasma free fatty acids (FFA). However, their exact mechanism of action has not been fully elucidated...
  22. ncbi request reprint Ischemic preconditioning, insulin, and morphine all cause hexokinase redistribution
    Coert J Zuurbier
    Dept of Anesthesiology, Academic Medical Center, Univ of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 289:H496-9. 2005
    ..Association of HK with mitochondria may promote inhibition of the mitochondrial permeability transition pore and thereby reduce cell death and apoptosis...
  23. ncbi request reprint Low-fat, high-carbohydrate and high-fat, low-carbohydrate diets decrease primary bile acid synthesis in humans
    Peter H Bisschop
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Netherlands
    Am J Clin Nutr 79:570-6. 2004
    ..Dietary fat content influences bile salt metabolism, but quantitative data from controlled studies in humans are scarce...
  24. ncbi request reprint A low-carbohydrate/high-fat diet improves glucoregulation in type 2 diabetes mellitus by reducing postabsorptive glycogenolysis
    Gideon Allick
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands
    J Clin Endocrinol Metab 89:6193-7. 2004
    ....
  25. ncbi request reprint Hepatic amino acid-dependent signaling is under the control of AMP-dependent protein kinase
    Peter F Dubbelhuis
    Department of Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    FEBS Lett 521:39-42. 2002
    ..Protein synthesis is strongly inhibited when AMPK is activated. It is concluded that amino acid-dependent signaling, a protein-anabolic signal, can be effectively antagonized by activation of AMPK...
  26. doi request reprint Amino acid regulation of autophagosome formation
    Alfred J Meijer
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
    Methods Mol Biol 445:89-109. 2008
    ..The mechanism by which amino acids stimulate mTORdependent signaling (and other signaling pathways), and its molecular connection with the autophagic machinery, is still unknown...
  27. ncbi request reprint Wash-out of the non-heart-beating donor liver: a matter of flush solution and temperature?
    Maud Bessems
    Surgical Laboratory, Department of Surgery, Academic Medical Center, AZ Amsterdam, The Netherlands
    Liver Int 26:880-8. 2006
    ..The aim of this study was to investigate the type of flush solution, temperature and anticoagulant content on the wash-out of the non-heart-beating donor (NHBD) rat liver...
  28. ncbi request reprint Sphingomyelinase treatment of rat hepatocytes inhibits cell-swelling-stimulated glycogen synthesis by causing cell shrinkage
    D A Van Sluijters
    Department of Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Biochem 266:653-9. 1999
    ..It is concluded that the decrease in cell volume, following the breakdown of sphingomyelin in the plasma membrane of the hepatocyte, may contribute to the abnormal metabolism of glucose when TNF-alpha levels are high...
  29. doi request reprint Regulation of adiponectin secretion by insulin and amino acids in 3T3-L1 adipocytes
    Regje M E Blumer
    Department of Endocrinology and Metabolism, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Metabolism 57:1655-62. 2008
    ..In conclusion, adiponectin production is substrate driven. Phosphatidylinositol 3-kinase and an acidic lysosomal pH, but not amino acid-mediated mTOR signaling or lysosomal breakdown, are involved in adiponectin secretion...
  30. ncbi request reprint Improved machine perfusion preservation of the non-heart-beating donor rat liver using Polysol: a new machine perfusion preservation solution
    Maud Bessems
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Liver Transpl 11:1379-88. 2005
    ..In conclusion, preservation of the NHBD rat liver by hypothermic MP is superior to CS. Furthermore, MP using Polysol results in better-quality liver preservation compared with using UW-G...
  31. ncbi request reprint Regulation and role of autophagy in mammalian cells
    Alfred J Meijer
    Department of Biochemistry, Academic Medical Center, University of Amsterdam, Meibergreef 15, 1105 AZ Amsterdam, The Netherlands
    Int J Biochem Cell Biol 36:2445-62. 2004
    ..The aim of the present review is to give an overview of autophagy and to discuss its regulation by activators and effectors of mTOR and GTPases...
  32. ncbi request reprint AMP-activated protein kinase and the regulation of autophagic proteolysis
    Daniel Meley
    INSERM U756, Faculte de Pharmacie, Universite Paris Sud 11, 92296 Chatenay Malabry, France
    J Biol Chem 281:34870-9. 2006
    ..These results suggest that the inhibition of autophagy by AICAR is not related to its ability to activate AMPK. We conclude that in mammalian cells, as in yeast, AMPK is required for autophagy...
  33. doi request reprint Nutrient sensing: TOR's Ragtime
    Alfred J Meijer
    Nat Cell Biol 10:881-3. 2008