V V Lukashov

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Epidemiological networks and drug resistance of HIV type 1 in Krasnoyarsk region, Russia
    Olga A Rumyantseva
    Krasnoyarsk Regional AIDS Center, Krasnoyarsk, Russia
    AIDS Res Hum Retroviruses 25:931-6. 2009
  2. pmc Cell-associated HIV RNA: a dynamic biomarker of viral persistence
    Alexander O Pasternak
    Department of Medical Microbiology, Laboratory of Experimental Virology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam 1105 AZ, The Netherlands
    Retrovirology 10:41. 2013
  3. pmc Occult hepatitis B infection: an evolutionary scenario
    Formijn J van Hemert
    Department of Medical Microbiology, Laboratory of Experimental Virology, Center for Infection and Immunity Amsterdam Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Virol J 5:146. 2008
  4. pmc Different rates of (non-)synonymous mutations in astrovirus genes; correlation with gene function
    Formijn J van Hemert
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, The Netherlands
    Virol J 4:25. 2007
  5. ncbi request reprint Epidemiology of HIV-1 and emerging problems
    V V Lukashov
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Int J Antimicrob Agents 16:463-6. 2000
  6. pmc Evolutionary relationships among parvoviruses: virus-host coevolution among autonomous primate parvoviruses and links between adeno-associated and avian parvoviruses
    V V Lukashov
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Virol 75:2729-40. 2001
  7. ncbi request reprint Selection by AZT and rapid replacement in the absence of drugs of HIV type 1 resistant to multiple nucleoside analogs
    V V Lukashov
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 17:807-18. 2001
  8. ncbi request reprint Evolutionary relationships among Astroviridae
    Vladimir V Lukashov
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Gen Virol 83:1397-405. 2002
  9. ncbi request reprint Genetic differences between human immunodeficiency virus type 1 subpopulations in faeces and serum
    L van der Hoek
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Gen Virol 79:259-67. 1998
  10. ncbi request reprint Host-related nucleotide composition and codon usage as driving forces in the recent evolution of the Astroviridae
    Formijn J van Hemert
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Virology 361:447-54. 2007

Collaborators

Detail Information

Publications31

  1. doi request reprint Epidemiological networks and drug resistance of HIV type 1 in Krasnoyarsk region, Russia
    Olga A Rumyantseva
    Krasnoyarsk Regional AIDS Center, Krasnoyarsk, Russia
    AIDS Res Hum Retroviruses 25:931-6. 2009
    ..Remarkably, 26 of 47 (55%) patients under HAART with detectable virus loads did not have any known drug-resistant mutation, indicating the need to increase compliance to therapy...
  2. pmc Cell-associated HIV RNA: a dynamic biomarker of viral persistence
    Alexander O Pasternak
    Department of Medical Microbiology, Laboratory of Experimental Virology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam 1105 AZ, The Netherlands
    Retrovirology 10:41. 2013
    ..Potential value of this biomarker for monitoring the response to ART and to novel HIV eradication therapies is highlighted...
  3. pmc Occult hepatitis B infection: an evolutionary scenario
    Formijn J van Hemert
    Department of Medical Microbiology, Laboratory of Experimental Virology, Center for Infection and Immunity Amsterdam Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Virol J 5:146. 2008
    ..To gain insight into the mechanism of the development of occult infection, we compared the full-length HBV genome from a blood donor carrying an occult infection (d4) with global genotype D genomes...
  4. pmc Different rates of (non-)synonymous mutations in astrovirus genes; correlation with gene function
    Formijn J van Hemert
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, The Netherlands
    Virol J 4:25. 2007
    ..Analyses of synonymous substitutions displayed a loss of tree structure, suggesting either saturation of the substitution model or a deviant pattern of synonymous substitutions in certain virus species...
  5. ncbi request reprint Epidemiology of HIV-1 and emerging problems
    V V Lukashov
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Int J Antimicrob Agents 16:463-6. 2000
    ..These viruses are highly resistant to AZT, 3TC, and d4T, and moderately resistant to ddI and ddC...
  6. pmc Evolutionary relationships among parvoviruses: virus-host coevolution among autonomous primate parvoviruses and links between adeno-associated and avian parvoviruses
    V V Lukashov
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Virol 75:2729-40. 2001
    ..The two lineages of human parvoviruses may have resulted from independent ancient zoonotic infections. Our results provide an argument for reclassification of Parvovirinae based on evolutionary relationships among viruses...
  7. ncbi request reprint Selection by AZT and rapid replacement in the absence of drugs of HIV type 1 resistant to multiple nucleoside analogs
    V V Lukashov
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 17:807-18. 2001
    ..The insertion mutants attained high virus loads, demonstrating that virus load cannot be used as a direct measure of virus fitness...
  8. ncbi request reprint Evolutionary relationships among Astroviridae
    Vladimir V Lukashov
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Gen Virol 83:1397-405. 2002
    ....
  9. ncbi request reprint Genetic differences between human immunodeficiency virus type 1 subpopulations in faeces and serum
    L van der Hoek
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Gen Virol 79:259-67. 1998
    ..The faecal subpopulations in these 4 persons showed limited nonsynonymous substitutions compared to synonymous substitutions, indicating that purifying selection is operational on these subpopulations...
  10. ncbi request reprint Host-related nucleotide composition and codon usage as driving forces in the recent evolution of the Astroviridae
    Formijn J van Hemert
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Virology 361:447-54. 2007
    ..This is the first demonstration of nucleotide composition and codon usage being active driving forces during the recent evolutionary history of a virus group in the host-parasite system...
  11. ncbi request reprint Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses
    J Zsiros
    Department of Pediatric Oncology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Gen Virol 79:61-70. 1998
    ..The evolution of this class of endogenous retroelements is discussed...
  12. ncbi request reprint Subtype-specific sequence variation of the HIV type 1 long terminal repeat and primer-binding site
    M P de Baar
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 16:499-504. 2000
    ..After analysis of all sequences, we could describe subtype-specific differences in sequences encompassing the regulatory elements of the LTR and the PBS motif...
  13. ncbi request reprint Recent evolutionary history of human immunodeficiency virus type 1 subtype B: reconstruction of epidemic onset based on sequence distances to the common ancestor
    Vladimir V Lukashov
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, Meibergdreef 15, 1105 AZ The Netherlands
    J Mol Evol 54:680-91. 2002
    ..In contrast, analysis of synonymous env V3 distances provided accurate estimates of the onset years for the outbreaks we studied...
  14. ncbi request reprint Simultaneous introduction of HIV type 1 subtype A and B viruses into injecting drug users in southern Ukraine at the beginning of the epidemic in the former Soviet Union
    Alexey A Nabatov
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 18:891-5. 2002
    ..Phylogenetic analysis of viruses from the FSU supported the epidemiological data suggesting that the HIV-1 epidemic in the FSU started in southern Ukraine...
  15. doi request reprint Transmission networks of HIV-1 among men having sex with men in the Netherlands
    Daniela Bezemer
    HIV Monitoring Foundation, Academic Medical Centre, Amsterdam, The Netherlands
    AIDS 24:271-82. 2010
    ..To obtain insight in the HIV-1 transmission networks among men having sex with men (MSM) in the Netherlands...
  16. ncbi request reprint Mosaic amino acid conservation in 3D-structures of surface protein and polymerase of hepatitis B virus
    Formijn J van Hemert
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Virology 370:362-72. 2008
    ....
  17. ncbi request reprint Independent evolution of overlapping polymerase and surface protein genes of hepatitis B virus
    Hans L Zaaijer
    Laboratory of Clinical Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Gen Virol 88:2137-43. 2007
    ....
  18. ncbi request reprint Characterization of an HIV-1 group M variant that is distinct from the known subtypes
    Lia van der Hoek
    Laboratory of Experimental Virology, and Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 23:466-70. 2007
    ..Awaiting the discovery of at least two additional, epidemiologically unrelated patients with a phylogenetically related HIV-1 variant, we can designate this variant a new HIV-1 subtype, or a distinct branch of subtype K...
  19. ncbi request reprint Codon and amino acid usage in retroviral genomes is consistent with virus-specific nucleotide pressure
    Ben Berkhout
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 18:133-41. 2002
    ..For instance, the typical trends in nucleotide usage could influence the molecular phylogenetic reconstruction of the family Retroviridae...
  20. ncbi request reprint Combination antiretroviral therapy failure and HIV super-infection
    Daniela Bezemer
    HIV Monitoring Foundation, Academic Medical Centre, University of Amsterdam, The Netherlands
    AIDS 22:309-11. 2008
    ..We analysed HIV pol genes obtained before start of initially successful cART and during failure while still on cART in 101 patients. Difference in precART and cART failure sequences were explained by evolution and not by super-infection...
  21. pmc Cellular levels of HIV unspliced RNA from patients on combination antiretroviral therapy with undetectable plasma viremia predict the therapy outcome
    Alexander O Pasternak
    Department of Medical Microbiology, Laboratory of Experimental Virology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 4:e8490. 2009
    ..Yet, cART fails in a substantial proportion of patients after the apparent success. No laboratory markers are known that are predictive of cART outcome in initial responders during the period of undetectable plasma viremia...
  22. pmc Identification of sequential viral escape mutants associated with altered T-cell responses in a human immunodeficiency virus type 1-infected individual
    Mark J Geels
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Virol 77:12430-40. 2003
    ..These results demonstrate the sequential accumulation of CTL escape in a patient during disease progression, indicating that multiple combinations of T-cell epitopes are required to control viremia...
  23. pmc Highly sensitive methods based on seminested real-time reverse transcription-PCR for quantitation of human immunodeficiency virus type 1 unspliced and multiply spliced RNA and proviral DNA
    Alexander O Pasternak
    Department of Medical Microbiology, Laboratory of Experimental Virology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam 1105 AZ, The Netherlands
    J Clin Microbiol 46:2206-11. 2008
    ..These easy-to-perform methods can be widely used in research, including clinical studies, to monitor intracellular processes of virus replication...
  24. pmc Reversal of human immunodeficiency virus type 1 IIIB to a neutralization-resistant phenotype in an accidentally infected laboratory worker with a progressive clinical course
    T Beaumont
    Department of Clinical Viro-Immunology, CLB Sanquin, and Laboratory for Experimental and Clinical Immunology, Amsterdam, The Netherlands
    J Virol 75:2246-52. 2001
    ..Our results imply that the neutralization resistance of primary HIV may indeed be considered an escape mechanism from humoral immune control...
  25. pmc Shortening of the symptom-free period in rhesus macaques is associated with decreasing nonsynonymous variation in the env variable regions of simian immunodeficiency virus SIVsm during passage
    P J Valli
    Department of Human Retrovirology, Academic Medical Centre, Amsterdam, The Netherlands
    J Virol 72:7494-500. 1998
    ....
  26. ncbi request reprint The HIV type 1 epidemic in Belarus: predominance of Eastern European subtype A strains and circulation of subtype B viruses
    Natallia V Lazouskaya
    Department of Clinical Virology, Institute for Epidemiology and Microbiology, 220114 Minsk, Belarus
    AIDS Res Hum Retroviruses 21:830-3. 2005
    ..Extrapolation of these results to the total population of HIV-1-infected individuals in Belarus allowed us to estimate that IDU-A viruses account for nearly 95% of HIV-1 infections in Belarus...
  27. ncbi request reprint Analysis of two human parvovirus PARV4 genotypes identified in human plasma for fractionation
    Jacqueline F Fryer
    Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK
    J Gen Virol 88:2162-7. 2007
    ..This extended analysis of nearly full-length PARV4 and PARV5 sequences suggests that they are closely related genotypes and the use of a single virus name, PARV4, comprising genotypes 1 and 2 (previously termed PARV5) is proposed...
  28. pmc Discovery of a novel human picornavirus in a stool sample from a pediatric patient presenting with fever of unknown origin
    Morris S Jones
    Clinical Investigation Facility, David Grant USAF Medical Center, 101 Bodin Circle, Travis AFB, CA 94535, USA
    J Clin Microbiol 45:2144-50. 2007
    ..Nearly full-length viral genome sequencing and phylogenetic analysis demonstrate that this virus is a member of the Cardiovirus genus of the Picornaviridae family...
  29. ncbi request reprint The rate of epidemiological and virological changes during the transition from nascent to concentrated HIV epidemic stage in the former Soviet Union countries
    Alexey A Nabatov
    Department of Molecular Cellular Biology and Immunology, VU Medical Center, Free University Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 23:183-92. 2007
    ....
  30. pmc New DNA viruses identified in patients with acute viral infection syndrome
    Morris S Jones
    Blood Systems Research Institute, 270 Masonic Ave, San Francisco, California 94118, USA
    J Virol 79:8230-6. 2005
    ....
  31. ncbi request reprint Identification, phenotypic analysis, and full-length nucleotide sequence of a Dutch Coxsackievirus A20 isolate
    Hein J Boot
    Laboratory of Vaccine Preventable Diseases, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Virus Genes 34:75-85. 2007
    ..On the basis of the phylogenetic analysis of the P2 and P3 region we expect that strain 89490 can act as recombination partner for the attenuated poliovirus strains of the Oral Polio Vaccine (OPV)...