B G Loos

Summary

Affiliation: Academic Centre for Dentistry Amsterdam
Country: The Netherlands

Publications

  1. ncbi Lymphocyte numbers and function in relation to periodontitis and smoking
    Bruno G Loos
    Department of Periodontology, Academic Center for Dentistry Amsterdam, Amsterdam, The Netherlands
    J Periodontol 75:557-64. 2004
  2. ncbi [Genetics and periodontitis]
    B G Loos
    Afdeling Parodontologie, Secties Parodontologie en Orale Microbiologie van het Academisch Centrum Tandheelkunde Amsterdam ACTA
    Ned Tijdschr Tandheelkd 115:87-92. 2008
  3. ncbi Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients
    B G Loos
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, The Netherlands
    J Periodontol 71:1528-34. 2000
  4. doi What is the Contribution of Genetics to Periodontal Risk?
    Bruno G Loos
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam, VU University Amsterdam, Gustav Mahlerlaan 3004, Amsterdam 1081 LA, The Netherlands Electronic address
    Dent Clin North Am 59:761-80. 2015
  5. ncbi Identification of genetic risk factors for periodontitis and possible mechanisms of action
    Bruno G Loos
    Department of Periodontology, Acadcemic Center for Dentistry Amsterdam ACTA, University of Amsterdam, The Netherlands
    J Clin Periodontol 32:159-79. 2005
  6. ncbi Systemic markers of inflammation in periodontitis
    Bruno G Loos
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, University of Amsterdam and Vrije University, Amsterdam, The Netherlands
    J Periodontol 76:2106-15. 2005
  7. ncbi Fcgamma receptor polymorphisms in relation to periodontitis
    B G Loos
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, The Netherlands
    J Clin Periodontol 30:595-602. 2003
  8. ncbi Systemic effects of periodontitis
    B G Loos
    Department of Periodontology, Academic Centre for Dentistry, Amsterdam, The Netherlands
    Int J Dent Hyg 4:34-8; discussion 50-2. 2006
  9. ncbi Use of barrier membranes and systemic antibiotics in the treatment of intraosseous defects
    B G Loos
    Departments of Periodontology and Dental Basic Sciences, Academic Medical Center AMC, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Periodontol 29:910-21. 2002
  10. doi NOD1 gene polymorphisms in relation to aggressive periodontitis
    B G Loos
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, Universiteit van Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands
    Innate Immun 15:225-32. 2009

Collaborators

Detail Information

Publications44

  1. ncbi Lymphocyte numbers and function in relation to periodontitis and smoking
    Bruno G Loos
    Department of Periodontology, Academic Center for Dentistry Amsterdam, Amsterdam, The Netherlands
    J Periodontol 75:557-64. 2004
    ..Taking smoking into consideration, the aim of this study was to analyze numbers of circulating T (CD3+) cells and their CD4+ and CD8+ subpopulations, B (CD19+) cells, and T-cell proliferative capacity in periodontitis...
  2. ncbi [Genetics and periodontitis]
    B G Loos
    Afdeling Parodontologie, Secties Parodontologie en Orale Microbiologie van het Academisch Centrum Tandheelkunde Amsterdam ACTA
    Ned Tijdschr Tandheelkd 115:87-92. 2008
    ..However till today there is no strong evidence for target genes and gene polymorphisms that play a key role in the susceptibility to and severity of periodontitis. Therefore genetic testing for periodontitis is currently not indicated...
  3. ncbi Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients
    B G Loos
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, The Netherlands
    J Periodontol 71:1528-34. 2000
    ..Since C-reactive protein (CRP) and other systemic markers of inflammation have been identified as risk factors for cardiovascular diseases, we investigated whether these factors were elevated in periodontitis...
  4. doi What is the Contribution of Genetics to Periodontal Risk?
    Bruno G Loos
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam, VU University Amsterdam, Gustav Mahlerlaan 3004, Amsterdam 1081 LA, The Netherlands Electronic address
    Dent Clin North Am 59:761-80. 2015
    ....
  5. ncbi Identification of genetic risk factors for periodontitis and possible mechanisms of action
    Bruno G Loos
    Department of Periodontology, Acadcemic Center for Dentistry Amsterdam ACTA, University of Amsterdam, The Netherlands
    J Clin Periodontol 32:159-79. 2005
    ..To review the literature for genetic risk factors associated with periodontitis...
  6. ncbi Systemic markers of inflammation in periodontitis
    Bruno G Loos
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, University of Amsterdam and Vrije University, Amsterdam, The Netherlands
    J Periodontol 76:2106-15. 2005
    ....
  7. ncbi Fcgamma receptor polymorphisms in relation to periodontitis
    B G Loos
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, The Netherlands
    J Clin Periodontol 30:595-602. 2003
    ..The present aim was to investigate genetic polymorphisms in three FcgammaR in relation to susceptibility and severity of periodontitis...
  8. ncbi Systemic effects of periodontitis
    B G Loos
    Department of Periodontology, Academic Centre for Dentistry, Amsterdam, The Netherlands
    Int J Dent Hyg 4:34-8; discussion 50-2. 2006
  9. ncbi Use of barrier membranes and systemic antibiotics in the treatment of intraosseous defects
    B G Loos
    Departments of Periodontology and Dental Basic Sciences, Academic Medical Center AMC, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Periodontol 29:910-21. 2002
    ..Therefore, the purpose of the present controlled study was to evaluate both the use of membranes (MEM) and antibiotics (AB), separately and in combination...
  10. doi NOD1 gene polymorphisms in relation to aggressive periodontitis
    B G Loos
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, Universiteit van Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands
    Innate Immun 15:225-32. 2009
    ..They play a role in epithelial barrier functions and inflammatory responses to bacteria. Single nucleotide polymorphisms (SNPs) in the NOD1 gene have proven to be associated with inflammatory bowel disease (IBD) and asthma...
  11. ncbi Oral microbiota in smokers and non-smokers in natural and experimentally-induced gingivitis
    M A Lie
    Department of Periodontology, Academic Centre for Dentistry Amsterdam, The Netherlands
    J Clin Periodontol 25:677-86. 1998
    ..It is concluded that differences in response to experimental gingivitis are not caused by major differences in the composition of the oral microbiota...
  12. ncbi Plasma antibody levels in periodontitis patients and controls
    J E M Graswinckel
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, Amsterdam, The Netherlands
    J Clin Periodontol 31:562-8. 2004
    ..Several risk and susceptibility factors for periodontitis, including smoking, age and composition of the subgingival microflora, have also been suggested to influence antibody production...
  13. ncbi Increased release of IL-12p70 by monocytes after periodontal therapy
    S J Fokkema
    Department of Periodontology, Academic Center for Dentistry Amsterdam, 1066 EA Amsterdam, The Netherlands
    J Clin Periodontol 30:1091-6. 2003
    ..The present study investigated whether this different response of periodontitis patients' monocytes is intrinsic or acquired...
  14. doi Effects of smoking on the ex vivo cytokine production in periodontitis
    G L Torres de Heens
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, The Netherlands
    J Periodontal Res 44:28-34. 2009
    ....
  15. ncbi Lower numbers of erythrocytes and lower levels of hemoglobin in periodontitis patients compared to control subjects
    J W Hutter
    Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA, Amsterdam, The Netherlands
    J Clin Periodontol 28:930-6. 2001
    ..CONCLUSIONS: The present study provides further evidence that periodontitis has systemic effects and that periodontitis may tend towards anemia. This phenomenon may be explained by a depressed erythropoiesis...
  16. ncbi Java project on periodontal diseases. The natural development of periodontitis: risk factors, risk predictors and risk determinants
    U Van der Velden
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, Amsterdam, The Netherlands
    J Clin Periodontol 33:540-8. 2006
    ..To identify risk factors, risk predictors and risk determinants for onset and progression of periodontitis...
  17. pmc Expression of FcgammaRs and mCD14 on polymorphonuclear neutrophils and monocytes may determine periodontal infection
    E A Nicu
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam, The Netherlands
    Clin Exp Immunol 154:177-86. 2008
    ..The higher proportion of FcgammaRIII(+) monocytes may be involved in the chronicity of this condition. Hyper-reactive PMNs in Aa(+) subjects may contribute to accelerated breakdown of tooth-supportive tissues...
  18. doi Elevated platelet and leukocyte response to oral bacteria in periodontitis
    E A Nicu
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 7:162-70. 2009
    ..Recently, we showed that platelets from periodontitis patients are more activated than those from controls...
  19. ncbi Salivary cystatin activity and cystatin C in natural and experimental gingivitis in smokers and non-smokers
    M A Lie
    Department of Periodontology, Academic Centre for Dentistry Amsterdam, The Netherlands
    J Clin Periodontol 28:979-84. 2001
    ..CONCLUSION: Smoking is associated with lower cystatin activity and output of cystatin C during gingival inflammation...
  20. ncbi The combined use of enamel matrix proteins and a tetracycline-coated expanded polytetrafluoroethylene barrier membrane in the treatment of intra-osseous defects
    P M Sipos
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, 1066 EA Amsterdam, The Netherlands
    J Clin Periodontol 32:765-72. 2005
    ....
  21. doi Cytokine and matrix metalloproteinase expression in fibroblasts from peri-implantitis lesions in response to viable Porphyromonas gingivalis
    M Irshad
    Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
    J Periodontal Res 48:647-56. 2013
    ....
  22. ncbi Phenotypical and functional analysis of T cells in periodontitis
    M D Petit
    Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA, The Netherlands
    J Periodontal Res 36:214-20. 2001
    ..The current explorative study suggests that further research into the role of CD8+ T cells in the pathogenesis of periodontitis is warranted...
  23. ncbi Occurrence of Prevotella intermedia and Prevotella nigrescens in relation to gingivitis and gingival health
    M A Lie
    Department of Periodontology, Academic Centre for Dentistry Amsterdam, The Netherlands
    J Clin Periodontol 28:189-93. 2001
    ..CONCLUSION: In natural gingivitis, at the start and after 14 days of experimental gingivitis, Pn was the predominant micro-organism...
  24. doi Comparing culture, real-time PCR and fluorescence resonance energy transfer technology for detection of Porphyromonas gingivalis in patients with or without peri-implant infections
    F Galassi
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and VU University, Amsterdam, The Netherlands
    J Periodontal Res 47:616-25. 2012
    ..P. gingivalis was considered as a marker for a pathogenic microbiota...
  25. ncbi Effect of smoking and periodontal treatment on the subgingival microflora
    U Van der Velden
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, Amsterdam, The Netherlands
    J Clin Periodontol 30:603-10. 2003
    ..The aim of this retrospective study was to investigate the influence of smoking on the treatment of periodontitis and the composition of the subgingival microflora...
  26. ncbi Periodontitis is characterized by elevated PAI-1 activity
    S Bizzarro
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, University of Amsterdam and Vrije University, Amsterdam, The Netherlands
    J Clin Periodontol 34:574-80. 2007
    ..We investigated whether plasma levels of markers of a prothrombotic state were elevated in patients with periodontitis in comparison with healthy controls...
  27. ncbi Hyper-reactive PMNs in FcgammaRIIa 131 H/H genotype periodontitis patients
    E A Nicu
    Department of Periodontology, Academic Center for Dentistry Amsterdam, Universiteit van Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands
    J Clin Periodontol 34:938-45. 2007
    ..Previous results show that one of the genetic variants of the FcgammaRIIa, the 131 H/H, is associated with more periodontal breakdown than the R/R. This may be due to hyper-reactivity of the H/H-PMNs upon interaction with bacteria...
  28. doi Modeling susceptibility to periodontitis
    M L Laine
    Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam, Amsterdam, The Netherlands
    J Dent Res 92:45-50. 2013
    ..Modern bioinformatics tools are valuable in modeling the multifactorial and complex nature of periodontitis...
  29. ncbi Parotid salivary S-IgA antibodies during experimental gingivitis in smokers and non-smokers
    M A Lie
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, The Netherlands
    J Periodontal Res 37:86-92. 2002
    ....
  30. doi Cigarette smoking enhances T cell activation and a Th2 immune response; an aspect of the pathophysiology in periodontal disease
    G L Torres de Heens
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and VU University Amsterdam, Louwesweg 1, 1066 EA Amsterdam, The Netherlands
    Cytokine 47:157-61. 2009
    ..This phenomenon may be equally important in other conditions, where connective tissue and bone loss are hallmarks of disease pathophysiology...
  31. pmc Monocyte-derived RANTES is intrinsically elevated in periodontal disease while MCP-1 levels are related to inflammation and are inversely correlated with IL-12 levels
    S J Fokkema
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, The Netherlands
    Clin Exp Immunol 131:477-83. 2003
    ..This indicates that the disease state regulates the release of IL-12p70 and MCP-1 in E. coli LPS-stimulated WBCC. In contrast, the persistent augmented levels of RANTES after therapy are suggestive for an intrinsic behaviour...
  32. doi Validation of a dental image analyzer tool to measure alveolar bone loss in periodontitis patients
    W J Teeuw
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and Vrije University, Amsterdam, The Netherlands
    J Periodontal Res 44:94-102. 2009
    ....
  33. doi Arterial stiffness in periodontitis patients and controls
    W Houcken
    Department of Periodontology, Academic Centre of Dentistry Amsterdam ACTA, University of Amsterdam and VU University, Amsterdam, The Netherlands
    J Hum Hypertens 30:24-9. 2016
    ..This confirms with a new parameter the association of periodontitis with ACVD. Although periodontal treatment did not lower AS significantly, a modest reduction of SBP after 6 months was observed. ..
  34. pmc A type 2 response in lipopolysaccharide (LPS)-stimulated whole blood cell cultures from periodontitis patients
    S J Fokkema
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, The Netherlands
    Clin Exp Immunol 127:374-8. 2002
    ....
  35. ncbi Plasma levels of mannan-binding lectin in relation to periodontitis and smoking
    Gaia Maffei
    Department of Periodontology, Academic Center for Dentistry Amsterdam, University of Amsterdam and Vrije University, Amsterdam, The Netherlands
    J Periodontol 76:1881-9. 2005
    ..Moreover, it has been suggested that MBL acts as a weak acute phase protein. We investigated whether MBL levels are increased in periodontitis, and we tested whether individuals deficient for MBL are more susceptible to periodontitis...
  36. ncbi Tumor necrosis factor-alpha gene polymorphisms in relation to periodontitis
    Jeroen Craandijk
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, Amsterdam, The Netherlands
    J Clin Periodontol 29:28-34. 2002
    ..The polymorphisms were all transitions from G to A, 3 in the promoter positions: -376, -308, -238; and one in the first intron at position +489...
  37. doi Formation of osteoclast-like cells from peripheral blood of periodontitis patients occurs without supplementation of macrophage colony-stimulating factor
    Stanley T S Tjoa
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, Universiteit van Amsterdam and Vrije Universteit, Amsterdam, The Netherlands
    J Clin Periodontol 35:568-75. 2008
    ..To determine whether peripheral blood mononuclear cells (PBMCs) from chronic periodontitis patients differ from PBMCs from matched control patients in their capacity to form osteoclast-like cells...
  38. doi A systematic review and meta-analyses on C-reactive protein in relation to periodontitis
    Spiros Paraskevas
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and Vrije University, Amsterdam, The Netherlands
    J Clin Periodontol 35:277-90. 2008
    ..This systematic review explored the robustness of observations that CRP is elevated in periodontitis. Similarly, the effect of periodontal therapy on CRP levels was investigated...
  39. ncbi Systemic effects of periodontitis
    Bruno G Loos
    Department of Periodontology, Academic Centre for Dentistry, Amsterdam ACTA, Amsterdam, The Netherlands
    Ann R Australas Coll Dent Surg 18:27-9. 2006
    ....
  40. ncbi Polymorphisms in an interferon-gamma receptor-1 gene marker and susceptibility to periodontitis
    David A Fraser
    Department of Oral Biology, Faculty of Dentistry, University of Oslo, Norway
    Acta Odontol Scand 61:297-302. 2003
    ..56 (1.16<OR<36.31), P=0.014, Pcorr=0.027] with periodontitis. Our results support the multigene-environment interaction model of disease susceptibility to periodontitis...
  41. ncbi A pilot study into measurements of markers of atherosclerosis in periodontitis
    Efstratios Leivadaros
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, University of Amsterdam and Vrije University, Amsterdam, The Netherlands
    J Periodontol 76:121-8. 2005
    ..Periodontitis may be a possible risk factor for atherosclerosis. The current pilot study explored arterial wall thickness and other variables associated with atherosclerosis in healthy subjects with and without periodontitis...
  42. ncbi Automatic mining of the literature to generate new hypotheses for the possible link between periodontitis and atherosclerosis: lipopolysaccharide as a case study
    Kristina M Hettne
    Safety Assessment, AstraZeneca R and D Molndal, Sweden
    J Clin Periodontol 34:1016-24. 2007
    ..The aim of the current report was to generate and explore new hypotheses into how, in a pathophysiological sense, atherosclerosis and periodontitis could be linked...
  43. ncbi Long-term effect of full-mouth tooth extraction on the responsiveness of peripheral blood monocytes
    Schelte J Fokkema
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, The Netherlands
    J Clin Periodontol 30:756-60. 2003
    ....
  44. ncbi Host-derived diagnostic markers for periodontitis: do they exist in gingival crevice fluid?
    Bruno G Loos
    Department of Periodontology, Academic Centre for Dentistry Amsterdam, Universiteit van Amsterdam and Vrije Universiteit Amsterdam, The Netherlands
    Periodontol 2000 39:53-72. 2005