J C Leemans

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Differential role of interleukin-6 in lung inflammation induced by lipoteichoic acid and peptidoglycan from Staphylococcus aureus
    Jaklien C Leemans
    Laboratory of Experimental Internal Medicine, Division of Clinical Immunology and Rheumatology, Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam
    Am J Respir Crit Care Med 165:1445-50. 2002
  2. pmc Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis
    Madelijn Geldhoff
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    BMC Infect Dis 13:358. 2013
  3. pmc The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury
    Jaklien C Leemans
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 4:e5704. 2009
  4. pmc Mice overexpressing p40 in lungs have reduced leucocyte influx and slightly impaired resistance during tuberculosis
    Jaklien C Leemans
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Immunology 117:409-18. 2006
  5. pmc Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney
    Jaklien C Leemans
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 115:2894-903. 2005
  6. ncbi request reprint Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice
    J C Leemans
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 166:4604-11. 2001
  7. ncbi request reprint Macrophages play a dual role during pulmonary tuberculosis in mice
    Jaklien C Leemans
    Laboratory of Experimental Internal Medicine, Department of Infectious Diseases, Tropical Medicine and AIDS, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 191:65-74. 2005
  8. pmc Lipoteichoic acid and peptidoglycan from Staphylococcus aureus synergistically induce neutrophil influx into the lungs of mice
    Jaklien C Leemans
    Laboratory of Experimental Internal Medicine, Utrecht University, Utrecht, The Netherlands
    Clin Diagn Lab Immunol 10:950-3. 2003
  9. pmc CD44 is a macrophage binding site for Mycobacterium tuberculosis that mediates macrophage recruitment and protective immunity against tuberculosis
    Jaklien C Leemans
    Laboratory of Experimental Internal Medicine, Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 111:681-9. 2003
  10. pmc Mice lacking the multidrug resistance protein 1 have a transiently impaired immune response during tuberculosis
    A Verbon
    Department of Infectious Diseases, Tropical Medicine and AIDS, Laboratory of Experimental Internal Medicine and Department of Pathology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Immunol 130:32-6. 2002

Detail Information

Publications29

  1. ncbi request reprint Differential role of interleukin-6 in lung inflammation induced by lipoteichoic acid and peptidoglycan from Staphylococcus aureus
    Jaklien C Leemans
    Laboratory of Experimental Internal Medicine, Division of Clinical Immunology and Rheumatology, Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam
    Am J Respir Crit Care Med 165:1445-50. 2002
    ..Thus, the contribution of IL-6 to lung inflammation may vary with the stimulus used...
  2. pmc Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis
    Madelijn Geldhoff
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    BMC Infect Dis 13:358. 2013
    ..In a murine model of pneumococcal meningitis we examined the pathophysiological roles of two inflammasome proteins, NLRP3 (Nod-like receptor protein-3) and adaptor protein ASC (apoptosis-associated speck-like protein)...
  3. pmc The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury
    Jaklien C Leemans
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 4:e5704. 2009
    ..Together, these data demonstrate that TLR2 can initiate renal inflammation during progressive renal injury and that the absence of TLR2 does not affect the development of chronic renal injury and fibrosis...
  4. pmc Mice overexpressing p40 in lungs have reduced leucocyte influx and slightly impaired resistance during tuberculosis
    Jaklien C Leemans
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Immunology 117:409-18. 2006
    ..This suggests a novel antagonistic role for p40 homodimers in regulating the chemotactic bioactivity of IL-12 after pulmonary mycobacterial infection...
  5. pmc Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney
    Jaklien C Leemans
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 115:2894-903. 2005
    ..These data imply that TLR2 blockade could provide a basis for therapeutic strategies to treat or prevent renal ischemic injury...
  6. ncbi request reprint Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice
    J C Leemans
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 166:4604-11. 2001
    ..These data demonstrate that depletion of AMs is protective during pulmonary tuberculosis...
  7. ncbi request reprint Macrophages play a dual role during pulmonary tuberculosis in mice
    Jaklien C Leemans
    Laboratory of Experimental Internal Medicine, Department of Infectious Diseases, Tropical Medicine and AIDS, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 191:65-74. 2005
    ....
  8. pmc Lipoteichoic acid and peptidoglycan from Staphylococcus aureus synergistically induce neutrophil influx into the lungs of mice
    Jaklien C Leemans
    Laboratory of Experimental Internal Medicine, Utrecht University, Utrecht, The Netherlands
    Clin Diagn Lab Immunol 10:950-3. 2003
    ..Lipoteichoic acid (LTA) and peptidoglycan (PepG) are part of the staphylococcal cell wall. Here we show that LTA and PepG act in synergy to cause polymorphonuclear cell recruitment in the pulmonary compartment during S. aureus pneumonia...
  9. pmc CD44 is a macrophage binding site for Mycobacterium tuberculosis that mediates macrophage recruitment and protective immunity against tuberculosis
    Jaklien C Leemans
    Laboratory of Experimental Internal Medicine, Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 111:681-9. 2003
    ..In summary, we have identified CD44 as a new Mphi binding site for M. tuberculosis that mediates mycobacterial phagocytosis, Mphi recruitment, and protective immunity against pulmonary tuberculosis...
  10. pmc Mice lacking the multidrug resistance protein 1 have a transiently impaired immune response during tuberculosis
    A Verbon
    Department of Infectious Diseases, Tropical Medicine and AIDS, Laboratory of Experimental Internal Medicine and Department of Pathology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Immunol 130:32-6. 2002
    ..These data suggest that Mrp1 plays an early but dispensable role in the protective immune response to pulmonary tuberculosis...
  11. ncbi request reprint The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense
    Jaklien C Leemans
    Laboratory for Experimental Internal Medicine, Department of Pathology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    J Immunol 172:1125-31. 2004
    ..This was associated with a significantly enhanced outgrowth of bacteria in the lungs at 44 h and a strongly diminished survival. Together, these findings indicate an essential role for CD97 in the migration of neutrophils...
  12. pmc CpG oligodeoxynucleotides enhance host defense during murine tuberculosis
    Nicole P Juffermans
    Laboratory of Experimental Internal Medicine, Department of Internal Medicine, University of Amsterdam, The Netherlands
    Infect Immun 70:147-52. 2002
    ..Administration of CpG ODNs to IFN-gamma-gene-deficient mice failed to reduce mycobacterial outgrowth. These data suggest that CpG ODNs improve host defense during pulmonary tuberculosis by an IFN-gamma-dependent mechanism...
  13. ncbi request reprint Enhanced mobilization of bone marrow cells does not ameliorate renal fibrosis
    Geurt Stokman
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nephrol Dial Transplant 23:483-91. 2008
    ..We describe here the effect of stem cell mobilization therapy on the progression of renal fibrosis in a mouse model of chronic obstructive nephropathy...
  14. pmc Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury
    Wilco P Pulskens
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 3:e3596. 2008
    ..In conclusion, we identified TLR4 as a cellular sentinel for acute renal damage that subsequently controls the induction of an innate immune response...
  15. pmc Haematopoietic stem cell migration to the ischemic damaged kidney is not altered by manipulating the SDF-1/CXCR4-axis
    Ingrid Stroo
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nephrol Dial Transplant 24:2082-8. 2009
    ..Therefore, we hypothesized that SDF-1/CXCR4 interactions are implicated in the migration of HSC to the injured kidney...
  16. pmc Chemokine expression in renal ischemia/reperfusion injury is most profound during the reparative phase
    Ingrid Stroo
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Immunol 22:433-42. 2010
    ..In conclusion, we propose that temporal expression of chemokines is a crucial factor in the regulation of renal I/R injury and repair...
  17. pmc TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury
    Wilco P Pulskens
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    J Am Soc Nephrol 21:1299-308. 2010
    ..These data suggest that TLR4 signaling may be a therapeutic target for the prevention of renal fibrosis...
  18. doi request reprint Intragraft Toll-like receptor profiling in acute renal allograft rejection
    Mark C Dessing
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nephrol Dial Transplant 25:4087-92. 2010
    ..Our goal was to determine if profiling of TLR1-10 and TLR-related genes could be used as a prognostic value for renal function and late clinical outcome after transplantation...
  19. pmc S100A8/A9 is not involved in host defense against murine urinary tract infection
    Mark C Dessing
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 5:e13394. 2010
    ..S100A8/A9 promote endotoxin- and Escherichia (E.) coli-induced sepsis showing its contribution in systemic infection. The role of S100A8/A9 during a local infection of the urinary tract system caused by E. coli remains unknown...
  20. pmc Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis
    Sebastiaan Weijer
    Laboratory of Experimental Internal Medicine, Department of Infectious Diseases, Tropical Medicine and AIDS, Department of Pathology, Academic Medical Centre, University of Amsterdam, The Netherlands
    Immunology 109:552-6. 2003
    ..These data suggest that PAF is not involved in the protective immune response to tuberculosis...
  21. ncbi request reprint Tissue-type plasminogen activator modulates inflammatory responses and renal function in ischemia reperfusion injury
    Joris J T H Roelofs
    Department of Pathology, Room H2 131, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Am Soc Nephrol 17:131-40. 2006
    ..This study shows that targeting tPA could be of therapeutic importance in treating I/R injury by diminishing neutrophil influx and preserving renal function...
  22. ncbi request reprint Pre-transplant plasma and cellular levels of CD44 correlate with acute renal allograft rejection
    Kasper M A Rouschop
    Department of Pathology, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Nephrol Dial Transplant 20:2248-54. 2005
    ..Since CD44 is involved in activation, proliferation, rolling and extravasation of lymphocytes, we hypothesized that it could be involved in the pathophysiology of acute renal allograft rejection...
  23. ncbi request reprint Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice
    Catharina W Wieland
    Laboratory of Experimental Internal Medicine, and Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Immunol 17:1399-408. 2005
    ..Leptin replacement restored the reduced IFNgamma response observed in ob/ob mice. Mortality did not differ between ob/ob and Wt mice. These data suggest that leptin plays a role in the early immune response to pulmonary tuberculosis...
  24. ncbi request reprint Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia
    Sylvia Knapp
    Laboratory of Experimental Internal Medicine, Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Respir Crit Care Med 167:171-9. 2003
    ..These data suggest that AMs are indispensable in the host response to pneumococcal pneumonia by means of their capacity to modulate inflammation, possibly via elimination of apoptotic PMNs...
  25. ncbi request reprint Hematopoietic stem cell mobilization therapy accelerates recovery of renal function independent of stem cell contribution
    Geurt Stokman
    Department of Pathology, Academic Medical Center, University of Amsterdam, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    J Am Soc Nephrol 16:1684-92. 2005
    ..Although cytokine treatment improved renal function rapidly after ischemic injury, the results show that the underlying mechanism likely is not based on stem cell transdifferentiation but rather on altered inflammatory kinetics...
  26. ncbi request reprint LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia
    Judith Branger
    Department of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Int Immunol 16:1605-11. 2004
    ..These data suggest that LBP is important for a protective immune response in Klebsiella pneumonia, but does not contribute to an effective host response in pneumococcal pneumonia...
  27. ncbi request reprint Toll-like receptor 4 plays a protective role in pulmonary tuberculosis in mice
    Judith Branger
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Int Immunol 16:509-16. 2004
    ..These data suggest that TLR4 plays a protective role in host defense against lung infection by M. tuberculosis...
  28. pmc Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice
    Judith Branger
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Infect Immun 72:788-94. 2004
    ..These data suggest that TLR4 contributes to a protective immune response in both pneumococcal and Klebsiella pneumonia and that its role is more important in respiratory tract infection caused by the latter (gram-negative) pathogen...
  29. ncbi request reprint Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection
    Judith Branger
    Department of Experimental Internal Medicine, Academic Medical Center, Room F4 222, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Clin Immunol 116:174-81. 2005
    ..The clearance of pulmonary infection with the non-pathogenic M. smegmatis was also unaltered in LBP-/- mice. These data suggest that LBP does not contribute to an effective host response in M. tuberculosis infection...