F N Lauw

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Interleukin-12 induces sustained activation of multiple host inflammatory mediator systems in chimpanzees
    F N Lauw
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 179:646-52. 1999
  2. ncbi request reprint Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis
    F N Lauw
    Laboratory of Experimental Internal Medicine, Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 180:1878-85. 1999
  3. pmc Reduced Th1, but not Th2, cytokine production by lymphocytes after in vivo exposure of healthy subjects to endotoxin
    F N Lauw
    Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 68:1014-8. 2000
  4. ncbi request reprint Proinflammatory effects of IL-10 during human endotoxemia
    F N Lauw
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 165:2783-9. 2000
  5. ncbi request reprint Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria
    F N Lauw
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 182:206-13. 2000
  6. ncbi request reprint The effect of a metalloproteinase inhibitor (GI5402) on tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha receptors during human endotoxemia
    P E Dekkers
    Academic Medical Center, University of Amsterdam, Laboratory of Experimental Internal Medicine, Amsterdam, The Netherlands
    Blood 94:2252-8. 1999
  7. ncbi request reprint Interleukin 10 inhibits the release of CC chemokines during human endotoxemia
    D P Olszyna
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 181:613-20. 2000
  8. pmc The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans
    P E Dekkers
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 68:3036-9. 2000
  9. pmc Role of endogenous interleukin-12 in immune response to staphylococcal enterotoxin B in mice
    F N Lauw
    Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 69:5949-52. 2001

Detail Information

Publications9

  1. ncbi request reprint Interleukin-12 induces sustained activation of multiple host inflammatory mediator systems in chimpanzees
    F N Lauw
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 179:646-52. 1999
    ..These data may contribute to understanding the role of IL-12 in the pathogenesis of sepsis syndrome and the toxicity found after repeated injections of IL-12...
  2. ncbi request reprint Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis
    F N Lauw
    Laboratory of Experimental Internal Medicine, Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 180:1878-85. 1999
    ..This effect of anti-IL-12 was further enhanced by anti-IL-18. These data suggest that during gram-negative sepsis, IFN-gamma production is controlled at least in part by endogenous IL-18, IL-12, and IL-15...
  3. pmc Reduced Th1, but not Th2, cytokine production by lymphocytes after in vivo exposure of healthy subjects to endotoxin
    F N Lauw
    Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 68:1014-8. 2000
    ..LPS exposure influences lymphocyte cytokine production, resulting in a shift toward a Th2 cytokine response, an effect that may be mediated in part by soluble factors present in serum after LPS administration in vivo...
  4. ncbi request reprint Proinflammatory effects of IL-10 during human endotoxemia
    F N Lauw
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 165:2783-9. 2000
    ..These data indicate that high-dose IL-10 treatment in patients with inflammatory disorders can be associated with undesired proinflammatory effects...
  5. ncbi request reprint Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria
    F N Lauw
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 182:206-13. 2000
    ..The interaction between the cytokine network and granzymes may play an important immunoregulatory role during bacterial infections...
  6. ncbi request reprint The effect of a metalloproteinase inhibitor (GI5402) on tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha receptors during human endotoxemia
    P E Dekkers
    Academic Medical Center, University of Amsterdam, Laboratory of Experimental Internal Medicine, Amsterdam, The Netherlands
    Blood 94:2252-8. 1999
    ..Furthermore, unlike in vitro, no evidence has been found in vivo with MP inhibition for a potential proinflammatory effect due to increases in membrane-bound TNF-alpha and TNF-alpha receptor number...
  7. ncbi request reprint Interleukin 10 inhibits the release of CC chemokines during human endotoxemia
    D P Olszyna
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 181:613-20. 2000
    ....
  8. pmc The metalloproteinase inhibitor GI5402 inhibits endotoxin-induced soluble CD27 and CD16 release in healthy humans
    P E Dekkers
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 68:3036-9. 2000
    ..Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans...
  9. pmc Role of endogenous interleukin-12 in immune response to staphylococcal enterotoxin B in mice
    F N Lauw
    Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 69:5949-52. 2001
    ..These data suggest that the role of IL-12 in SEB-induced responses is limited to sustaining gamma interferon release by an IL-18-independent mechanism...