Genomes and Genes
Affiliation: Academic Medical Center
Country: The Netherlands
- Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domainJamila Laoukili
Laboratory of Experimental Oncology, Department of Medical Oncology, University Medical Center, Stratenum 2 118, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Mol Cell Biol 28:3076-87. 2008....
- Protein phosphatase 2A (B55α) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylationMonica Alvarez-Fernandez
Department of Medical Oncology and Cancer Genomics Centre, UMC Utrecht, Universiteitsweg 100, Stratenum 2 118, Utrecht 3584 CG, The Netherlands
J Biol Chem 286:33029-36. 2011..Taken together, these data demonstrate that B55α acts to antagonize Cyclin A/Cdk-dependent activation of FoxM1, to ensure that FoxM1 activity is restricted to the G(2) phase of the cell cycle...
- FoxM1 is degraded at mitotic exit in a Cdh1-dependent mannerJamila Laoukili
Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Cell Cycle 7:2720-6. 2008..Based on these data we propose that Cdh1-dependent degradation of FoxM1 is required to shut down transcriptional activation of mitotic regulators during exit from mitosis...
- FoxM1: at the crossroads of ageing and cancerJamila Laoukili
Department of Medical Oncology, Laboratory of Experimental Oncology, University Medical Center Utrecht, Universiteitsweg 100, Utrecht, The Netherlands
Biochim Biophys Acta 1775:92-102. 2007..In this review, several aspects of FoxM1 function will be discussed, as well as their implication in tumorigenesis...
- FoxM1 is required for execution of the mitotic programme and chromosome stabilityJamila Laoukili
Division of Molecular Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Nat Cell Biol 7:126-36. 2005..Thus, our data uncover a transcriptional cluster regulated by FoxM1 that is essential for proper mitotic progression...