T W Kuijpers

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi LAD-1/variant syndrome is caused by mutations in FERMT3
    Taco W Kuijpers
    Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Emma Children s Hospital, Amsterdam, The Netherlands
    Blood 113:4740-6. 2009
  2. doi Leukocyte adhesion deficiencies
    Edith van de Vijver
    Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Hematol Oncol Clin North Am 27:101-16, viii. 2013
  3. pmc Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1
    Fedde Groot
    Department of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 3:75. 2006
  4. pmc Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study
    Koert M Dolman
    Department of Pediatric Hematology, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef, Amsterdam, 1105 AZ, The Netherlands
    Arthritis Res Ther 10:R32. 2008
  5. ncbi Natural history and early diagnosis of LAD-1/variant syndrome
    Taco W Kuijpers
    Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood 109:3529-37. 2007
  6. ncbi Aicardi-Goutières syndrome: immunophenotyping in relation to interferon-alpha
    Taco W Kuijpers
    Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Paediatr Neurol 6:A59-64; discussion A65-6, A77-86. 2002
  7. ncbi Neutrophils in Barth syndrome (BTHS) avidly bind annexin-V in the absence of apoptosis
    Taco W Kuijpers
    Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, The Netherlands
    Blood 103:3915-23. 2004
  8. pmc Inflammation and repeated infections in CGD: two sides of a coin
    Taco Kuijpers
    Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cell Mol Life Sci 69:7-15. 2012
  9. ncbi Apoptotic neutrophils in the circulation of patients with glycogen storage disease type 1b (GSD1b)
    Taco W Kuijpers
    Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, The Netherlands
    Blood 101:5021-4. 2003
  10. ncbi Frequencies of circulating cytolytic, CD45RA+CD27-, CD8+ T lymphocytes depend on infection with CMV
    Taco W Kuijpers
    Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 170:4342-8. 2003

Detail Information

Publications93

  1. doi LAD-1/variant syndrome is caused by mutations in FERMT3
    Taco W Kuijpers
    Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Emma Children s Hospital, Amsterdam, The Netherlands
    Blood 113:4740-6. 2009
    ..Kindlin-3 protein expression was undetectable in the leukocytes and platelets of all patients tested. These results indicate that the LAD1v syndrome is caused by truncating mutations in FERMT3...
  2. doi Leukocyte adhesion deficiencies
    Edith van de Vijver
    Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Hematol Oncol Clin North Am 27:101-16, viii. 2013
    ..Although dependent on the genetic defect, hematopoietic stem cell transplantation is often the only curative treatment...
  3. pmc Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1
    Fedde Groot
    Department of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 3:75. 2006
    ..To corroborate the importance of the ICAM-1- LFA-1 interaction, we performed transmission experiments to LFA-1 negative leukocytes from Leukocyte Adhesion Deficiency type 1 (LAD-1) patients...
  4. pmc Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study
    Koert M Dolman
    Department of Pediatric Hematology, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef, Amsterdam, 1105 AZ, The Netherlands
    Arthritis Res Ther 10:R32. 2008
    ..The aim of our study was to determine whether genetically determined MBL deficiency is associated with susceptibility to juvenile rheumatoid arthritis (JRA) and whether MBL2 genotypes are associated with JRA severity...
  5. ncbi Natural history and early diagnosis of LAD-1/variant syndrome
    Taco W Kuijpers
    Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood 109:3529-37. 2007
    ..Defining the primary defect awaits genetic linkage analysis, which may be greatly helped by a more precise understanding and awareness of the disease combined with the early identification of affected patients...
  6. ncbi Aicardi-Goutières syndrome: immunophenotyping in relation to interferon-alpha
    Taco W Kuijpers
    Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Paediatr Neurol 6:A59-64; discussion A65-6, A77-86. 2002
  7. ncbi Neutrophils in Barth syndrome (BTHS) avidly bind annexin-V in the absence of apoptosis
    Taco W Kuijpers
    Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, The Netherlands
    Blood 103:3915-23. 2004
    ..These neutrophils expose an alternative substrate for annexin-V different from PS and not recognized by macrophages, excluding early clearance as an explanation for the neutropenia...
  8. pmc Inflammation and repeated infections in CGD: two sides of a coin
    Taco Kuijpers
    Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cell Mol Life Sci 69:7-15. 2012
    ..Preventive measures as well as rapid (invasive) diagnostic procedures are required to successfully treat CGD. Hematopoietic stem cell transplantation may be a serious option in some of the patients...
  9. ncbi Apoptotic neutrophils in the circulation of patients with glycogen storage disease type 1b (GSD1b)
    Taco W Kuijpers
    Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, The Netherlands
    Blood 101:5021-4. 2003
    ..Current understanding of neutrophil apoptosis and the accompanying functional demise suggests that GSD1b granulocytes are dysfunctional because they are apoptotic...
  10. ncbi Frequencies of circulating cytolytic, CD45RA+CD27-, CD8+ T lymphocytes depend on infection with CMV
    Taco W Kuijpers
    Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 170:4342-8. 2003
    ..Preferential expansion of CD8(+)CD45RA(+)CD27(-) cytolytic T cells seems unique for CMV...
  11. ncbi Longstanding obliterative panarteritis in Kawasaki disease: lack of cyclosporin A effect
    Taco W Kuijpers
    Emma Children s Hospital, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Pediatrics 112:986-92. 2003
    ..Unremitting coronary arteritis and excessive smooth muscle hyperplasia resulted in coronary occlusion despite the use of cyclosporin A...
  12. ncbi Clinical symptoms and neutropenia: the balance of neutrophil development, functional activity, and cell death
    Taco W Kuijpers
    Emma Children s Hospital, Academic Medical Centre G8 205, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Eur J Pediatr 161:S75-82. 2002
    ..The background of functional neutrophil defects is briefly reviewed...
  13. ncbi Congenital aplastic anemia caused by mutations in the SBDS gene: a rare presentation of Shwachman-Diamond syndrome
    Taco W Kuijpers
    Emma Children s Hospital, Amsterdam, Netherlands
    Pediatrics 114:e387-91. 2004
    ..Clinical and radiologic symptoms gradually became typical for Shwachman-Diamond syndrome. Two common mutations in the SBDS gene (183-184TA-->CT [K62X] and IVS2(258)+2T--> C [C84fs]) were found...
  14. doi Complement factor 7 gene mutations in relation to meningococcal infection and clinical recurrence of meningococcal disease
    Taco W Kuijpers
    Academic Medical Center, Center for Infection and Immunity Amsterdam, Emma Children s Hospital, Div of Pediatric Hematology, Immunology and Infectious Diseases, University of Amsterdam, Amsterdam, The Netherlands
    Mol Immunol 47:671-7. 2010
    ..The results endorse the lack of clinical recurrences once antibodies are present, whereas in C7Q0 patients the anti-meningococcal antibodies may not suffice to protect from recurrent meningococcal infection...
  15. pmc The impact of platelet-activating factor (PAF)-like mediators on the functional activity of neutrophils: anti-inflammatory effects of human PAF-acetylhydrolase
    T W Kuijpers
    Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Immunol 123:412-20. 2001
    ....
  16. ncbi Kawasaki disease: a maturational defect in immune responsiveness
    T W Kuijpers
    Emma Children s Hospital, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 180:1869-77. 1999
    ..An inherent immaturity to clear certain antigens may be an important cause that precipitates KD and the immune dysregulation during acute disease...
  17. ncbi Hematologic abnormalities in Shwachman Diamond syndrome: lack of genotype-phenotype relationship
    Taco W Kuijpers
    Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood 106:356-61. 2005
    ..CFU-GMs were impaired in all patients tested. From the SBDS sequence data, we conclude that in patients with genetically proven SDS a genotype-phenotype relationship in SDS does not exist in clinical and hematologic terms...
  18. ncbi Vasoactive side effects of intravenous immunoglobulin preparations in a rat model and their treatment with recombinant platelet-activating factor acetylhydrolase
    W K Bleeker
    CLB, Amsterdam, The Netherlands
    Blood 95:1856-61. 2000
    ..If so, rPAF-AH can be used for the treatment of those adverse reactions. (Blood. 2000;95:1856-1861)..
  19. pmc Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease
    W B Breunis
    Emma Children s Hospital, Academic Medical Center AMC, Amsterdam, The Netherlands
    Clin Exp Immunol 150:83-90. 2007
    ..In conclusion, in a Dutch cohort of KD patients an association of KD occurrence with common genetic variants in the chemokine receptor gene-cluster CCR3-CCR2-CCR5 was observed...
  20. doi Mannose-binding lectin (MBL) and the risk for febrile neutropenia and infection in pediatric oncology patients with chemotherapy
    F N J Frakking
    Department of Pediatric Oncology, Emma Children s Hospital Academic Medical Center ECH AMC, Amsterdam, The Netherlands
    Pediatr Blood Cancer 57:89-96. 2011
    ..We determined whether mannose-binding lectin (MBL) deficiency is associated with an increased risk of febrile neutropenia (FN) and/or infection in pediatric oncology patients...
  21. ncbi Intravenous immunoglobulin preparations induce mild activation of neutrophils in vivo via triggering of macrophages--studies in a rat model
    J L Teeling
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory of Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Br J Haematol 112:1031-40. 2001
    ..For this reason, IVIG preparations with a high content of dimers may not always be as harmless as generally believed and may be responsible for some of the side-effects observed during IVIG infusions...
  22. pmc Mannose-binding lectin (MBL) as prognostic factor in paediatric oncology patients
    F N J Frakking
    Emma Children s Hospital, Academic Medical Center AMC, Sanquin Research and Landsteiner Laboratory, AMC, University of Amsterdam, The Netherlands
    Clin Exp Immunol 165:51-9. 2011
    ..These findings suggest prognosis to be worse in MBL-deficient compared to MBL-sufficient paediatric oncology patients...
  23. pmc Low mannose-binding lectin (MBL) levels in neonates with pneumonia and sepsis
    F N J Frakking
    Departments of Clinical Immunology, Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    Clin Exp Immunol 150:255-62. 2007
    ..3; P = 0.02). These results were confirmed by genetic analysis of MBL deficiency. Low MBL levels at birth are associated with an increased risk of early-onset sepsis, culture-proven sepsis and pneumonia during the first month of life...
  24. ncbi The role of mannose-binding lectin (MBL) in paediatric oncology patients with febrile neutropenia
    F N J Frakking
    Emma Children s Hospital, Academic Medical Center AMC, F8 245 Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Cancer 42:909-16. 2006
    ..However, most patients (61%) were severely neutropenic (<100 cells/microL), compromising the opsonophagocytic effector function of MBL. MBL substitution might still be beneficial in patients with phagocytic activity...
  25. ncbi Pulse methylprednisolone therapy for impending cardiac tamponade in immunoglobulin-resistant Kawasaki disease
    P G Dahlem
    Division of Pediatric Intensive Care, Department of Pediatrics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Intensive Care Med 25:1137-9. 1999
    ..Upon treatment with pulsed methylprednisolone, the pericardial and pleural effusions and ascites rapidly disappeared within 48 h. This is the first case reported with a polyserositis syndrome and impending cardiac tamponade during KD...
  26. ncbi Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis
    N A Maianski
    Emma Childrens Hospital, Academic Medical Center, University of Amsterdam, The Netherlands
    Cell Death Differ 11:143-53. 2004
    ..We suggest that other proapoptotic factors such as Smac/DIABLO and HtrA2/Omi, which are massively released from the mitochondria, have an important role in neutrophil apoptosis...
  27. doi Mannose-binding lectin and infection risk in newborns: a systematic review
    J Israels
    Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    Arch Dis Child Fetal Neonatal Ed 95:F452-61. 2010
    ..However, the influence of confounding factors was analysed insufficiently. Variant MBL2 genotypes appear to have less influence...
  28. pmc High prevalence of mannose-binding lectin (MBL) deficiency in premature neonates
    F N J Frakking
    Emma Children s Hospital, Academic Medical Centre AMC, Amsterdam, The Netherlands
    Clin Exp Immunol 145:5-12. 2006
    ..These infants may be at increased risk of neonatal infections. MBL concentration can reliably be measured in umbilical cord blood and it is positively correlated with gestational and postnatal age...
  29. ncbi Vascular endothelial growth factor gene haplotypes in Kawasaki disease
    W B Breunis
    Emma Children s Hospital, Academic Medical Center, and Sanquin Research Institute at the Central Laboratory of the Blood Transfusion Service, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 54:1588-94. 2006
    ..To investigate whether common genetic variants in the vascular endothelial growth factor (VEGF) gene are associated with Kawasaki disease (KD) and the subsequent development of coronary artery lesions...
  30. ncbi Mitochondria in neutrophil apoptosis
    B J van Raam
    Sanquin Research and Landsteiner Laboratory, Department of Blood Cell Research, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Int J Hematol 84:199-204. 2006
    ....
  31. ncbi Granulocyte transfusions in neutropaenic children: a systematic review of the literature
    M D van de Wetering
    Emma Children s Hospital, Academic Medical Centre, Amsterdam, The Netherlands
    Eur J Cancer 43:2082-92. 2007
    ..We reviewed all the paediatric data available on GTX, to gain a insight in to the indications for use, favourable effects and side effects in patients and donors...
  32. pmc Sustained activation of neutrophils in the course of Kawasaki disease: an association with matrix metalloproteinases
    M H Biezeveld
    Emma Children s Hospital, Academic Medical Centre, Amsterdam, The Netherlands
    Clin Exp Immunol 141:183-8. 2005
    ..The potential relationship between this prolonged neutrophil activation, coronary artery lesion formation and their persistence, as well as the risk of premature atherosclerosis warrants further evaluation...
  33. ncbi Clinical and laboratory work-up of patients with neutrophil shortage or dysfunction
    T W Kuijpers
    Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    J Immunol Methods 232:211-29. 1999
    ..A few of the most common causes of neutropenia and neutrophil dysfunctions are described in detail, including recent genetic information regarding the cause of these diseases...
  34. ncbi Analysis of the role of leukocyte function-associated antigen-1 in activation of human influenza virus-specific T cell clones
    K C Kuijpers
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
    J Immunol 144:3281-7. 1990
    ....
  35. ncbi Adrenocorticotropic hormone and cortisol levels in relation to inflammatory response and disease severity in children with meningococcal disease
    J B van Woensel
    Emma Children s Hospital, Academic Medical Center, Pediatric Intensive Care Unit, 1100 DE Amsterdam, The Netherlands
    J Infect Dis 184:1532-7. 2001
    ..04). These results suggest that the adrenal reserve in children is insufficient to handle the extreme conditions and stress associated with severe meningococcal disease...
  36. ncbi SBDS mutations and isochromosome 7q in a patient with Shwachman-Diamond syndrome: no predisposition to malignant transformation?
    C H M Mellink
    Department of Clinical Genetics, Academic Medical Center, 1100 DE Amsterdam, The Netherlands
    Cancer Genet Cytogenet 154:144-9. 2004
    ..At the age of 25 years, the patient suffers from mild aplastic anemia but does not show any clinical sign of myelodysplasia or leukemic transformation...
  37. ncbi Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia
    J L Teeling
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Academical Medical Center, University of Amsterdam, The Netherlands
    Blood 98:1095-9. 2001
    ..In this model, it is shown that IgG dimers present in IVIG preparations are responsible for the increase in platelet counts. (Blood. 2001;98:1095-1099)..
  38. ncbi Beta1 integrin activation on human neutrophils promotes beta2 integrin-mediated adhesion to fibronectin
    J M van den Berg
    CLB, Sanquin Blood Supply Foundation and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 31:276-84. 2001
    ..As transmigrated neutrophils are surrounded by both beta1 and beta2 ligands in the ECM, this integrin cross-talk could play a role in modifying migration and cellular activation in inflamed tissues...
  39. ncbi Apoptosis of neutrophils
    N A Maianski
    Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Acta Haematol 111:56-66. 2004
    ....
  40. doi Identification of purine nucleoside phosphorylase deficiency in dried blood spots by a non-radiochemical assay using reversed-phase high-performance liquid chromatography
    A B P van Kuilenburg
    Academic Medical Center, Emma Children s Hospital, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands
    Nucleosides Nucleotides Nucleic Acids 29:466-70. 2010
    ..614A > C mutation (p.E205A) in the PNP gene was 34% compared to controls. Thus, the analysis of the PNP activity in blood spots can readily detect patients with a PNP deficiency...
  41. doi Transmission networks of HIV-1 among men having sex with men in the Netherlands
    Daniela Bezemer
    HIV Monitoring Foundation, Academic Medical Centre, Amsterdam, The Netherlands
    AIDS 24:271-82. 2010
    ..To obtain insight in the HIV-1 transmission networks among men having sex with men (MSM) in the Netherlands...
  42. ncbi Pseudomembranous and neutropenic enterocolitis in pediatric oncology patients
    M D van de Wetering
    Academic Medical Center, Emma Children s Hospital, Amsterdam, The Netherlands
    Support Care Cancer 11:581-6. 2003
    ..By allowing an insight into the pathology, immunology and culture results, we demonstrated that early diagnosis leads to improved management and therefore improved outcome...
  43. doi Determination of adenosine deaminase activity in dried blood spots by a nonradiochemical assay using reversed-phase high-performance liquid chromatography
    A B P van Kuilenburg
    Academic Medical Center, Emma Children s Hospital, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands
    Nucleosides Nucleotides Nucleic Acids 29:461-5. 2010
    ..In addition, increased ADA activity as found in a rare form of congenital anemia can be assessed, as observed in a bloodspot from a patient diagnosed with Diamond Blackfan anemia (ADA activity 150 nmol/mg/h)...
  44. doi Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals
    Ard I van Sighem
    Stichting HIV monitoring, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands
    AIDS 24:1527-35. 2010
    ..To compare life expectancies between recently diagnosed HIV-infected patients and age and sex-matched uninfected individuals from the general population...
  45. doi The comparison of the performance of two screening strategies identifying newly-diagnosed HIV during pregnancy
    Kees Boer
    Department of Obstetrics, Academic Medical Centre, Amsterdam, The Netherlands
    Eur J Public Health 21:632-7. 2011
    ..In case of infection, screening was followed by prevention of mother-to-child-transmission (PMTCT). We compared the performance of the two strategies in terms of detection of new cases of HIV and vertical transmission...
  46. ncbi Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils
    W J Lie
    Sanquin Research at CLB, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam
    Clin Exp Allergy 33:1125-34. 2003
    ..LTC4 synthesis by human basophils has been studied quite extensively. However, not much is known about the synthesis of PAF by human basophils...
  47. doi Predictors of health-related quality of life in children and adolescents with juvenile idiopathic arthritis: results from a Web-based survey
    L Haverman
    Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    Arthritis Care Res (Hoboken) 64:694-703. 2012
    ..The aim of our present study was to assess health-related quality of life (HRQOL) and its predictors in a group of children and adolescents with JIA...
  48. doi Plasmacytoid dendritic cells and interferon-alpha in Aicardi-Goutières syndrome
    J T van Heteren
    Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    Neuropediatrics 38:269-75. 2007
    ..These data indicate that the origin of IFN-alpha in AGS is different from that in the autoimmune diseases tested...
  49. ncbi Severity of enterocolitis is predicted by IL-8 in paediatric oncology patients
    M D van de Wetering
    Emma Children s Hospital, Academic Medical Center, F8 245, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Cancer 40:571-8. 2004
    ..Rectal biopsies and pathology could not predict outcome (P=0.22). IL-8 analysis at the onset of enterocolitis symptoms can identify high-risk patients, which might be used clinically to design future intervention trials...
  50. doi Lower mortality and earlier start of combination antiretroviral therapy in patients tested repeatedly for HIV than in those with a positive first test
    Luuk Gras
    Stichting HIV monitoring, Academic Medical Center, Amsterdam, The Netherland
    AIDS 25:813-8. 2011
    ..We compared mortality rates and CD4 cell counts at start of combination antiretroviral therapy (cART) in patients with different frequencies of diagnostic testing for HIV...
  51. ncbi [Takayasu arteritis: a chronic vasculitis that is rare in children]
    P M Greidanus
    afd Kindergeneeskunde, Academisch Medisch Centrum Universiteit van Amsterdam, Emma Kinderziekenhuis, Meibergdreef 9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 150:2549-54. 2006
    ..Treatment consists of corticosteroids and other immunosuppressants, such as cyclophosphamide, methotrexate, azathioprine, and antagonists of tumour-necrosis factor alpha. In addition, balloon dilatation or stenting is often necessary...
  52. ncbi Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura
    Willemijn B Breunis
    Department of Pediatric Hematology, Immunology and Infectious Disease, Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    Blood 111:1029-38. 2008
    ..Therefore, we propose that the activating FCGR2C-ORF genotype predisposes to ITP by altering the balance of activating and inhibitory FcgammaR on immune cells...
  53. doi Astrocytes produce interferon-alpha and CXCL10, but not IL-6 or CXCL8, in Aicardi-Goutières syndrome
    Jane T van Heteren
    Emma Children s Hospital, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Glia 56:568-78. 2008
    ..The lack of the inflammatory cytokines IL-6 and CXCL8 in AGS suggest that the neuroinflammatory reaction in this disease is distinct from viral disease...
  54. ncbi Beneficial effect of modified peptide inhibitor of alpha4 integrins on experimental allergic encephalomyelitis in Lewis rats
    Luc J W van der Laan
    Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    J Neurosci Res 67:191-9. 2002
    ..Our results show that small-molecule inhibitors of alpha4 integrins act therapeutically in EAE possibly by interfering with cell adhesion events involved in this autoimmune disease...
  55. ncbi CD27 defines phenotypically and functionally different human NK cell subsets
    Mireille T M Vossen
    Department of Experimental Immunology, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 180:3739-45. 2008
    ..Thus, the absence of CD27 expression allows the definition of cytotoxic effector cells within the known mature NK cell subsets in humans...
  56. ncbi Mannose-binding lectin (MBL) facilitates opsonophagocytosis of yeasts but not of bacteria despite MBL binding
    Nannette Brouwer
    Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands
    J Immunol 180:4124-32. 2008
    ....
  57. doi Granulocyte concentrates: prolonged functional capacity during storage in the presence of phenotypic changes
    Agata Drewniak
    Sanquin, Research Institute, Academic Medical Centre, University of Amsterdam, Plesmanlaan, 125, 1066 CX Amsterdam, The Netherlands
    Haematologica 93:1058-67. 2008
    ..The aim of this study was to assess the functional characteristics and efficacy of granulocyte colony-stimulating factor/dexamethasone-mobilized granulocytes used for transfusions...
  58. ncbi Restoration of the CD4 T cell compartment after long-term highly active antiretroviral therapy without phenotypical signs of accelerated immunological aging
    Nienke Vrisekoop
    Department of Immunology, University Medical Center, Utrecht, The Netherlands
    J Immunol 181:1573-81. 2008
    ..Irrespective of baseline CD4 T cell counts, reconstitution occurred without a significant effect on T cell aging as reflected by markers for replicative history...
  59. doi Human NK cells can control CMV infection in the absence of T cells
    Taco W Kuijpers
    Blood 112:914-5. 2008
  60. ncbi A pharmacokinetic and pharmacogenetic study of efavirenz in children: dosing guidelines can result in subtherapeutic concentrations
    Rob ter Heine
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    Antivir Ther 13:779-87. 2008
    ..Our main objectives were to study the population pharmacokinetics of efavirenz and to explore the adequacy of dosing guidelines...
  61. ncbi Growth factors G-CSF and GM-CSF differentially preserve chemotaxis of neutrophils aging in vitro
    Baruch Wolach
    Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Exp Hematol 35:541-50. 2007
    ..The ability of human neutrophils to migrate was studied during culture in vitro...
  62. ncbi Granulocyte colony-stimulating factor inhibits the mitochondria-dependent activation of caspase-3 in neutrophils
    Nikolai A Maianski
    Emma Children s Hospital, Academic Medical Center, University of Amsterdam, The Netherlands
    Blood 99:672-9. 2002
    ..Moreover, G-CSF exerts its antiapoptotic effect in the first, that is, mitochondria-dependent, route and has no impact on the second...
  63. pmc Persistent detection of varicella-zoster virus DNA in a previously healthy child after severe chickenpox
    Mireille T M Vossen
    Academic Medical Center, Emma Children s Hospital, Room G8 205, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Clin Microbiol 43:5614-21. 2005
    ..In contrast, during the persistent phase of VZV DNA detection, the viral DNA was primarily located in CD8(+) T cells. For the first time, we describe the persistent detection of VZV DNA in a previously healthy child...
  64. ncbi Elastase and granzymes during meningococcal disease in children: correlation to disease severity
    Job B M van Woensel
    Paediatric Intensive Care Unit, Emma Children s Hospital, Academic Medical Center, P O Box 22660, 1100DD Amsterdam, The Netherlands
    Intensive Care Med 31:1239-47. 2005
    ..To investigate the levels of human neutrophil elastase and lymphocyte-derived granzymes A and B in relation to disease severity in children with meningococcal disease...
  65. ncbi Cytomegalovirus rather than HIV triggers the outgrowth of effector CD8+CD45RA+CD27- T cells in HIV-1-infected children
    Vincent Bekker
    Emma Children s Hospital, Sanquin Research and Landsteiner Laboratory, Academic Medical Center fInternational Antiviral Therapy Evaluation Center, Amsterdam, The Netherlands
    AIDS 19:1025-34. 2005
    ..To analyse the effect of viral coinfections on immune reconstitution in HIV-1-infected children (< 18 years) taking highly active antiretroviral therapy (HAART)...
  66. ncbi Absence of circulating natural killer and primed CD8+ cells in life-threatening varicella
    Mireille T M Vossen
    Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    J Infect Dis 191:198-206. 2005
    ..Because both homozygous twin sisters in the study had a severe course of varicella, particular genetic factors may contribute to severe varicella...
  67. ncbi Establishment of the CD4+ T-cell pool in healthy children and untreated children infected with HIV-1
    Mette D Hazenberg
    Department of Clinical Viro Immunology, Sanquin Research at CLB, Amsterdam, The Netherlands
    Blood 104:3513-9. 2004
    ..We postulate that in children infected with HIV, similar to adults infected with HIV, continuous activation of naive T cells leads to erosion of the naive T-cell pool and may be a major factor in lowering CD4(+) T-cell numbers...
  68. ncbi Development of virus-specific CD4+ T cells on reexposure to Varicella-Zoster virus
    Mireille T M Vossen
    Emma Children s Hospital, Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    J Infect Dis 190:72-82. 2004
    ..These memory responses to VZV were compared with the primary immune responses of children experiencing varicella. VZV-specific memory CD4(+) T cell responses largely resemble the primary immune response to VZV...
  69. ncbi Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor
    Nikolai A Maianski
    Emma Childrens Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 172:7024-30. 2004
    ..Together our results support an integrative role of the mitochondria in induction and/or amplification of caspase activity and show that G-CSF may act by blocking Bid/Bax redistribution and inhibiting caspase activation...
  70. ncbi Spontaneous outgrowth of EBV-transformed B-cells reflects EBV-specific immunity in vivo; a useful tool in the follow-up of EBV-driven immunoproliferative disorders in allograft recipients
    Mireille T M Vossen
    Department of Experimental Immunology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Transpl Int 17:89-96. 2004
    ....
  71. ncbi Liver failure in a child receiving highly active antiretroviral therapy and voriconazole
    Henriette J Scherpbier
    Emma Children s Hospital, Academic Medical Centre, Amsterdam, The Netherlands
    Clin Infect Dis 37:828-30. 2003
    ..We describe a 10-year-old child with vertically transmitted acquired immunodeficiency syndrome who was receiving antiretroviral combination therapy and died of liver failure after beginning voriconazole therapy...
  72. ncbi Effect of dexamethasone on tracheal viral load and interleukin-8 tracheal concentration in children with respiratory syncytial virus infection
    Job B van Woensel
    Academic Medical Center, Emma Children s Hospital, Pediatric Intensive Care Unit G8ZW, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Pediatr Infect Dis J 22:721-6. 2003
    ..Our aim was to assess the effect of dexamethasone on tracheal viral load and airway inflammation in patients with RSV infection...
  73. ncbi Association of mannose-binding lectin genotype with cardiovascular abnormalities in Kawasaki disease
    Maarten H Biezeveld
    Emma Children s Hospital, Academic Medical Centre, Netherlands
    Lancet 361:1268-70. 2003
    ..7, 95% CI 1.4-176.5, p=0.026). Our findings suggest that the innate immune system contributes differently to pathophysiology of Kawasaki disease at various ages...
  74. ncbi Tumor necrosis factor alpha induces a caspase-independent death pathway in human neutrophils
    Nikolai A Maianski
    Sanquin Research at Central Laboratory of the Netherlands Blood Transfusion Service, Landsteiner Laboratory, and Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 101:1987-95. 2003
    ..Thus, TNF-alpha can induce a "classical," caspase-dependent and a "nonclassical" caspase-independent cell death...
  75. ncbi Facial nerve palsy in a thirteen-year-old male youth with Kawasaki disease
    Maarten H Biezeveld
    Department of Pediatrics, Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    Pediatr Infect Dis J 21:442-3. 2002
    ..In the course of the disease he developed a facial nerve palsy and an aneurysm of the right coronary artery. After treatment with immunoglobulins both complications disappeared within 10 days and 1 month, respectively...
  76. ncbi Haematological parameters of HIV-1-uninfected infants born to HIV-1-infected mothers
    Madeleine J Bunders
    Department of Paediatric Haematology, Immunology and Infectious Diseases, Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Acta Paediatr 94:1571-7. 2005
    ..To investigate haematological parameters in infants born to HIV-1-infected mothers and exposed to combination antiretroviral therapy (ART) used to prevent mother-to-child transmission (MTCT)...
  77. ncbi Mannan-binding lectin (MBL)-mediated opsonization is enhanced by the alternative pathway amplification loop
    Nannette Brouwer
    Sanquin Research Academic Medical Centre Landsteiner Laboratory, Amsterdam, The Netherlands
    Mol Immunol 43:2051-60. 2006
    ..In conclusion, our data demonstrate that the MBL-mediated route of complement activation depends on the alternative pathway amplification loop for optimal opsonization of zymosan...
  78. ncbi Neutrophil responsiveness to IgG, as determined by fixed ratios of mRNA levels for activating and inhibitory FcgammaRII (CD32), is stable over time and unaffected by cytokines
    Edwin van Mirre
    Department of Blood Cell Research, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, The Netherlands
    Blood 108:584-90. 2006
    ..4 haplotype of the FCGR2B promoter with increased transcriptional activity in individuals with 1:1 ratios and the more common low-expression 2B.1 haplotype in individuals with FcgammaRIIa/FcgammaRIIb2 mRNA ratios of 2:1, 3:1, or 4:1...
  79. ncbi Long-term experience with combination antiretroviral therapy that contains nelfinavir for up to 7 years in a pediatric cohort
    Henriette J Scherpbier
    Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    Pediatrics 117:e528-36. 2006
    ..We sought to provide long-term data on the clinical, immunologic, and virologic response to highly active antiretroviral therapy in infants and children who are naive to protease inhibitors...
  80. ncbi Persistent humoral immune defect in highly active antiretroviral therapy-treated children with HIV-1 infection: loss of specific antibodies against attenuated vaccine strains and natural viral infection
    Vincent Bekker
    Emma Children s Hospital, Academic Medical Center, Room G8 205, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
    Pediatrics 118:e315-22. 2006
    ..In the pre-highly active antiretroviral therapy era, a loss of specific antibodies was seen. Our objective with this study was to describe the loss of specific antibodies during treatment with highly active antiretroviral therapy...
  81. ncbi Population pharmacokinetics and pharmacodynamics of nelfinavir and its active metabolite M8 in HIV-1-infected children
    Kristel M L Crommentuyn
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    Pediatr Infect Dis J 25:538-43. 2006
    ....
  82. ncbi Viral dynamics after starting first-line HAART in HIV-1-infected children
    Vincent Bekker
    Emma Children s Hospital, Academic Medical Center, The Netherlands
    AIDS 20:517-23. 2006
    ..Therefore viral decay and time to reach a pVL of < 400 copies/ml during the first weeks after starting HAART were studied in a cohort of HIV-1-infected children...
  83. ncbi A neonate with macrosomia, cardiomyopathy and hepatomegaly born to an HIV-infected mother
    Mieke H Godfried
    Department of Internal Medicine, AMC, Amsterdam, The Netherlands
    Eur J Pediatr 164:190-2. 2005
  84. ncbi Once-daily highly active antiretroviral therapy for HIV-infected children: safety and efficacy of an efavirenz-containing regimen
    Henriette J Scherpbier
    Emma Children s Hospital, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Pediatrics 119:e705-15. 2007
    ....
  85. ncbi Polymorphisms in the mannose-binding lectin gene as determinants of age-defined risk of coronary artery lesions in Kawasaki disease
    Maarten H Biezeveld
    Emma Children s Hospital, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Arthritis Rheum 54:369-76. 2006
    ..To evaluate the relationship between polymorphisms in the gene coding for mannose-binding lectin (MBL) and the occurrence of coronary artery lesions (CALs) among different age groups of patients with Kawasaki disease...
  86. ncbi Early determinants of long-term T-cell reconstitution after hematopoietic stem cell transplantation for severe combined immunodeficiency
    Jose A Borghans
    Department of Immunology, University Medical Center Utrecht, The Netherlands
    Blood 108:763-9. 2006
    ..Frequent monitoring of T-cell immunity and TREC numbers early after HSCT may thus serve to timely identify patients who will fail to reconstitute properly and who may need additional treatment...
  87. ncbi Fulminant mulch pneumonitis: an emergency presentation of chronic granulomatous disease
    Sophia Siddiqui
    Laboratory of Immune Regulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Infect Dis 45:673-81. 2007
    ..In patients with CGD, invasive pulmonary infection with Aspergillus species remains the greatest cause of mortality and is typically insidious in onset. Acute fulminant presentations of fungal pneumonia are catastrophic...
  88. pmc Granulocyte colony-stimulating factor delays neutrophil apoptosis by inhibition of calpains upstream of caspase-3
    Bram J van Raam
    Sanquin Research and Landsteiner Laboratory, Department of Blood Cell Research and Phagocytes, Amsterdam, The Netherlands
    Blood 112:2046-54. 2008
    ..Thus, neutrophil apoptosis is controlled by G-CSF after initial activation of caspase-8 and mitochondrial permeabilization by the control of postmitochondrial calpain activity...
  89. pmc Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation
    Bram J van Raam
    Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands
    PLoS ONE 3:e2013. 2008
    ..We investigated the source of Deltapsi(m) in neutrophils, as compared to peripheral blood mononuclear leukocytes and HL-60 cells, and whether neutrophils can still utilise this Deltapsi(m) for the generation of ATP...
  90. ncbi Increased attack rate of meningococcal disease in children with a pregnant mother
    Elske J van Gils
    Emma Children s Hospital, Amsterdam, The Netherlands
    Pediatrics 115:e590-3. 2005
    ..To investigate the relationship between meningococcal disease and family composition, especially pregnancy in mothers...
  91. pmc Human coronavirus NL63 and 229E seroconversion in children
    Ronald Dijkman
    Department of Medical Microbiology, Laboratory of Experimental Virology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Microbiol 46:2368-73. 2008
    ..5 to 3.5 years were HCoV-NL63 and HCoV-229E seropositive, respectively. We conclude that on average, HCoV-NL63 and HCoV-229E seroconversion occurs before children reach the age of 3.5 years...
  92. pmc Human coronavirus NL63 is not detected in the respiratory tracts of children with acute Kawasaki disease
    Chisato Shimizu
    Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, 92093, USA
    J Infect Dis 192:1767-71. 2005
    ..Only 1 (2%) of 48 patients with acute KD was positive by RT-PCR for HCoV-NL63/NH in a nasopharyngeal swab. These data do not support an association between these HCoVs and KD...
  93. pmc Complement receptor 3 and Toll-like receptor 4 act sequentially in uptake and intracellular killing of unopsonized Salmonella enterica serovar Typhimurium by human neutrophils
    Robin van Bruggen
    Sanquin Research, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Infect Immun 75:2655-60. 2007
    ..In sum, our data identify the sequential recognition of unopsonized Salmonella strains by CR3 and TLR4 as essential events in the efficient uptake and killing of this intracellular pathogen...