Andreas E Kremer

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Immune-mediated liver diseases: programmed cell death ligands and circulating apoptotic markers
    Andreas E Kremer
    AMC Liver Center, S1 164, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Expert Rev Mol Diagn 9:139-56. 2009
  2. ncbi request reprint Pathogenesis and treatment of pruritus in cholestasis
    Andreas E Kremer
    Liver Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Drugs 68:2163-82. 2008
  3. doi request reprint Lysophosphatidic acid is a potential mediator of cholestatic pruritus
    Andreas E Kremer
    Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, Amsterdam, The Netherlands
    Gastroenterology 139:1008-18, 1018.e1. 2010
  4. ncbi request reprint Pathophysiology and current management of pruritus in liver disease
    Andreas E Kremer
    Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, S1 164, University of Amsterdam, Meibergdreef 69 71, NL 1105 BK Amsterdam, The Netherlands
    Clin Res Hepatol Gastroenterol 35:89-97. 2011
  5. doi request reprint The molecular mechanism of cholestatic pruritus
    Ronald P J Oude Elferink
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Dig Dis 29:66-71. 2011
  6. doi request reprint Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions
    Andreas E Kremer
    Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Hepatology 56:1391-400. 2012
  7. doi request reprint Mediators of pruritus during cholestasis
    Ronald P J Oude Elferink
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Curr Opin Gastroenterol 27:289-93. 2011
  8. ncbi request reprint [Pruritus in liver disease. Pathogenesis and treatment]
    Andreas E Kremer
    Tytgat Instituut voor Lever en Gastrointestinaal Onderzoek en afd Maag, Darm, leverziekten, Academisch Medisch Centrum, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 155:A4045. 2011
  9. doi request reprint The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies
    Ulrich Beuers
    Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Hepatology 52:1489-96. 2010
  10. doi request reprint Fibroblast growth factor 21 is induced by endoplasmic reticulum stress
    Frank G Schaap
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Meibergdreef 69 71, 1105 BK Amsterdam, The Netherlands
    Biochimie 95:692-9. 2013

Detail Information

Publications10

  1. doi request reprint Immune-mediated liver diseases: programmed cell death ligands and circulating apoptotic markers
    Andreas E Kremer
    AMC Liver Center, S1 164, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Expert Rev Mol Diagn 9:139-56. 2009
    ..This review summarizes current knowledge on apoptotic mechanisms, death receptor ligands and circulating apoptotic markers in immune-mediated liver diseases...
  2. ncbi request reprint Pathogenesis and treatment of pruritus in cholestasis
    Andreas E Kremer
    Liver Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Drugs 68:2163-82. 2008
    ....
  3. doi request reprint Lysophosphatidic acid is a potential mediator of cholestatic pruritus
    Andreas E Kremer
    Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, Amsterdam, The Netherlands
    Gastroenterology 139:1008-18, 1018.e1. 2010
    ..Pruritus is a common and disabling symptom in cholestatic disorders. However, its causes remain unknown. We hypothesized that potential pruritogens accumulate in the circulation of cholestatic patients and activate sensory neurons...
  4. ncbi request reprint Pathophysiology and current management of pruritus in liver disease
    Andreas E Kremer
    Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, S1 164, University of Amsterdam, Meibergdreef 69 71, NL 1105 BK Amsterdam, The Netherlands
    Clin Res Hepatol Gastroenterol 35:89-97. 2011
    ....
  5. doi request reprint The molecular mechanism of cholestatic pruritus
    Ronald P J Oude Elferink
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Dig Dis 29:66-71. 2011
    ..LPA then activates these neurons through one of the LPA receptors, which in turn potentiates action potentials along itch fibers...
  6. doi request reprint Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions
    Andreas E Kremer
    Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Hepatology 56:1391-400. 2012
    ..The beneficial antipruritic action of RMP may be explained, at least partly, by the PXR-dependent transcriptional inhibition of ATX expression. Thus, ATX likely represents a novel therapeutic target for pruritus of cholestasis...
  7. doi request reprint Mediators of pruritus during cholestasis
    Ronald P J Oude Elferink
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Curr Opin Gastroenterol 27:289-93. 2011
    ..Pruritus is a frequent symptom in patients with cholestatic liver diseases. Itching may be excruciating, may seriously impair quality of life and even induce suicidal ideation in the most severe cases...
  8. ncbi request reprint [Pruritus in liver disease. Pathogenesis and treatment]
    Andreas E Kremer
    Tytgat Instituut voor Lever en Gastrointestinaal Onderzoek en afd Maag, Darm, leverziekten, Academisch Medisch Centrum, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 155:A4045. 2011
    ..In cases of unbearable, treatment-resistant itching, consideration may be given to experimental therapies such as UV light therapy or nasobiliary drainage...
  9. doi request reprint The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies
    Ulrich Beuers
    Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Hepatology 52:1489-96. 2010
    ..Genetic and acquired functional defects leading to destabilization of the biliary HCO(3)(-) umbrella may contribute to development and progression of various forms of fibrosing/sclerosing cholangitis...
  10. doi request reprint Fibroblast growth factor 21 is induced by endoplasmic reticulum stress
    Frank G Schaap
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Meibergdreef 69 71, 1105 BK Amsterdam, The Netherlands
    Biochimie 95:692-9. 2013
    ..Our findings suggest that increased cellular stress in fatty livers may underlie the elevated FGF21 levels observed in patients with NAFLD...