Affiliation: Academic Medical Center
Country: The Netherlands
- A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterolEric L Klett
Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA
BMC Med 2:5. 2004..No phenotypic difference has yet been described in humans with complete defects in either ABCG5 or ABCG8. These proteins, based upon the defects in humans, are responsible for regulating dietary sterol entry and biliary sterol secretion...
- Genetic background of cholesterol gallstone diseaseAstrid Kosters
Department of Experimental Hepatology, AMC Liver Center S1 172, Academic Medical Center, Meibergdreef 69 71, 1105 BK, Amsterdam, The Netherlands
Biochim Biophys Acta 1637:1-19. 2003....
- Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in miceAstrid Kosters
Department of Experimental Hepatology, AMC Liver Center, Academic Medical Center, Meibergdreef 69 71, Amsterdam 1105 BK, The Netherlands
J Hepatol 38:710-6. 2003..The aim of our study was to correlate the expression levels of Abcg5 and Abcg8 to biliary cholesterol secretion in various (genetically-modified) mouse models...
- The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in miceAstrid Kosters
AMC Liver Center, Academic Medical Center, Amsterdam, The Netherlands
J Lipid Res 47:1959-66. 2006..Our data support the model that ABCG5/ABCG8 primarily play a role in flopping cholesterol (and sterols) from the inner leaflet to the outer leaflet of the canalicular membrane...
- Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8Astrid Kosters
AMC Liver Center Academic Medical Center, Amsterdam, The Netherlands
Hepatology 41:141-50. 2005..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...