Liudmila L Kodach

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers
    Liudmila L Kodach
    Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 134:1332-41. 2008
  2. ncbi Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells
    Liudmila L Kodach
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Carcinogenesis 27:508-16. 2006
  3. ncbi The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer
    Liudmila L Kodach
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Cancer 112:300-6. 2008
  4. doi Evaluation of the prognostic value of pSMAD immunohistochemistry in colorectal cancer
    Philip W Voorneveld
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Cancer Prev 22:420-4. 2013
  5. ncbi The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway
    Liudmila L Kodach
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 133:1272-81. 2007
  6. doi Bone morphogenetic protein signalling in colorectal cancer
    James C Hardwick
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Nat Rev Cancer 8:806-12. 2008

Collaborators

Detail Information

Publications6

  1. doi The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers
    Liudmila L Kodach
    Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 134:1332-41. 2008
    ..The finding of bone morphogenetic protein (BMP) receptor 1a mutations in juvenile polyposis suggests that BMPs are important in colorectal cancer (CRC). We investigated the BMP pathway in sporadic CRC...
  2. ncbi Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells
    Liudmila L Kodach
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Carcinogenesis 27:508-16. 2006
    ..Taken together, our findings suggest that violacein will be active in the treatment of colorectal tumors and offers new prospects for overcoming 5-FU resistance...
  3. ncbi The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer
    Liudmila L Kodach
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Cancer 112:300-6. 2008
    ..Bone morphogenetic proteins (BMPs), a subgroup within the TGFbeta superfamily, recently also have been implicated in CRC, but their precise role in CRC has yet to be investigated...
  4. doi Evaluation of the prognostic value of pSMAD immunohistochemistry in colorectal cancer
    Philip W Voorneveld
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Cancer Prev 22:420-4. 2013
    ..Combining different SMAD stainings did not improve the prediction. SMAD4 expression is a prognostic marker in CRC. Nuclear expressions of pSMAD1,5,8 and pSMAD2,3 are not useful prognostic markers in CRC. ..
  5. ncbi The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway
    Liudmila L Kodach
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 133:1272-81. 2007
    ..Statins induce bone morphogenetic protein (BMP) expression in bone cells. We have previously shown that BMPs act as tumor suppressors in CRC. We hypothesized that the action of statins in CRC involves the induction of BMPs...
  6. doi Bone morphogenetic protein signalling in colorectal cancer
    James C Hardwick
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Nat Rev Cancer 8:806-12. 2008
    ..Further evidence in mice suggests a primary role for mesenchymal loss of BMP signalling in hamartoma development. Here, we examine this evidence and question its relevance to sporadic colorectal carcinogenesis...