John J P Kastelein

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: the EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands Electronic address
    J Clin Lipidol 8:94-106. 2014
  2. ncbi request reprint LDL-C-lowering therapy: current and future therapeutic targets
    Maartje E Visser
    Department of Vascular Medicine, Room F4 159 2, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Curr Cardiol Rep 10:512-20. 2008
  3. doi request reprint Lipids, apolipoproteins, and their ratios in relation to cardiovascular events with statin treatment
    John J P Kastelein
    Academic Medical Center, Department of Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 117:3002-9. 2008
  4. doi request reprint Simvastatin with or without ezetimibe in familial hypercholesterolemia
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    N Engl J Med 358:1431-43. 2008
  5. doi request reprint Ultrasound imaging techniques for the evaluation of cardiovascular therapies
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur Heart J 29:849-58. 2008
  6. ncbi request reprint Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia
    John J P Kastelein
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    N Engl J Med 356:1620-30. 2007
  7. doi request reprint Rationale and design of dal-VESSEL: a study to assess the safety and efficacy of dalcetrapib on endothelial function using brachial artery flow-mediated vasodilatation
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Curr Med Res Opin 27:141-50. 2011
  8. ncbi request reprint Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Center, Meibergdreef 9, PO Box 22700, Room F4 159 2, 1100 DE Amsterdam, The Netherlands
    Circulation 114:1729-35. 2006
  9. ncbi request reprint Refocusing on use of cholesteryl ester transfer protein inhibitors
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    Am J Cardiol 100:n47-52. 2007
  10. ncbi request reprint The relationship between cholesteryl ester transfer protein levels and risk factor profile in patients with familial hypercholesterolemia
    Greetje J de Grooth
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Atherosclerosis 173:261-7. 2004

Detail Information

Publications126 found, 100 shown here

  1. doi request reprint Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: the EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands Electronic address
    J Clin Lipidol 8:94-106. 2014
    ..Omega-3 fatty acids in free fatty acid form have enhanced bioavailability, and plasma levels are less influenced by food than for ethyl ester forms...
  2. ncbi request reprint LDL-C-lowering therapy: current and future therapeutic targets
    Maartje E Visser
    Department of Vascular Medicine, Room F4 159 2, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Curr Cardiol Rep 10:512-20. 2008
    ..Finally, compounds modifying protein convertase subtilisin/kexin type 9 levels are currently in the preclinical phase. In the present article, we discuss these LDL-C-lowering strategies...
  3. doi request reprint Lipids, apolipoproteins, and their ratios in relation to cardiovascular events with statin treatment
    John J P Kastelein
    Academic Medical Center, Department of Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 117:3002-9. 2008
    ....
  4. doi request reprint Simvastatin with or without ezetimibe in familial hypercholesterolemia
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    N Engl J Med 358:1431-43. 2008
    ..Ezetimibe, a cholesterol-absorption inhibitor, reduces levels of low-density lipoprotein (LDL) cholesterol when added to statin treatment. However, the effect of ezetimibe on the progression of atherosclerosis remains unknown...
  5. doi request reprint Ultrasound imaging techniques for the evaluation of cardiovascular therapies
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur Heart J 29:849-58. 2008
    ..The rationale for the use of CIMT- and IVUS-based surrogates, with supporting evidence from historical and recent trials, is presented in this review article...
  6. ncbi request reprint Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia
    John J P Kastelein
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    N Engl J Med 356:1620-30. 2007
    ..Torcetrapib, an inhibitor of cholesteryl ester transfer protein, may reduce atherosclerotic vascular disease by increasing levels of high-density lipoprotein (HDL) cholesterol...
  7. doi request reprint Rationale and design of dal-VESSEL: a study to assess the safety and efficacy of dalcetrapib on endothelial function using brachial artery flow-mediated vasodilatation
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Curr Med Res Opin 27:141-50. 2011
    ..Brachial flow-mediated dilatation (FMD) measured by B-mode ultrasound represents endothelial function and is a validated marker for early atherosclerosis and cardiovascular disease risk...
  8. ncbi request reprint Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Center, Meibergdreef 9, PO Box 22700, Room F4 159 2, 1100 DE Amsterdam, The Netherlands
    Circulation 114:1729-35. 2006
    ..In the present study, we describe the outcome of the first-in-humans study on the safety and efficacy of an antisense oligonucleotide inhibitor of apoB...
  9. ncbi request reprint Refocusing on use of cholesteryl ester transfer protein inhibitors
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    Am J Cardiol 100:n47-52. 2007
    ..This article discusses the use of CETP inhibitors and their effects on lipoprotein metabolism and whether they can ultimately lead to reductions in cardiovascular events...
  10. ncbi request reprint The relationship between cholesteryl ester transfer protein levels and risk factor profile in patients with familial hypercholesterolemia
    Greetje J de Grooth
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Atherosclerosis 173:261-7. 2004
    ..The role of CETP in atherogenesis is controversial. To better understand the relationships between plasma CETP levels, lipoproteins and atherosclerosis, we assessed these parameters in patients with an enhanced risk for atherosclerosis...
  11. doi request reprint Chemokine ligand 2 genetic variants, serum monocyte chemoattractant protein-1 levels, and the risk of coronary artery disease
    Diederik F van Wijk
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 30:1460-6. 2010
    ..In humans, evidence about the association between levels of monocyte chemoattractant protein-1 (MCP-1), its coding gene chemokine (C-C motif) ligand 2 (CCL2), and risk of coronary artery disease (CAD) is contradictory...
  12. ncbi request reprint Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia
    Emily S van Aalst-Cohen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Hum Genet 13:1137-42. 2005
    ....
  13. doi request reprint Efficacy and safety of mipomersen, an antisense inhibitor of apolipoprotein B, in hypercholesterolemic subjects receiving stable statin therapy
    Fatima Akdim
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 55:1611-8. 2010
    ..The aim of this study was to evaluate the efficacy and safety of mipomersen in hypercholesterolemic subjects taking stable statin therapy...
  14. doi request reprint Patients with low HDL-cholesterol caused by mutations in LCAT have increased arterial stiffness
    Bas van den Bogaard
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Atherosclerosis 225:481-5. 2012
    ..We investigated whether LCAT mutation carriers have increased arterial stiffness as a marker of cardiovascular disease and whether arterial stiffness was associated with carotid wall thickening...
  15. doi request reprint The 719Arg variant of KIF6 and cardiovascular outcomes in statin-treated, stable coronary patients of the treating to new targets and incremental decrease in end points through aggressive lipid-lowering prospective studies
    Benoit J Arsenault
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Circ Cardiovasc Genet 5:51-7. 2012
    ..Our objective was to investigate whether carriers of the KIF6 719Arg genetic variant (rs20455) are at increased cardiovascular risk and obtain more benefit from high-dose statin therapy than do noncarriers...
  16. ncbi request reprint C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: the EPIC-Norfolk prospective population study 1993-2003
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 187:415-22. 2006
    ..Measurement of C-reactive protein (CRP) levels has been proposed as a useful marker to improve the prediction of future coronary artery disease (CAD) risk, but this notion has been challenged recently...
  17. ncbi request reprint Designs of RADIANCE 1 and 2: carotid ultrasound studies comparing the effects of torcetrapib/atorvastatin with atorvastatin alone on atherosclerosis
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Curr Med Res Opin 23:885-94. 2007
    ..Further outcome measures included lipid and safety assessments. Current status: The number of subjects randomized was 904 in RADIANCE 1 and 752 in RADIANCE 2. Results are anticipated in 2007...
  18. ncbi request reprint Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study
    Stefan F C Vaessen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Lipid Res 47:2064-70. 2006
    ..The positive correlation of apoA-V levels with TG levels, negative correlation with LPL levels, and lack of association with CAD risk highlight the need for further human studies to clarify the role of apoA-V...
  19. doi request reprint Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia
    Nathan O Stitziel
    From the Cardiovascular Division, Department of Medicine N O S and Division of Statistical Genomics N O S, Washington University School of Medicine, Saint Louis, MO Department of Vascular Medicine B S, S S, J J P K, G K H Department of Experimental Vascular Medicine S W F, J C D, and Radiology A J N, Academic Medical Center, Amsterdam, The Netherlands Center for Human Genetic Research, Boston, MA G M P, A M M, D A, S K Program in Medical and Population Genetics, Broad Institute, Cambridge, MA G M P, A M M, D A, S K Fred Hutchinson Cancer Research Center, Seattle, WA P L A, C K Wellcome Trust Centre for Human Genetics A G, M F, H W and Cardiovascular Medicine, Radcliffe Department of Medicine A G, M F, H W, University of Oxford, Oxford, United Kingdom Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Department of Medicine
    Arterioscler Thromb Vasc Biol 33:2909-14. 2013
    ..The aim of this study was to identify the molecular pathogenesis of autosomal recessive hypercholesterolemia in this family...
  20. ncbi request reprint Carriers of the frequent lipoprotein lipase S447X variant exhibit enhanced postprandial apoprotein B-48 clearance
    Melchior C Nierman
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Metabolism 54:1499-503. 2005
    ..This combination might suggest a role for increased ligand action of LPL in LPLS447X carriers contributing to the cardiovascular protection in carriers of this mutation...
  21. ncbi request reprint Regression of carotid and femoral artery intima-media thickness in familial hypercholesterolemia: treatment with simvastatin
    Pernette R W de Sauvage Nolting
    Departments of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Arch Intern Med 163:1837-41. 2003
    ..To investigate whether high-dose simvastatin therapy could reduce carotid and femoral artery intima-media thickness (IMT) in patients with familial hypercholesterolemia (FH) to prevent cardiovascular disease...
  22. doi request reprint Atherogenic lipoprotein particle size and concentrations and the effect of pravastatin in children with familial hypercholesterolemia
    Anouk van der Graaf
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands
    J Pediatr 152:873-8. 2008
    ..To determine lipoprotein particle concentrations and size in children with familial hypercholesterolemia (FH) and investigate the effect of pravastatin therapy on these measures...
  23. ncbi request reprint Role of the apolipoprotein B-apolipoprotein A-I ratio in cardiovascular risk assessment: a case-control analysis in EPIC-Norfolk
    Wim A van der Steeg
    Academic Medical Center, Amsterdam, The Netherlands
    Ann Intern Med 146:640-8. 2007
    ..It is not known whether this ratio is better than traditional lipid values for risk assessment and prediction and whether it adds predictive value to the Framingham risk score...
  24. ncbi request reprint Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study
    Karim El Harchaoui
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 49:547-53. 2007
    ..We assessed relations of low-density lipoprotein (LDL) particle number (LDL-P) and LDL particle size as measured by nuclear magnetic resonance spectroscopy with LDL cholesterol (LDL-C) and the risk of future coronary artery disease (CAD)...
  25. ncbi request reprint Adeno-associated virus LPL(S447X) gene therapy in LDL receptor knockout mice
    Jaap Rip
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Atherosclerosis 194:55-61. 2007
    ..Overexpression of lipoprotein lipase (LPL) protects against atherosclerosis in genetically engineered mice. We tested whether a gene therapy vector that delivers human (h) LPL(S447X) cDNA to skeletal muscle could induce similar effects...
  26. ncbi request reprint Effect of atorvastatin (80 mg) and simvastatin (40 mg) on plasma fibrinogen levels and on carotid intima media thickness in patients with familial hypercholesterolemia
    Mieke D Trip
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Cardiol 91:604-6. 2003
  27. doi request reprint Endothelial shear stress: a critical determinant of arterial remodeling and arterial stiffness in humans--a carotid 3.0-T MRI study
    Raphael Duivenvoorden
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Cardiovasc Imaging 3:578-85. 2010
    ..However, the relationship between ESS and arterial remodeling and arterial stiffness is unknown in humans. We developed a 3.0-T MRI protocol to evaluate the contribution of ESS to arterial remodeling and stiffness...
  28. doi request reprint Effect of mipomersen, an apolipoprotein B synthesis inhibitor, on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia
    Fatima Akdim
    Department of Vascular Medicine, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
    Am J Cardiol 105:1413-9. 2010
    ..In conclusion, mipomersen has an incremental LDL cholesterol lowering effect when added to conventional lipid-lowering therapy...
  29. ncbi request reprint Measurement of arterial wall thickness as a surrogate marker for atherosclerosis
    Eric de Groot
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Circulation 109:III33-8. 2004
    ..Results are presented from a study that estimated atherosclerosis progression from childhood into old age by measuring intima-media thickness in subjects with familial hypercholesterolemia compared with healthy controls...
  30. ncbi request reprint The significance of femoral intima-media thickness and plaque scoring in the Atorvastatin versus Simvastatin on Atherosclerosis Progression (ASAP) study
    Sanne van Wissen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Cardiovasc Prev Rehabil 10:451-5. 2003
    ..We studied the long-term effects of statins on femoral IMT and plaque scoring in the Atorvastatin versus Simvastatin on Atherosclerosis Progression (ASAP) study...
  31. doi request reprint Carotid intima-media thickness in children with familial hypercholesterolemia
    Dorothé M Kusters
    From the Departments of Vascular Medicine D M K, J J P K, Pediatrics D M K, A W, and Clinical Epidemiology, Biostatistics, and Bioinformatics B A H, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 114:307-10. 2014
    ..Familial hypercholesterolemia (FH) predisposes patients to premature cardiovascular disease, with the process of atherosclerosis initiated in early childhood...
  32. ncbi request reprint Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability
    Max Nieuwdorp
    Department of Vascular Medicine, Academic Medical Center, Amsterdam
    J Appl Physiol (1985) 104:845-52. 2008
    ..It remains to be tested whether glycocalyx dimension can be used as an early marker of vascular damage and whether therapies aimed at glycocalyx repair can protect the vasculature against pathogenic challenges...
  33. ncbi request reprint Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study
    Sabine Pinedo
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Lipid Res 48:139-44. 2007
    ..29) and the adjusted OR was 0.97 (95% CI = 0.68-1.39). In this large prospective study, higher levels of plant sterols, at least in the physiological range, do not appear to be adversely related to CAD in apparently healthy individuals...
  34. ncbi request reprint Serum lipoprotein lipase concentration and risk for future coronary artery disease: the EPIC-Norfolk prospective population study
    Jaap Rip
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 26:637-42. 2006
    ..Recent retrospective studies, however, indicate that LPL concentration can be reliably measured in serum that enabled evaluation of the prospective association between LPL and future CAD...
  35. doi request reprint ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: the CAPTIVATE randomized trial
    Marijn C Meuwese
    Department of Vascular Medicine, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    JAMA 301:1131-9. 2009
    ..Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT), an intracellular enzyme involved in cholesterol accumulation, with pactimibe was developed to assist in the prevention of cardiovascular disease...
  36. doi request reprint ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden
    Andrea E Bochem
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Eur Heart J 34:286-91. 2013
    ..To study the consequences of low plasma levels of high-density lipoprotein cholesterol (HDL-C) due to ATP-binding cassette transporter A1 (ABCA1) dysfunction for atherosclerotic vascular disease in the carotid arteries...
  37. doi request reprint Carriers of lecithin cholesterol acyltransferase gene mutations have accelerated atherogenesis as assessed by carotid 3.0-T magnetic resonance imaging [corrected]
    Raphael Duivenvoorden
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    J Am Coll Cardiol 58:2481-7. 2011
    ..The aim of this study was to investigate the role of reduced lecithin: cholesterol acyltransferase (LCAT) function on atherogenesis using 3.0-T carotid magnetic resonance imaging (MRI) and B-mode ultrasound...
  38. pmc Relative risk for cardiovascular atherosclerotic events after smoking cessation: 6-9 years excess risk in individuals with familial hypercholesterolemia
    Anneke Kramer
    Department of Medical Informatics, Academic Medical Center, University of Amsterdam, The Netherlands
    BMC Public Health 6:262. 2006
    ..In particular, individuals do not smoke at birth, there is usually a wide variation with respect to smoking history, and smoking cessation must also be considered...
  39. ncbi request reprint Enhanced apoB48 metabolism in lipoprotein lipase X447 homozygotes
    Melchior C Nierman
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Atherosclerosis 194:446-51. 2007
    ..Therefore, we evaluated apoB48 kinetics in X447 homozygotes in the fed state by infusion of isotope L-[1-(13)C]-valine and subsequent compartmental modeling...
  40. doi request reprint Physical activity, metabolic syndrome, and coronary risk: the EPIC-Norfolk prospective population study
    Lysette N Broekhuizen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Cardiovasc Prev Rehabil 18:209-17. 2011
    ..We investigated the association between physical activity, metabolic syndrome (MS), and the risk of future coronary heart disease (CHD) and mortality due to CHD in middle-aged men and women...
  41. doi request reprint Molecular basis of autosomal dominant hypercholesterolemia: assessment in a large cohort of hypercholesterolemic children
    Anouk van der Graaf
    Academic Medical Center, Department of Pediatrics, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
    Circulation 123:1167-73. 2011
    ..We therefore investigated a large pediatric population with an unequivocal ADH phenotype to assess the molecular basis of hereditary hypercholesterolemia and to define the percentage of individuals with unexplained dyslipidemia...
  42. doi request reprint Effects of short-term and long-term danazol treatment on lipoproteins, coagulation, and progression of atherosclerosis: two clinical trials in healthy volunteers and patients with hereditary angioedema
    Rakesh S Birjmohun
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Clin Ther 30:2314-23. 2008
    ..However, danazol has been reported to decrease high-density lipoprotein cholesterol (HDL-C) levels and to adversely affect coagulation parameters, which are considered to be proatherothrombotic...
  43. doi request reprint Genetic variant of the scavenger receptor BI in humans
    Menno Vergeer
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    N Engl J Med 364:136-45. 2011
    ..Paradoxically, elevated HDL cholesterol levels are associated with increased atherosclerosis in SR-BI-knockout mice. It is unclear what role SR-BI plays in human metabolism...
  44. doi request reprint Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice
    Lily Jakulj
    Department of Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    FEBS Lett 584:3625-8. 2010
    ..Ezetimibe stimulates fecal sterol excretion of non-biliary and non-dietary origin, probably through stimulation of trans-intestinal cholesterol excretion. We show that this effect depends on intact abcg8 function...
  45. doi request reprint Colesevelam added to combination therapy with a statin and ezetimibe in patients with familial hypercholesterolemia: a 12-week, multicenter, randomized, double-blind, controlled trial
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Clin Ther 32:615-25. 2010
    ..Some patients with FH do not reach LDL-C goals despite intensive combination therapy...
  46. pmc Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia
    Maartje E Visser
    Department of Vascular Medicine, Academic Medical Center Amsterdam, The Netherlands
    J Lipid Res 51:1057-62. 2010
    ..Future studies evaluating the effects of long-term use of mipomersen reaching more profound reductions in apoB are required prior to broader use of this compound...
  47. doi request reprint Dyslipidemia of mothers with familial hypercholesterolemia deteriorates lipids in adult offspring
    Anouk van der Graaf
    Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 30:2673-7. 2010
    ..Because this could have important consequences for cardiovascular prevention in mother and child, we explored the relationship between maternal familial hypercholesterolemia (FH) and lipids in adult offspring...
  48. ncbi request reprint Atorvastatin
    Sander I van Leuven
    Department of Vascular Medicine, Academic Medical Center of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Expert Opin Pharmacother 6:1191-203. 2005
    ....
  49. ncbi request reprint Compromised LCAT function is associated with increased atherosclerosis
    G Kees Hovingh
    Department of Vascular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Circulation 112:879-84. 2005
    ..Better insight into CVD risk in these individuals may provide clues toward the potential of LCAT as a pharmaceutical target to raise HDL-C levels...
  50. ncbi request reprint Inherited disorders of HDL metabolism and atherosclerosis
    G Kees Hovingh
    Department of Vascular Medicine, Academic Medical Center, AZ Amsterdam, The Netherlands
    Curr Opin Lipidol 16:139-45. 2005
    ..Ultrasound imaging of carotid arteries has provided a tool to assess the risk in hereditary hypo and hyperalphalipoproteinemia. This review gives a comprehensive summary...
  51. ncbi request reprint A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease
    G Kees Hovingh
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 44:1429-35. 2004
    ..We investigated the consequences of an apolipoprotein A-I (apoA-I) gene defect with regard to lipid metabolism, endothelial function, arterial wall thickness, and coronary artery disease (CAD) risk...
  52. ncbi request reprint Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women: the prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 110:1418-23. 2004
    ..Evidence exists that the effect of CETP depends on metabolic context, in particular on triglyceride levels...
  53. doi request reprint Clinical implications of JUPITER in a contemporary European population: the EPIC-Norfolk prospective population study
    Brigitte M Sondermeijer
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Eur Heart J 34:1350-7. 2013
    ..We quantified the proportion of individuals meeting the JUPITER criteria, determined their risk profile, and their risk of coronary heart disease (CHD) events during a long-term follow-up in a contemporary European cohort...
  54. ncbi request reprint CETP gene variation: relation to lipid parameters and cardiovascular risk
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Curr Opin Lipidol 15:393-8. 2004
    ..Research on naturally occurring variants in the CETP gene has yielded numerous insights that have been relevant for understanding lipoprotein metabolism, and crucial to the development of pharmacological CETP inhibition...
  55. pmc Lipid oxidation in carriers of lecithin:cholesterol acyltransferase gene mutations
    Adriaan G Holleboom
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 32:3066-75. 2012
    ..In this study, we investigated processes and parameters relevant to lipid oxidation in carriers of functional LCAT mutations...
  56. doi request reprint Asymptomatic individuals with a positive family history for premature coronary artery disease and elevated coronary calcium scores benefit from statin treatment: a post hoc analysis from the St. Francis Heart Study
    Ties A Mulders
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    JACC Cardiovasc Imaging 5:252-60. 2012
    ..The goal of this study was to evaluate whether individuals with a positive family history for premature coronary artery disease (CAD) and coronary calcium scoring (CCS) above the 80th percentile might benefit from preventive treatment...
  57. ncbi request reprint Interaction between a genetic variant of the platelet fibrinogen receptor and fibrinogen levels in determining the risk of cardiovascular events
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Am Heart J 147:181-6. 2004
    ..We investigated whether the effect of this genetic variant of the platelet fibrinogen receptor on the risk of cardiovascular events is affected by fibrinogen plasma levels...
  58. pmc Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study
    Rakesh S Birjmohun
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 4:e6809. 2009
    ..In order to evaluate the atheroprotective potential of PON1, we assessed the relationships among PON1-genotype, PON1-activity and risk of future coronary artery disease (CAD), in a large prospective case-control study...
  59. doi request reprint Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT
    Menno Vergeer
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 211:558-64. 2010
    ..We determined whether five tagging single nucleotide polymorphisms (SNP) in LIPG were associated with lipid parameters, the risk of CAD and the risk of DVT...
  60. ncbi request reprint Apolipoprotein A-II is inversely associated with risk of future coronary artery disease
    Rakesh S Birjmohun
    Academic Medical Center, Department of Vascular Medicine, 1100 DD, Amsterdam, The Netherlands
    Circulation 116:2029-35. 2007
    ..To study this suggestion more closely, we evaluated how serum levels of apoA-II and apoA-I relate to the risk of future coronary artery disease (CAD) in a large, prospective study...
  61. ncbi request reprint Effects of CRP infusion on endothelial function and coagulation in normocholesterolemic and hypercholesterolemic subjects
    Radjesh J Bisoendial
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Lipid Res 48:952-60. 2007
    ..These findings suggest that particularly in hypercholesterolemia, CRP-lowering strategies should be considered in addition to LDL reduction...
  62. doi request reprint Surrogate markers in clinical trials--challenges and opportunities
    Raphael Duivenvoorden
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Atherosclerosis 206:8-16. 2009
    ..Subsequently, we will focus on vascular imaging modalities as tools to investigate atherosclerosis...
  63. ncbi request reprint Familial defective apolipoprotein B versus familial hypercholesterolemia: an assessment of risk
    Sigrid W Fouchier
    Department of Vascular Medicine, Academic Medical Center at the University of Amsterdam, 1100 DD Amsterdam, The Netherlands
    Semin Vasc Med 4:259-64. 2004
    ..However, FDB patients are still exposed to a substantially higher CAD risk compared with unaffected relatives...
  64. ncbi request reprint High-density lipoprotein attenuates inflammation and coagulation response on endotoxin challenge in humans
    Rakesh S Birjmohun
    Academic Medical Center of Amsterdam, Department of Vascular Medicine, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 27:1153-8. 2007
    ..In the present study, we evaluated whether there is a relation between HDL and sensitivity toward a low-dose endotoxin challenge...
  65. doi request reprint High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-I: significance for cardiovascular risk: the IDEAL and EPIC-Norfolk studies
    Wim A van der Steeg
    Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    J Am Coll Cardiol 51:634-42. 2008
    ....
  66. ncbi request reprint Myeloperoxidase levels are not associated with carotid atherosclerosis progression in patients with familial hypercholesterolemia
    Marijn C Meuwese
    Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Atherosclerosis 197:916-21. 2008
    ..Furthermore, we evaluated the relation between MPO levels and atherosclerosis progression, as determined by intima media thickness (IMT)...
  67. ncbi request reprint Plant stanols do not restore endothelial function in pre-pubertal children with familial hypercholesterolemia despite reduction of low-density lipoprotein cholesterol levels
    Lily Jakulj
    Department of Vascular Medicine, and Emma Children s Hospital, Academic Medical Centre, Amsterdam, The Netherlands
    J Pediatr 148:495-500. 2006
    ..To examine the effect of plant stanols on lipids and endothelial function in pre-pubertal children with familial hypercholesterolemia (FH)...
  68. doi request reprint Partial recovery of the endothelial glycocalyx upon rosuvastatin therapy in patients with heterozygous familial hypercholesterolemia
    Marijn C Meuwese
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Lipid Res 50:148-53. 2009
    ..1 +/- 0.4 L, P = 0.04). The endothelial glycocalyx is profoundly reduced in FH patients, which may contribute to increased atherogenic vulnerability. This perturbation is partially restored upon short-term statin therapy...
  69. ncbi request reprint Pleiotropic effects of statins: stabilization of the vulnerable atherosclerotic plaque?
    Fatima Akdim
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Curr Pharm Des 13:1003-12. 2007
    ..In the present review we will discuss different determinants which lead to plaque vulnerability and subsequently we will expand on the plaque stabilizing or "pleiotropic" effects of statin treatment...
  70. ncbi request reprint Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia
    Jan Albert Kuivenhoven
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Am J Cardiol 95:1085-8. 2005
    ..001), and a 5% decrease in low-density lipoprotein cholesterol (p <0.03). Combination therapy using JTT-705 and pravastatin effectively increases HDL cholesterol levels and is safe and well tolerated up to 4 weeks of administration...
  71. doi request reprint Efficacy and safety of coadministration of ezetimibe and simvastatin in adolescents with heterozygous familial hypercholesterolemia
    Anouk van der Graaf
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 52:1421-9. 2008
    ..The study evaluated the efficacy and safety of long-term coadministration of ezetimibe and simvastatin in adolescents with heterozygous familial hypercholesterolemia (HeFH)...
  72. doi request reprint The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight
    Geesje M Dallinga-Thie
    Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 211:1-8. 2010
    ..In this review, we will provide an overview of novel data on both peripheral TG hydrolysis and hepatic remnant clearance that will improve our knowledge of plasma triglyceride metabolism...
  73. doi request reprint Comparison between gradient gel electrophoresis and nuclear magnetic resonance spectroscopy in estimating coronary heart disease risk associated with LDL and HDL particle size
    Benoit J Arsenault
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Clin Chem 56:789-98. 2010
    ..However, whether or not GGE- or NMR-measured LDL or HDL particle size predicts coronary heart disease (CHD) risk to a similar extent is currently unknown...
  74. ncbi request reprint Diagnosing familial hypercholesterolaemia: the relevance of genetic testing
    Emily S van Aalst-Cohen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Eur Heart J 27:2240-6. 2006
    ..We therefore set out to determine in these patients whether patients with a DNA diagnosis would differ significantly from those diagnosed clinically...
  75. ncbi request reprint Patients with premature coronary artery disease who carry the ABCC6 R1141X mutation have no Pseudoxanthoma Elasticum phenotype
    Jurgen J Wegman
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Int J Cardiol 100:389-93. 2005
    ..The objective of our study was to determine if skin and/or eye abnormalities related to a PXE phenotype could be found in patients with premature coronary artery disease, with and without the R1141X mutation...
  76. ncbi request reprint Serum levels of type II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 25:839-46. 2005
    ..To study the prospective relationship between serum levels of type II secretory phospholipase A2 (sPLA2) and the risk of future coronary artery disease (CAD) in apparently healthy men and women...
  77. ncbi request reprint Long-term safety and efficacy of high-dose atorvastatin treatment in patients with familial hypercholesterolemia
    Sanne van Wissen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Am J Cardiol 95:264-6. 2005
    ....
  78. ncbi request reprint Low-density lipoprotein receptor gene mutations and cardiovascular risk in a large genetic cascade screening population
    Marina A W Umans-Eckenhausen
    Department of Vascular Medicine, Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands
    Circulation 106:3031-6. 2002
    ..Multivariate analyses with adjustment for age, sex, and specific family ties were performed...
  79. ncbi request reprint Differential hs-CRP reduction in patients with familial hypercholesterolemia treated with aggressive or conventional statin therapy
    Sanne van Wissen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, P O Box 22 700, 1105 AZ, Amsterdam, The Netherlands
    Atherosclerosis 165:361-6. 2002
    ..High sensitivity C-reactive protein (hs-CRP) has emerged as the best studied and most promising marker of inflammation in atherosclerotic vascular disease...
  80. ncbi request reprint Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomized phase II dose-response study
    Greetje J de Grooth
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Circulation 105:2159-65. 2002
    ..This study describes the first results using this CETP inhibitor in humans...
  81. doi request reprint The genetics of high-density lipoprotein metabolism: clinical relevance for therapeutic approaches
    Aart C Strang
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Cardiol 104:22E-31E. 2009
    ..These might be instrumental in the ongoing fight against atherosclerosis...
  82. ncbi request reprint Surrogate markers of atherosclerosis: impact of statins
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Centre of Amsterdam, Meibergdreef 9, Room G1 146 1105 AZ, Amsterdam, The Netherlands
    Atheroscler Suppl 4:31-6. 2003
    ....
  83. ncbi request reprint Current and future pharmacologic options for the management of patients unable to achieve low-density lipoprotein-cholesterol goals with statins
    Karim El Harchaoui
    Department of Vascular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Am J Cardiovasc Drugs 8:233-42. 2008
    ..The inhibition of apolipoprotein B mRNA is in advanced development and mipomersen sodium (ISIS 301012) has shown striking results in phase II studies both as monotherapy as well as in combination with statins...
  84. ncbi request reprint The cholesteryl ester transfer protein (CETP) TaqIB polymorphism in the cholesterol and recurrent events study: no interaction with the response to pravastatin therapy and no effects on cardiovascular outcome: a prospective analysis of the CETP TaqIB poly
    Greetje J de Grooth
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 43:854-7. 2004
    ....
  85. doi request reprint Carotid atherosclerosis progression in familial hypercholesterolemia patients: a pooled analysis of the ASAP, ENHANCE, RADIANCE 1, and CAPTIVATE studies
    Menno Vergeer
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Circ Cardiovasc Imaging 3:398-404. 2010
    ..Our aims were to investigate whether contemporary statin-treated HeFH patients still show accelerated cIMT increase and to assess the impact of statin treatment, before and after random assignment, on atherosclerosis progression...
  86. ncbi request reprint Atherosclerosis measured by B-mode ultrasonography: effect of statin therapy on disease progression
    John J P Kastelein
    Department of Vascular Medicine, Academic Medical Centre of Amsterdam, The Netherlands
    Am J Med 116:31S-36S. 2004
    ....
  87. ncbi request reprint Clinical, diagnostic, and therapeutic aspects of familial hypercholesterolemia
    Emily S van Aalst-Cohen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Semin Vasc Med 4:31-41. 2004
    ..New lipid-lowering agents are presently being developed for clinical use. This review provides an update on the clinical, diagnostic, and therapeutic aspects of heterozygous familial hypercholesterolemia...
  88. ncbi request reprint Predictive value of mild, residual descending aortic narrowing for blood pressure and vascular damage in patients after repair of aortic coarctation
    Joris W J Vriend
    Department of Cardiology, Room B2 240, Academic Medical Centre, Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Eur Heart J 26:84-90. 2005
    ..The aim of our study was to investigate the influence of mild residual descending aortic narrowing on blood pressure and vascular damage in patients after repair of aortic coarctation...
  89. ncbi request reprint Enhanced conversion of triglyceride-rich lipoproteins and increased low-density lipoprotein removal in LPLS447X carriers
    Melchior C Nierman
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 25:2410-5. 2005
    ..The common LPLS447X variant has been associated with cardiovascular protection, for which the mechanism is unknown. We therefore evaluated enzymatic and nonenzymatic consequences of this LPL variant on TRL metabolism...
  90. ncbi request reprint Genetic determinants of cardiovascular disease risk in familial hypercholesterolemia
    Angelique C M Jansen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 25:1475-81. 2005
    ..To investigate the contribution of polymorphisms in multiple candidate genes to cardiovascular disease (CVD) risk in a large cohort of patients with heterozygous familial hypercholesterolemia (FH)...
  91. ncbi request reprint Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study
    Marijn C Meuwese
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 50:159-65. 2007
    ..We evaluated whether serum myeloperoxidase (MPO) levels are associated with the risk of future development of coronary artery disease (CAD) in apparently healthy individuals...
  92. ncbi request reprint Measurement of subclinical atherosclerosis: beyond risk factor assessment
    Radjesh J Bisoendial
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Curr Opin Lipidol 13:595-603. 2002
    ..e. surrogate end-points). The present review addresses benefits and limitations of flow-mediated dilatation, intima-media thickness, electron-beam computed tomography and magnetic resonance coronary angiography...
  93. ncbi request reprint Premature cardiovascular disease in young women with heterozygous familial hypercholesterolemia
    Anouk van der Graaf
    Academic Medical Centre, Dept Vascular Medicine, Meibergdreef 9 room F4 159 2 1105 AZ, Amsterdam, The Netherlands
    Expert Rev Cardiovasc Ther 4:345-51. 2006
    ..In this review, information of age-specific incidence, risk factors and therapeutic avenues in women with heterozygous familial hypercholesterolemia are discussed...
  94. ncbi request reprint Prolactin does not affect human platelet aggregation or secretion
    Anne Q Reuwer
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Thromb Haemost 101:1119-27. 2009
    ..Finally, prolactin receptors could not be detected on the surface of platelets. The present data indicate that prolactin does not directly modulate platelet function...
  95. doi request reprint Apolipoprotein A-I mimetic peptides
    G K Hovingh
    Department Vascular Medicine, Academic Medical Center, Meibergdreef 9 F4 159 2, 1100DD Amsterdam, The Netherlands
    Curr Opin Lipidol 21:481-6. 2010
    ..To review published data related to the potential applicability of apolipoprotein A-I mimetic peptides...
  96. doi request reprint Targeting cardiovascular risk in rheumatoid arthritis: a dual role for statins
    Radjesh J Bisoendial
    Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Nat Rev Rheumatol 6:157-64. 2010
    ....
  97. ncbi request reprint Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized, double-blind, placebo-controlled trial with simvastatin
    Saskia de Jongh
    Department of Vascular Medicine, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 106:2231-7. 2002
    ....
  98. ncbi request reprint Familial hypercholesterolemia in children
    J Rodenburg
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands
    Curr Opin Lipidol 15:405-11. 2004
    ..This review provides an update on recent advances in the diagnosis and management of children with familial hypercholesterolemia...
  99. ncbi request reprint Adherence to and dosing of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors in the general population differs according to apolipoprotein E-genotypes
    Anke Hilse Maitland-van der Zee
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Pharmacogenetics 13:219-23. 2003
    ..18 (CI 1.01-10.03) in men. The apoE genotype is associated with discontinuation of statins. This suggests that subjects who are genetically prone to develop hypercholesterolemia show the highest risk of discontinuation of treatment...
  100. ncbi request reprint Expression of type III hyperlipoproteinemia in apolipoprotein E2 (Arg158 --> Cys) homozygotes is associated with hyperinsulinemia
    Femke de Beer
    Department of General Internal Medicine, Leiden University Medical Center, Gaubius Laboratory, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 22:294-9. 2002
    ..In addition, in female apoE2 homozygotes, the expression increases with age; this increase is most likely due to the loss of estrogen production...
  101. ncbi request reprint Raised serum levels of soluble CD40 ligand in patients with familial hypercholesterolemia: downregulatory effect of statin therapy
    Anne G Semb
    Cardiologic Department, Aker Hospital, Oslo, Norway
    J Am Coll Cardiol 41:275-9. 2003
    ..In the present study, we investigated the effects of statins on serum levels of soluble CD40 ligand (sCD40L) in patients with familial hypercholesterolemia (FH)...