M L Kapsenberg

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Dendritic cell-mediated T cell polarization
    Esther C de Jong
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ, Amsterdam, The Netherlands
    Springer Semin Immunopathol 26:289-307. 2005
  2. doi request reprint Viral dsRNA-activated human dendritic cells produce IL-27, which selectively promotes cytotoxicity in naive CD8+ T cells
    Rosa De Groot
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Leukoc Biol 92:605-10. 2012
  3. ncbi request reprint Dendritic-cell control of pathogen-driven T-cell polarization
    Martien L Kapsenberg
    Department of Cell Biology and Histology and Department of Dermatology, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Nat Rev Immunol 3:984-93. 2003
  4. doi request reprint Gammadelta T cell receptors without a job
    Martien L Kapsenberg
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands
    Immunity 31:181-3. 2009
  5. ncbi request reprint The role of antigen-presenting cells in the regulation of allergen-specific T cell responses
    M L Kapsenberg
    Department of Cell Biology and Histology Academic Medical Center of the University of Amsterdam Meibergdreef 15 1105 AZ Amsterdam The Netherlands
    Curr Opin Immunol 10:607-13. 1998
  6. ncbi request reprint IL-12-induced reversal of human Th2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression
    H H Smits
    Academic Medical Centre, University of Amsterdam, Department of Cell Biology and Histology, Amsterdam, The Netherlands
    Eur J Immunol 31:1055-65. 2001
  7. ncbi request reprint Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation
    P Kalinski
    Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Immunol 161:2804-9. 1998
  8. ncbi request reprint Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction
    P L Vieira
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 164:4507-12. 2000
  9. ncbi request reprint Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells
    P Kalinski
    Department of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Immunol 162:3231-6. 1999
  10. ncbi request reprint IL-4 is a mediator of IL-12p70 induction by human Th2 cells: reversal of polarized Th2 phenotype by dendritic cells
    P Kalinski
    Department of Cell Biology and Histology and Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 165:1877-81. 2000

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Dendritic cell-mediated T cell polarization
    Esther C de Jong
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ, Amsterdam, The Netherlands
    Springer Semin Immunopathol 26:289-307. 2005
    ..This review discusses the way DC adapt the T cell response to the type of pathogen, focusing on the tools that DC use in this management of the T cell response...
  2. doi request reprint Viral dsRNA-activated human dendritic cells produce IL-27, which selectively promotes cytotoxicity in naive CD8+ T cells
    Rosa De Groot
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Leukoc Biol 92:605-10. 2012
    ..These data support the concept that viral dsRNA-activated human DCs produce IL-27 to act as a specialized procytotoxic, antiviral cytokine in the development of effector CD8(+) T cells...
  3. ncbi request reprint Dendritic-cell control of pathogen-driven T-cell polarization
    Martien L Kapsenberg
    Department of Cell Biology and Histology and Department of Dermatology, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Nat Rev Immunol 3:984-93. 2003
  4. doi request reprint Gammadelta T cell receptors without a job
    Martien L Kapsenberg
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands
    Immunity 31:181-3. 2009
    ..2009) and Martin et al. (2009) indicate that gammadelta T cells are innate cells that rapidly produce interleukin (IL)-17 in response to cytokines or pathogens without the need for T cell receptor engagement...
  5. ncbi request reprint The role of antigen-presenting cells in the regulation of allergen-specific T cell responses
    M L Kapsenberg
    Department of Cell Biology and Histology Academic Medical Center of the University of Amsterdam Meibergdreef 15 1105 AZ Amsterdam The Netherlands
    Curr Opin Immunol 10:607-13. 1998
    ..This generalized bias may follow from intrinsic abnormalities of antigen-presenting cells and also from a low degree of cross-regulation by micro-organisms...
  6. ncbi request reprint IL-12-induced reversal of human Th2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression
    H H Smits
    Academic Medical Centre, University of Amsterdam, Department of Cell Biology and Histology, Amsterdam, The Netherlands
    Eur J Immunol 31:1055-65. 2001
    ....
  7. ncbi request reprint Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation
    P Kalinski
    Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Immunol 161:2804-9. 1998
    ..These data imply that the character of pathogen-induced local inflammatory reaction can "instruct" local DC to initiate Th1 or Th2-biased responses...
  8. ncbi request reprint Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction
    P L Vieira
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 164:4507-12. 2000
    ..Type 1-polarized effector DC are resistant to further modulation, which may facilitate their potential use in immunotherapy...
  9. ncbi request reprint Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells
    P Kalinski
    Department of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Immunol 162:3231-6. 1999
    ....
  10. ncbi request reprint IL-4 is a mediator of IL-12p70 induction by human Th2 cells: reversal of polarized Th2 phenotype by dendritic cells
    P Kalinski
    Department of Cell Biology and Histology and Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 165:1877-81. 2000
    ....
  11. ncbi request reprint Evidence for suppressed activity of the transcription factor NFAT1 at its proximal binding element P0 in the IL-4 promoter associated with enhanced IL-4 gene transcription in T cells of atopic patients
    E A Wierenga
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Immunol 11:297-306. 1999
    ....
  12. ncbi request reprint IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Immunol 159:28-35. 1997
    ..Since type 2 Th responses are protective in several Th1-related autoimmune disorders, PGE2-DC may be considered for use in immunotherapy...
  13. ncbi request reprint How to deal with polarized Th2 cells: exploring the Achilles' heel
    H H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Arch Allergy Immunol 126:102-10. 2001
    ..The development of new therapies for atopic allergy now focuses on local IL-12-promoting substances to target both the development of new Th2 cells and the persistent population of established allergen-specific Th2 cells...
  14. ncbi request reprint Reduced IL-12 production by monocytes upon ultraviolet-B irradiation selectively limits activation of T helper-1 cells
    I B Kremer
    Department of Dermatology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Immunol 157:1913-8. 1996
    ..Our results thus indicate that UVB irradiation of APC selectively impairs Th1-like responses, a phenomenon caused by the UVB-induced suppression of monocyte IL-12 production...
  15. ncbi request reprint Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Blood 97:3466-9. 2001
    ..Selective induction of IL-12p40 and suppression of bioactive IL-12p70 may have negative impact on anticancer vaccination with PGE(2)-matured DCs. (Blood. 2001;97:3466-3469)..
  16. ncbi request reprint Analysis of the CD4+ T cell responses to house dust mite allergoid
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Allergy 58:648-56. 2003
    ..Modified allergen extracts (allergoids) with reduced IgE-binding capacity are successfully used in immunotherapy of atopic allergy. Their reduced T-cell stimulatory capacity is less well studied and is a subject of the present study...
  17. ncbi request reprint Type I IFNs differentially modulate IL-12p70 production by human dendritic cells depending on the maturation status of the cells and counteract IFN-gamma-mediated signaling
    H C Heystek
    Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    Clin Immunol 107:170-7. 2003
    ..The differential modulatory effect of IFNalpha/beta on the IL-12-producing capacity of DCs and their cross-regulatory effect on IFN-gamma may reduce inflammatory processes and therefore be therapeutically effective in MS...
  18. ncbi request reprint Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit
    A Snijders
    Laboratory of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Immunol 156:1207-12. 1996
    ....
  19. pmc Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN
    Mathijs P Bergman
    Department of Medical Microbiology and Infection Control, Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands
    J Exp Med 200:979-90. 2004
    ..Our data indicate a role for LPS phase variation and Le antigen expression by H. pylori in suppressing immune responses through DC-SIGN...
  20. ncbi request reprint alpha-type-1 polarized dendritic cells: a novel immunization tool with optimized CTL-inducing activity
    Robbie B Mailliard
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
    Cancer Res 64:5934-7. 2004
    ..Serum-free generation of alphaDC1 allows, for the first time, the clinical application of DCs that combine the key three features important for their efficacy as anticancer vaccines...
  21. ncbi request reprint Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
    Hermelijn H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Allergy Clin Immunol 115:1260-7. 2005
    ..On the basis of pathogenic or tissue-specific priming, dendritic cells (DC) acquire different T cell-instructive signals and drive the differentiation of naive T H cells into either T H 1, T H 2, or regulatory effector T cells...
  22. ncbi request reprint Differential expression of inflammatory chemokines by Th1- and Th2-cell promoting dendritic cells: a role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation
    M Cristina Lebre
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Immunol Cell Biol 83:525-35. 2005
    ....
  23. ncbi request reprint An improved protocol for generation of immuno-potent dendritic cells through direct electroporation of CD14+ monocytes
    Francesca Milano
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol Methods 321:94-106. 2007
    ..This improved method may represent an attractive approach for RNA-based DC immunotherapy...
  24. ncbi request reprint Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation
    Sander W Tas
    Division of Clinical Immunology and Rheumatology, Academic Medical Center AMC University of Amsterdam, Amsterdam, The Netherlands
    Blood 110:1540-9. 2007
    ..These findings reveal an important role of the noncanonical NF-kappaB pathway in the regulation of immunity...
  25. ncbi request reprint Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells
    Astrid J van Beelen
    Department of Cell Biology and Histology, Academic Medical Centre of the University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Immunity 27:660-9. 2007
    ..Thus, antibacterial Th17-mediated immunity in humans is orchestrated by DCs upon sensing bacterial NOD2-ligand MDP...
  26. ncbi request reprint ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells
    Lianne Wassink
    Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 173:1779-86. 2004
    ....
  27. ncbi request reprint A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization
    Desiree van der Kleij
    Department of Parasitology, Leiden University Medical Center, The Netherlands
    J Biol Chem 277:48122-9. 2002
    ..Taken together, these findings provide evidence for a novel host-parasite interaction that may be central to long term survival of the parasite and limited host pathology with implications beyond parasitology...
  28. pmc Complementary dendritic cell-activating function of CD8+ and CD4+ T cells: helper role of CD8+ T cells in the development of T helper type 1 responses
    Robbie B Mailliard
    Department of Surgery, Cancer Institute, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Exp Med 195:473-83. 2002
    ....
  29. ncbi request reprint Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development
    Hermelijn H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, and Department of Molecular Cell Biology, Free University Medical Center, Amsterdam, The Netherlands
    J Immunol 168:1710-6. 2002
    ..This mechanism may be operational during viral infections...
  30. ncbi request reprint Glatiramer acetate (copolymer-1, copaxone) promotes Th2 cell development and increased IL-10 production through modulation of dendritic cells
    Pedro L Vieira
    Department of Cell Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 170:4483-8. 2003
    ..Together, these results reveal that APC are essential for the GA-mediated shift in the Th cell profiles and indicate that DC are a prime target for the immunomodulatory effects of GA...
  31. ncbi request reprint Double-stranded RNA-exposed human keratinocytes promote Th1 responses by inducing a Type-1 polarized phenotype in dendritic cells: role of keratinocyte-derived tumor necrosis factor alpha, type I interferons, and interleukin-18
    M Cristina Lebre
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Invest Dermatol 120:990-7. 2003
    ....
  32. ncbi request reprint Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals
    Esther C de Jong
    Department of Cell Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 168:1704-9. 2002
    ..The data suggest that the molecular basis of Th1/Th2 polarization via DCs is unexpectedly diverse and is adapted to the nature of the microbial compounds...
  33. pmc Differential transmission of human immunodeficiency virus type 1 by distinct subsets of effector dendritic cells
    Rogier W Sanders
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Virol 76:7812-21. 2002
    ..The ICAM-1-LFA-1 interaction is known to be important for immunological cross talk between DC and T cells, and our results indicate that this cell-cell contact is exploited by HIV-1 for efficient transmission...
  34. ncbi request reprint Dichotomy between Lactobacillus rhamnosus and Klebsiella pneumoniae on dendritic cell phenotype and function
    Henri Braat
    Academic Medical Center, Department of Experimental Internal Medicine, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    J Mol Med (Berl) 82:197-205. 2004
    ..Thus our results strongly support the concept that differential modulation of DC explains the differences in the immune response to various bacterial strains and indicates that K. pneumoniae induces Th1 immune responses via DC...
  35. ncbi request reprint ICOS-mediated signaling regulates cytokine production by human T cells and provides a unique signal to selectively control the clonal expansion of Th2 helper cells
    Pedro L Vieira
    Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 34:1282-90. 2004
    ..These data suggest that ICOS-mediated signaling plays a discrete role in the regulation of human T helper cell responses...
  36. ncbi request reprint Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development
    Hermelijn H Smits
    Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 34:1371-80. 2004
    ..Importantly, this study gives indications that the expression of the different IL-12 family members is dictated by different priming conditions of immature DC...
  37. ncbi request reprint Triggering of innate immune responses by schistosome egg glycolipids and their carbohydrate epitope GalNAc beta 1-4(Fuc alpha 1-2Fuc alpha 1-3)GlcNAc
    Desiree van der Kleij
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 185:531-9. 2002
    ..The LDN-DF neoglycoconjugate was the most potent cytokine inducer, which indicates that this difucosylated glycan can act at the host-parasite interface and can trigger innate immune responses...
  38. ncbi request reprint Loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition
    Angelic M G van der Aar
    Department of Dermatology and
    J Immunol 178:1986-90. 2007
    ..Unresponsiveness of LCs to bacteria may be a mechanism that contributes to tolerance to bacterial commensals that colonize the skin...
  39. ncbi request reprint Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9
    Maria C Lebre
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Invest Dermatol 127:331-41. 2007
    ..Altogether, these findings stress an unexpectedly multifaceted role of keratinocytes in innate immunity as evident by their differential, TLR-mediated responses to PAMPs associated with different classes of pathogens...
  40. ncbi request reprint Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition
    Fedde Groot
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Blood 108:1957-64. 2006
    ..This study shows that the 2 main types of DCs have opposing roles in HIV-1 infection of T cells...
  41. ncbi request reprint Allergen immunotherapy induces a suppressive memory response mediated by IL-10 in a mouse asthma model
    Joost L M Vissers
    Department of Pharmacology and Pathophysiology, Faculty of Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    J Allergy Clin Immunol 113:1204-10. 2004
    ..Previously, we established a mouse model in which allergen immunotherapy was effective in the suppression of allergen-induced asthma manifestations...
  42. ncbi request reprint Different faces of regulatory DCs in homeostasis and immunity
    Hermelijn H Smits
    Departments of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ Amsterdam, The Netherlands
    Trends Immunol 26:123-9. 2005
  43. pmc Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
    Clare L Bennett
    Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
    J Cell Biol 169:569-76. 2005
    ..Our results establish Langerin-DTR mice as a unique tool to study LC function in the steady state and to explore their relative importance compared with dDC in orchestrating skin immunity and tolerance...