Research Topics
Species | A KalsbeekSummaryAffiliation: Academic Medical Center Country: The Netherlands Publications
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Publications
Daily regulation of hormone profilesAndries Kalsbeek
Department of Endocrinology and Metabolism, G2 133, Academic Medical Center AMC of the University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Handb Exp Pharmacol 217:185-226. 2013..In this way the net result of the activity of the hypothalamic and peripheral clocks ensures an optimal endocrine adaptation of the metabolism of the organism to its time-structured environment...
Differential involvement of the suprachiasmatic nucleus in lipopolysaccharide-induced plasma glucose and corticosterone responsesAndries Kalsbeek
Department of Endocrinology and Metabolism, Academic Medical Center AMC, University of Amsterdam, Amsterdam, The Netherlands
Chronobiol Int 29:835-49. 2012..The latter effects are more likely due to direct interactions of LPS with peripheral tissues, such as the liver...
Standards of evidence in chronobiology: critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is sufficient to restore circadian food anticipatory rhythms in Bmal1-/- miceRalph E Mistlberger
Department of Psychology, Simon Fraser University, Burnaby, BC Canada
J Circadian Rhythms 7:3. 2009..missing data and methodological details. The Fuller et al results are therefore considered inconclusive, and fail to clarify the role of either the DMH or Bmal1 in the expression of food-entrainable circadian rhythms in rodents...
Food anticipation in Bmal1-/- and AAV-Bmal1 rescued mice: a reply to Fuller et alRalph E Mistlberger
Department of Psychology, Simon Fraser University, Burnaby, BC Canada
J Circadian Rhythms 7:11. 2009..We conclude that the original results of Fuller et al remain inconclusive and fail to clarify the role of Bmal1 or the dorsomedial hypothalamus in the generation of food-entrainable rhythms in mice...
Circadian control of the daily plasma glucose rhythm: an interplay of GABA and glutamateAndries Kalsbeek
Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
PLoS ONE 3:e3194. 2008....
Vasopressin and the output of the hypothalamic biological clockA Kalsbeek
Department of Endocrinology and Metabolism, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
J Neuroendocrinol 22:362-72. 2010....
The hypothalamic clock and its control of glucose homeostasisAndries Kalsbeek
Department of Endocrinology and Metabolism, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
Trends Endocrinol Metab 21:402-10. 2010..Recently, large-scale genetic studies in humans provided the first evidence for the involvement of disrupted (clock gene) rhythms in the pathogenesis of type 2 diabetes...
Hypothalamic control of energy metabolism via the autonomic nervous systemA Kalsbeek
Department of Endocrinology and Metabolism, Academic Medical Center AMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
Ann N Y Acad Sci 1212:114-29. 2010....
Circadian disruption and SCN control of energy metabolismAndries Kalsbeek
Department of Endocrinology and Metabolism, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
FEBS Lett 585:1412-26. 2011....
Circadian rhythms in the hypothalamo-pituitary-adrenal (HPA) axisA Kalsbeek
Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
Mol Cell Endocrinol 349:20-9. 2012..The HPA-axis thus still is an excellent model for studying the transmission of circadian information in the body...
Mammalian clock output mechanismsAndries Kalsbeek
Division of Gastroenterology and Hepatology, Academic Medical Center AMC, AZ, Amsterdam, The Netherlands
Essays Biochem 49:137-51. 2011....
Role for the pineal and melatonin in glucose homeostasis: pinealectomy increases night-time glucose concentrationsS E La Fleur
Netherlands Institute for Brain Research, Amsterdam, The Netherlands
J Neuroendocrinol 13:1025-32. 2001..The present study also demonstrates that removal of the pineal gland cannot be compensated by mimicking plasma melatonin concentrations only...
A network of (autonomic) clock outputsA Kalsbeek
Netherlands Institute for Brain Research, Hypothalamic Integration Mechanisms, Amsterdam, The Netherlands
Chronobiol Int 23:201-15. 2006..Moreover, the specialization of the SCN may go as far as a single body structure; i.e., the SCN seems to contain neurons that specifically target the liver, pineal, and adrenal...
Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathwayR M Buijs
Netherlands Institute for Brain Research, Amsterdam, The Netherlands
Eur J Neurosci 11:1535-44. 1999..As a consequence, it is proposed that the SCN utilizes neuronal pathways to spread its time of the day message, not only to the pineal, but also to other organs, including the adrenal, utilizing the autonomic nervous system...
The stimulatory effect of vasopressin on the luteinizing hormone surge in ovariectomized, estradiol-treated rats is time-dependentI F Palm
Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
Brain Res 901:109-16. 2001..The time window is the result of other SCN regulatory systems that are involved in the preparation of the LH surge...
SCN outputs and the hypothalamic balance of lifeA Kalsbeek
Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
J Biol Rhythms 21:458-69. 2006..Moreover, the specialization of the SCN may go as far as a single body structure, that is, the SCN seems to contain neurons that specifically target the liver, pineal, and adrenal...
A network of (autonomic) clock outputsA Kalsbeek
Netherlands Institute for Brain Research, Hypothalamic Integration Mechanisms, Amsterdam, The Netherlands
Chronobiol Int 23:521-35. 2006..Moreover, the specialization of the SCN may go as far as a single body structure, i.e., the SCN seems to contain neurons that specifically target the liver, pineal gland, and adrenal gland...
The diurnal modulation of hormonal responses in the rat varies with different stimuliA Kalsbeek
Netherlands Institute for Brain Research, Amsterdam, The Netherlands
J Neuroendocrinol 15:1144-55. 2003..This observation warrants a thorough examination of possible functional explanations for the observed differences...
A daily rhythm in glucose tolerance: a role for the suprachiasmatic nucleusS E La Fleur
Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
Diabetes 50:1237-43. 2001..We hypothesized that the biological clock prepares the individual for the upcoming activity period by two separate mechanisms: increasing plasma glucose concentrations and making tissue more tolerant to glucose...
White adipose tissue: getting nervousE Fliers
Academic Medical Center of the University of Amsterdam, Department of Endocrinology and Metabolism, Amsterdam, The Netherlands
J Neuroendocrinol 15:1005-10. 2003..The developments in this research area are likely to increase our insights in the pathogenesis of metabolic disorders such as hypertriglyceridemia, diabetes mellitus type 2 and lipodystrophy syndromes...
The hypothalamic clock and its control of glucose homeostasisA Kalsbeek
Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
Prog Brain Res 153:283-307. 2006
A suprachiasmatic nucleus generated rhythm in basal glucose concentrationsS E La Fleur
Netherlands Institute for Brain Research, Amsterdam, The Netherlands
J Neuroendocrinol 11:643-52. 1999..At the same time, we found no consistent evidence for a strong impact of the SCN on basal insulin concentrations...
Hyper and hypothyroidism change the expression and diurnal variation of thyroid hormone receptor isoforms in rat liver without major changes in their zonal distributionB Zandieh-Doulabi
Department of Endocrinology and Metabolism, F5-171, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Mol Cell Endocrinol 219:69-75. 2004..Zonal distribution of the isoforms is not affected by hypo- or hyperthyroidism. We therefore conclude that thyroid hormone influences both the levels and the diurnal expression of its receptor isoforms but not the zonal distribution...
Polysynaptic neural pathways between the hypothalamus, including the suprachiasmatic nucleus, and the liverS E La Fleur
Netherlands Institute for Brain Research Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
Brain Res 871:50-6. 2000..The presence of third-order neurons in the suprachiasmatic nucleus suggests an involvement of the biological clock in the neural control of the liver...
Control of the estradiol-induced prolactin surge by the suprachiasmatic nucleusI F Palm
Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands
Endocrinology 142:2296-302. 2001..Simultaneously the SCN is involved in the regulation of the secretory capacity of the pituitary, possibly via specific PRL-releasing factors...
The biological clock tunes the organs of the body: timing by hormones and the autonomic nervous systemR M Buijs
Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
J Endocrinol 177:17-26. 2003..The physiological data collected in humans thus far seem to support this hypothesis, while pathological changes in the SCN of humans suffering from depression or hypertension indicate a role for the SCN in the etiology of these diseases...
HIV-associated adipose redistribution syndrome as a selective autonomic neuropathyE Fliers
Department of Endocrinology and Metabolism, Academic Medical Centre of the University of Amsterdam, 1105 AZ, Amsterdam, Netherlands
Lancet 362:1758-60. 2003..We propose that HARS is mediated by effects of antiretroviral treatment on the CNS and could indicate a change in autonomic balance resulting in redistribution of adipose tissue...
In vivo evidence for a controlled offset of melatonin synthesis at dawn by the suprachiasmatic nucleus in the ratS Perreau-Lenz
Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
Neuroscience 130:797-803. 2005..Therefore, these results show that an increased GABAergic inhibition of the PVN neurones that control the sympathetic innervation of the pineal gland, at dawn, is not sufficient to explain the early morning decline of melatonin release...
Diurnal variation in rat liver thyroid hormone receptor (TR)-alpha messenger ribonucleic acid (mRNA) is dependent on the biological clock in the suprachiasmatic nucleus, whereas diurnal variation of TR beta 1 mRNA is modified by food intakeB Zandieh Doulabi
Department of Endocrinology and Metabolism, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands
Endocrinology 145:1284-9. 2004..The findings may have physiological relevance for diurnal variation of T(3)-dependent gene expression, which is supported by a diurnal variation in the expression of the 5'-deiodinase gene...
The suprachiasmatic nucleus-paraventricular nucleus interactions: a bridge to the neuroendocrine and autonomic nervous systemR M Buijs
Netherlands Institute for Brain Research, Amsterdam, The Netherlands
Prog Brain Res 119:365-82. 1998..Subjecting rats or humans to light affects heart rate in a dose-dependent manner. These results suggest an important role for the SCN and VP in the SCN in the regulation of neuroendocrine and autonomic functions...
An online solid-phase extraction-liquid chromatography-tandem mass spectrometry method to study the presence of thyronamines in plasma and tissue and their putative conversion from 13C6-thyroxineM T Ackermans
Laboratory of Endocrinology, F2 131 1, Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
J Endocrinol 206:327-34. 2010....
A free-choice high-fat high-sugar diet induces glucose intolerance and insulin unresponsiveness to a glucose load not explained by obesityS E La Fleur
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Int J Obes (Lond) 35:595-604. 2011..In these free-choice diets, saturated fat and/or a 30% sugar solution are provided in an addition to normal chow pellets...
Plasma insulin concentrations during a hyperinsulinaemic clamp: what do we measure?M T Ackermans
Laboratory of Endocrinology, Department of Clinical Chemistry, University of Amsterdam
Ann Clin Biochem 45:429-30. 2008..The aim of this study is to compare the performance of three commonly used insulin assays with respect to the detection of exogenous human and porcine insulin added to human or rat plasma...
[Adipose tissue: an innervated endocrine gland]E Fliers
Academisch Medisch Centrum Universiteit van Amsterdam, afd Endocrinologie en Metabolisme, Meibergdreef 9, 1105 AZ Amsterdam
Ned Tijdschr Geneeskd 146:1976-9. 2002..The developments in this research area have the potential to increase our insights into the pathogenesis of metabolic disorders such as hypertriglyceridaemia and type-2 diabetes mellitus...
