Margot Jak

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi request reprint CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti-CD20 mAb GA101
    Margot Jak
    Department of Hematology, Academic Medical Centre, Amsterdam, The Netherlands
    Blood 118:5178-88. 2011
  2. doi request reprint Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia
    Margot Jak
    Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
    Leuk Lymphoma 50:788-801. 2009
  3. doi request reprint CD40 stimulation sensitizes CLL cells to rituximab-induced cell death
    M Jak
    Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
    Leukemia 25:968-78. 2011
  4. ncbi request reprint Cutting edge: CD95 maintains effector T cell homeostasis in chronic immune activation
    Ramon Arens
    Departments of Experimental Immunology and Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 174:5915-20. 2005

Detail Information

Publications4

  1. doi request reprint CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti-CD20 mAb GA101
    Margot Jak
    Department of Hematology, Academic Medical Centre, Amsterdam, The Netherlands
    Blood 118:5178-88. 2011
    ..Our findings indicate that GA101 has efficacy against chemoresistant CLL, and provide a rationale for combining cytotoxic drugs with anti-CD20 mAbs...
  2. doi request reprint Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia
    Margot Jak
    Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
    Leuk Lymphoma 50:788-801. 2009
    ..In conclusion, T(reg) cells in CLL may accumulate both by increased formation, facilitated by CD27-CD70 interaction in the lymph node proliferation centres, and decreased sensitivity to apoptosis because of a shifted Noxa-Bcl-2 balance...
  3. doi request reprint CD40 stimulation sensitizes CLL cells to rituximab-induced cell death
    M Jak
    Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
    Leukemia 25:968-78. 2011
    ..By increasing basal ROS production, CD40 stimulation sensitizes CLL cells to rituximab-mediated death. Our findings provide a rationale for combination treatment of CLL with cytotoxic drugs and anti-CD20 monoclonal antibodies...
  4. ncbi request reprint Cutting edge: CD95 maintains effector T cell homeostasis in chronic immune activation
    Ramon Arens
    Departments of Experimental Immunology and Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 174:5915-20. 2005
    ..These findings establish that CD95 is a critical regulator of effector T cell homeostasis in chronic immune activation...