Roeland Huijgen

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi Cardiovascular risk in relation to functionality of sequence variants in the gene coding for the low-density lipoprotein receptor: a study among 29,365 individuals tested for 64 specific low-density lipoprotein-receptor sequence variants
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur Heart J 33:2325-30. 2012
  2. doi Discriminative ability of LDL-cholesterol to identify patients with familial hypercholesterolemia: a cross-sectional study in 26,406 individuals tested for genetic FH
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Cardiovasc Genet 5:354-9. 2012
  3. pmc Plasma levels of PCSK9 and phenotypic variability in familial hypercholesterolemia
    R Huijgen
    Department of Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    J Lipid Res 53:979-83. 2012
  4. doi Familial hypercholesterolemia: current treatment and advances in management
    Roeland Huijgen
    Academic Medical Center, Department of Vascular Medicine, Meibergreef 9 Room F4 146, 1105 AZ, Amsterdam, The Netherlands
    Expert Rev Cardiovasc Ther 6:567-81. 2008
  5. ncbi Assessment of carotid atherosclerosis in normocholesterolemic individuals with proven mutations in the low-density lipoprotein receptor or apolipoprotein B genes
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Cardiovasc Genet 4:413-7. 2011
  6. pmc The extent of the preserved feathers on the four-winged dinosaur Microraptor gui under ultraviolet light
    David W E Hone
    Key Laboratory of Evolutionary Systematics of Vertebrates, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 5:e9223. 2010
  7. pmc Two years after molecular diagnosis of familial hypercholesterolemia: majority on cholesterol-lowering treatment but a minority reaches treatment goal
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 5:e9220. 2010
  8. ncbi Functionality of sequence variants in the genes coding for the low-density lipoprotein receptor and apolipoprotein B in individuals with inherited hypercholesterolemia
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Hum Mutat 31:752-60. 2010
  9. doi Genetic variation in APOB, PCSK9, and ANGPTL3 in carriers of pathogenic autosomal dominant hypercholesterolemic mutations with unexpected low LDL-Cl Levels
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands
    Hum Mutat 33:448-55. 2012
  10. doi Molecular basis of autosomal dominant hypercholesterolemia: assessment in a large cohort of hypercholesterolemic children
    Anouk van der Graaf
    Academic Medical Center, Department of Pediatrics, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
    Circulation 123:1167-73. 2011

Detail Information

Publications19

  1. doi Cardiovascular risk in relation to functionality of sequence variants in the gene coding for the low-density lipoprotein receptor: a study among 29,365 individuals tested for 64 specific low-density lipoprotein-receptor sequence variants
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur Heart J 33:2325-30. 2012
    ..The latter variants should not exhibit such an association with CAD...
  2. doi Discriminative ability of LDL-cholesterol to identify patients with familial hypercholesterolemia: a cross-sectional study in 26,406 individuals tested for genetic FH
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Cardiovasc Genet 5:354-9. 2012
    ..The purpose of the current study was to assess to what extent this overlap is influenced by the severity of specific FH mutations...
  3. pmc Plasma levels of PCSK9 and phenotypic variability in familial hypercholesterolemia
    R Huijgen
    Department of Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    J Lipid Res 53:979-83. 2012
    ..Therefore, the results of pharmaceutical inhibition of PCSK9 in FH patients are eagerly awaited...
  4. doi Familial hypercholesterolemia: current treatment and advances in management
    Roeland Huijgen
    Academic Medical Center, Department of Vascular Medicine, Meibergreef 9 Room F4 146, 1105 AZ, Amsterdam, The Netherlands
    Expert Rev Cardiovasc Ther 6:567-81. 2008
    ..In this review the various treatment options are discussed...
  5. ncbi Assessment of carotid atherosclerosis in normocholesterolemic individuals with proven mutations in the low-density lipoprotein receptor or apolipoprotein B genes
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Circ Cardiovasc Genet 4:413-7. 2011
    ..We assessed whether cardiovascular risk for these individuals differs from that of hypercholesterolemic FH heterozygotes and unaffected relatives...
  6. pmc The extent of the preserved feathers on the four-winged dinosaur Microraptor gui under ultraviolet light
    David W E Hone
    Key Laboratory of Evolutionary Systematics of Vertebrates, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 5:e9223. 2010
    ..This taxon has important implications for the origin of flight in birds and the possibility of a four-winged gliding phase...
  7. pmc Two years after molecular diagnosis of familial hypercholesterolemia: majority on cholesterol-lowering treatment but a minority reaches treatment goal
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 5:e9220. 2010
    ..In the present study, we determined whether these goals are reflected in current clinical practice once FH has been diagnosed...
  8. ncbi Functionality of sequence variants in the genes coding for the low-density lipoprotein receptor and apolipoprotein B in individuals with inherited hypercholesterolemia
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Hum Mutat 31:752-60. 2010
    ..Segregation analysis also indicated nonpathogenicity. According to our criteria, three sequence variants were nonpathogenic. The criteria may help to identify nonpathogenic sequence changes in genetic cascade screening programs...
  9. doi Genetic variation in APOB, PCSK9, and ANGPTL3 in carriers of pathogenic autosomal dominant hypercholesterolemic mutations with unexpected low LDL-Cl Levels
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands
    Hum Mutat 33:448-55. 2012
    ..While we found a low prevalence of rare variants in our cohort, our data suggest that regions in proximity of the analyzed loci, and linked to specific common haplotypes, might harbor additional variants that correct an ADH phenotype...
  10. doi Molecular basis of autosomal dominant hypercholesterolemia: assessment in a large cohort of hypercholesterolemic children
    Anouk van der Graaf
    Academic Medical Center, Department of Pediatrics, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
    Circulation 123:1167-73. 2011
    ..We therefore investigated a large pediatric population with an unequivocal ADH phenotype to assess the molecular basis of hereditary hypercholesterolemia and to define the percentage of individuals with unexplained dyslipidemia...
  11. pmc Inheritance pattern of familial hypercholesterolemia and markers of cardiovascular risk
    D Meeike Kusters
    Academic Medical Center, Amsterdam, The Netherlands
    J Lipid Res 54:2543-9. 2013
    ..07 (0.00,0.14) mmol/l, P = 0.08], or c-IMT [mean difference -0.00 (-0.01,0.01) mm, P = 0.86]. Our data do not support the hypothesis that cardiovascular risk markers are different between offspring from FH mothers and FH fathers. ..
  12. doi Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia
    Mohammad Mahdi Motazacker
    Department of Experimental Vascular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Eur Heart J 33:1360-6. 2012
    ....
  13. doi Follow-up of children diagnosed with familial hypercholesterolemia in a national genetic screening program
    Hans J Avis
    Department of Pediatrics, Academic Medical Center, Amsterdam, The Netherlands
    J Pediatr 161:99-103. 2012
    ..To assess the follow-up of children diagnosed as having familial hypercholesterolemia (FH) in the nationwide DNA-based cascade screening program (the Netherlands)...
  14. pmc Improved access to life insurance after genetic diagnosis of familial hypercholesterolaemia: cross-sectional postal questionnaire study
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Hum Genet 20:722-8. 2012
    ..Therefore, we argue that limited access to life insurance on the basis of 'DNA discrimination' is no longer a valid argument against genetic cascade testing for FH, at least not in our country...
  15. pmc Increasing levels of free thyroxine as a risk factor for a first venous thrombosis: a case-control study
    Bregje van Zaane
    Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
    Blood 115:4344-9. 2010
    ..0 (95% CI, 1.1-154.1) for FT(4) levels above reference range. Our data suggest increasing levels of FT(4) to be a risk factor for VT and may have implications for both the prevention and management of this disease...
  16. ncbi Carotid atherosclerosis progression in familial hypercholesterolemia patients: a pooled analysis of the ASAP, ENHANCE, RADIANCE 1, and CAPTIVATE studies
    Menno Vergeer
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Circ Cardiovasc Imaging 3:398-404. 2010
    ..Our aims were to investigate whether contemporary statin-treated HeFH patients still show accelerated cIMT increase and to assess the impact of statin treatment, before and after random assignment, on atherosclerosis progression...
  17. doi Plasma PCSK9 levels and clinical outcomes in the TNT (Treating to New Targets) trial: a nested case-control study
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 59:1778-84. 2012
    ..The purpose of this study was to investigate whether high levels of circulating proprotein convertase subtilisin kexin type 9 (PCSK9) would increase cardiovascular risk in statin-treated patients...
  18. doi Colesevelam added to combination therapy with a statin and ezetimibe in patients with familial hypercholesterolemia: a 12-week, multicenter, randomized, double-blind, controlled trial
    Roeland Huijgen
    Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands
    Clin Ther 32:615-25. 2010
    ..Some patients with FH do not reach LDL-C goals despite intensive combination therapy...