Sander Michel Houten

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Genetic basis of hyperlysinemia
    Sander M Houten
    Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, AZ 1105, The Netherlands
    Orphanet J Rare Dis 8:57. 2013
  2. doi request reprint Functional redundancy of mitochondrial enoyl-CoA isomerases in the oxidation of unsaturated fatty acids
    Michel van Weeghel
    Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases F0 222, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    FASEB J 26:4316-26. 2012
  3. pmc Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids
    Sander M Houten
    Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Lipid Res 53:1296-303. 2012
  4. pmc Critical assessment of human metabolic pathway databases: a stepping stone for future integration
    Miranda D Stobbe
    Bioinformatics Laboratory, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE, Amsterdam, The Netherlands
    BMC Syst Biol 5:165. 2011
  5. doi request reprint Metabolomics: unraveling the chemical individuality of common human diseases
    Sander M Houten
    Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Ann Med 41:402-7. 2009
  6. doi request reprint Pyruvate dehydrogenase kinase 4 expression is synergistically induced by AMP-activated protein kinase and fatty acids
    S M Houten
    Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Cell Mol Life Sci 66:1283-94. 2009
  7. pmc A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation
    Sander Michel Houten
    Department of Clinical Chemistry, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Inherit Metab Dis 33:469-77. 2010

Collaborators

Detail Information

Publications7

  1. pmc Genetic basis of hyperlysinemia
    Sander M Houten
    Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, AZ 1105, The Netherlands
    Orphanet J Rare Dis 8:57. 2013
    ..To date only one causal mutation in the AASS gene encoding α-aminoadipic semialdehyde synthase has been reported. We aimed to better define the genetic basis of hyperlysinemia...
  2. doi request reprint Functional redundancy of mitochondrial enoyl-CoA isomerases in the oxidation of unsaturated fatty acids
    Michel van Weeghel
    Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases F0 222, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    FASEB J 26:4316-26. 2012
    ..05). We conclude that Eci2 compensates for Eci1 deficiency explaining the mild phenotype of Eci1-deficient mice. Hypoglycemia and accumulation of C12:1 acylcarnitine might be diagnostic markers to identify ECI1 deficiency in humans...
  3. pmc Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids
    Sander M Houten
    Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Lipid Res 53:1296-303. 2012
    ..We conclude that Ehhadh is indispensable for the production of medium-chain dicarboxylic acids, providing an explanation for the coordinated induction of mitochondrial and peroxisomal oxidative pathways during fasting...
  4. pmc Critical assessment of human metabolic pathway databases: a stepping stone for future integration
    Miranda D Stobbe
    Bioinformatics Laboratory, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE, Amsterdam, The Netherlands
    BMC Syst Biol 5:165. 2011
    ..Moreover, the outcomes of such a comparison are important for ongoing integration efforts...
  5. doi request reprint Metabolomics: unraveling the chemical individuality of common human diseases
    Sander M Houten
    Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Ann Med 41:402-7. 2009
    ..The next challenging step is then to determine whether these metabolites are only biomarkers for the presence of a disease or new leads to an unknown etiology...
  6. doi request reprint Pyruvate dehydrogenase kinase 4 expression is synergistically induced by AMP-activated protein kinase and fatty acids
    S M Houten
    Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Cell Mol Life Sci 66:1283-94. 2009
    ..Finally, we show that this synergistic induction of PDK4 decreases cellular glucose oxidation. In conclusion, AMPK and fatty acids play a direct role in fuel selection in response to cellular energy status in order to spare glucose...
  7. pmc A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation
    Sander Michel Houten
    Department of Clinical Chemistry, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Inherit Metab Dis 33:469-77. 2010
    ..Studies of patients and mouse models will contribute to our understanding of the pathogenesis and will ultimately lead to better treatment...