Anton J G Horrevoets

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes
    A J Horrevoets
    Departments of Biochemistry and Vascular Medicine of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 93:3418-31. 1999
  2. doi Primary cilia sensitize endothelial cells for fluid shear stress
    Beerend P Hierck
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Dev Dyn 237:725-35. 2008
  3. ncbi Plasminogen activator inhibitor 1 (PAI-1): in vitro activities and clinical relevance
    Anton J G Horrevoets
    Department of Biochemistry K1 161, Academic Medical Centre, Meibergdreef, Amsterdam, The Netherlands
    Br J Haematol 125:12-23. 2004
  4. ncbi Comparative proteomics of human endothelial cell caveolae and rafts using two-dimensional gel electrophoresis and mass spectrometry
    Richard R Sprenger
    Department of Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Electrophoresis 25:156-72. 2004
  5. ncbi Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2
    Joost O Fledderus
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 109:4249-57. 2007
  6. ncbi SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function
    Ruud D Fontijn
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 294:H891-900. 2008
  7. ncbi Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization
    Johannes V van Thienen
    Department of Medical Biochemistry, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Cardiovasc Res 72:231-40. 2006
  8. doi Suppression of inflammatory signaling in monocytes from patients with coronary artery disease
    Stephan H Schirmer
    Department of Cardiology, Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, The Netherlands
    J Mol Cell Cardiol 46:177-85. 2009
  9. pmc Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis
    Oscar L Volger
    Department of Medical Biochemistry, Room K1 114, Academic Medical Center, University of Amsterdam, Meibergdreef 15, NL 1105 AZ, Amsterdam, The Netherlands
    Am J Pathol 171:326-37. 2007
  10. ncbi Limited contribution of claudin-5-dependent tight junction strands to endothelial barrier function
    Ruud D Fontijn
    Department of Medical Biochemistry, University of Amsterdam, Academic Medical Center K1 114, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Eur J Cell Biol 85:1131-44. 2006

Collaborators

Detail Information

Publications35

  1. ncbi Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes
    A J Horrevoets
    Departments of Biochemistry and Vascular Medicine of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 93:3418-31. 1999
    ..These results substantiate the complex change in the gene expression pattern of vascular endothelial cells, which accompanies the inflammatory reaction of atherosclerotic lesions...
  2. doi Primary cilia sensitize endothelial cells for fluid shear stress
    Beerend P Hierck
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Dev Dyn 237:725-35. 2008
    ..In addition, we targeted and stabilized the connection of the cilium to the cytoplasm by treatment with Colchicine and Taxol/Paclitaxel, respectively, and show that microtubular integrity is essential to sense shear stress...
  3. ncbi Plasminogen activator inhibitor 1 (PAI-1): in vitro activities and clinical relevance
    Anton J G Horrevoets
    Department of Biochemistry K1 161, Academic Medical Centre, Meibergdreef, Amsterdam, The Netherlands
    Br J Haematol 125:12-23. 2004
  4. ncbi Comparative proteomics of human endothelial cell caveolae and rafts using two-dimensional gel electrophoresis and mass spectrometry
    Richard R Sprenger
    Department of Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Electrophoresis 25:156-72. 2004
    ..These findings and various optimized procedures can serve as a reference to study the differential composition of endothelial cell caveolae and rafts, known to be involved in pathologies like cancer and cardiovascular disease...
  5. ncbi Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2
    Joost O Fledderus
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 109:4249-57. 2007
    ....
  6. ncbi SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function
    Ruud D Fontijn
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 294:H891-900. 2008
    ....
  7. ncbi Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization
    Johannes V van Thienen
    Department of Medical Biochemistry, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Cardiovasc Res 72:231-40. 2006
    ..We studied KLF2-dependent induction of important determinants of the atheroprotective status of the endothelium to determine whether pharmacological intervention, e.g. by statins, can potentially replace shear stress...
  8. doi Suppression of inflammatory signaling in monocytes from patients with coronary artery disease
    Stephan H Schirmer
    Department of Cardiology, Academic Medical Center, University of Amsterdam, 1105AZ Amsterdam, The Netherlands
    J Mol Cell Cardiol 46:177-85. 2009
    ..Transcriptome differences of circulating cells possibly play less of a role than hitherto thought in the individual patient's susceptibility to atherosclerotic CAD, when appropriately matched for clinical symptoms and medication taken...
  9. pmc Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis
    Oscar L Volger
    Department of Medical Biochemistry, Room K1 114, Academic Medical Center, University of Amsterdam, Meibergdreef 15, NL 1105 AZ, Amsterdam, The Netherlands
    Am J Pathol 171:326-37. 2007
    ..Thus, we identified truly common, local molecular denominators of pathological changes to vascular endothelium, with a marked distinction of endothelial phenotype between early and advanced plaques...
  10. ncbi Limited contribution of claudin-5-dependent tight junction strands to endothelial barrier function
    Ruud D Fontijn
    Department of Medical Biochemistry, University of Amsterdam, Academic Medical Center K1 114, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Eur J Cell Biol 85:1131-44. 2006
    ....
  11. pmc Spatial segregation of transport and signalling functions between human endothelial caveolae and lipid raft proteomes
    Richard R Sprenger
    Department of Medical Biochemistry, Academic Medical Center K1 114, Meibergdreef 15, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands
    Biochem J 400:401-10. 2006
    ..These results provide direct evidence for the previously suggested segregation of transport and signalling functions between specialized domains of the endothelial plasma membrane...
  12. ncbi KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium
    Rob J Dekker
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Blood 107:4354-63. 2006
    ..These results establish that KLF2 acts as a central transcriptional switch point between the quiescent and activated states of the adult endothelial cell...
  13. pmc Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes
    Rob J Dekker
    Department of Medical Biochemistry, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Am J Pathol 167:609-18. 2005
    ..05). Thus, we demonstrate that endothelial LKLF is regulated by flow in vivo and is a transcriptional regulator of several endothelial genes that control vascular tone in response to flow...
  14. ncbi KLF2 suppresses TGF-beta signaling in endothelium through induction of Smad7 and inhibition of AP-1
    Reinier A Boon
    Department of Medical Biochemistry, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 27:532-9. 2007
    ..Here, we describe its detailed effects on transforming growth factor-beta (TGF-beta) signaling, which normally has proatherogenic effects on endothelium...
  15. ncbi Proteomic study of caveolae and rafts isolated from human endothelial cells
    Richard R Sprenger
    Department of Medical Biochemistry, University of Amsterdam, The Netherlands
    Methods Mol Biol 357:199-213. 2007
    ..These mixtures allow dynamic monitoring of composition and posttranslational modification of the raft/caveola subproteome using peptide mass fingerprinting and direct peptide sequencing tandem mass spectrometry...
  16. doi Local cytokine concentrations and oxygen pressure are related to maturation of the collateral circulation in humans
    Stephan H Schirmer
    Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Am Coll Cardiol 53:2141-7. 2009
    ..Our aim was to determine cytokine and oxygen gradients over the collateral circulation in humans...
  17. doi Kruppel-like factor 2 improves neovascularization capacity of aged proangiogenic cells
    Reinier A Boon
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Eur Heart J 32:371-7. 2011
    ..The aim of this study is to identify whether KLF2 can reverse negative effects of ageing on PAC function...
  18. doi Endothelial CD81 is a marker of early human atherosclerotic plaques and facilitates monocyte adhesion
    Jakub Rohlena
    Department of Medical Biochemistry, Academic Medical Centre, Amsterdam, The Netherlands
    Cardiovasc Res 81:187-96. 2009
    ....
  19. ncbi Focusing on transcription factor families in atherogenesis: the function of LKLF and TR3
    E Karin Arkenbout
    Academic Medical Center, Department of Biochemistry K1 159, Meibergdreef 15, 1105 Amsterdam, The Netherlands
    Thromb Haemost 89:522-9. 2003
    ....
  20. ncbi Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2)
    Rob J Dekker
    Department of Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands
    Blood 100:1689-98. 2002
    ..To date LKLF is the first endothelial transcription factor that is uniquely induced by flow and might therefore be at the molecular basis of the physiological healthy, flow-exposed state of the endothelial cell...
  21. doi Proteomic screen identifies IGFBP7 as a novel component of endothelial cell-specific Weibel-Palade bodies
    Dorothee van Breevoort
    Department of Plasma Proteins, Sanquin AMC Landsteiner Laboratory, Amsterdam, The Netherlands
    J Proteome Res 11:2925-36. 2012
    ..IGFBP7 remained attached to ultralarge VWF strings released upon exocytosis of WPBs under flow. The presence of IGFBP7 in WPBs highlights the role of this subcellular compartment in regulation of angiogenesis...
  22. doi Activin A induces a non-fibrotic phenotype in smooth muscle cells in contrast to TGF-β
    Bianca C W Groenendijk
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands
    Exp Cell Res 317:131-42. 2011
    ..Activin A and transforming growth factor-β1 (TGF-β1) belong to the same family of growth and differentiation factors that modulate vascular lesion formation in distinct ways, which we wish to understand mechanistically...
  23. doi The diverse identity of angiogenic monocytes
    Julie Favre
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Clin Invest 43:100-7. 2013
    ..The role of bone marrow-derived cells in stimulating angiogenesis, vascular repair or remodelling has been well established, but the nature of the circulating angiogenic cells is still controversial...
  24. pmc The shear stress-induced transcription factor KLF2 affects dynamics and angiopoietin-2 content of Weibel-Palade bodies
    Ellen L van Agtmaal
    Department of Plasma Proteins, Sanquin AMC Landsteiner Laboratory, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e38399. 2012
    ..In this study we characterized the effect of the shear stress-induced transcription factor KLF2 on regulation and composition of Weibel-Palade bodies (WPBs) using peripheral blood derived ECs...
  25. ncbi The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue
    Houshang Monajemi
    Department of Biochemistry of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands 1105 AZ
    Genomics 79:539-46. 2002
    ..Our results show that the APOL1-APOL4 cluster might contribute to the substantial differences in the lipid metabolism of humans and mice, as dictated by the variable expression of genes involved in this process...
  26. doi The coronary collateral circulation: genetic and environmental determinants in experimental models and humans
    Paul F A Teunissen
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Mol Cell Cardiol 52:897-904. 2012
    ..The present review focuses on this heterogeneity of genetic as well as non-genetic determinants of the coronary collateral circulation. This article is part of a Special Issue entitled "Coronary Blood Flow"...
  27. ncbi A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin
    Rob J Dekker
    Department of Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Biochem 270:1942-51. 2003
    ..This competition will be physiologically significant in controlling the mitogenic activity of thrombin during vascular disease...
  28. ncbi The ins and outs of lipid domain proteomics
    Richard R Sprenger
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Proteomics 7:2895-903. 2007
    ..This integrative view tries to tentatively define the core composition, the associated functions, the topology, as well as the dynamics of lipid domain proteomes. In other words: who's in and who's out...
  29. doi Interferon-beta signaling is enhanced in patients with insufficient coronary collateral artery development and inhibits arteriogenesis in mice
    Stephan H Schirmer
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Circ Res 102:1286-94. 2008
    ..Inhibition of IFN-beta signaling may serve as a novel approach for the stimulation of collateral artery growth...
  30. pmc Angiogenic monocytes: another colorful blow to endothelial progenitors
    Anton J G Horrevoets
    VU University Medical Center, Molecular Cell Biology and Immunology, Amsterdam, The Netherlands
    Am J Pathol 174:1594-6. 2009
    ....
  31. doi Magnetic resonance imaging-defined areas of microvascular obstruction after acute myocardial infarction represent microvascular destruction and haemorrhage
    Lourens F H J Robbers
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Eur Heart J 34:2346-53. 2013
    ..However, the exact histopathological correlate of the contrast-devoid core and its relation to IMH is unknown...
  32. doi Mycophenolate mofetil attenuates plaque inflammation in patients with symptomatic carotid artery stenosis
    Sander I van Leuven
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Atherosclerosis 211:231-6. 2010
    ..These changes include reduced inflammatory cell presence with a concomitant decrease in pro-inflammatory gene expression...
  33. ncbi KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells
    Joost O Fledderus
    Department of Molecular Cell Biology and Immunology, Room B244, VU University Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 28:1339-46. 2008
    ..Our aim was to investigate the role of KLF2 in shear stress-mediated activation of Nrf2 in human umbilical vein endothelial cells (HUVECs)...
  34. ncbi Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: evidence for antiinflammatory effects of rosuvastatin
    Robert Kleemann
    Gaubius Laboratory, The Netherlands Organization for Applied Scientific Research TNO Prevention and Health, PO Box 2215, 2301 CE Leiden the Netherlands
    Circulation 108:1368-74. 2003
    ..We addressed the question whether the anti-inflammatory activities of statins can reduce atherosclerosis beyond the reduction achieved by cholesterol lowering per se...
  35. pmc Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles
    Andrea Caporali
    Experimental Cardiovascular Medicine Division, Bristol Heart Institute, University of Bristol, UK
    Circ Res 103:e15-26. 2008
    ..Collectively, our data newly demonstrate the antiangiogenic action of p75(NTR) and open new avenues for the therapeutic use of p75(NTR) inhibition to combat diabetes-induced microvascular liabilities...