Research Topics
Species | J J M HoozemansSummaryAffiliation: Academic Medical Center Country: The Netherlands Publications
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Detail Information
Publications
The unfolded protein response is activated in Alzheimer's diseaseJ J M Hoozemans
Neurogenetics Laboratory, Academic Medical Center, University of Amsterdam, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
Acta Neuropathol 110:165-72. 2005..Although the initial participation of the UPR in AD pathogenesis might be neuroprotective, sustained activation of the UPR in AD might initiate or mediate neurodegeneration...- The unfolded protein response affects neuronal cell cycle protein expression: implications for Alzheimer's disease pathogenesisJeroen J M Hoozemans
Department of Neuropathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Exp Gerontol 41:380-6. 2006..These data suggest that activation of the UPR affects cell cycle protein expression in neurons during neurodegeneration in AD... - Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathologyJ J M Hoozemans
Department of Neuropathology, Academic Medical Center, University of Amsterdam, P O Box 22700, 110DE Amsterdam, The Netherlands
Int J Dev Neurosci 24:157-65. 2006..This review will discuss the relationship between neuroinflammation and neuroregeneration in the early stages of Alzheimer's disease pathogenesis... - The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugsJeroen J M Hoozemans
Neurogenetics Laboratory, Academic Medical Center, 1100 DE Amsterdam, The Netherlands
Curr Drug Targets CNS Neurol Disord 4:307-15. 2005..Understanding the pathological, physiological and neuroprotective role of cyclooxygenase will contribute to the development of a therapy for the treatment or prevention of AD... - Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stressW Scheper
Neurogenetics Laboratory, Academic Medical Center, Amsterdam, The Netherlands
Neuropathol Appl Neurobiol 33:523-32. 2007..Our data suggest that ER and post-ER protein quality control mechanisms are activated early in the pathology of AD... - Activation of the unfolded protein response in Parkinson's diseaseJ J M Hoozemans
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Biochem Biophys Res Commun 354:707-11. 2007..These data show that the UPR is activated in PD and that UPR activation is closely associated with the accumulation and aggregation of alpha-synuclein... - Always around, never the same: pathways of amyloid beta induced neurodegeneration throughout the pathogenic cascade of Alzheimer's diseaseJ J M Hoozemans
Academic Medical Center, Neurogenetics Laboratory, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands
Curr Med Chem 13:2599-605. 2006..Insight into the role of different Abeta species during AD pathogenesis is essential for the development of disease modifying drugs and therapeutical strategies... - The significance of neuroinflammation in understanding Alzheimer's diseaseP Eikelenboom
Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
J Neural Transm 113:1685-95. 2006..We also discuss the possibilities of inflammation-based therapeutic strategies in AD... 
Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's diseaseD A T Nijholt
Department of Genome Analysis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Cell Death Differ 18:1071-81. 2011..Our data suggest that autophagy is the major degradational pathway following UPR activation in neuronal cells and indicate a connection between UPR activation and autophagic pathology in AD brain...- The early involvement of the innate immunity in the pathogenesis of late-onset Alzheimer's disease: neuropathological, epidemiological and genetic evidenceP Eikelenboom
Department of Neurology, Academic Medical Center, University of Amsterdam, Valeriusplein 9, 1075 BG, The Netherlands
Curr Alzheimer Res 8:142-50. 2011.... - Neuroinflammation in Alzheimer's disease and prion diseaseP Eikelenboom
Department of Psychiatry, Graduate School of Neurosciences, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
Glia 40:232-9. 2002.... - Removing protein aggregates: the role of proteolysis in neurodegenerationD A T Nijholt
Academic Medical Center, Department of Genome Analysis, P O Box 22660, 1100 DD Amsterdam, The Netherlands
Curr Med Chem 18:2459-76. 2011..These differences have important implications for the design of therapeutic strategies. The opportunities and caveats of targeting the UPS and autophagy/lysosomal system as a therapeutic strategy in neurodegeneration will be discussed... - Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent mannerSidhartha M Chafekar
Neurogenetics Laboratory, University of Amsterdam, Amsterdam, The Netherlands
Antioxid Redox Signal 9:2245-54. 2007..Because UPR activation is observed in AD brain at a stage that precedes the massive fibrillar Abeta deposition and tangle formation, this may indicate a role for nonfibrillar Abeta in the induction of the UPR in AD neurons... 
Neuroinflammation in plaque and vascular beta-amyloid disorders: clinical and therapeutic implicationsPiet Eikelenboom
Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Neurodegener Dis 5:190-3. 2008..The cerebral beta-amyloid (Abeta) disorders show a great variability in the distribution of parenchymal and vascular amyloid deposits...- Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicityGiuseppe Pollio
Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100 Siena, Italy
Neurobiol Dis 31:145-58. 2008.... - Microglia activation in sepsis: a case-control studyAfina W Lemstra
Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
J Neuroinflammation 4:4. 2007..The aim of this study was to investigate whether activation of microglia can be detected in patients who died of sepsis... - The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to deathAgata Copani
Department of Pharmaceutical Sciences, University of Catania, Italy
Biochim Biophys Acta 1772:409-12. 2007..The increasing knowledge of the main actors of the unscheduled DNA replication in neurons will pave the way for novel therapeutic interventions in Alzheimer's disease and other neurodegenerative disorders... - DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloidAgata Copani
Department of Pharmaceutical Sciences, University of Catania, 95125 Catania, Italy
J Neurosci 26:10949-57. 2006..Accordingly, by investigating the neuronal expression of DNA pol-beta, along with phosphorylated retinoblastoma protein and neurofibrillary changes in AD brain, we show an early involvement of DNA pol-beta in the pathogenesis of AD... - Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E2Robert Veerhuis
Research Institute Neurosciences Vrije Universiteit, Department of Psychiatry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
Brain Res 925:195-203. 2002..Furthermore, PrP105-132 did not stimulate microglial PGE(2) synthesis. We conclude that, unlike IL-1beta-induced IL-6 synthesis in astrocytes, the PrP-induced IL-6 synthesis in human adult microglia is not PGE2 mediated... - Cyclin D1 and cyclin E are co-localized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortexJeroen J M Hoozemans
Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, Vrije Universiteit, Department of Pathology, VU University Medical Center, The Netherlands
J Neuropathol Exp Neurol 61:678-88. 2002..Our findings suggest a relationship between the neuronal expression of COX-2 and cell cycle markers, which may be involved early in AD pathology... - The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: implications for Alzheimer's diseaseJeroen J M Hoozemans
Department of Pathology, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
Brain Res 951:218-26. 2002.... - The pathological cascade of Alzheimer's disease: the role of inflammation and its therapeutic implicationsJeroen J M Hoozemans
Department of Pathology, Graduate School of Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit, VU University Medical Center, The Netherlands
Drugs Today (Barc) 38:429-43. 2002..This review will outline several pathological mechanisms in Alzheimer's disease as well as some means of therapeutic intervention following the amyloid cascade hypothesis... - Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's diseaseJeroen J M Hoozemans
Department of Pathology, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
Curr Drug Targets 4:461-8. 2003..Understanding the role of COX in AD pathogenesis could contribute to the development of an anti-inflammatory therapy for the treatment or prevention of AD... - Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortexJeroen J M Hoozemans
Department of Psychiatry, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
Neurobiol Dis 15:492-9. 2004..These results suggest that p38 MAPK does not mediate COX-2 expression and pRb inactivation, which are involved in cellular changes in pyramidal neurons early in AD pathogenesis... - Amyloid beta peptide (25-35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytesMichael Hull
Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
Neurochem Int 48:663-72. 2006..The potential role of astroglial cells in the phagocytosis of amyloid and the involvement of PGs in this process suggests that a modulation of PGs synthesis may be a putative target in the prevention of amyloid deposition... - Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1qRobert Veerhuis
Institute for Clinical and Experimental Neurosciences VU ICEN VU, Department of Psychiatry, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
Neurobiol Dis 19:273-82. 2005..Combined, ultrastructural and thioflavin assays, together with microglial cytokine release measurements, provide a test system to screen potential, fibrillarity impeding therapeutics for prion disease... - Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaBAnne Waschbisch
Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
J Neurochem 96:680-93. 2006.... - Pin1 levels are downregulated during ER stress in human neuroblastoma cellsYolanda S Kap
Neurogenetics Laboratory, Academic Medical Center, PO Box 22700, Amsterdam, 1100 DE, The Netherlands
Neurogenetics 8:21-7. 2007..This study creates a starting point to investigate whether modulation of the ER stress response may prevent or delay tau pathology in AD...