J J M Hoozemans

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi The unfolded protein response affects neuronal cell cycle protein expression: implications for Alzheimer's disease pathogenesis
    Jeroen J M Hoozemans
    Department of Neuropathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Exp Gerontol 41:380-6. 2006
  2. ncbi The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs
    Jeroen J M Hoozemans
    Neurogenetics Laboratory, Academic Medical Center, 1100 DE Amsterdam, The Netherlands
    Curr Drug Targets CNS Neurol Disord 4:307-15. 2005
  3. ncbi The unfolded protein response is activated in Alzheimer's disease
    J J M Hoozemans
    Neurogenetics Laboratory, Academic Medical Center, University of Amsterdam, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    Acta Neuropathol 110:165-72. 2005
  4. ncbi Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology
    J J M Hoozemans
    Department of Neuropathology, Academic Medical Center, University of Amsterdam, P O Box 22700, 110DE Amsterdam, The Netherlands
    Int J Dev Neurosci 24:157-65. 2006
  5. ncbi Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress
    W Scheper
    Neurogenetics Laboratory, Academic Medical Center, Amsterdam, The Netherlands
    Neuropathol Appl Neurobiol 33:523-32. 2007
  6. ncbi Activation of the unfolded protein response in Parkinson's disease
    J J M Hoozemans
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Biochem Biophys Res Commun 354:707-11. 2007
  7. ncbi The significance of neuroinflammation in understanding Alzheimer's disease
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neural Transm 113:1685-95. 2006
  8. ncbi Always around, never the same: pathways of amyloid beta induced neurodegeneration throughout the pathogenic cascade of Alzheimer's disease
    J J M Hoozemans
    Academic Medical Center, Neurogenetics Laboratory, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Curr Med Chem 13:2599-605. 2006
  9. pmc Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease
    D A T Nijholt
    Department of Genome Analysis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cell Death Differ 18:1071-81. 2011
  10. ncbi The early involvement of the innate immunity in the pathogenesis of late-onset Alzheimer's disease: neuropathological, epidemiological and genetic evidence
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Valeriusplein 9, 1075 BG, The Netherlands
    Curr Alzheimer Res 8:142-50. 2011

Collaborators

Detail Information

Publications29

  1. ncbi The unfolded protein response affects neuronal cell cycle protein expression: implications for Alzheimer's disease pathogenesis
    Jeroen J M Hoozemans
    Department of Neuropathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Exp Gerontol 41:380-6. 2006
    ..These data suggest that activation of the UPR affects cell cycle protein expression in neurons during neurodegeneration in AD...
  2. ncbi The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs
    Jeroen J M Hoozemans
    Neurogenetics Laboratory, Academic Medical Center, 1100 DE Amsterdam, The Netherlands
    Curr Drug Targets CNS Neurol Disord 4:307-15. 2005
    ..Understanding the pathological, physiological and neuroprotective role of cyclooxygenase will contribute to the development of a therapy for the treatment or prevention of AD...
  3. ncbi The unfolded protein response is activated in Alzheimer's disease
    J J M Hoozemans
    Neurogenetics Laboratory, Academic Medical Center, University of Amsterdam, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    Acta Neuropathol 110:165-72. 2005
    ..Although the initial participation of the UPR in AD pathogenesis might be neuroprotective, sustained activation of the UPR in AD might initiate or mediate neurodegeneration...
  4. ncbi Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology
    J J M Hoozemans
    Department of Neuropathology, Academic Medical Center, University of Amsterdam, P O Box 22700, 110DE Amsterdam, The Netherlands
    Int J Dev Neurosci 24:157-65. 2006
    ..This review will discuss the relationship between neuroinflammation and neuroregeneration in the early stages of Alzheimer's disease pathogenesis...
  5. ncbi Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress
    W Scheper
    Neurogenetics Laboratory, Academic Medical Center, Amsterdam, The Netherlands
    Neuropathol Appl Neurobiol 33:523-32. 2007
    ..Our data suggest that ER and post-ER protein quality control mechanisms are activated early in the pathology of AD...
  6. ncbi Activation of the unfolded protein response in Parkinson's disease
    J J M Hoozemans
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Biochem Biophys Res Commun 354:707-11. 2007
    ..These data show that the UPR is activated in PD and that UPR activation is closely associated with the accumulation and aggregation of alpha-synuclein...
  7. ncbi The significance of neuroinflammation in understanding Alzheimer's disease
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neural Transm 113:1685-95. 2006
    ..We also discuss the possibilities of inflammation-based therapeutic strategies in AD...
  8. ncbi Always around, never the same: pathways of amyloid beta induced neurodegeneration throughout the pathogenic cascade of Alzheimer's disease
    J J M Hoozemans
    Academic Medical Center, Neurogenetics Laboratory, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Curr Med Chem 13:2599-605. 2006
    ..Insight into the role of different Abeta species during AD pathogenesis is essential for the development of disease modifying drugs and therapeutical strategies...
  9. pmc Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease
    D A T Nijholt
    Department of Genome Analysis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cell Death Differ 18:1071-81. 2011
    ..Our data suggest that autophagy is the major degradational pathway following UPR activation in neuronal cells and indicate a connection between UPR activation and autophagic pathology in AD brain...
  10. ncbi The early involvement of the innate immunity in the pathogenesis of late-onset Alzheimer's disease: neuropathological, epidemiological and genetic evidence
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Valeriusplein 9, 1075 BG, The Netherlands
    Curr Alzheimer Res 8:142-50. 2011
    ....
  11. ncbi Removing protein aggregates: the role of proteolysis in neurodegeneration
    D A T Nijholt
    Academic Medical Center, Department of Genome Analysis, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Curr Med Chem 18:2459-76. 2011
    ..These differences have important implications for the design of therapeutic strategies. The opportunities and caveats of targeting the UPS and autophagy/lysosomal system as a therapeutic strategy in neurodegeneration will be discussed...
  12. ncbi Neuroinflammation in Alzheimer's disease and prion disease
    P Eikelenboom
    Department of Psychiatry, Graduate School of Neurosciences, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Glia 40:232-9. 2002
    ....
  13. ncbi Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E2
    Robert Veerhuis
    Research Institute Neurosciences Vrije Universiteit, Department of Psychiatry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Brain Res 925:195-203. 2002
    ..Furthermore, PrP105-132 did not stimulate microglial PGE(2) synthesis. We conclude that, unlike IL-1beta-induced IL-6 synthesis in astrocytes, the PrP-induced IL-6 synthesis in human adult microglia is not PGE2 mediated...
  14. ncbi Cyclin D1 and cyclin E are co-localized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex
    Jeroen J M Hoozemans
    Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, Vrije Universiteit, Department of Pathology, VU University Medical Center, The Netherlands
    J Neuropathol Exp Neurol 61:678-88. 2002
    ..Our findings suggest a relationship between the neuronal expression of COX-2 and cell cycle markers, which may be involved early in AD pathology...
  15. ncbi The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: implications for Alzheimer's disease
    Jeroen J M Hoozemans
    Department of Pathology, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Brain Res 951:218-26. 2002
    ....
  16. doi Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity
    Giuseppe Pollio
    Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100 Siena, Italy
    Neurobiol Dis 31:145-58. 2008
    ....
  17. doi Neuroinflammation in plaque and vascular beta-amyloid disorders: clinical and therapeutic implications
    Piet Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurodegener Dis 5:190-3. 2008
    ..The cerebral beta-amyloid (Abeta) disorders show a great variability in the distribution of parenchymal and vascular amyloid deposits...
  18. ncbi Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner
    Sidhartha M Chafekar
    Neurogenetics Laboratory, University of Amsterdam, Amsterdam, The Netherlands
    Antioxid Redox Signal 9:2245-54. 2007
    ..Because UPR activation is observed in AD brain at a stage that precedes the massive fibrillar Abeta deposition and tangle formation, this may indicate a role for nonfibrillar Abeta in the induction of the UPR in AD neurons...
  19. ncbi The pathological cascade of Alzheimer's disease: the role of inflammation and its therapeutic implications
    Jeroen J M Hoozemans
    Department of Pathology, Graduate School of Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit, VU University Medical Center, The Netherlands
    Drugs Today (Barc) 38:429-43. 2002
    ..This review will outline several pathological mechanisms in Alzheimer's disease as well as some means of therapeutic intervention following the amyloid cascade hypothesis...
  20. pmc Microglia activation in sepsis: a case-control study
    Afina W Lemstra
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    J Neuroinflammation 4:4. 2007
    ..The aim of this study was to investigate whether activation of microglia can be detected in patients who died of sepsis...
  21. ncbi The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to death
    Agata Copani
    Department of Pharmaceutical Sciences, University of Catania, Italy
    Biochim Biophys Acta 1772:409-12. 2007
    ..The increasing knowledge of the main actors of the unscheduled DNA replication in neurons will pave the way for novel therapeutic interventions in Alzheimer's disease and other neurodegenerative disorders...
  22. ncbi DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid
    Agata Copani
    Department of Pharmaceutical Sciences, University of Catania, 95125 Catania, Italy
    J Neurosci 26:10949-57. 2006
    ..Accordingly, by investigating the neuronal expression of DNA pol-beta, along with phosphorylated retinoblastoma protein and neurofibrillary changes in AD brain, we show an early involvement of DNA pol-beta in the pathogenesis of AD...
  23. ncbi Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease
    Jeroen J M Hoozemans
    Department of Pathology, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
    Curr Drug Targets 4:461-8. 2003
    ..Understanding the role of COX in AD pathogenesis could contribute to the development of an anti-inflammatory therapy for the treatment or prevention of AD...
  24. ncbi Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex
    Jeroen J M Hoozemans
    Department of Psychiatry, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Dis 15:492-9. 2004
    ..These results suggest that p38 MAPK does not mediate COX-2 expression and pRb inactivation, which are involved in cellular changes in pyramidal neurons early in AD pathogenesis...
  25. ncbi Amyloid beta peptide (25-35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytes
    Michael Hull
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Neurochem Int 48:663-72. 2006
    ..The potential role of astroglial cells in the phagocytosis of amyloid and the involvement of PGs in this process suggests that a modulation of PGs synthesis may be a putative target in the prevention of amyloid deposition...
  26. ncbi Pin1 levels are downregulated during ER stress in human neuroblastoma cells
    Yolanda S Kap
    Neurogenetics Laboratory, Academic Medical Center, PO Box 22700, Amsterdam, 1100 DE, The Netherlands
    Neurogenetics 8:21-7. 2007
    ..This study creates a starting point to investigate whether modulation of the ER stress response may prevent or delay tau pathology in AD...
  27. ncbi Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1q
    Robert Veerhuis
    Institute for Clinical and Experimental Neurosciences VU ICEN VU, Department of Psychiatry, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    Neurobiol Dis 19:273-82. 2005
    ..Combined, ultrastructural and thioflavin assays, together with microglial cytokine release measurements, provide a test system to screen potential, fibrillarity impeding therapeutics for prion disease...
  28. ncbi Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB
    Anne Waschbisch
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 96:680-93. 2006
    ....