Michal Heger

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Non-invasive quantification of triglyceride content in steatotic rat livers by (1)H-MRS: when water meets (too much) fat
    Michal Heger
    Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Acad Radiol 18:1582-92. 2011
  2. pmc An overview of three promising mechanical, optical, and biochemical engineering approaches to improve selective photothermolysis of refractory port wine stains
    Guillermo Aguilar
    Department of Mechanical Engineering, University of California, Riverside, CA, USA
    Ann Biomed Eng 40:486-506. 2012
  3. pmc Multi-site and multi-depth near-infrared spectroscopy in a model of simulated (central) hypovolemia: lower body negative pressure
    Sebastiaan A Bartels
    Department of Intensive Care, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands
    Intensive Care Med 37:671-7. 2011
  4. ncbi request reprint Fluorescent labeling of platelets with polyanionic fluorescein derivatives
    Michal Heger
    Laser Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anal Quant Cytol Histol 31:227-32. 2009
  5. doi request reprint Laser-induced primary and secondary hemostasis dynamics and mechanisms in relation to selective photothermolysis of port wine stains
    Michal Heger
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Dermatol Sci 63:139-47. 2011
  6. doi request reprint On the interaction of fluorophore-encapsulating PEGylated lecithin liposomes with hamster and human platelets
    Michal Heger
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Microvasc Res 78:57-66. 2009
  7. ncbi request reprint Raman microspectrometry of laser-reshaped rabbit auricular cartilage: preliminary study on laser-induced cartilage mineralization
    Michal Heger
    University of Amsterdam, Academic Medical Center, Laser Center, Amsterdam, The Netherlands
    J Biomed Opt 11:024003. 2006
  8. ncbi request reprint Towards optimization of selective photothermolysis: prothrombotic pharmaceutical agents as potential adjuvants in laser treatment of port wine stains. A theoretical study
    Michal Heger
    Laser Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Thromb Haemost 93:242-56. 2005
  9. doi request reprint Quantitative assessment of liver function after ischemia-reperfusion injury and partial hepatectomy in rats
    Wilmar de Graaf
    Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Surg Res 172:85-94. 2012
  10. doi request reprint Physiological and biochemical basis of clinical liver function tests: a review
    Lisette T Hoekstra
    Academic Medical Center, Amsterdam, The Netherlands
    Ann Surg 257:27-36. 2013

Collaborators

Detail Information

Publications47

  1. doi request reprint Non-invasive quantification of triglyceride content in steatotic rat livers by (1)H-MRS: when water meets (too much) fat
    Michal Heger
    Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Acad Radiol 18:1582-92. 2011
    ..The approximations commonly used to derive steatosis degrees from magnetic resonance spectra include the generic types TG/water and TG/(TG + water)...
  2. pmc An overview of three promising mechanical, optical, and biochemical engineering approaches to improve selective photothermolysis of refractory port wine stains
    Guillermo Aguilar
    Department of Mechanical Engineering, University of California, Riverside, CA, USA
    Ann Biomed Eng 40:486-506. 2012
    ....
  3. pmc Multi-site and multi-depth near-infrared spectroscopy in a model of simulated (central) hypovolemia: lower body negative pressure
    Sebastiaan A Bartels
    Department of Intensive Care, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands
    Intensive Care Med 37:671-7. 2011
    ..We simultaneously applied multi-site (thenar and forearm) and multi-depth (15-2.5 and 25-2.5 mm probe distance) NIRS in a model of simulated hypovolemia: lower body negative pressure (LBNP)...
  4. ncbi request reprint Fluorescent labeling of platelets with polyanionic fluorescein derivatives
    Michal Heger
    Laser Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anal Quant Cytol Histol 31:227-32. 2009
    ..To investigate whether polyanionic fluorescein derivatives are capable of labeling resting and activated hamster and human platelets...
  5. doi request reprint Laser-induced primary and secondary hemostasis dynamics and mechanisms in relation to selective photothermolysis of port wine stains
    Michal Heger
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Dermatol Sci 63:139-47. 2011
    ..Currently it is not known whether the hemodynamic response encompasses both primary and secondary hemostasis, which platelet receptors are involved, and what the SP-induced thrombosis kinetics are in low-flow venules...
  6. doi request reprint On the interaction of fluorophore-encapsulating PEGylated lecithin liposomes with hamster and human platelets
    Michal Heger
    Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Microvasc Res 78:57-66. 2009
    ..35 mM. In contrast, these drug carriers may become valuable in thrombosis- and drug delivery-related research and applications at concentrations of >or=1.35 mM...
  7. ncbi request reprint Raman microspectrometry of laser-reshaped rabbit auricular cartilage: preliminary study on laser-induced cartilage mineralization
    Michal Heger
    University of Amsterdam, Academic Medical Center, Laser Center, Amsterdam, The Netherlands
    J Biomed Opt 11:024003. 2006
    ....
  8. ncbi request reprint Towards optimization of selective photothermolysis: prothrombotic pharmaceutical agents as potential adjuvants in laser treatment of port wine stains. A theoretical study
    Michal Heger
    Laser Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Thromb Haemost 93:242-56. 2005
    ..We have termed this modality site-specific pharmaco-laser therapy...
  9. doi request reprint Quantitative assessment of liver function after ischemia-reperfusion injury and partial hepatectomy in rats
    Wilmar de Graaf
    Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Surg Res 172:85-94. 2012
    ....
  10. doi request reprint Physiological and biochemical basis of clinical liver function tests: a review
    Lisette T Hoekstra
    Academic Medical Center, Amsterdam, The Netherlands
    Ann Surg 257:27-36. 2013
    ..To review the literature on the most clinically relevant and novel liver function tests used for the assessment of hepatic function before liver surgery...
  11. doi request reprint Enhanced tumor growth after portal vein embolization in a rabbit tumor model
    Lisette T Hoekstra
    Department of Surgery Surgical Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Surg Res 180:89-96. 2013
    ..The VX2 carcinoma is derived from a virus-induced papilloma tumor in rabbits. The tumor grows rapidly, and its blood supply is similar to that of human hepatocellular carcinoma...
  12. doi request reprint Biodegradable polymer scaffold, semi-solid solder, and single-spot lasing for increasing solder-tissue bonding in suture-free laser-assisted vascular repair
    Dara R Pabittei
    Department of Cardio Thoracic Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands
    J Tissue Eng Regen Med 6:803-12. 2012
    ..The improvement in adhesive bonding was associated with enhanced weld stability during hydration...
  13. doi request reprint Omega-3 fatty acids reduce hepatic steatosis and consequently attenuate ischemia-reperfusion injury following partial hepatectomy in rats
    Hendrik A Marsman
    Department of Surgery Surgical Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dig Liver Dis 43:984-90. 2011
    ..The aim of this study was to investigate omega-3 fatty acids (FAs) treatment of experimental steatosis and the consequent effect on ischemia-reperfusion (IR) injury...
  14. doi request reprint Liver regeneration after portal vein embolization using absorbable and permanent embolization materials in a rabbit model
    Jacomina W van den Esschert
    Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Ann Surg 255:311-8. 2012
    ..To compare the safety and hypertrophy response after portal vein embolization (PVE) using 2 absorbable and 3 permanent embolization materials...
  15. doi request reprint Transporters involved in the hepatic uptake of (99m)Tc-mebrofenin and indocyanine green
    Wilmar de Graaf
    Department of Experimental Surgery, Academic Medical Center, Amsterdam, The Netherlands
    J Hepatol 54:738-45. 2011
    ..The aim of this study was to identify the specific human hepatic transporters of (99m)Tc-mebrofenin and ICG...
  16. doi request reprint Sterile inflammation in hepatic ischemia/reperfusion injury: present concepts and potential therapeutics
    Rowan F van Golen
    Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Gastroenterol Hepatol 28:394-400. 2013
    ..Moreover, novel therapeutic modalities are addressed, including MitoSNO and nilotinib, and metalloporphyrins on the basis of the updated paradigm of hepatic I/R injury...
  17. doi request reprint Short-term effects of combined hepatic vein embolization and portal vein embolization for the induction of liver regeneration in a rabbit model
    Krijn P van Lienden
    Department of Interventional Radiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Vasc Interv Radiol 23:962-7. 2012
    ..This study assessed the effect of hepatic vein embolization (HVE) in addition to PVE on liver hypertrophy response in a standardized rabbit model...
  18. doi request reprint The microcirculatory response to compensated hypovolemia in a lower body negative pressure model
    Sebastiaan A Bartels
    Department of Intensive Care, Erasmus MC, University Medical Center Rotterdam, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Microvasc Res 82:374-80. 2011
    ..Furthermore, using a VOT we found that resting tissue oxygen consumption was maintained under conditions of adequately compensated central hypovolemia...
  19. doi request reprint Antibiotic prophylaxis in (sub)normothermic organ preservation: in vitro efficacy and toxicity of cephalosporins
    Bote G Bruinsma
    Department of Surgery Surgical Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Transplantation 95:1064-9. 2013
    ..However, with organ preservation steering toward (sub)normothermic temperatures, bacterial contamination may be detrimental with limited evidence to support the choice of antibiotic...
  20. doi request reprint The sterile immune response during hepatic ischemia/reperfusion
    Rowan F van Golen
    Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cytokine Growth Factor Rev 23:69-84. 2012
    ..This review focuses on the temporal organization of sterile hepatic inflammation, using surgery-induced trauma as a template disease state...
  21. doi request reprint Electrospun poly(ɛ-caprolactone) scaffold for suture-free solder-mediated laser-assisted vessel repair
    Dara R Pabittei
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Photomed Laser Surg 29:19-25. 2011
    ..This study investigated the possibility of using electrospun poly(ɛ-caprolactone) (PCL) as reinforcement material in scaffold and solder-mediated LAVR (ssLAVR)...
  22. doi request reprint Real-time assessment of renal cortical microvascular perfusion heterogeneities using near-infrared laser speckle imaging
    Rick Bezemer
    Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Opt Express 18:15054-61. 2010
    ....
  23. doi request reprint Portal vein embolization induces more liver regeneration than portal vein ligation in a standardized rabbit model
    Jacomina W van den Esschert
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Surgery 149:378-85. 2011
    ..The aim of our study was to compare the hypertrophy response of the liver after PVL versus PVE in a rabbit model...
  24. doi request reprint Efficacy of liver graft washout as a function of the perfusate, pressure, and temperature
    Ivo C J H Post
    Department of Surgery Surgical Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Liver Transpl 19:843-51. 2013
    ..Simultaneous arterial and portal washout with RL at 37°C and 100 mm Hg resulted in the least RBC retention and the shortest washout time. Liver Transpl 19:843-851, 2013. © 2013 AASLD. ..
  25. pmc Optimal flow and pressure management in machine perfusion systems for organ preservation
    Ivo C J H Post
    Department of Surgery Surgical Laboratory, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Ann Biomed Eng 40:2698-707. 2012
    ..Conclusively, CFS-based MPS are more suitable for organ preservation than UFS-based MPS. Our CFS-based MPS provides a versatile yet robust experimental platform for testing and validating different types of clinical and experimental MPS...
  26. doi request reprint Effects of prolonged pneumoperitoneum on hepatic perfusion during laparoscopy
    Lisette T Hoekstra
    Department of Surgery Surgical Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Ann Surg 257:302-7. 2013
    ..To assess the influence of prolonged pneumoperitoneum (PP) on liver function and perfusion in a clinically relevant porcine model of laparoscopic abdominal insufflation...
  27. doi request reprint Reversal of hepatic steatosis by omega-3 fatty acids measured non-invasively by (1) H-magnetic resonance spectroscopy in a rat model
    Hendrik A Marsman
    Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Gastroenterol Hepatol 26:356-63. 2011
    ..The aim of the present study was to investigate whether administration of omega-3 FA is effective in reducing steatosis...
  28. doi request reprint Mechanistic overview of reactive species-induced degradation of the endothelial glycocalyx during hepatic ischemia/reperfusion injury
    Rowan F van Golen
    Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Free Radic Biol Med 52:1382-402. 2012
    ..The majority of the glycocalyx-related mechanisms elucidated for hepatic ischemia/reperfusion are extrapolatable to the other aforementioned disease states...
  29. doi request reprint An overview of clinical and experimental treatment modalities for port wine stains
    Jennifer K Chen
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, California, USA
    J Am Acad Dermatol 67:289-304. 2012
    ....
  30. doi request reprint Microcirculation follows macrocirculation in heart and gut in the acute phase of hemorrhagic shock and isovolemic autologous whole blood resuscitation in pigs
    Mat van Iterson
    Department of Translational Physiology, University of Amsterdam, Amsterdam, The Netherlands
    Transfusion 52:1552-9. 2012
    ....
  31. doi request reprint Effect of preoperative biliary drainage on coagulation and fibrinolysis in severe obstructive cholestasis
    Jaap J Kloek
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Gastroenterol 44:646-52. 2010
    ..To evaluate the function of coagulation and fibrinolysis in cholestatic patients before and after preoperative biliary drainage (PBD)...
  32. doi request reprint Validation of near-infrared laser speckle imaging for assessing microvascular (re)perfusion
    Rick Bezemer
    Department of Intensive Care, Erasmus MC University Hospital Rotterdam, Rotterdam, The Netherlands
    Microvasc Res 79:139-43. 2010
    ..In conclusion, LSI can be employed to accurately quantitate microvascular reactivity following ischemic and hyperthermic challenges...
  33. doi request reprint Controversies in the use of portal vein embolization
    Thomas M van Gulik
    Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dig Surg 25:436-44. 2008
    ..The aim of this overview is to point out and discuss current controversies in the application of PVE...
  34. pmc Assessment of tissue oxygen saturation during a vascular occlusion test using near-infrared spectroscopy: the role of probe spacing and measurement site studied in healthy volunteers
    Rick Bezemer
    Department of Intensive Care, Erasmus MC, University Medical Center Rotterdam, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Crit Care 13:S4. 2009
    ....
  35. pmc Volumetric and functional recovery of the remnant liver after major liver resection with prior portal vein embolization : recovery after PVE and liver resection
    Jacomina W van den Esschert
    Department of Surgery, Academic Medical Center, IWO 1, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    J Gastrointest Surg 13:1464-9. 2009
    ..The aim of this study was to assess the effect of preoperative portal vein embolization on liver volume and function 3 months after major liver resection...
  36. doi request reprint Characterization and quantification of porcine circulating endothelial cells
    Ivo C J H Post
    Department of Surgery Surgical Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Xenotransplantation 20:18-26. 2013
    ..While (xeno) transplantation and cardiovascular research is regularly performed in porcine models, the paucity of antibodies against porcine endothelium epitopes hinders the use of CEC as damage marker...
  37. doi request reprint A novel oxygenated machine perfusion system for preservation of the liver
    Marcel C Dirkes
    Department of Surgery Surgical Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    Artif Organs 37:719-24. 2013
    ....
  38. doi request reprint Cholestasis is associated with hepatic microvascular dysfunction and aberrant energy metabolism before and during ischemia-reperfusion
    Jaap J Kloek
    Department of Experimental Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Antioxid Redox Signal 17:1109-23. 2012
    ....
  39. ncbi request reprint Appraisal of the porcine kidney autotransplantation model
    Ivo C J H Post
    Department of Surgery Surgical Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Front Biosci (Elite Ed) 4:1345-57. 2012
    ..With the detailed discussion of these determinants and the pitfalls in diagnosing animal discomfort, an attempt is made to provide a uniform porcine kidney autotransplantation model with tools to improve currently used models...
  40. pmc Rapid automatic assessment of microvascular density in sidestream dark field images
    Rick Bezemer
    Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Med Biol Eng Comput 49:1269-78. 2011
    ..The new method was shown to be much faster than the conventional (semi-)manual method. Due to current SDF imaging hardware limitations, we were not able to automatically detect microvascular perfusion...
  41. pmc Optimization of suture-free laser-assisted vessel repair by solder-doped electrospun poly(ε-caprolactone) scaffold
    Dara R Pabittei
    Department of Cardiothoracic Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Ann Biomed Eng 39:223-34. 2011
    ..In conclusion, ssLAVR produced supraphysiological LPPs and limited tissue damage. Despite heat-induced structural/mechanical alterations of the scaffold, PCL is a suitable polymer for weld reinforcement in medium-sized vessel ssLAVR...
  42. pmc Evaluation of multi-exponential curve fitting analysis of oxygen-quenched phosphorescence decay traces for recovering microvascular oxygen tension histograms
    Rick Bezemer
    Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Med Biol Eng Comput 48:1233-42. 2010
    ....
  43. doi request reprint Quantitative assessment of hepatic function during liver regeneration in a standardized rat model
    Wilmar de Graaf
    Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Nucl Med 52:294-302. 2011
    ..The aim of this study was therefore to compare (99m)Tc-GSA scintigraphy, (99m)Tc-mebrofenin HBS, the ICG clearance test, and GEC in the assessment of hepatic function during liver regeneration in rats...
  44. ncbi request reprint Cholestasis enhances liver ischemia/reperfusion-induced coagulation activation in rats
    Jaap J Kloek
    Departments of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Hepatol Res 40:204-15. 2010
    ..Conclusions: Cholestasis significantly enhances I/R-induced hepatic damage and inflammation that concurs with an increased activation of coagulation and fibrinolysis...
  45. pmc Simultaneous multi-depth assessment of tissue oxygen saturation in thenar and forearm using near-infrared spectroscopy during a simple cardiovascular challenge
    Rick Bezemer
    Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Crit Care 13:S5. 2009
    ....
  46. doi request reprint Absence of 633-nm laser irradiation-induced effects on glucose phosphorylation by hexokinase
    Michal Heger
    Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Photochem Photobiol B 98:216-22. 2010
    ..Consequently, it is questionable, albeit not unequivocal, that NROF exerts an effect on other ATP-driven reactions in cell metabolic pathways through a direct impact on ATP...
  47. doi request reprint Suture-free laser-assisted vessel repair using CO2 laser and liquid albumin solder
    Ingrid C D Y M Wolf-de Jonge
    Academic Medical Center, Department of Vascular Surgery, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Biomed Opt 13:044032. 2008
    ..Thermal damage was confined primarily to the adventitial layers, with limited heat diffusion into the media below the solder around the coaptation interface...