J C Hardwick

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi Leptin is a growth factor for colonic epithelial cells
    J C Hardwick
    Department of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Gastroenterology 121:79-90. 2001
  2. ncbi Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon
    James C H Hardwick
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 126:111-21. 2004
  3. ncbi DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1
    James C H Hardwick
    Department of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Carcinogenesis 25:1293-8. 2004
  4. ncbi Sonic hedgehog regulates gastric gland morphogenesis in man and mouse
    G R van den Brink
    Department of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Gastroenterology 121:317-28. 2001
  5. ncbi The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway
    Liudmila L Kodach
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 133:1272-81. 2007
  6. ncbi NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps
    J C Hardwick
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Oncogene 20:819-27. 2001
  7. ncbi Transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND-study)
    Frank J C van den Broek
    Dept of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands
    BMC Surg 9:4. 2009
  8. ncbi Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells
    Liudmila L Kodach
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Carcinogenesis 27:508-16. 2006
  9. ncbi Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
    Gijs R van den Brink
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Nat Genet 36:277-82. 2004
  10. ncbi Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach
    S A Bleuming
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands, and Department of Gastroenterology and Hepatology, Geneva University Hospital, Switzerland
    J Pathol 209:190-7. 2006

Collaborators

Detail Information

Publications16

  1. ncbi Leptin is a growth factor for colonic epithelial cells
    J C Hardwick
    Department of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Gastroenterology 121:79-90. 2001
    ..The aim of this study was to investigate whether leptin is a growth factor for colonic epithelial cells...
  2. ncbi Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon
    James C H Hardwick
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 126:111-21. 2004
    ..We investigated the role of BMP2 in the colon...
  3. ncbi DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1
    James C H Hardwick
    Department of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Carcinogenesis 25:1293-8. 2004
    ..Furthermore, they point towards a role for Rac1 in the action of aspirin in colon cancer...
  4. ncbi Sonic hedgehog regulates gastric gland morphogenesis in man and mouse
    G R van den Brink
    Department of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Gastroenterology 121:317-28. 2001
    ..We investigated whether Sonic hedgehog (Shh), an established polarizing signal protein during development, is expressed and functional in the adult human and murine stomach...
  5. ncbi The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway
    Liudmila L Kodach
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 133:1272-81. 2007
    ..Statins induce bone morphogenetic protein (BMP) expression in bone cells. We have previously shown that BMPs act as tumor suppressors in CRC. We hypothesized that the action of statins in CRC involves the induction of BMPs...
  6. ncbi NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps
    J C Hardwick
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Oncogene 20:819-27. 2001
    ..In the case of NF-kappaB this coincides with the cellular localisation of COX-2. These results support evidence that NSAIDs may act through effects on stromal cells rather than epithelial cells...
  7. ncbi Transanal endoscopic microsurgery versus endoscopic mucosal resection for large rectal adenomas (TREND-study)
    Frank J C van den Broek
    Dept of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands
    BMC Surg 9:4. 2009
    ..Furthermore, EMR appears to be associated with fewer complications.The aim of this study is to compare the cost-effectiveness and cost-utility of TEM and EMR for the resection of large rectal adenomas...
  8. ncbi Violacein synergistically increases 5-fluorouracil cytotoxicity, induces apoptosis and inhibits Akt-mediated signal transduction in human colorectal cancer cells
    Liudmila L Kodach
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Carcinogenesis 27:508-16. 2006
    ..Taken together, our findings suggest that violacein will be active in the treatment of colorectal tumors and offers new prospects for overcoming 5-FU resistance...
  9. ncbi Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
    Gijs R van den Brink
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Nat Genet 36:277-82. 2004
    ..These data identify a new Wnt-Hh axis in colonic epithelial renewal...
  10. ncbi Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach
    S A Bleuming
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands, and Department of Gastroenterology and Hepatology, Geneva University Hospital, Switzerland
    J Pathol 209:190-7. 2006
    ..The data suggest that morphological changes in epithelial histology may result from alterations in the morphogenetic landscape secondary to changes in the cellular composition of the lamina propria...
  11. ncbi Narrow-band imaging compared with conventional colonoscopy for the detection of dysplasia in patients with longstanding ulcerative colitis
    E Dekker
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Endoscopy 39:216-21. 2007
    ..The aim of this study was to compare the accuracy of narrow-band imaging (NBI), a new imaging technique, with standard colonoscopy for the detection of neoplasia in patients with longstanding ulcerative colitis...
  12. ncbi The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer
    Liudmila L Kodach
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Cancer 112:300-6. 2008
    ..Bone morphogenetic proteins (BMPs), a subgroup within the TGFbeta superfamily, recently also have been implicated in CRC, but their precise role in CRC has yet to be investigated...
  13. ncbi Combining autofluorescence imaging and narrow-band imaging for the differentiation of adenomas from non-neoplastic colonic polyps among experienced and non-experienced endoscopists
    Frank J C van den Broek
    Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Gastroenterol 104:1498-507. 2009
    ..In this study, we aimed to assess the interobserver variability and accuracy of HR-WLE, NBI, and AFI for polyp differentiation and to evaluate the combined use of AFI and NBI...
  14. ncbi Clinical evaluation of endoscopic trimodal imaging for the detection and differentiation of colonic polyps
    Frank J C van den Broek
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Gastroenterol Hepatol 7:288-95. 2009
    ..This was a randomized trial of tandem colonoscopies. The study was performed at the Academic Medical Center in Amsterdam...
  15. ncbi The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers
    Liudmila L Kodach
    Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 134:1332-41. 2008
    ..The finding of bone morphogenetic protein (BMP) receptor 1a mutations in juvenile polyposis suggests that BMPs are important in colorectal cancer (CRC). We investigated the BMP pathway in sporadic CRC...
  16. ncbi Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activity
    Carina L Bos
    Laboratory of Experimental Oncology and Radiobiology, Department of Oncology, University of Amsterdam, The Netherlands
    Carcinogenesis 27:2371-82. 2006
    ..This study shows, using concentrations of mesalazine identical to concentrations seen in patients with inflammatory bowel disease, that mesalazine inhibits the Wnt/beta-catenin pathway via inhibition of PP2A...