Jörg Hamann

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts
    Olga N Karpus
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e35606. 2012
  2. ncbi request reprint The EGF-TM7 family of the rat
    Jörg Hamann
    Laboratory for Experimental Immunology, G1 106, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Immunogenetics 56:679-81. 2004
  3. ncbi request reprint EMR1, the human homolog of F4/80, is an eosinophil-specific receptor
    Jörg Hamann
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 37:2797-802. 2007
  4. ncbi request reprint CD97 in Leukocyte Trafficking
    Jörg Hamann
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Adv Exp Med Biol 706:128-37. 2011
  5. ncbi request reprint CD97 in leukocyte trafficking
    Jörg Hamann
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Adv Exp Med Biol 706:128-37. 2010
  6. ncbi request reprint Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence
    Jörg Hamann
    Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 33:1365-71. 2003
  7. ncbi request reprint Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells
    Mark J Kwakkenbos
    Laboratory of Expermential Immunology, Academic Medical Centre, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    J Leukoc Biol 77:112-9. 2005
  8. doi request reprint Viral double-stranded RNA sensors induce antiviral, pro-inflammatory, and pro-apoptotic responses in human renal tubular epithelial cells
    Kirstin M Heutinck
    Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    Kidney Int 82:664-75. 2012
  9. ncbi request reprint Identification of the epidermal growth factor-TM7 receptor EMR2 and its ligand dermatan sulfate in rheumatoid synovial tissue
    Else N Kop
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 52:442-50. 2005
  10. pmc A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense
    Henrike Veninga
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e24431. 2011

Detail Information

Publications42

  1. pmc Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblasts
    Olga N Karpus
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e35606. 2012
    ..CD55 is also a ligand for CD97, an adhesion-type G protein-coupled receptor abundantly present on leukocytes. Little is known regarding the regulation of CD55 expression in FLS...
  2. ncbi request reprint The EGF-TM7 family of the rat
    Jörg Hamann
    Laboratory for Experimental Immunology, G1 106, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Immunogenetics 56:679-81. 2004
    ..Like the mouse, the rat has three EGF-TM7 receptors--CD97, EMR1 and EMR4. The highest conservation between the orthologues lies within the membrane-spanning part and emphasizes the functional importance of this region...
  3. ncbi request reprint EMR1, the human homolog of F4/80, is an eosinophil-specific receptor
    Jörg Hamann
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 37:2797-802. 2007
    ..Absence on other leukocytes, including basophils, implies that EMR1 is a highly specific marker for eosinophils in humans...
  4. ncbi request reprint CD97 in Leukocyte Trafficking
    Jörg Hamann
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Adv Exp Med Biol 706:128-37. 2011
    ....
  5. ncbi request reprint CD97 in leukocyte trafficking
    Jörg Hamann
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Adv Exp Med Biol 706:128-37. 2010
    ....
  6. ncbi request reprint Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence
    Jörg Hamann
    Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 33:1365-71. 2003
    ..Thus, EMR4 surprisingly accounts for a genetic difference between humans and primates related to immunity...
  7. ncbi request reprint Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells
    Mark J Kwakkenbos
    Laboratory of Expermential Immunology, Academic Medical Centre, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    J Leukoc Biol 77:112-9. 2005
    ..The interaction between CD97/EMR2 and CS may therefore play a role in the interaction of activated T cells, dendritic cells, and macrophages with B cells...
  8. doi request reprint Viral double-stranded RNA sensors induce antiviral, pro-inflammatory, and pro-apoptotic responses in human renal tubular epithelial cells
    Kirstin M Heutinck
    Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    Kidney Int 82:664-75. 2012
    ..Thus, sensors of viral dsRNA promote antiviral, pro-inflammatory, and pro-apoptotic responses in tubular epithelial cells, which may orchestrate the control of viral infection in the kidney...
  9. ncbi request reprint Identification of the epidermal growth factor-TM7 receptor EMR2 and its ligand dermatan sulfate in rheumatoid synovial tissue
    Else N Kop
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 52:442-50. 2005
    ..CS have been implicated in the pathogenesis of rheumatoid arthritis (RA). We undertook this study to determine the expression of EMR2 and the distribution of EMR2 and CD97 ligands within RA synovial tissue (ST)...
  10. pmc A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense
    Henrike Veninga
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e24431. 2011
    ..We previously showed that mice lacking a functional CD97 gene have increased numbers of granulocytes...
  11. ncbi request reprint The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells
    Mark J Kwakkenbos
    Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Leukoc Biol 71:854-62. 2002
    ..Different expression patterns and the inability of EMR2 to interact with the CD97 ligand CD55 indicate that the molecular twins EMR2 and CD97 likely have nonredundant functions...
  12. ncbi request reprint The EGF-TM7 family: a postgenomic view
    Mark J Kwakkenbos
    Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, G1 106, PO Box 22700, 1100 DE, Amsterdam, The Netherlands
    Immunogenetics 55:655-66. 2004
    ..Here we discuss the currently available information on this intriguing receptor family...
  13. ncbi request reprint An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2
    Mark J Kwakkenbos
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    FASEB J 20:2582-4. 2006
    ..alternative splicing) prevent CD55 binding by EMR2 in hominoids. Our findings illustrate how various and partially opposing evolutionary events have shaped the structure and ligand specificity of a modern mammalian gene family...
  14. doi request reprint CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism
    Henrike Veninga
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Leukoc Biol 89:413-21. 2011
    ..Notably, depletion of granulocytes by CD97 antibody required acute inflammation, suggesting a mechanism of conditional, antibody-mediated granulocytopenia...
  15. ncbi request reprint CD70-driven chronic immune activation is protective against atherosclerosis
    Ronald W van Olffen
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Innate Immun 2:344-52. 2010
    ..This unexpected outcome provides a new insight into the consequences of costimulatory signals and their impact on innate immunity...
  16. ncbi request reprint Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration
    Henrike Veninga
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 181:6574-83. 2008
    ..Hence, we conclude that CD97 mAbs actively induce an inhibitory effect that disturbs normal granulocyte trafficking, which is not perturbed by the absence of the molecule...
  17. doi request reprint Differential expression of CD97 on human lymphocyte subsets and limited effect of CD97 antibodies on allogeneic T-cell stimulation
    Else N Kop
    Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Immunol Lett 123:160-8. 2009
    ..Mixed lymphocyte cultures revealed a limited ability of the stalk region-specific monoclonal antibody CLB-CD97/3 to inhibit CD8(+) and CD4(+) allogeneic T-cell proliferation...
  18. doi request reprint Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease
    Marco van Eijk
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Immunol Lett 129:64-71. 2010
    ..These findings indicate that complex cellular expression programmes rather than activation modes regulate the expression of EGF-TM7 receptors in macrophages...
  19. pmc CD97 neutralisation increases resistance to collagen-induced arthritis in mice
    Else N Kop
    Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, P, O, Box 22700, 1100 DE Amsterdam, The Netherlands
    Arthritis Res Ther 8:R155. 2006
    ..When treatment was started on day 35, CD97 mAb treatment had similar effects, albeit less pronounced. The results support the notion that CD97 contributes to synovial inflammation and joint destruction in arthritis...
  20. doi request reprint Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55
    Olga N Karpus
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Immunol 190:3740-8. 2013
    ..This regulation can restrict CD97-CD55-mediated cell adhesion to tissue sites...
  21. ncbi request reprint The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes
    Mourad Matmati
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    J Leukoc Biol 81:440-8. 2007
    ..These results demonstrate that the expression of EGF-TM7 receptors on myeloid cells is differentially regulated. EMR3 is the first family member found mainly on granulocytes...
  22. ncbi request reprint Microglia in normal appearing white matter of multiple sclerosis are alerted but immunosuppressed
    Jeroen Melief
    Neuroimmunology Group, Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Glia 61:1848-61. 2013
    ....
  23. doi request reprint SerpinB9 expression in human renal tubular epithelial cells is induced by triggering of the viral dsRNA sensors TLR3, MDA5 and RIG-I
    Kirstin M Heutinck
    Department of Experimental Immunology, Renal Transplant Unit, Academic Medical Center, Amsterdam, The Netherlands
    Nephrol Dial Transplant 27:2746-54. 2012
    ..Previously, we found that tubular serpinB9 expression was increased during subclinical rejection. Here, we studied the regulation of serpinB9 expression in tubular epithelial cells (TECs) under inflammatory conditions...
  24. ncbi request reprint Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation
    Klaas P J M van Gisbergen
    Department of Hematopoiesis, Sanquin Research at CLB and Landsteiner Laboratory, Amsterdam, The Netherlands
    Nat Immunol 13:864-71. 2012
    ..Thus, reminiscent of the function of Blimp-1 in other lymphocytes, Hobit controlled the maintenance of quiescent, fully differentiated NKT cells and regulated their immediate effector functions...
  25. ncbi request reprint Dedicated pinhole SPECT of intestinal neutrophil recruitment in a mouse model of dextran sulfate sodium-induced colitis
    Roelof J Bennink
    Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Nucl Med 46:526-31. 2005
    ..This study evaluated a noninvasive scintigraphic technique able to assess neutrophil trafficking in a mouse model of dextran sulfate sodium (DSS)-induced colitis...
  26. ncbi request reprint Chronic exposure to glucocorticoids shapes gene expression and modulates innate and adaptive activation pathways in macrophages with distinct changes in leukocyte attraction
    Martijn D B van de Garde
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Immunol 192:1196-208. 2014
    ..Thus, GCs do not generally suppress macrophage effector functions, but they cause a shift in the innate-adaptive balance of the immune response, with distinct changes in the chemokine-chemokine receptor network. ..
  27. doi request reprint Deletion of either CD55 or CD97 ameliorates arthritis in mouse models
    Robert M Hoek
    Academic Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 62:1036-42. 2010
    ..This study was undertaken to investigate the role of CD55 in experimental RA...
  28. ncbi request reprint Expression of the inhibitory CD200 receptor is associated with alternative macrophage activation
    Nathalie Koning
    Department of Neuroimmunology, Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy for Arts and Sciences, Amsterdam, The Netherlands
    J Innate Immun 2:195-200. 2010
    ..Our data identify CD200R as a suitable marker for alternatively activated macrophages in humans and corroborate observations of distinct species- and/or site-specific mechanisms regulating macrophage polarization in mouse and man...
  29. pmc Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype
    Samuel Garcia
    Department of Experimental Immunology, University of Amsterdam, Amsterdam, the Netherlands Department of Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 9:e82088. 2014
    ..Our findings suggest a general role for Tie2 in cooperatively promoting the inflammatory activation of macrophages, independently of polarization conditions. ..
  30. doi request reprint Characteristics of differentiated CD8(+) and CD4 (+) T cells present in the human brain
    Joost Smolders
    Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands
    Acta Neuropathol 126:525-35. 2013
    ..The presence of these cells in this tightly regulated environment likely enables a fast response to local threats. Our results will enable future detailed exploration of T-cell subsets in the brain involved in neurological diseases. ..
  31. ncbi request reprint The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense
    Jaklien C Leemans
    Laboratory for Experimental Internal Medicine, Department of Pathology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    J Immunol 172:1125-31. 2004
    ..This was associated with a significantly enhanced outgrowth of bacteria in the lungs at 44 h and a strongly diminished survival. Together, these findings indicate an essential role for CD97 in the migration of neutrophils...
  32. pmc Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons
    Viviana Cobos Jiménez
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam CINIMA at the Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    Sci Rep 2:763. 2012
    ..IL-4, IL-10 or IL-32 polarization did not affect the expression of cellular factors and miRNAs, suggesting only a limited role for these cellular factors in restricting HIV-1 replication in macrophages...
  33. doi request reprint GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo
    Ronald W van Olffen
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 182:7490-500. 2009
    ..These data indicate that GITR regulates the balance between regulatory and effector CD4(+) T cells by enhancing proliferation of both populations in parallel...
  34. pmc Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis
    Daphne de Launay
    Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Am J Pathol 177:3010-24. 2010
    ....
  35. doi request reprint Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis
    Sarah Krausz
    Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
    Ann Rheum Dis 71:1402-10. 2012
    ....
  36. doi request reprint The prolactin receptor is expressed in macrophages within human carotid atherosclerotic plaques: a role for prolactin in atherogenesis?
    Anne Q Reuwer
    Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    J Endocrinol 208:107-17. 2011
    ..We therefore propose that prolactin receptor signaling contributes to the local inflammatory response within the atherosclerotic plaque and thus to atherogenesis...
  37. doi request reprint HPA axis activity in multiple sclerosis correlates with disease severity, lesion type and gene expression in normal-appearing white matter
    Jeroen Melief
    Department of Neuroimmunology, Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands
    Acta Neuropathol 126:237-49. 2013
    ....
  38. doi request reprint Serine proteases of the human immune system in health and disease
    Kirstin M Heutinck
    Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    Mol Immunol 47:1943-55. 2010
    ..Understanding the mode of action of serine proteases will help to unravel molecular processes involved in immunological disorders and will facilitate the identification of new therapeutic targets...
  39. doi request reprint Selective upregulation of scavenger receptors in and around demyelinating areas in multiple sclerosis
    Debbie A E Hendrickx
    Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 72:106-18. 2013
    ..As demyelination continues, additional upregulation of LOX-1, FcγRIII, and LRP-1 may facilitate this process...
  40. ncbi request reprint CD27 defines phenotypically and functionally different human NK cell subsets
    Mireille T M Vossen
    Department of Experimental Immunology, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 180:3739-45. 2008
    ..Thus, the absence of CD27 expression allows the definition of cytotoxic effector cells within the known mature NK cell subsets in humans...
  41. ncbi request reprint Activation of Wnt signaling in the intestinal mucosa of Apc +/min mice does not cause overexpression of the receptor tyrosine kinase Met
    Elles M J Boon
    Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Cancer Sci 97:710-5. 2006
    ..Our findings thus reveal important interspecies differences in the regulation of Met expression during intestinal tumorigenesis...
  42. ncbi request reprint Macrophages and HIV-1
    Viviana Cobos-Jiménez
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam at Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    Curr Opin HIV AIDS 6:385-90. 2011
    ..This review will discuss new insights into HIV-1 infection in macrophages and the effect of infection on immune function and pathology...