Research Topics
Genomes and Genes
| Jörg HamannSummaryAffiliation: Academic Medical Center Country: The Netherlands Publications
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Detail Information
Publications
CD97 neutralisation increases resistance to collagen-induced arthritis in miceElse N Kop
Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, P, O, Box 22700, 1100 DE Amsterdam, The Netherlands
Arthritis Res Ther 8:R155. 2006..When treatment was started on day 35, CD97 mAb treatment had similar effects, albeit less pronounced. The results support the notion that CD97 contributes to synovial inflammation and joint destruction in arthritis...
CD97 in leukocyte traffickingJörg Hamann
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Adv Exp Med Biol 706:128-37. 2010....- EMR1, the human homolog of F4/80, is an eosinophil-specific receptorJörg Hamann
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Eur J Immunol 37:2797-802. 2007..Absence on other leukocytes, including basophils, implies that EMR1 is a highly specific marker for eosinophils in humans... - The EGF-TM7 family of the ratJörg Hamann
Laboratory for Experimental Immunology, G1 106, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
Immunogenetics 56:679-81. 2004..Like the mouse, the rat has three EGF-TM7 receptors--CD97, EMR1 and EMR4. The highest conservation between the orthologues lies within the membrane-spanning part and emphasizes the functional importance of this region... - Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergenceJörg Hamann
Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Eur J Immunol 33:1365-71. 2003..Thus, EMR4 surprisingly accounts for a genetic difference between humans and primates related to immunity... - CD97 in Leukocyte TraffickingJörg Hamann
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Adv Exp Med Biol 706:128-37. 2011.... - Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cellsMark J Kwakkenbos
Laboratory of Expermential Immunology, Academic Medical Centre, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
J Leukoc Biol 77:112-9. 2005..The interaction between CD97/EMR2 and CS may therefore play a role in the interaction of activated T cells, dendritic cells, and macrophages with B cells... 
Viral double-stranded RNA sensors induce antiviral, pro-inflammatory, and pro-apoptotic responses in human renal tubular epithelial cellsKirstin M Heutinck
Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
Kidney Int 82:664-75. 2012..Thus, sensors of viral dsRNA promote antiviral, pro-inflammatory, and pro-apoptotic responses in tubular epithelial cells, which may orchestrate the control of viral infection in the kidney...- Identification of the epidermal growth factor-TM7 receptor EMR2 and its ligand dermatan sulfate in rheumatoid synovial tissueElse N Kop
Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Arthritis Rheum 52:442-50. 2005..CS have been implicated in the pathogenesis of rheumatoid arthritis (RA). We undertook this study to determine the expression of EMR2 and the distribution of EMR2 and CD97 ligands within RA synovial tissue (ST)... - The EGF-TM7 family: a postgenomic viewMark J Kwakkenbos
Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, G1 106, PO Box 22700, 1100 DE, Amsterdam, The Netherlands
Immunogenetics 55:655-66. 2004..Here we discuss the currently available information on this intriguing receptor family... - The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cellsMark J Kwakkenbos
Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, The Netherlands
J Leukoc Biol 71:854-62. 2002..Different expression patterns and the inability of EMR2 to interact with the CD97 ligand CD55 indicate that the molecular twins EMR2 and CD97 likely have nonredundant functions... - A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defenseHenrike Veninga
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
PLoS ONE 6:e24431. 2011..We previously showed that mice lacking a functional CD97 gene have increased numbers of granulocytes... - An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2Mark J Kwakkenbos
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
FASEB J 20:2582-4. 2006..alternative splicing) prevent CD55 binding by EMR2 in hominoids. Our findings illustrate how various and partially opposing evolutionary events have shaped the structure and ligand specificity of a modern mammalian gene family... - CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanismHenrike Veninga
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
J Leukoc Biol 89:413-21. 2011..Notably, depletion of granulocytes by CD97 antibody required acute inflammation, suggesting a mechanism of conditional, antibody-mediated granulocytopenia... - CD70-driven chronic immune activation is protective against atherosclerosisRonald W van Olffen
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Innate Immun 2:344-52. 2010..This unexpected outcome provides a new insight into the consequences of costimulatory signals and their impact on innate immunity... - Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher diseaseMarco van Eijk
Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
Immunol Lett 129:64-71. 2010..These findings indicate that complex cellular expression programmes rather than activation modes regulate the expression of EGF-TM7 receptors in macrophages... - Differential expression of CD97 on human lymphocyte subsets and limited effect of CD97 antibodies on allogeneic T-cell stimulationElse N Kop
Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Immunol Lett 123:160-8. 2009..Mixed lymphocyte cultures revealed a limited ability of the stalk region-specific monoclonal antibody CLB-CD97/3 to inhibit CD8(+) and CD4(+) allogeneic T-cell proliferation... - Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migrationHenrike Veninga
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 181:6574-83. 2008..Hence, we conclude that CD97 mAbs actively induce an inhibitory effect that disturbs normal granulocyte trafficking, which is not perturbed by the absence of the molecule... - The human EGF-TM7 receptor EMR3 is a marker for mature granulocytesMourad Matmati
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
J Leukoc Biol 81:440-8. 2007..These results demonstrate that the expression of EGF-TM7 receptors on myeloid cells is differentially regulated. EMR3 is the first family member found mainly on granulocytes... - Deletion of either CD55 or CD97 ameliorates arthritis in mouse modelsRobert M Hoek
Academic Medical Center, Amsterdam, The Netherlands
Arthritis Rheum 62:1036-42. 2010..This study was undertaken to investigate the role of CD55 in experimental RA... - SerpinB9 expression in human renal tubular epithelial cells is induced by triggering of the viral dsRNA sensors TLR3, MDA5 and RIG-IKirstin M Heutinck
Department of Experimental Immunology, Renal Transplant Unit, Academic Medical Center, Amsterdam, The Netherlands
Nephrol Dial Transplant 27:2746-54. 2012..Previously, we found that tubular serpinB9 expression was increased during subclinical rejection. Here, we studied the regulation of serpinB9 expression in tubular epithelial cells (TECs) under inflammatory conditions... - Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiationKlaas P J M van Gisbergen
Department of Hematopoiesis, Sanquin Research at CLB and Landsteiner Laboratory, Amsterdam, The Netherlands
Nat Immunol 13:864-71. 2012..Thus, reminiscent of the function of Blimp-1 in other lymphocytes, Hobit controlled the maintenance of quiescent, fully differentiated NKT cells and regulated their immediate effector functions... - Dedicated pinhole SPECT of intestinal neutrophil recruitment in a mouse model of dextran sulfate sodium-induced colitisRoelof J Bennink
Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands
J Nucl Med 46:526-31. 2005..This study evaluated a noninvasive scintigraphic technique able to assess neutrophil trafficking in a mouse model of dextran sulfate sodium (DSS)-induced colitis... - The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defenseJaklien C Leemans
Laboratory for Experimental Internal Medicine, Department of Pathology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
J Immunol 172:1125-31. 2004..This was associated with a significantly enhanced outgrowth of bacteria in the lungs at 44 h and a strongly diminished survival. Together, these findings indicate an essential role for CD97 in the migration of neutrophils... - Expression of the inhibitory CD200 receptor is associated with alternative macrophage activationNathalie Koning
Department of Neuroimmunology, Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy for Arts and Sciences, Amsterdam, The Netherlands
J Innate Immun 2:195-200. 2010..Our data identify CD200R as a suitable marker for alternatively activated macrophages in humans and corroborate observations of distinct species- and/or site-specific mechanisms regulating macrophage polarization in mouse and man... - Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferonsViviana Cobos Jiménez
Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam CINIMA at the Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
Sci Rep 2:763. 2012..IL-4, IL-10 or IL-32 polarization did not affect the expression of cellular factors and miRNAs, suggesting only a limited role for these cellular factors in restricting HIV-1 replication in macrophages... - GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivoRonald W van Olffen
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 182:7490-500. 2009..These data indicate that GITR regulates the balance between regulatory and effector CD4(+) T cells by enhancing proliferation of both populations in parallel... - Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55Olga N Karpus
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
J Immunol 190:3740-8. 2013..This regulation can restrict CD97-CD55-mediated cell adhesion to tissue sites... - Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritisSarah Krausz
Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
Ann Rheum Dis 71:1402-10. 2012.... - Triggering of the dsRNA sensors TLR3, MDA5, and RIG-I induces CD55 expression in synovial fibroblastsOlga N Karpus
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
PLoS ONE 7:e35606. 2012..CD55 is also a ligand for CD97, an adhesion-type G protein-coupled receptor abundantly present on leukocytes. Little is known regarding the regulation of CD55 expression in FLS... - The prolactin receptor is expressed in macrophages within human carotid atherosclerotic plaques: a role for prolactin in atherogenesis?Anne Q Reuwer
Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
J Endocrinol 208:107-17. 2011..We therefore propose that prolactin receptor signaling contributes to the local inflammatory response within the atherosclerotic plaque and thus to atherogenesis... - Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritisDaphne de Launay
Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Am J Pathol 177:3010-24. 2010.... - Selective upregulation of scavenger receptors in and around demyelinating areas in multiple sclerosisDebbie A E Hendrickx
Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
J Neuropathol Exp Neurol 72:106-18. 2013..As demyelination continues, additional upregulation of LOX-1, FcγRIII, and LRP-1 may facilitate this process... - CD27 defines phenotypically and functionally different human NK cell subsetsMireille T M Vossen
Department of Experimental Immunology, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 180:3739-45. 2008..Thus, the absence of CD27 expression allows the definition of cytotoxic effector cells within the known mature NK cell subsets in humans... - Macrophages and HIV-1Viviana Cobos-Jiménez
Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam at Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
Curr Opin HIV AIDS 6:385-90. 2011..This review will discuss new insights into HIV-1 infection in macrophages and the effect of infection on immune function and pathology... - Serine proteases of the human immune system in health and diseaseKirstin M Heutinck
Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
Mol Immunol 47:1943-55. 2010..Understanding the mode of action of serine proteases will help to unravel molecular processes involved in immunological disorders and will facilitate the identification of new therapeutic targets... - Activation of Wnt signaling in the intestinal mucosa of Apc +/min mice does not cause overexpression of the receptor tyrosine kinase MetElles M J Boon
Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Cancer Sci 97:710-5. 2006..Our findings thus reveal important interspecies differences in the regulation of Met expression during intestinal tumorigenesis...