Sonja I Gringhuis

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 13:246-54. 2012
  2. ncbi Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 10:1081-8. 2009
  3. ncbi HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells
    Sonja I Gringhuis
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 11:419-26. 2010
  4. ncbi Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam and Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS Pathog 7:e1001259. 2011
  5. ncbi Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization
    Joppe W R Hovius
    Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    PLoS Pathog 4:e31. 2008
  6. ncbi Dusting the sugar fingerprint: C-type lectin signaling in adaptive immunity
    Jeroen den Dunnen
    Center of Infection and Immunity Amsterdam and Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Immunol Lett 128:12-6. 2010
  7. ncbi TNF-alpha and TLR agonists increase susceptibility to HIV-1 transmission by human Langerhans cells ex vivo
    Marein A W P de Jong
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Invest 118:3440-52. 2008
  8. ncbi Carbohydrate signaling by C-type lectin DC-SIGN affects NF-kappaB activity
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Methods Enzymol 480:151-64. 2010
  9. ncbi Innate signaling in HIV-1 infection of dendritic cells
    Michiel van der Vlist
    Center for Experimental and Molecular Medicine and Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Curr Opin HIV AIDS 6:348-52. 2011
  10. ncbi Gene expression analysis of glycosylation-related genes by real-time polymerase chain reaction
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, Free University Medical Center, Amsterdam, The Netherlands
    Methods Mol Biol 347:187-209. 2006

Collaborators

Detail Information

Publications17

  1. ncbi Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 13:246-54. 2012
    ..Thus, dectin-1 acted as an extracellular sensor for pathogens that induced both IL-1β production and maturation through a noncanonical caspase-8-dependent inflammasome for protective immunity...
  2. ncbi Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 10:1081-8. 2009
    ..Our study reveals another level of plasticity in tailoring adaptive immunity to pathogens...
  3. ncbi HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells
    Sonja I Gringhuis
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 11:419-26. 2010
    ..Inhibition of either pathway abrogated replication and prevented HIV-1 transmission. Thus, HIV-1 subverts crucial components of the immune system for replication that might be targeted to prevent infection and dissemination...
  4. ncbi Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam and Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS Pathog 7:e1001259. 2011
    ..Thus, dectin-1 and dectin-2 control adaptive T(H)-17 immunity to fungi via Malt1-dependent activation of c-Rel...
  5. ncbi Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization
    Joppe W R Hovius
    Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    PLoS Pathog 4:e31. 2008
    ..Insight into the molecular mechanism of immunosuppression by tick salivary proteins might provide innovative strategies to combat Lyme disease and could lead to the development of novel anti-inflammatory or immunosuppressive agents...
  6. ncbi Dusting the sugar fingerprint: C-type lectin signaling in adaptive immunity
    Jeroen den Dunnen
    Center of Infection and Immunity Amsterdam and Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Immunol Lett 128:12-6. 2010
    ..Here we will discuss our current understanding of the innate signaling pathways induced by C-type lectins DC-SIGN and dectin-1 in humans and how these pathways shape adaptive immunity...
  7. ncbi TNF-alpha and TLR agonists increase susceptibility to HIV-1 transmission by human Langerhans cells ex vivo
    Marein A W P de Jong
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Invest 118:3440-52. 2008
    ..Our data demonstrate a decisive role for LCs in HIV-1 transmission during genital coinfections and suggest antiinflammatory therapies as potential strategies to prevent HIV-1 transmission...
  8. ncbi Carbohydrate signaling by C-type lectin DC-SIGN affects NF-kappaB activity
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Methods Enzymol 480:151-64. 2010
    ..Here, we will discuss the various methods that we have used to identify the innate signaling by the C-type lectin DC-SIGN, and how to analyze the consequences on NF-kappaB activation...
  9. ncbi Innate signaling in HIV-1 infection of dendritic cells
    Michiel van der Vlist
    Center for Experimental and Molecular Medicine and Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Curr Opin HIV AIDS 6:348-52. 2011
    ..This review summarizes the current knowledge of innate signaling events that are involved in HIV-1 infection. We here focus on dendritic cells, which are among the first cells that encounter HIV-1 after exposure...
  10. ncbi Gene expression analysis of glycosylation-related genes by real-time polymerase chain reaction
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, Free University Medical Center, Amsterdam, The Netherlands
    Methods Mol Biol 347:187-209. 2006
    ....
  11. ncbi Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes
    Philip H J Remans
    Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 173:920-31. 2004
    ..Introduction of dominant-negative Ras into synovial fluid T cells restored redox balance, providing evidence that deregulated Ras and Rap1 signaling underlies oxidative stress and consequent altered T cell function observed in RA...
  12. ncbi Signalling through C-type lectin receptors: shaping immune responses
    Teunis B H Geijtenbeek
    Academic Medical Center, University of Amsterdam, The Netherlands
    Nat Rev Immunol 9:465-79. 2009
    ..In this Review we describe the role of CLR signalling in regulating adaptive immunity and immunopathogenesis and discuss how this knowledge can be harnessed for the development of innovative vaccination approaches...
  13. ncbi Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, Amsterdam, The Netherlands
    Nat Immunol 7:1200-8. 2006
    ..Thus, regulation of effector T cells by MGL expressed on APCs may provide a target for regulating chronic inflammatory and autoimmune diseases...
  14. ncbi Pathogen recognition by DC-SIGN shapes adaptive immunity
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MC Amsterdam, The Netherlands
    Future Microbiol 4:879-90. 2009
    ..In this article, we will discuss the signaling pathways induced by DC-SIGN and its central role in the regulation of adaptive immunity to bacterial, fungal and viral pathogens...
  15. ncbi An evolutionary perspective on C-type lectins in infection and immunity
    Linda M van den Berg
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Ann N Y Acad Sci 1253:149-58. 2012
    ..This review provides an update on the role of C-type lectins in HIV-1, mycobacterial, and Candida infections, and the coevolution of hosts and pathogens...
  16. ncbi Activation of human endothelial cells by tumor necrosis factor-alpha results in profound changes in the expression of glycosylation-related genes
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    J Cell Physiol 206:203-10. 2006
    ....
  17. ncbi Oxidants and tyrosine phosphorylation: role of acute and chronic oxidative stress in T-and B-lymphocyte signaling
    Cornelis L Verweij
    Department of Molecular and Cellular Biology, VU Medical Center, Amsterdam, The Netherlands
    Antioxid Redox Signal 4:543-51. 2002
    ..In this report, the redox regulation of signaling involving protein tyrosine kinase activity, in particular in T- and B-lymphocyte signaling, is reviewed...