J Goudsmit

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint [AIDS vaccines: promises and reality]
    J Goudsmit
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Humane Retrovirologie, Meibergdreef 15, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 145:1241-5. 2001
  2. pmc Human herpesvirus 8 infections in the Amsterdam Cohort Studies (1984-1997): analysis of seroconversions to ORF65 and ORF73
    J Goudsmit
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 97:4838-43. 2000
  3. ncbi request reprint Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy
    J M Prins
    Department of Internal Medicine, Tropical Medicine, and AIDS, Academic Medical Center, University of Amsterdam, The Netherlands
    AIDS 13:2405-10. 1999
  4. ncbi request reprint Immune reconstitution after 2 years of successful potent antiretroviral therapy in previously untreated human immunodeficiency virus type 1-infected adults
    D W Notermans
    National AIDS Therapy Evaluation Centre NATEC, Academic Medical Centre, 1100 DE, Amsterdam, The Netherlands
    J Infect Dis 180:1050-6. 1999
  5. ncbi request reprint Genetic differences between human immunodeficiency virus type 1 subpopulations in faeces and serum
    L van der Hoek
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Gen Virol 79:259-67. 1998
  6. ncbi request reprint Natural residues versus antiretroviral drug-selected mutations in HIV type 1 group O reverse transcriptase and protease related to virological drug failure in vivo
    M P de Baar
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 16:1385-94. 2000
  7. ncbi request reprint Numbers of CD4+ cells and the levels of core antigens of and antibodies to the human immunodeficiency virus as predictors of AIDS among seropositive homosexual men
    F de Wolf
    Department of Virology, University of Amsterdam, The Netherlands
    J Infect Dis 158:615-22. 1988
  8. ncbi request reprint Evidence that both HIV and HIV-induced immunodeficiency enhance HCV replication among HCV seroconverters
    M Beld
    Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, The Netherlands
    Virology 244:504-12. 1998
  9. pmc Distribution of baboon endogenous virus among species of African monkeys suggests multiple ancient cross-species transmissions in shared habitats
    A C van Der Kuyl
    Human Retrovirus Laboratory, Academic Medical Centre, Amsterdam, The Netherlands
    J Virol 69:7877-87. 1995
  10. ncbi request reprint Consistent risk group-associated differences in human immunodeficiency virus type 1 vpr, vpu and V3 sequences despite independent evolution
    C L Kuiken
    Department of Human Retrovirology, University of Amersterdam, The Netherlands
    J Gen Virol 77:783-92. 1996

Collaborators

Detail Information

Publications65

  1. ncbi request reprint [AIDS vaccines: promises and reality]
    J Goudsmit
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Humane Retrovirologie, Meibergdreef 15, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 145:1241-5. 2001
    ..The Netherlands has a key role in the aids vaccine programmes of the European Union (Eurovac) and is making important contributions to the International AIDS Vaccine Initiative...
  2. pmc Human herpesvirus 8 infections in the Amsterdam Cohort Studies (1984-1997): analysis of seroconversions to ORF65 and ORF73
    J Goudsmit
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 97:4838-43. 2000
    ..Together with the previously reported link between unprotected orogenital sex and HHV8 seroconversion, our observations suggest that HHV8 seroconversions result from primary infections...
  3. ncbi request reprint Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy
    J M Prins
    Department of Internal Medicine, Tropical Medicine, and AIDS, Academic Medical Center, University of Amsterdam, The Netherlands
    AIDS 13:2405-10. 1999
    ..This is a major barrier for the eradication of HIV by antiretroviral agents alone. Activation of these cells in the presence of antiretroviral therapy might be a strategy to increase the turnover rate of this reservoir...
  4. ncbi request reprint Immune reconstitution after 2 years of successful potent antiretroviral therapy in previously untreated human immunodeficiency virus type 1-infected adults
    D W Notermans
    National AIDS Therapy Evaluation Centre NATEC, Academic Medical Centre, 1100 DE, Amsterdam, The Netherlands
    J Infect Dis 180:1050-6. 1999
    ..Our data indicate that long-term immunological recovery is gradual, even during strong suppression of viral replication, not always complete, and dependent on the preexisting level of naive CD4+ T cells...
  5. ncbi request reprint Genetic differences between human immunodeficiency virus type 1 subpopulations in faeces and serum
    L van der Hoek
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Gen Virol 79:259-67. 1998
    ..The faecal subpopulations in these 4 persons showed limited nonsynonymous substitutions compared to synonymous substitutions, indicating that purifying selection is operational on these subpopulations...
  6. ncbi request reprint Natural residues versus antiretroviral drug-selected mutations in HIV type 1 group O reverse transcriptase and protease related to virological drug failure in vivo
    M P de Baar
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 16:1385-94. 2000
    ..This probably results from preexisting protease residues contributing to reduced sensitivity of group O viruses to protease inhibitors, as is observed in vitro...
  7. ncbi request reprint Numbers of CD4+ cells and the levels of core antigens of and antibodies to the human immunodeficiency virus as predictors of AIDS among seropositive homosexual men
    F de Wolf
    Department of Virology, University of Amsterdam, The Netherlands
    J Infect Dis 158:615-22. 1988
    ..Four more cases of AIDS developed among the antigen-negative, core antibody-positive men with low CD4+ cell counts. Only one patient with AIDS escaped detection by using these three markers...
  8. ncbi request reprint Evidence that both HIV and HIV-induced immunodeficiency enhance HCV replication among HCV seroconverters
    M Beld
    Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, The Netherlands
    Virology 244:504-12. 1998
    ....
  9. pmc Distribution of baboon endogenous virus among species of African monkeys suggests multiple ancient cross-species transmissions in shared habitats
    A C van Der Kuyl
    Human Retrovirus Laboratory, Academic Medical Centre, Amsterdam, The Netherlands
    J Virol 69:7877-87. 1995
    ....
  10. ncbi request reprint Consistent risk group-associated differences in human immunodeficiency virus type 1 vpr, vpu and V3 sequences despite independent evolution
    C L Kuiken
    Department of Human Retrovirology, University of Amersterdam, The Netherlands
    J Gen Virol 77:783-92. 1996
    ..Recombination, combined with restrictions on certain amino acids because of epistatic interactions between the genes, could be an alternative explanation of this phenomenon...
  11. ncbi request reprint T cell telomere length in HIV-1 infection: no evidence for increased CD4+ T cell turnover
    K C Wolthers
    Department of Clinical Viro Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
    Science 274:1543-7. 1996
    ..These results are compatible with CD4(+) T cell decline in HIV-1 infection caused by interference with cell renewal...
  12. ncbi request reprint Decline of antibody reactivity to outer viral core protein p17 is an earlier serological marker of disease progression in human immunodeficiency virus infection than anti-p24 decline
    J M Lange
    Department of Virology, Academic Medical Centre, University of Amsterdam, The Netherlands
    AIDS 1:155-9. 1987
    ....
  13. ncbi request reprint Spread of distinct human immunodeficiency virus type 1 AG recombinant lineages in Africa
    M Cornelissen
    Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, Meibergdreef 45, 1105BA Amsterdam, The Netherlands
    J Gen Virol 81:515-23. 2000
    ..The recovery of AG recombinants from African countries a thousand miles apart indicates the active spread of new recombinants...
  14. pmc Full-length proviruses of baboon endogenous virus (BaEV) and dispersed BaEV reverse transcriptase retroelements in the genome of baboon species
    A C van Der Kuyl
    Human Retrovirus Laboratory, Academic Medical Centre, Amsterdam, The Netherlands
    J Virol 69:5917-24. 1995
    ....
  15. ncbi request reprint Carrier rate of zidovudine-resistant HIV-1: the impact of failing therapy on transmission of resistant strains
    J Goudsmit
    Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    AIDS 15:2293-301. 2001
    ....
  16. pmc Establishment of new transmissible and drug-sensitive human immunodeficiency virus type 1 wild types due to transmission of nucleoside analogue-resistant virus
    A de Ronde
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Virol 75:595-602. 2001
    ..Monitoring of patients for the presence of new HIV-1 wild types with D, S, or N residues at position 215 may be warranted in order to estimate the threat to long-term efficacy of regimens including nucleoside analogues...
  17. pmc pol gene diversity of five human immunodeficiency virus type 1 subtypes: evidence for naturally occurring mutations that contribute to drug resistance, limited recombination patterns, and common ancestry for subtypes B and D
    M Cornelissen
    Department of Human Retrovirology, Academic Medical Centre, Amsterdam, The Netherlands
    J Virol 71:6348-58. 1997
    ..Our analysis suggests a common ancestry for subtypes B and D that is distinct from that of subtypes A and E...
  18. ncbi request reprint Sexual risk behaviour relates to the virological and immunological improvements during highly active antiretroviral therapy in HIV-1 infection
    N H Dukers
    Division of Public Health and Environment, Municipal Health Service, Amsterdam, The Netherlands
    AIDS 15:369-78. 2001
    ....
  19. pmc Design and evaluation of a human immunodeficiency virus type 1 RNA assay using nucleic acid sequence-based amplification technology able to quantify both group M and O viruses by using the long terminal repeat as target
    M P de Baar
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Microbiol 37:1813-8. 1999
    ..These data indicate that LTR-based assays, including the NASBA format chosen here, are better suited to monitoring HIV-1 therapy than are gag-based assays in an era in which multiple HIV-1 subtypes and groups are spreading worldwide...
  20. ncbi request reprint Lymphoproliferative response to HIV type 1 p24 in long-term survivors of HIV type 1 infection is predictive of persistent AIDS-free infection
    O Pontesilli
    Department of Clinical Viro Immunology, Academic Medical Center, University of Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 15:973-81. 1999
    ..01). Our data suggest that the presence of circulating p24-specific CD4+ T cells may reflect effective viral control and be predictive of subsequent favorable clinical course in long-term asymptomatic individuals...
  21. pmc Papio cynocephalus endogenous retrovirus among old world monkeys: evidence for coevolution and ancient cross-species transmissions
    R Mang
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Virol 74:1578-86. 2000
    ..One strain of PcEV was apparently transmitted from a papionin ancestor to an ancestor of the central African lowland C. guereza...
  22. ncbi request reprint Subtype-specific sequence variation of the HIV type 1 long terminal repeat and primer-binding site
    M P de Baar
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 16:499-504. 2000
    ..After analysis of all sequences, we could describe subtype-specific differences in sequences encompassing the regulatory elements of the LTR and the PBS motif...
  23. ncbi request reprint Independent introduction of transmissible F/D recombinant HIV-1 from Africa into Belgium and The Netherlands
    E Op de Coul
    Division of Public Health and Environment, Municipal Health Service, Nieuwe Achtergracht 100, Amsterdam, 1018 WT, The Netherlands
    Virology 270:267-77. 2000
    ..Two included large or smaller F1 fragments in gag and pol. The third strain was subtype D along the entire gag and pol fragment. A parental African subtype F that showed no evidence for recombination was not found...
  24. ncbi request reprint Potent antiretroviral therapy initiates normalization of hypergammaglobulinemia and a decline in HIV type 1-specific antibody responses
    D W Notermans
    Division of Infectious Diseases, Tropical Medicine, and AIDS, AMC, 1105 AZ, Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 17:1003-8. 2001
    ..The weakening of antiviral immunity with therapy may be relevant for current attempts to gain immunological control over the virus through structured treatment interruptions or therapeutic vaccinations...
  25. pmc Discovery of a new endogenous type C retrovirus (FcEV) in cats: evidence for RD-114 being an FcEV(Gag-Pol)/baboon endogenous virus BaEV(Env) recombinant
    A C van Der Kuyl
    Department of Human Retrovirology, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands
    J Virol 73:7994-8002. 1999
    ..Although BaEV did appear to have infected an ancestor of the domestic cat lineage, it was a de novo recombinant that made its way into the cat germ line...
  26. pmc Single rapid real-time monitored isothermal RNA amplification assay for quantification of human immunodeficiency virus type 1 isolates from groups M, N, and O
    M P de Baar
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Clin Microbiol 39:1378-84. 2001
    ..In conclusion, the newly developed real-time monitored HIV-1 assay is a fast and sensitive assay with a large dynamic range of quantification and is suitable for quantification of most if not all subtypes and groups of HIV-1...
  27. ncbi request reprint Kaposi's sarcoma and human herpesvirus 8 infection do not protect HIV-1 infected homosexual men from AIDS dementia complex
    N Renwick
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands
    AIDS 15:2165-9. 2001
    ..CONCLUSIONS: KS or HHV8 does not significantly influence the risk for developing ADC in a group with a uniform risk for developing KS therefore we recommend caution in searching for a KS-associated or HHV8-derived therapy for ADC...
  28. pmc Circulation of HIV antigen in blood according to stage of infection, risk group, age and geographic origin
    J Goudsmit
    Virology Department, Academic Medical Center, University of Amsterdam, Netherlands
    Epidemiol Infect 99:701-10. 1987
    ....
  29. ncbi request reprint Genetic evidence of multiple transmissions of HIV type 1 subtype F within Romania from adult blood donors to children
    E Op de Coul
    Division of Public Health and Environment, Municipal Health Service, Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 16:327-36. 2000
    ..The juvenile population was most likely infected with the HIV-1 subtype F virus on more than one occasion, presumably through HIV-contaminated blood (products) obtained from adults...
  30. ncbi request reprint Low AIDS attack rate among Dutch haemophiliacs compared to homosexual men: a correlate of HIV antigenaemia frequencies
    T F Wolfs
    Virology Department, University of Amsterdam, The Netherlands
    Vox Sang 57:127-32. 1989
    ..These data indicate a slower progression of HIV-related disease in seropositive haemophiliacs compared to seropositive homosexual men...
  31. ncbi request reprint Epidemiology of HIV-1 and emerging problems
    V V Lukashov
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Int J Antimicrob Agents 16:463-6. 2000
    ..These viruses are highly resistant to AZT, 3TC, and d4T, and moderately resistant to ddI and ddC...
  32. pmc Complete nucleotide sequence of simian endogenous type D retrovirus with intact genome organization: evidence for ancestry to simian retrovirus and baboon endogenous virus
    A C van Der Kuyl
    Department of Human Retrovirology, Academic Medical Centre, Amsterdam, The Netherlands
    J Virol 71:3666-76. 1997
    ..Comparison of the evolution of BaEV, exogenous simian retrovirus types 1 to 3 (SRV1 to SRV3), and SERV suggests that SERV is ancestral to both BaEV and the SRVs...
  33. pmc Different hepatitis C virus (HCV) RNA load profiles following seroconversion among injecting drug users without correlation with HCV genotype and serum alanine aminotransferase levels
    M Beld
    Department of Human Retrovirology, Academic Medical Centre, Amsterdam, The Netherlands
    J Clin Microbiol 36:872-7. 1998
    ..Three distinct HCV RNA load profiles were found, without apparent relationship to genotype and serum ALT levels in the first 5 years of HCV infection...
  34. ncbi request reprint A comparison of serum HIV-1 RNA levels as measured by two quantitative assays in zidovudine-treated, asymptomatic, HIV-infected individuals
    G J Weverling
    National AIDS Therapy Evaluation Center, Department of Clinical Epidemiology and Biostatistics, University of Amsterdam, The Netherlands
    Antivir Ther 1:255-63. 1996
    ..These differences should be considered in interpreting analyses of clinical trials and relationships between HIV-1 RNA level and clinical outcome, as well as in the use of RNA level in the management of HIV-infected patients...
  35. ncbi request reprint Selection by AZT and rapid replacement in the absence of drugs of HIV type 1 resistant to multiple nucleoside analogs
    V V Lukashov
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 17:807-18. 2001
    ..The insertion mutants attained high virus loads, demonstrating that virus load cannot be used as a direct measure of virus fitness...
  36. ncbi request reprint Favourable effect of chemotherapy on clinical symptoms and human herpesvirus-8 DNA load in a patient with Kaposi's sarcoma presenting with fever and anemia
    J M Prins
    Department of Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Clin Microbiol Infect Dis 18:499-502. 1999
    ....
  37. ncbi request reprint Primate genus Miopithecus: evidence for the existence of species and subspecies of dwarf guenons based on cellular and endogenous viral sequences
    A C van Der Kuyl
    Department of Human Retrovirology, Amsterdam Institute of Viral Genomics, Meibergdreef 45, Amsterdam, 1105 BA, The Netherlands
    Mol Phylogenet Evol 14:403-13. 2000
    ....
  38. ncbi request reprint Gross defects in the vpr and vpu genes of HIV type 1 cannot explain the differences in RNA copy number between long-term asymptomatics and progressors
    M Cornelissen
    Department of Human Retrovirology, Academic Medical Centre, Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 13:247-52. 1997
    ..We therefore concluded that nonprogression is not likely to be explained by deletion of vpr and vpu, or by gross sequence abnormality in these genes...
  39. pmc Novel endogenous type C retrovirus in baboons: complete sequence, providing evidence for baboon endogenous virus gag-pol ancestry
    R Mang
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Virol 73:7021-6. 1999
    ..Earlier it was shown that another endogenous type D virus (simian endogenous retrovirus) provided the env gene for BaEV (A. C. van der Kuyl et al., J. Virol. 71:3666-3676, 1997)...
  40. ncbi request reprint High prevalence of Epstein-Barr virus type 2 among homosexual men is caused by sexual transmission
    D van Baarle
    Dept of Clinical Viro Immunology, CLB, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands
    J Infect Dis 181:2045-9. 2000
    ..These data support the conclusion that EBV type 2 infection is more prevalent among white homosexual men and is caused by sexual transmission...
  41. pmc HIV infection and STD in drug addicted prostitutes in Amsterdam: potential for heterosexual HIV transmission
    J A van den Hoek
    Department of Public Health and Environment, University of Amsterdam, The Netherlands
    Genitourin Med 65:146-50. 1989
    ....
  42. ncbi request reprint Effect of human immunodeficiency virus (HIV) antibody knowledge on high-risk sexual behavior with steady and nonsteady sexual partners among homosexual men
    G J van Griensven
    Municipal Health Service, Dept of Public Health and Environment, Amsterdam, The Netherlands
    Am J Epidemiol 129:596-603. 1989
    ..05). In the majority of cases, condoms were not used antibody testing in the three groups studied. The generalizability of these results, however, is limited...
  43. pmc One-tube real-time isothermal amplification assay to identify and distinguish human immunodeficiency virus type 1 subtypes A, B, and C and circulating recombinant forms AE and AG
    M P de Baar
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Clin Microbiol 39:1895-902. 2001
    ..Because of the low sensitivity, the assay in this format would not be suited for clinical use but can possibly be used for epidemiological monitoring as well as vaccine research studies...
  44. ncbi request reprint Human immunodeficiency virus type 1 in faeces and serum: evidence against independently evolving subpopulations
    L van der Hoek
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Gen Virol 79:2455-9. 1998
    ....
  45. pmc Development of real-time NASBA assays with molecular beacon detection to quantify mRNA coding for HHV-8 lytic and latent genes
    Abeltje M Polstra
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    BMC Infect Dis 2:18. 2002
    ..To examine the expression of HHV-8 in PBMC, four HHV-8 mRNA specific NASBA assays were developed..
  46. ncbi request reprint Baboon endogenous virus evolution and ecology
    A C van Der Kuyl
    Dept of Human Retrovirology, Academic Medical Centre, Amsterdam, The Netherlands
    Trends Microbiol 4:455-9. 1996
    ..The distribution of baboon endogenous virus among non-human primates resembles that of exogenous viruses and appears to be a consequence of different primate species sharing the same habitat...
  47. pmc Structured-tree topology and adaptive evolution of the simian immunodeficiency virus SIVsm envelope during serial passage in rhesus macaques according to likelihood mapping and quartet puzzling
    P J Valli
    Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, The Netherlands
    J Virol 72:3673-83. 1998
    ..The adaptation of SIVsm to Asian rhesus macaques appears to be an ordered process in which the env evolves in a tree-like manner, particularly in its constant regions...
  48. ncbi request reprint CD11a/CD18 (LFA-1) epitopes involved in syncytium formation among CD4+ T-cells following cell free HIV-1 infection
    J Goudsmit
    Human Retrovirus Laboratory, Department of Virology, Amsterdam, The Netherlands
    Viral Immunol 3:289-93. 1990
    ..Our results indicate that a limited number of LFA-1 epitopes is involved in syncytium formation among T-cells, none of which is required for virus entry in the cell or virus spread in the culture...
  49. pmc Hepatitis C virus serotype-specific core and NS4 antibodies in injecting drug users participating in the Amsterdam cohort studies
    M Beld
    Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Microbiol 36:3002-6. 1998
    ..Therefore, the prevalence of genotypes other than genotype 1 could be underestimated if they are determined by serotyping, and improvements in specificity are recommended...
  50. ncbi request reprint Greater and more rapid depletion of mitochondrial DNA in blood of patients treated with dual (zidovudine+didanosine or zidovudine+zalcitabine) vs. single (zidovudine) nucleoside reverse transcriptase inhibitors
    P Reiss
    Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, The Netherlands
    HIV Med 5:11-4. 2004
    ..Unfortunately, there are no validated laboratory markers for clinically assessing, let alone predicting, the onset of mitochondrial toxicity associated with NRTI therapy...
  51. ncbi request reprint OKT3 and IL-2 treatment for purging of the latent HIV-1 reservoir in vivo results in selective long-lasting CD4+ T cell depletion
    R M van Praag
    Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Immunol 21:218-26. 2001
    ..CD8+ cells were also depleted in the blood, but less severely in lymph nodes, and returned to baseline levels within several weeks...
  52. pmc Evolutionary relationships among parvoviruses: virus-host coevolution among autonomous primate parvoviruses and links between adeno-associated and avian parvoviruses
    V V Lukashov
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Virol 75:2729-40. 2001
    ..The two lineages of human parvoviruses may have resulted from independent ancient zoonotic infections. Our results provide an argument for reclassification of Parvovirinae based on evolutionary relationships among viruses...
  53. ncbi request reprint Routine DNA analysis based on 12S rRNA gene sequencing as a tool in the management of captive primates
    A C van Der Kuyl
    Department of Human Retrovirology, Academic Medical Center, Amsterdam Institute of Viral Genomics, The Netherlands
    J Med Primatol 29:309-17. 2000
    ..Many individuals were found to harbor a 12S sequence identical to one of the reference sequences. For others, phylogenetic methods were used for species estimation, which was especially informative in Cercopithecus species...
  54. pmc Shortening of the symptom-free period in rhesus macaques is associated with decreasing nonsynonymous variation in the env variable regions of simian immunodeficiency virus SIVsm during passage
    P J Valli
    Department of Human Retrovirology, Academic Medical Centre, Amsterdam, The Netherlands
    J Virol 72:7494-500. 1998
    ....
  55. ncbi request reprint Identification of a novel type C porcine endogenous retrovirus: evidence that copy number of endogenous retroviruses increases during host inbreeding
    R Mang
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Gen Virol 82:1829-34. 2001
    ..Among all of the pig genomes tested, the wild boar genome had the lowest copy number of all PERVs, suggesting that the number of integrations of complete endogenous retroviruses is increased by inbreeding...
  56. pmc Quantitative detection of hepatitis B virus DNA by real-time nucleic acid sequence-based amplification with molecular beacon detection
    S Yates
    Department of Human Retrovirology, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Microbiol 39:3656-65. 2001
    ..Compared with other HBV DNA assays, our assay provides good sensitivity, a wide dynamic range, and high-throughput applicability, making it a viable alternative to those based on other amplification or detection methods...
  57. ncbi request reprint Is there a difference in the efficacy of peripartum antiretroviral regimens in reducing mother-to-child transmission of HIV in Africa?
    Valeriane Leroy
    INSERM U 593, Institut d Epidémiologie, Santé Publique et Développement ISPED, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    AIDS 19:1865-75. 2005
    ....
  58. ncbi request reprint HIV-1 subtype C syncytium- and non-syncytium-inducing phenotypes and coreceptor usage among Ethiopian patients with AIDS
    A Abebe
    Ethiopian Netherlands AIDS Research Project, Ethiopian Health and Nutrition Research Institute, Addis Ababa
    AIDS 13:1305-11. 1999
    ..To assess syncytium-inducing (SI) and non-syncytium-inducing (NSI) frequencies, coreceptor usage and gp120 V3 sequences of HIV-1 isolates from Ethiopian AIDS patients...
  59. ncbi request reprint Adenovirus fibre exchange alters cell tropism in vitro but not transgene-specific T CD8+ immune responses in vivo
    S Mercier
    UMR INRA AFSSA ENVA 1161, Virologie, Ecole Nationale Veterinaire d Alfort, 94704 Maisons Alfort cedex, France
    J Gen Virol 85:1227-36. 2004
    ....
  60. ncbi request reprint The impact of immigration on env HIV-1 subtype distribution among heterosexuals in the Netherlands: influx of subtype B and non-B strains
    E L Op de Coul
    Department of Infectious Diseases Epidemiology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    AIDS 15:2277-86. 2001
    ..Despite continuing introductions of non-B subtypes, the B/non-B distribution has been stable over time, most likely as a result of introductions of subtype B strains from Caribbean and South American countries...
  61. ncbi request reprint Timing of the HIV-1 subtype C epidemic in Ethiopia based on early virus strains and subsequent virus diversification
    A Abebe
    Ethiopian-Netherlands AIDS Research Project (ENARP) at the Ethiopian Health and Nutrition Research Institute (EHNRI, Addis Ababa, Ethiopia
    AIDS 15:1555-61. 2001
    ..Based on the rate of synonymous diversification of HIV-1 strains within the Ethiopian population, we were able to estimate 1983 (95% confidence interval, 1980-1984) as the year of HIV-1 C introduction into Ethiopia...
  62. ncbi request reprint [Results from the 'Ethiopia-Netherlands AIDS Research Project'; 1995-2000]
    T F De Wit
    Ethiopia-Netherlands AIDS Research Project, Ethiopian Health and Nutrition Research Institute, Addis Abeba, Ethiopie
    Ned Tijdschr Geneeskd 145:1236-40. 2001
    ..The emphasis for this should be on robust and applicable laboratory methods, research in the field of HIV vaccine trials and information transfer to the various partners combating HIV infection/aids in Ethiopia...
  63. ncbi request reprint Association of antibodies blocking HIV-1 gp 160-sCD4 attachment with virus neutralizing activity in human sera
    N K Back
    Department of Virology, Academic Medical Centre, Amsterdam, The Netherlands
    J Med Virol 31:200-8. 1990
    ..abstract truncated at 250 words)..
  64. pmc Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry
    M Cayabyab
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 74:11972-6. 2000
    ....
  65. ncbi request reprint [The molecular epidemiology of HIV-1 in Belarus in (1996-2004): a predominance of subtype A variants and circulation of subtype B variants]
    V V Lukashov
    Vopr Virusol 51:22-6. 2006
    ..Circulation of epidemiologically unrelated subtype B viruses was also established...