Dirk Geerts

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi The role of the MEIS homeobox genes in neuroblastoma
    Dirk Geerts
    Department of Human Genetics M1 159, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Cancer Lett 197:87-92. 2003
  2. ncbi MEIS homeobox genes in neuroblastoma
    Dirk Geerts
    Department of Human Genetics M1 131, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cancer Lett 228:43-50. 2005
  3. doi MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3
    Ingrid Revet
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands
    Cancer Lett 289:195-207. 2010
  4. doi Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex
    Maarten E Witte
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Acta Neuropathol 125:231-43. 2013
  5. pmc The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization
    Bart Jan de Kreuk
    Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066CX Amsterdam, The Netherlands
    J Biol Chem 287:43438-53. 2012
  6. doi Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma
    Michiel Smits
    Neuro oncology Research Group, Department of Neurosurgery, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    FASEB J 26:2639-47. 2012
  7. pmc The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification
    Dirk Geerts
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Cancer 126:2012-24. 2010
  8. doi The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma
    Ingrid Revet
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Exp Cell Res 314:707-19. 2008
  9. ncbi P-glycoprotein regulates trafficking of CD8(+) T cells to the brain parenchyma
    Gijs Kooij
    Blood Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Acta Neuropathol 127:699-711. 2014
  10. pmc Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier
    Ruben van Doorn
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands
    J Neuroinflammation 9:133. 2012

Collaborators

Detail Information

Publications25

  1. ncbi The role of the MEIS homeobox genes in neuroblastoma
    Dirk Geerts
    Department of Human Genetics M1 159, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Cancer Lett 197:87-92. 2003
    ..These include genes involved in developmental signalling pathways, chromatin binding, cell cycle control, proliferation, and apoptosis. The results presented provide important clues for the oncogenic function of MEIS1 in neuroblastoma...
  2. ncbi MEIS homeobox genes in neuroblastoma
    Dirk Geerts
    Department of Human Genetics M1 131, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cancer Lett 228:43-50. 2005
    ..To date however, the connotation of these genes in neuroblastoma pathogenesis is scant. This review recapitulates data on the MEIS homeobox control genes in cancer and focuses on neuroblastoma...
  3. doi MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3
    Ingrid Revet
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands
    Cancer Lett 289:195-207. 2010
    ..These results suggest involvement of MSX1 in Wnt signalling and demonstrate activity of the more upstream Wnt pathway in neuroblastic cells...
  4. doi Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex
    Maarten E Witte
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Acta Neuropathol 125:231-43. 2013
    ..Taken together, our data indicate that reduced neuronal PGC-1α expression in MS cortex partly underlies mitochondrial dysfunction in MS grey matter and thereby contributes to neurodegeneration in MS cortex...
  5. pmc The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization
    Bart Jan de Kreuk
    Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066CX Amsterdam, The Netherlands
    J Biol Chem 287:43438-53. 2012
    ..In conclusion, this study identifies a novel role for the F-BAR-domain protein PACSIN2 in regulating EGF receptor surface levels and EGF-induced downstream signaling...
  6. doi Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma
    Michiel Smits
    Neuro oncology Research Group, Department of Neurosurgery, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    FASEB J 26:2639-47. 2012
    ..This loop is functionally impeded by the VEGF receptor inhibitor vandetanib, and our results may contribute to the further development of inhibitors of tumor-angiogenesis...
  7. pmc The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification
    Dirk Geerts
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Cancer 126:2012-24. 2010
    ....
  8. doi The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma
    Ingrid Revet
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Exp Cell Res 314:707-19. 2008
    ..This suggests a block in differentiation of these tumours at distinct developmental stages or lineages...
  9. ncbi P-glycoprotein regulates trafficking of CD8(+) T cells to the brain parenchyma
    Gijs Kooij
    Blood Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Acta Neuropathol 127:699-711. 2014
    ....
  10. pmc Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier
    Ruben van Doorn
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands
    J Neuroinflammation 9:133. 2012
    ..Here we demonstrate that the brain endothelial receptor S1P5 largely contributes to the maintenance of brain endothelial barrier function...
  11. pmc Inhibition of HIV-1 replication with stable RNAi-mediated knockdown of autophagy factors
    Julia Jm Eekels
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center of the University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Virol J 9:69. 2012
    ..Stable knockdown of several autophagy factors inhibit HIV-1 replication without any apparent cytotoxicity. We therefore propose that targeting of the autophagy pathway can be a novel therapeutic approach against HIV-1...
  12. doi Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene
    Gerben Schaaf
    Department of Human Genetics, Academic Medical Centre, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands
    Cancer Res 70:762-71. 2010
    ..Our findings argue that SPRY1 inhibition can offer a therapeutic strategy to treat childhood RMS and possibly other tumors carrying oncogenic RAS mutations...
  13. pmc Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells
    Jan J Molenaar
    Department of Human Genetics, Academic Medical Center, Department of Pediatric Oncology, Emma Kinderziekenhuis, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO Box 22700, 1105 AZ Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 106:12968-73. 2009
    ..The synthetically lethal relationship between CDK2 and MYCN indicates CDK2 inhibitors as potential MYCN-selective cancer therapeutics...
  14. pmc The human minor Histocompatibility Antigen1 is a RhoGAP
    Bart Jan de Kreuk
    Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e73962. 2013
    ..In conclusion, this study shows that HMHA1 acts as a RhoGAP to regulate GTPase activity, cytoskeletal remodeling and cell spreading, which are crucial functions in normal hematopoietic and cancer cells. ..
  15. pmc The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2
    Jos van Rijssel
    Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, 1066CX, The Netherlands
    Biol Open 2:569-79. 2013
    ..These data implicate Trio in regulating inflammation and provide novel targets for therapeutic purposes to treat inflammatory diseases such as rheumatoid arthritis. ..
  16. pmc In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma
    Shahryar E Mir
    Neuro oncology Research Group, Departments of Neurosurgery and Pediatric Oncology Hematology, VU University Medical Center, 1081 HV, Amsterdam, The Netherlands
    Cancer Cell 18:244-57. 2010
    ..Our results suggest that inhibition of WEE1 kinase holds potential as a therapeutic approach in treatment of glioblastoma...
  17. pmc The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation
    Ilse Timmerman
    Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
    Mol Biol Cell 23:4212-25. 2012
    ....
  18. doi Brain endothelial barrier passage by monocytes is controlled by the endothelin system
    Arie Reijerkerk
    Blood Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Neurochem 121:730-7. 2012
    ..Results from this study suggest that the endothelin system is a putative target within the brain for anti-inflammatory treatment in neurological diseases...
  19. pmc FHL2 protein is a novel co-repressor of nuclear receptor Nur77
    Kondababu Kurakula
    Department of Medical Biochemistry, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Biol Chem 286:44336-43. 2011
    ..Collectively, these studies suggest that association of FHL2 with Nur77 plays a pivotal role in vascular disease...
  20. doi Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors
    Julia J M Eekels
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center of University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Antiviral Res 89:43-53. 2011
    ..With these cells we could test the hypothesis that HIV-1 is not able to escape from RNAi-mediated suppression of cellular co-factors, which was indeed not detected...
  21. pmc Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts
    Micha Nethe
    Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Cell Sci 125:3430-42. 2012
    ..Together, these data reveal a novel Rac1-dependent signalling pathway that, through Nedd4-mediated ubiquitylation of Dvl1, stimulates the maturation of epithelial cell-cell contacts...
  22. doi Nod2 improves barrier function of intestinal epithelial cells via enhancement of TLR responses
    Ida H Hiemstra
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands
    Mol Immunol 52:264-72. 2012
    ..Failure of this protective mechanism may contribute to the increased risk of Crohn's disease in individuals with a loss-of-function mutation in NOD2...
  23. pmc Domain-wide regulation of gene expression in the human genome
    Hinco J Gierman
    Department of Human Genetics, Academic Medical Centre, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Genome Res 17:1286-95. 2007
    ..These results reveal a novel domain-wide regulatory mechanism that, together with transcription factors, exerts a dual control over gene transcription...
  24. ncbi Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation
    Dirk Geerts
    Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, HI 96813, USA
    Clin Cancer Res 13:6312-9. 2007
    ..In addition, we determined the localization of PRAF2 protein in neuroblastoma cells and studied its regulation in apoptosis...
  25. pmc Myeloid ecotropic viral integration site 1 (MEIS) 1 involvement in embryonic implantation
    Bei Xu
    Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong, University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, People s Republic of China
    Hum Reprod 23:1394-406. 2008
    ....