L E Gamadia

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Skewed maturation of virus-specific CTLs?
    Laila E Gamadia
    Nat Immunol 3:203. 2002
  2. ncbi request reprint Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers
    L E Gamadia
    Renal Transplant Unit, Department of Internal Medicine, Academic Medical Center, The Netherlands Cancer Institute, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood 98:754-61. 2001
  3. ncbi request reprint Cross-reactivity of cytomegalovirus-specific CD8+ T cells to allo-major histocompatibility complex class I molecules
    Laila E Gamadia
    Renal Transplant Unit, Department of Internal Medicine, Academic Medical Center G1 106, University of Amsterdam, PO Box 1100 DD Amsterdam, The Netherlands
    Transplantation 77:1879-85. 2004
  4. ncbi request reprint Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease
    Laila E Gamadia
    Renal Transplant Unit, Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Blood 101:2686-92. 2003
  5. pmc Development of virus-specific CD4(+) T cells during primary cytomegalovirus infection
    R J Rentenaar
    Renal Transplant Unit, Department of Medicine, Academic Medical Center, 1100 DE Amsterdam, The Netherlands
    J Clin Invest 105:541-8. 2000
  6. ncbi request reprint T-lymphocyte subset distribution in human spleen
    M Langeveld
    Laboratory for Experimental Immunology, University of Amsterdam, The Netherlands
    Eur J Clin Invest 36:250-6. 2006
  7. ncbi request reprint Expansion of CMV-specific CD8+CD45RA+CD27- T cells in B-cell chronic lymphocytic leukemia
    Wendelina J M Mackus
    Department of Hematology, Academic Medical Center, Rm F4 210, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Blood 102:1057-63. 2003
  8. ncbi request reprint Proliferation requirements of cytomegalovirus-specific, effector-type human CD8+ T cells
    Ester M van Leeuwen
    Department of Internal Medicine, Divisions of Nephrology and Clinical Immunology and Rheumatology, Academic Medical Center, Meibergsreef 9, 1105 AZ Amsterdam, The Netherlands
    J Immunol 169:5838-43. 2002
  9. ncbi request reprint The size and phenotype of virus-specific T cell populations is determined by repetitive antigenic stimulation and environmental cytokines
    Laila E Gamadia
    Renal Transplant Unit, Department of Internal Medicine, Laboratory for Experimental Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 172:6107-14. 2004
  10. ncbi request reprint Properties of CD4(+) T cells in human cytomegalovirus infection
    Laila E Gamadia
    Laboratory for Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    Hum Immunol 65:486-92. 2004

Collaborators

  • R J Rentenaar
  • R Boom
  • LOUIS J contact PICKER
  • Paul A Baars
  • Rene A W van Lier
  • Erwan R W A N Piriou
  • M Langeveld
  • Marinus H J van Oers
  • Wendelina J M Mackus
  • Ester M van Leeuwen
  • Karel van Dort
  • Debbie van Baarle
  • Frederike J Bemelman
  • I J M Ten Berge
  • Jan F L Weel
  • Florine N J Frakking
  • Godelieve J de Bree
  • Ineke J M ten Berge
  • Annette Grummels
  • Dorte Hamann
  • Rene A van Lier
  • Ineke J ten Berge
  • Ester B Remmerswaal

Detail Information

Publications12

  1. ncbi request reprint Skewed maturation of virus-specific CTLs?
    Laila E Gamadia
    Nat Immunol 3:203. 2002
  2. ncbi request reprint Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers
    L E Gamadia
    Renal Transplant Unit, Department of Internal Medicine, Academic Medical Center, The Netherlands Cancer Institute, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood 98:754-61. 2001
    ..Our data show that in response to immunosuppressive medication quantitative and qualitative changes occur in the CD8(+) T-cell compartment. These adaptations may be instrumental to maintain CMV latency. (Blood. 2001;98:754-761)..
  3. ncbi request reprint Cross-reactivity of cytomegalovirus-specific CD8+ T cells to allo-major histocompatibility complex class I molecules
    Laila E Gamadia
    Renal Transplant Unit, Department of Internal Medicine, Academic Medical Center G1 106, University of Amsterdam, PO Box 1100 DD Amsterdam, The Netherlands
    Transplantation 77:1879-85. 2004
    ..The underlying mechanism of this association could be the generation of CMV-specific CD8 T cells capable of cross-reacting with alloantigens present on graft and host, respectively...
  4. ncbi request reprint Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease
    Laila E Gamadia
    Renal Transplant Unit, Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Blood 101:2686-92. 2003
    ....
  5. pmc Development of virus-specific CD4(+) T cells during primary cytomegalovirus infection
    R J Rentenaar
    Renal Transplant Unit, Department of Medicine, Academic Medical Center, 1100 DE Amsterdam, The Netherlands
    J Clin Invest 105:541-8. 2000
    ..After the initial rise, circulating virus-specific CD4(+) T cells decline rapidly. During this phase, a strong rise in IgM and IgG anti-CMV antibody titers occurs, concomitant with the reduction of CMV-DNA in the circulation...
  6. ncbi request reprint T-lymphocyte subset distribution in human spleen
    M Langeveld
    Laboratory for Experimental Immunology, University of Amsterdam, The Netherlands
    Eur J Clin Invest 36:250-6. 2006
    ..To date the spleen has not been analyzed with regard to its role in adaptive cellular immunity and more notably not with respect to T-cell immune responses...
  7. ncbi request reprint Expansion of CMV-specific CD8+CD45RA+CD27- T cells in B-cell chronic lymphocytic leukemia
    Wendelina J M Mackus
    Department of Hematology, Academic Medical Center, Rm F4 210, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Blood 102:1057-63. 2003
    ..Furthermore, because in CMV-seronegative patients no increase in cytotoxic CD8+ T cells is found, our studies do not support the hypothesis that tumor-specific T cells account for T-cell expansion in B-CLL...
  8. ncbi request reprint Proliferation requirements of cytomegalovirus-specific, effector-type human CD8+ T cells
    Ester M van Leeuwen
    Department of Internal Medicine, Divisions of Nephrology and Clinical Immunology and Rheumatology, Academic Medical Center, Meibergsreef 9, 1105 AZ Amsterdam, The Netherlands
    J Immunol 169:5838-43. 2002
    ..Our data imply that CD45RA(+)CD27(-)CCR7(-) effector-type T cells contribute to immunity not only by direct execution of effector functions, but also by yielding progeny in situations of viral reinfection or reactivation...
  9. ncbi request reprint The size and phenotype of virus-specific T cell populations is determined by repetitive antigenic stimulation and environmental cytokines
    Laila E Gamadia
    Renal Transplant Unit, Department of Internal Medicine, Laboratory for Experimental Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 172:6107-14. 2004
    ..Thus, induction of CD70, which may vary in distinct viral infections, appears to be a key factor in determining the size and phenotype of the CMV-specific T cell population in latently infected individuals...
  10. ncbi request reprint Properties of CD4(+) T cells in human cytomegalovirus infection
    Laila E Gamadia
    Laboratory for Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    Hum Immunol 65:486-92. 2004
    ....
  11. ncbi request reprint Detailed kinetics of EBV-specific CD4+ and CD8+ T cells during primary EBV infection in a kidney transplant patient
    Erwan R W A N Piriou
    Department of Clinical Viro Immunology, Sanquin Research at CLB, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Immunol 119:16-20. 2006
    ....
  12. ncbi request reprint Human CD8(+) T-cell differentiation in response to viruses
    Rene A W van Lier
    Department of Experimental Immunology, Academic Medical Centre, P O Box 11600, 1100AZ Amsterdam, The Netherlands
    Nat Rev Immunol 3:931-9. 2003