W J Fokkens

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Long-term safety of fluticasone furoate nasal spray in adults and adolescents with perennial allergic rhinitis
    A Rosenblut
    Hospital Dr Sotero del Rio, Puente Alto, Santiago, Chile
    Allergy 62:1071-7. 2007
  2. ncbi request reprint Once daily fluticasone furoate nasal spray is effective in seasonal allergic rhinitis caused by grass pollen
    W J Fokkens
    Academisch Medisch Centrum, Divisie Neurozintuigspecialismen, Polikliniek KNO, Amsterdam, The Netherlands
    Allergy 62:1078-84. 2007
  3. ncbi request reprint Nebulized bacitracin/colimycin: a treatment option in recalcitrant chronic rhinosinusitis with Staphylococcus aureus? A double-blind, randomized, placebo-controlled, cross-over pilot study
    W J M Videler
    Dept of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 46:92-8. 2008
  4. pmc Histone deacetylase inhibitors up-regulate LL-37 expression independent of toll-like receptor mediated signalling in airway epithelial cells
    Quan Liu
    Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, 200031, China
    J Inflamm (Lond) 10:15. 2013
  5. pmc The skin prick test - European standards
    Lucie Heinzerling
    Department of Dermatology, University Hospital Erlangen, 91054 Erlangen, Germany
    Clin Transl Allergy 3:3. 2013
  6. pmc Diagnostic tools in Rhinology EAACI position paper
    Glenis Scadding
    Royal National Throat, Nose and Ear Institute, London, UK
    Clin Transl Allergy 1:2. 2011
  7. doi request reprint EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 50:1-12. 2012
  8. ncbi request reprint Perennial rhinitis in the under 4s: a difficult problem to treat safely and effectively? A comparison of intranasal fluticasone propionate and ketotifen in the treatment of 2-4-year-old children with perennial rhinitis
    W J Fokkens
    Department of Otorhinolaryngology, Academic Medical Hospital Amsterdam, Amsterdam, The Netherlands
    Pediatr Allergy Immunol 15:261-6. 2004
  9. doi request reprint Comparison of Timothy grass pollen extract- and single major allergen-induced gene expression and mediator release in airway epithelial cells: a meta-analysis
    K I L Röschmann
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Exp Allergy 42:1479-90. 2012
  10. doi request reprint Nasal endothelial interleukin-10 expression is negatively correlated with nasal symptoms after allergen provocation
    B Muller
    Department of Otorhinolaryngology, AMC, Amsterdam, The Netherlands
    Allergy 64:738-45. 2009

Detail Information

Publications68

  1. ncbi request reprint Long-term safety of fluticasone furoate nasal spray in adults and adolescents with perennial allergic rhinitis
    A Rosenblut
    Hospital Dr Sotero del Rio, Puente Alto, Santiago, Chile
    Allergy 62:1071-7. 2007
    ..This study was designed to assess the safety and tolerability of 12-month intranasal administration of fluticasone furoate in adult and adolescent patients with perennial allergic rhinitis (PAR)...
  2. ncbi request reprint Once daily fluticasone furoate nasal spray is effective in seasonal allergic rhinitis caused by grass pollen
    W J Fokkens
    Academisch Medisch Centrum, Divisie Neurozintuigspecialismen, Polikliniek KNO, Amsterdam, The Netherlands
    Allergy 62:1078-84. 2007
    ..Fluticasone furoate is a new enhanced-affinity glucocorticoid with a unique combination of pharmacodynamic and physicochemical properties suitable for topical activity...
  3. ncbi request reprint Nebulized bacitracin/colimycin: a treatment option in recalcitrant chronic rhinosinusitis with Staphylococcus aureus? A double-blind, randomized, placebo-controlled, cross-over pilot study
    W J M Videler
    Dept of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 46:92-8. 2008
    ..We have performed a pilot study in order to determine whether nebulized topical antibiotic therapy improves sinusitis symptoms more than saline-based placebo in patients with recalcitrant chronic rhinosinusitis...
  4. pmc Histone deacetylase inhibitors up-regulate LL-37 expression independent of toll-like receptor mediated signalling in airway epithelial cells
    Quan Liu
    Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, 200031, China
    J Inflamm (Lond) 10:15. 2013
    ..In addition, HDAC inhibitors significantly inhibited poly (I:C)-induced IL-6 production in both of the epithelial cells. In conclusion, HDAC inhibitors directly up-regulated LL-37 gene expression in human airway epithelial cells...
  5. pmc The skin prick test - European standards
    Lucie Heinzerling
    Department of Dermatology, University Hospital Erlangen, 91054 Erlangen, Germany
    Clin Transl Allergy 3:3. 2013
    ..Standardization of the skin test procedures and standard panels for different geographic locations are encouraged worldwide to permit better comparisons for diagnostic, clinical and research purposes...
  6. pmc Diagnostic tools in Rhinology EAACI position paper
    Glenis Scadding
    Royal National Throat, Nose and Ear Institute, London, UK
    Clin Transl Allergy 1:2. 2011
    ..A panel of European experts in the field of Rhinology has contributed to this consensus document on Diagnostic Tools in Rhinology...
  7. doi request reprint EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 50:1-12. 2012
    ..This executive summary for otorhinolaryngologists focuses on the most important changes and issues for otorhinolaryngologists. The full document can be downloaded for free on the website of this journal: http://www.rhinologyjournal.com...
  8. ncbi request reprint Perennial rhinitis in the under 4s: a difficult problem to treat safely and effectively? A comparison of intranasal fluticasone propionate and ketotifen in the treatment of 2-4-year-old children with perennial rhinitis
    W J Fokkens
    Department of Otorhinolaryngology, Academic Medical Hospital Amsterdam, Amsterdam, The Netherlands
    Pediatr Allergy Immunol 15:261-6. 2004
    ..FPANS may be an appropriate treatment to control the symptoms of rhinitis in children between 2 and 4 years old...
  9. doi request reprint Comparison of Timothy grass pollen extract- and single major allergen-induced gene expression and mediator release in airway epithelial cells: a meta-analysis
    K I L Röschmann
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Exp Allergy 42:1479-90. 2012
    ..As the allergic response with its clinical manifestations is triggered by only a few proteins within natural extracts, there is an increasing tendency for single-component-resolved diagnosis and immunotherapy...
  10. doi request reprint Nasal endothelial interleukin-10 expression is negatively correlated with nasal symptoms after allergen provocation
    B Muller
    Department of Otorhinolaryngology, AMC, Amsterdam, The Netherlands
    Allergy 64:738-45. 2009
    ....
  11. pmc Purified Timothy grass pollen major allergen Phl p 1 may contribute to the modulation of allergic responses through a pleiotropic induction of cytokines and chemokines from airway epithelial cells
    K I L Röschmann
    Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Immunol 167:413-21. 2012
    ..Further detailed comparison of grass pollen extract (GPE)- and Phl p 1-induced gene expression might be beneficial with regard to the application of single components within diagnosis and immunotherapy...
  12. ncbi request reprint Passive smoking causes an 'allergic' cell infiltrate in the nasal mucosa of non-atopic children
    J G Vinke
    Department of Otorhinolaryngology, Erasmus University Medical Centre Rotterdam, The Netherlands
    Int J Pediatr Otorhinolaryngol 51:73-81. 1999
    ..However, no sign of allergic sensitisation can be found in the nasal mucosa. Children with a genetic predisposition to allergic disease will probably suffer most from the 'unstable' nasal mucosa due to ETS...
  13. doi request reprint Predictors of post-operative response to treatment: a double blind placebo controlled study in chronic rhinosinusitis patients
    F A Ebbens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 49:413-9. 2011
    ..In this study we describe our search for one or more predictors predicting the response to surgery in combination with peri-operative oral glucocorticoids in CRS patients...
  14. doi request reprint The multi-faceted role of allergen exposure to the local airway mucosa
    K Golebski
    Department of Otorhinolanyngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Allergy 68:152-60. 2013
    ..This review presents the dual role of epithelium acting as a passive and active barrier when encountering an inhaled allergen and how this double role contributes to the start of local immune responses...
  15. ncbi request reprint Age- and infection-related maturation of the nasal immune response in 0-2-year-old children
    I J van Benten
    Department of Otorhinolaryngology, Erasmus Medical Center, Rotterdam, The Netherlands
    Allergy 60:226-32. 2005
    ..The hygiene hypothesis suggests that exposure to micro-organisms influences development of the immune system in children...
  16. doi request reprint Endothelial L-selectin ligand expression in nasal polyps
    Fenna A Ebbens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Allergy 65:95-102. 2010
    ..L-selectins on leukocytes and their counter-receptors on endothelial cells have been shown to be involved in leukocyte recruitment in chronic rhinosinusitis without nasal polyps (NP)...
  17. doi request reprint Timothy grass pollen extract-induced gene expression and signalling pathways in airway epithelial cells
    K I L Röschmann
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Exp Allergy 41:830-41. 2011
    ..Our understanding of the epithelial contribution to immune responses is limited as most studies focus on only a few individual genes or proteins...
  18. doi request reprint The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: a multicenter randomized controlled study
    Fenna A Ebbens
    Department of Otorhinolaryngology, Head and Neck Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Laryngoscope 119:401-8. 2009
    ..Based on this rationale, the use of topical antifungals (amphotericin B) has been advocated. Studies on its clinical effectiveness are, however, contradictory...
  19. doi request reprint Long-term low-dose antibiotics in recalcitrant chronic rhinosinusitis: a retrospective analysis
    W J M Videler
    Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands
    Rhinology 50:45-55. 2012
    ..Long-term low-dose administration of antibiotics has been suggested as a treatment option in these patients. We analysed the outpatient clinic population treated with different long-term low-dose antibiotics at the AMC Amsterdam...
  20. ncbi request reprint The fungal debate: where do we stand today?
    F A Ebbens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 45:178-89. 2007
    ..Presently, in the absence of convincing immunological data and evidence of clinical improvement of CRS upon therapy with antifungal agents, the case against the fungus remains unproven...
  21. ncbi request reprint Nasal hyper-reactivity is a common feature in both allergic and nonallergic rhinitis
    C L Segboer
    Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands
    Allergy 68:1427-34. 2013
    ..Differences in the prevalence or type of nasal hyper-reactivity in AR and NAR patients are largely unknown. In this study, we quantitatively and qualitatively assessed nasal hyper-reactivity in AR and NAR...
  22. ncbi request reprint Segmental bronchoprovocation in allergic rhinitis patients affects mast cell and basophil numbers in nasal and bronchial mucosa
    G J Braunstahl
    Department of Otorhinolaryngology, Erasmus University Medical Center Rotterdam, The Netherlands
    Am J Respir Crit Care Med 164:858-65. 2001
    ..At the same time, there is evidence for an influx of basophils from the blood into the nasal and bronchial mucosae...
  23. doi request reprint The microdebrider, a step forward or an expensive gadget?
    M E Cornet
    Department of Otorhinolaryngology, Academic Medical Centre Amsterdam, Amsterdam, The Netherlands
    Rhinology 50:191-8. 2012
    ..In this study we compared the use of the microdebrider to conventional instruments in FESS in these areas...
  24. ncbi request reprint Fluticasone propionate aqueous nasal spray does not influence the recurrence rate of chronic rhinosinusitis and nasal polyps 1 year after functional endoscopic sinus surgery
    M D Dijkstra
    Department of Otorhinolaryngology, Erasmus MC, Rotterdam, The Netherlands
    Clin Exp Allergy 34:1395-400. 2004
    ..Their efficacy after functional endoscopic sinus surgery (FESS) has not been fully established by placebo-controlled trials...
  25. ncbi request reprint Nasal epithelial cells express IL-10 at levels that negatively correlate with clinical symptoms in patients with house dust mite allergy
    B Muller
    Department of Otorhinolaryngology, AMC, Amsterdam, The Netherlands
    Allergy 62:1014-22. 2007
    ..Previous data from our group suggested that locally produced interleukin (IL)-10 could be involved in maintaining local homeostasis...
  26. doi request reprint Evidence-based recommendations regarding the differential diagnosis and assessment of nasal congestion: using the new GRADE system
    E Van Spronsen
    Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands
    Allergy 63:820-33. 2008
    ....
  27. ncbi request reprint Prolonged nasal eosinophilia in allergic patients after common cold
    I J van Benten
    Department of Otorhinolaryngology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Allergy 56:949-56. 2001
    ..What immunologic factors can induce prolonged eosinophil influx and whether this may increase the risk of subsequent allergen-induced hypersensitivity reactions must be studied further...
  28. doi request reprint Topical glucocorticoids downregulate COX-1 positive cells in nasal polyps
    F A Ebbens
    Department of Otorhinolaryngology Head and Neck Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Allergy 64:96-103. 2009
    ..As cyclooxygenases (COX) are key enzymes in the synthesis of both pro- (COX-1, COX-2) and anti-inflammatory prostanoids (COX-2), we investigated the role of topical GC on COX-1, COX-2 and inflammatory markers in nasal polyps (NP)...
  29. doi request reprint Lack of efficacy of long-term, low-dose azithromycin in chronic rhinosinusitis: a randomized controlled trial
    W J Videler
    Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands
    Allergy 66:1457-68. 2011
    ..The MACS (Macrolides in chronic rhinosinusitis) study is a randomized placebo-controlled trial evaluating the efficacy of azithromycin (AZM) in CRS...
  30. doi request reprint Comparison of expression profiles induced by dust mite in airway epithelia reveals a common pathway
    A B Vroling
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Allergy 63:461-7. 2008
    ..Airway epithelial cells have shown to be active participants in the defense against pathogens by producing signaling and other regulatory molecules in response to the encounter...
  31. doi request reprint Osteitic bone in recalcitrant chronic rhinosinusitis
    W J M Videler
    Department of Otorhinolaryngology Head and Neck Surgery, Academic Medical Centre AMC, Amsterdam, The Netherlands
    Rhinology 49:139-47. 2011
    ..Close inspection of CT scans often reveals areas of increased bone density and irregular thickening of the sinus walls. This osteitic bone could at least partly explain, why inflammation of the mucosa persists...
  32. doi request reprint Quality of life in extended endonasal approaches for skull base tumours
    C Georgalas
    Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 50:255-61. 2012
    ..To assess the quality of life (QOL) impact of extended endonasal approaches and nasoseptal flap reconstruction for benign skull base tumours..
  33. doi request reprint Fever is not a symptom of chronic rhinosinusitis
    W J M Videler
    Department of Otorhinolaryngology, Academic Medical Center Amsterdam, The Netherlands
    Rhinology 47:393-5. 2009
    ..In the EP3OS definition, fever is not mentioned as a contributing factor. The main aim of this study was to evaluate the role of fever in CRS...
  34. doi request reprint Long terms results of Draf type III (modified endoscopic Lothrop) frontal sinus drainage procedure in 122 patients: a single centre experience
    C Georgalas
    Department of Otorhinolaryngology Head and Neck Surgery, Academic Medical Centre AMC, Amsterdam, The Netherlands
    Rhinology 49:195-201. 2011
    ..To assess the effectiveness and factors associated with restenosis after Draf type III (Endoscopic Modified Lothrop) frontal sinus drainage procedure...
  35. doi request reprint Chronic rhinosinusitis in Europe--an underestimated disease. A GA²LEN study
    D Hastan
    Department of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Allergy 66:1216-23. 2011
    ....
  36. doi request reprint The use of biofeedback in the treatment of chronic dysphagia in stroke patients
    H C A Bogaardt
    Department of Otorhinolaryngology Head and Neck Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Folia Phoniatr Logop 61:200-5. 2009
    ..To evaluate the efficacy of the use of surface electromyographic feedback in the treatment of stroke patients with chronic dysphagia...
  37. doi request reprint Complications of acute rhinosinusitis in The Netherlands
    F S Hansen
    Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands
    Fam Pract 29:147-53. 2012
    ..In this study, we present epidemiological data about the incidence, course and severity of such complications in the Netherlands...
  38. ncbi request reprint Evaluation of an intranasal house dust mite provocation model as a tool in clinical research
    N B Oldenbeuving
    Department of Otorhinolaryngology, Erasmuc MC, Rotterdam, The Netherlands
    Allergy 60:751-9. 2005
    ..In this study, we investigated whether, despite these symptoms, we can still use nasal HDM provocations to study perennial allergic rhinitis and the effects of treatment...
  39. ncbi request reprint Interactions between epithelial cells and dendritic cells in airway immune responses: lessons from allergic airway disease
    J van Tongeren
    Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Neitherlands
    Allergy 63:1124-35. 2008
    ..A concept emerges where airway mucosal dendritic cells act as integrators of both immunostimulatory and immunosuppressive signals that act within actively-involved mucosal tissue...
  40. ncbi request reprint Allergen induced gene expression of airway epithelial cells shows a possible role for TNF-alpha
    A B Vroling
    Department of Otorhinolanyngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Allergy 62:1310-9. 2007
    ..Here, we fully characterize the expression profile of airway epithelial cells in response to house dust mite (HDM) allergen...
  41. ncbi request reprint Considerations on the application of microarray analysis in rhinology
    C M van Drunen
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 46:259-66. 2008
    ..New visualization and analysis tools for microarray data are discussed in this overview that deal with these complex issues...
  42. ncbi request reprint How epithelial cells detect danger: aiding the immune response
    A B Vroling
    Amsterdam Medical Center, Department of Otorhinolaryngology, Amsterdam, The Netherlands
    Allergy 63:1110-23. 2008
    ..In this review, we focus on signals acting on epithelium from the exterior environment, how these signals are processed and identify research challenges...
  43. pmc Viscosity is not a parameter of postdeglutitive pharyngeal residue: quantification and analysis with scintigraphy
    H C A Bogaardt
    Department of Otolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dysphagia 22:145-9. 2007
    ..In healthy persons viscosity does not seem to be a significant parameter for pharyngeal residue for boluses with viscosities ranging from tap water to solutions having a viscosity comparable to 3% fat yogurt...
  44. ncbi request reprint Desloratadine reduces systemic allergic inflammation following nasal provocation in allergic rhinitis and asthma patients
    S M Reinartz
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Allergy 60:1301-7. 2005
    ....
  45. ncbi request reprint Nasal polyposis: a cellular-based approach to answering questions
    A B Rinia
    Department of Otorhinolaryngology, Head and Neck Surgery, Academic Medical Centre, Amsterdam, The Netherlands
    Allergy 62:348-58. 2007
  46. ncbi request reprint Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study
    J B Van Rijswijk
    Department of Otorhinolaryngology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Allergy 58:754-61. 2003
    ..In the present study, we conducted a double-blind double-dummy parallel groups trial to determine whether a more practical capsaicin application schedule is equally effective...
  47. doi request reprint Normal peak nasal inspiratory flow rate values in healthy children aged 6 to 11 years in the Netherlands
    E Van Spronsen
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 50:22-5. 2012
    ..However, normative data are rare and not available for Dutch children aged 6 to 11 years...
  48. ncbi request reprint Quality-assessment of disease-specific quality of life questionnaires for rhinitis and rhinosinusitis: a systematic review
    C M van Oene
    Department of ENT, Academic Medical Centre, Amsterdam, The Netherlands
    Allergy 62:1359-71. 2007
    ..Of the top scoring instruments regarding the overall quality assessment, only four health related QOL questionnaires for rhinitis and rhinosinusitis met our criteria for the discriminant validity and responsiveness...
  49. ncbi request reprint Reduced nasal IL-10 and enhanced TNFalpha responses during rhinovirus and RSV-induced upper respiratory tract infection in atopic and non-atopic infants
    I J van Benten
    Department of Otorhinolaryngology, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Med Virol 75:348-57. 2005
    ..TNFalpha in turn could replace the immature production of IL-12, IL-18 and IFNgamma during URTI to induce an effective clearance of the viral infection and which could stimulate the maturation of Th1 cytokine production in infancy...
  50. doi request reprint Cross-cultural adaptation and validation of the Dutch version of SWAL-QoL
    H C A Bogaardt
    Department of Otorhinolaryngology D2 313, Academic Medical Center, Amsterdam, The Netherlands
    Dysphagia 24:66-70. 2009
    ..Internal consistency allows the use of nine subscales of SWAL-QoL-NL for comparisons on a group level (0.80 < alpha < 0.92) only. Also a Symptom score can be derived from the raw data...
  51. ncbi request reprint Nasal allergies and beyond: a clinical review of the pharmacology, efficacy, and safety of mometasone furoate
    C van Drunen
    Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, The Netherlands
    Allergy 60:5-19. 2005
    ..MFNS is a potent molecule with a rapid onset of action and excellent safety and efficacy profiles. Having recently received approval for the treatment of nasal polyposis, data indicate that MFNS may also be effective in rhinosinusitis...
  52. ncbi request reprint Pollutional and meteorological factors are closely related to complaints of non-allergic, non-infectious perennial rhinitis patients: a time series model
    J P M Braat
    Department of Otorhinolaryngology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Clin Exp Allergy 32:690-7. 2002
    ....
  53. ncbi request reprint The diagnosis and management of chronic cough
    A H Morice
    Division of Academic Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Eur Respir J 24:481-92. 2004
  54. ncbi request reprint Idiopathic rhinitis, the ongoing quest
    J B Van Rijswijk
    Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC, Rotterdam, The Netherlands
    Allergy 60:1471-81. 2005
    ..This review summarizes the currently known causes for nonallergic noninfectious rhinitis and possible treatments. Also possible pathophysiological mechanisms of IR are discussed...
  55. ncbi request reprint Cost analysis of regular and filgrastim treatment in patients with refractory chronic rhinosinusitis
    M van Agthoven
    Institute for Medical Technology Assessment, Erasmus Medical Centre, Rotterdam, The Netherlands
    Rhinology 40:69-74. 2002
    ..Furthermore, scheduled preventive visits in chronic sinusitis patients appear not to cause savings as compared to the situation in which patients are only seen in case of recurrences...
  56. pmc A hampered chemoattractant-induced cytoskeletal rearrangement in granulocytes of patients with unexplained severe chronic and relapsing infections of the upper and lower airways. In vitro restoration by G-CSF exposure
    P M J Kalkman
    Department of Immunology, Eramus University and University Hospital Dijkzigt, Rotterdam, The Netherlands
    Clin Exp Immunol 127:115-22. 2002
    ..Our data thus show that subtle abnormalities in chemoattractant-induced cytoskeletal and motile function of blood granulocytes are frequent in patients with severe therapy-refractory bacterial infections of the upper and lower airways...
  57. ncbi request reprint The Sophia Anatomical Infant Nose-Throat (Saint) model: a valuable tool to study aerosol deposition in infants
    H M Janssens
    Department of Pediatric Pulmonology, Sophia Children's Hospital/Erasmus Medical Centre Rotterdam, The Netherlands
    J Aerosol Med 14:433-41. 2001
    ..This model will be used to obtain insight in aerosol treatment that cannot be obtained in vivo...
  58. ncbi request reprint Refractory chronic sinusitis: evaluation of symptom improvement after Denker's procedure
    V B Wreesmann
    Department of Otolaryngology-Head and Neck Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Otolaryngol Head Neck Surg 125:495-500. 2001
    ..SIGNIFICANCE: A prospective study is warranted to validate this approach for refractory chronic rhinosinusitis...
  59. ncbi request reprint Inflammatory cells seem not to be involved in idiopathic rhinitis
    J B Van Rijswijk
    Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus Medical Centre, Rotterdam, The Netherlands
    Rhinology 41:25-30. 2003
    ..No significant differences were found, for any cell, between IR patients and controls. We conclude that inflammatory cells do not seem to play an important role in this meticulously characterised group of IR patients...
  60. ncbi request reprint Moderate local and systemic respiratory syncytial virus-specific T-cell responses upon mild or subclinical RSV infection
    L de Waal
    Institute of Virology, Erasmus MC, Rotterdam, The Netherlands
    J Med Virol 70:309-18. 2003
    ....
  61. ncbi request reprint Mucosal and systemic inflammatory changes in allergic rhinitis and asthma: a comparison between upper and lower airways
    G J Braunstahl
    Departments of Pulmonary Medicine and dagger Otorhinolaryngology, Erasmus University Medical Center Rotterdam, The Netherlands
    Clin Exp Allergy 33:579-87. 2003
    ..Local airway inflammation and airway remodelling are considered important in the clinical expression of allergic asthma...
  62. ncbi request reprint Nasal corticosteroids, first choice in moderate to severe allergic rhinitis. What prevents general practitioners from using them?
    W J Fokkens
    Allergy 58:724-6. 2003
  63. ncbi request reprint The 'best method' of topical nasal drug delivery: comparison of seven techniques
    P Merkus
    Department of Otorhinolaryngology and Head and Neck Surgery, VU Medical Center, Amsterdam, Netherlands
    Rhinology 44:102-7. 2006
    ..To determine whether there is a 'best' technique for delivering drugs to the middle meatus...
  64. ncbi request reprint Standard skin prick testing and sensitization to inhalant allergens across Europe--a survey from the GALEN network
    L Heinzerling
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 60:1287-300. 2005
    ..This overview may serve as reference for the practising doctor and suggests a GA(2)LEN Pan-European core SPT panel...
  65. ncbi request reprint Basophils and mast cells at the centre of the immunological response
    C M van Drunen
    Allergy 61:273-5. 2006
  66. ncbi request reprint Allergic rhinitis and its impact on otorhinolaryngology
    P W Hellings
    Laboratory of Experimental Immunology, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium
    Allergy 61:656-64. 2006
    ....
  67. doi request reprint Regulation of glucocorticoid receptor in nasal polyps by systemic and intranasal glucocorticoids
    L Pujols
    Clinical and Experimental Respiratory Immunoallergy, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Allergy 63:1377-86. 2008
    ..We aimed to evaluate the in vivo regulation of GR isoforms in GC-treated nasal polyps and to assess the relationship between clinical response to GCs and GR levels...
  68. ncbi request reprint Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways
    G J Braunstahl
    Departments of Otorhinolaryngology and Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Allergy Clin Immunol 107:469-76. 2001
    ..CONCLUSION: This study shows that NP in patients with AR results in generalized airway inflammation through upregulation of adhesion molecules...