Marc Engelen

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc High prevalence of primary adrenal insufficiency in Zellweger spectrum disorders
    Kevin Berendse
    Department of Paediatric Neurology, Emma Children s Hospital Academic Medical Centre, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    Orphanet J Rare Dis 9:133. 2014
  2. doi request reprint X-linked adrenoleukodystrophy: pathogenesis and treatment
    Marc Engelen
    Department of Pediatric Neurology Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, 1100 DD, The Netherlands
    Curr Neurol Neurosci Rep 14:486. 2014
  3. pmc X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management
    Marc Engelen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Orphanet J Rare Dis 7:51. 2012
  4. pmc A 64-year old man presenting with carotid artery occlusion and corticobasal syndrome: a case report
    Marc Engelen
    Department of Neurology, H2, 216, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    J Med Case Reports 5:357. 2011
  5. pmc Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation
    Marc Engelen
    Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Inherit Metab Dis 35:1137-45. 2012
  6. doi request reprint X-linked adrenoleukodystrophy in women: a cross-sectional cohort study
    Marc Engelen
    1 Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Brain 137:693-706. 2014
  7. pmc Bezafibrate for X-linked adrenoleukodystrophy
    Marc Engelen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e41013. 2012
  8. doi request reprint Hematopoietic cell transplantation does not prevent myelopathy in X-linked adrenoleukodystrophy: a retrospective study
    Bjorn M Van Geel
    Department of Neurology, Medical Center Alkmaar, Alkmaar, The Netherlands
    J Inherit Metab Dis 38:359-61. 2015
  9. doi request reprint Strokelike episodes and cutis marmorata telangiectatica congenita
    Sander M van Schaik
    Department of Pediatric Neurology, Academic Medical Center, Amsterdam, The Netherlands Department of Neurology, Saint Lucas Andreas Hospital, Amsterdam, The Netherlands
    J Child Neurol 30:129-32. 2015
  10. doi request reprint Frequent occurrence of cerebral demyelination in adrenomyeloneuropathy
    Marlijn de Beer
    From the Department of Neurology M d B, Haga Hospital, The Hague the Department of Pediatric Neurology M E, Emma Children s Hospital, Amsterdam the Department of Neurology M E, B M v G, Academic Medical Center, University of Amsterdam and the Department of Neurology B M v G, Medical Center Alkmaar, The Netherlands
    Neurology 83:2227-31. 2014

Collaborators

Detail Information

Publications12

  1. pmc High prevalence of primary adrenal insufficiency in Zellweger spectrum disorders
    Kevin Berendse
    Department of Paediatric Neurology, Emma Children s Hospital Academic Medical Centre, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    Orphanet J Rare Dis 9:133. 2014
    ..Primary adrenal insufficiency was found in 7/24 patients examined, with 4/7 being asymptomatic. Systematic evaluation of adrenal function, through a Synacthen test, should be included in the clinical management of these patients. ..
  2. doi request reprint X-linked adrenoleukodystrophy: pathogenesis and treatment
    Marc Engelen
    Department of Pediatric Neurology Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, 1100 DD, The Netherlands
    Curr Neurol Neurosci Rep 14:486. 2014
    ..This review proposes to simplify the classification of the clinical spectrum of X-ALD and reviews the largely unresolved pathophysiological mechanisms and the current treatment options. ..
  3. pmc X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management
    Marc Engelen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Orphanet J Rare Dis 7:51. 2012
    ..This review focuses on the diagnosis and management of patients with X-ALD and provides a guideline for clinicians that encounter patients with this highly complex disorder...
  4. pmc A 64-year old man presenting with carotid artery occlusion and corticobasal syndrome: a case report
    Marc Engelen
    Department of Neurology, H2, 216, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    J Med Case Reports 5:357. 2011
    ..abstract:..
  5. pmc Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation
    Marc Engelen
    Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Inherit Metab Dis 35:1137-45. 2012
    ..Taken together, our data indicate bezafibrate as a potential pharmacotherapeutic treatment for X-ALD. A clinical trial is currently ongoing to evaluate the effect in patients with X-ALD...
  6. doi request reprint X-linked adrenoleukodystrophy in women: a cross-sectional cohort study
    Marc Engelen
    1 Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Brain 137:693-706. 2014
    ..ABCD1 mutation analysis deserves a place in diagnostic protocols for chronic non-compressive myelopathy. ..
  7. pmc Bezafibrate for X-linked adrenoleukodystrophy
    Marc Engelen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e41013. 2012
    ..Our future work is aimed at the identification of highly-specific inhibitors of ELOVL1 that act at much lower concentrations than BF and are well tolerated. BF appears to have no therapeutic utility in X-ALD...
  8. doi request reprint Hematopoietic cell transplantation does not prevent myelopathy in X-linked adrenoleukodystrophy: a retrospective study
    Bjorn M Van Geel
    Department of Neurology, Medical Center Alkmaar, Alkmaar, The Netherlands
    J Inherit Metab Dis 38:359-61. 2015
    ..Cerebral ALD is treated with haematopoetic cell transplantation (HCT). It is unknown if AMN still develops in patients with X-ALD that underwent HCT for cerebral ALD in childhood...
  9. doi request reprint Strokelike episodes and cutis marmorata telangiectatica congenita
    Sander M van Schaik
    Department of Pediatric Neurology, Academic Medical Center, Amsterdam, The Netherlands Department of Neurology, Saint Lucas Andreas Hospital, Amsterdam, The Netherlands
    J Child Neurol 30:129-32. 2015
    ..To our knowledge, this is the first report of a stenosis of an intracranial artery in a patient with cutis marmorata telangiectatica congenita. ..
  10. doi request reprint Frequent occurrence of cerebral demyelination in adrenomyeloneuropathy
    Marlijn de Beer
    From the Department of Neurology M d B, Haga Hospital, The Hague the Department of Pediatric Neurology M E, Emma Children s Hospital, Amsterdam the Department of Neurology M E, B M v G, Academic Medical Center, University of Amsterdam and the Department of Neurology B M v G, Medical Center Alkmaar, The Netherlands
    Neurology 83:2227-31. 2014
    ..To study the frequency of additional cerebral demyelination in Dutch patients with adrenomyeloneuropathy (AMN)...
  11. doi request reprint Peroxisomal leukoencephalopathy
    Bwee Tien Poll-The
    Department of Pediatric Neurology Pediatrics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Semin Neurol 32:42-50. 2012
    ....