S H Diks

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Lipopolysaccharide recognition, internalisation, signalling and other cellular effects
    S H Diks
    Laboratory for Experimental Internal Medicine, Amsterdam Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Endotoxin Res 7:335-48. 2001
  2. ncbi request reprint Activation of the canonical beta-catenin pathway by histamine
    Sander H Diks
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, The Netherlands
    J Biol Chem 278:52491-6. 2003
  3. ncbi request reprint LPS signal transduction: the picture is becoming more complex
    Sander H Diks
    Laboratory for Experimental Internal Medicine, G2 105, Academic Medical Center, University of Amsterdam, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Curr Top Med Chem 4:1115-26. 2004
  4. ncbi request reprint Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac
    H H Versteeg
    Laboratory for Experimental Internal Medicine, G2 130, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Biol Chem 275:28750-6. 2000
  5. ncbi request reprint Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A
    C L Bos
    Laboratory of Experimental Oncology and Radiobiology, University of Amsterdam, The Netherlands
    Oncogene 25:6447-56. 2006
  6. ncbi request reprint FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production
    Henri H Versteeg
    Laboratory of Experimental Internal Medicine, G2 131, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Circ Res 94:1032-40. 2004
  7. ncbi request reprint Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia
    Jantine W P M van Baal
    Department of Cell Biology, University of Groningen, Groningen, The Netherlands
    Cancer Res 66:11605-12. 2006
  8. ncbi request reprint Kinome profiling for studying lipopolysaccharide signal transduction in human peripheral blood mononuclear cells
    Sander H Diks
    Department of Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Biol Chem 279:49206-13. 2004
  9. ncbi request reprint Profiling of the renal kinome: a novel tool to identify protein kinases involved in angiotensin II-dependent hypertensive renal damage
    Martin H de Borst
    Dept of Pathology, University of Groningen, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Am J Physiol Renal Physiol 293:F428-37. 2007
  10. pmc The novel gene asb11: a regulator of the size of the neural progenitor compartment
    Sander H Diks
    Department of Cell Biology, University Medical Center Groningen, University of Groningen, NL 9713 AV Groningen, Netherlands
    J Cell Biol 174:581-92. 2006

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Lipopolysaccharide recognition, internalisation, signalling and other cellular effects
    S H Diks
    Laboratory for Experimental Internal Medicine, Amsterdam Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Endotoxin Res 7:335-48. 2001
    ..Finally, we shall investigate how current knowledge may explain endotoxin neutralisation and subsequent detoxification, either through LPS internalisation or via LPS immobilisation, or through the actions of LPS-binding molecules...
  2. ncbi request reprint Activation of the canonical beta-catenin pathway by histamine
    Sander H Diks
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, The Netherlands
    J Biol Chem 278:52491-6. 2003
    ..The observation that inflammatory molecules, like histamine, activate the beta-catenin pathway may provide a molecular explanation for a possible link between inflammation and cancer...
  3. ncbi request reprint LPS signal transduction: the picture is becoming more complex
    Sander H Diks
    Laboratory for Experimental Internal Medicine, G2 105, Academic Medical Center, University of Amsterdam, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Curr Top Med Chem 4:1115-26. 2004
    ..Further insight into LPS-dependent signal transduction will assist the development of novel rational therapy...
  4. ncbi request reprint Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac
    H H Versteeg
    Laboratory for Experimental Internal Medicine, G2 130, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Biol Chem 275:28750-6. 2000
    ..We propose that this Src family member/PI3K/Rac-dependent signaling pathway is a major mediator of factor VIIa/TF effects in pathophysiology...
  5. ncbi request reprint Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A
    C L Bos
    Laboratory of Experimental Oncology and Radiobiology, University of Amsterdam, The Netherlands
    Oncogene 25:6447-56. 2006
    ....
  6. ncbi request reprint FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production
    Henri H Versteeg
    Laboratory of Experimental Internal Medicine, G2 131, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Circ Res 94:1032-40. 2004
    ..Finally, we demonstrated for the first time that TF/FVIIa-signal transduction is dependent on G12/G13 class G proteins...
  7. ncbi request reprint Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia
    Jantine W P M van Baal
    Department of Cell Biology, University of Groningen, Groningen, The Netherlands
    Cancer Res 66:11605-12. 2006
    ..These unique findings provide novel insight in the pathogenesis of Barrett's esophagus that will ultimately help to resolve the increasing problem of Barrett's esophagus and prevention of esophageal adenocarcinoma...
  8. ncbi request reprint Kinome profiling for studying lipopolysaccharide signal transduction in human peripheral blood mononuclear cells
    Sander H Diks
    Department of Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Biol Chem 279:49206-13. 2004
    ..We conclude that this first metabolic array is a useful method to determine the enzymatic activities of a large group of kinases, offering high throughput analysis of cellular metabolism and signal transduction...
  9. ncbi request reprint Profiling of the renal kinome: a novel tool to identify protein kinases involved in angiotensin II-dependent hypertensive renal damage
    Martin H de Borst
    Dept of Pathology, University of Groningen, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Am J Physiol Renal Physiol 293:F428-37. 2007
    ..Array-based profiling of tissue kinase activities in ANG II-mediated renal damage provides a powerful tool for identification of relevant kinase pathways in vivo and may lead to novel strategies for therapy...
  10. pmc The novel gene asb11: a regulator of the size of the neural progenitor compartment
    Sander H Diks
    Department of Cell Biology, University Medical Center Groningen, University of Groningen, NL 9713 AV Groningen, Netherlands
    J Cell Biol 174:581-92. 2006
    ..We conclude that d-Asb11 is a novel regulator of the neuronal progenitor compartment size by maintaining the neural precursors in the proliferating undifferentiated state possibly through the control of SoxB1 transcription factors...
  11. ncbi request reprint Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/beta-catenin pathway activity
    Carina L Bos
    Laboratory of Experimental Oncology and Radiobiology, Department of Oncology, University of Amsterdam, The Netherlands
    Carcinogenesis 27:2371-82. 2006
    ..This study shows, using concentrations of mesalazine identical to concentrations seen in patients with inflammatory bowel disease, that mesalazine inhibits the Wnt/beta-catenin pathway via inhibition of PP2A...
  12. ncbi request reprint Tetrahydroxyquinone induces apoptosis of leukemia cells through diminished survival signaling
    Alexandre D Martins Cavagis
    Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, Campinas, Sao Paulo, Brasil
    Exp Hematol 34:188-96. 2006
    ..Its potential as an anticancer drug has not been investigated...
  13. ncbi request reprint Single cell proteomics for personalised medicine
    Sander H Diks
    Department of Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Trends Mol Med 10:574-7. 2004
    ..Thus, single cell phosphoproteomic techniques might be superior to other proteomic approaches for the molecular diagnosis of disease and instrumental for the development of personalised medicine...
  14. doi request reprint d-Asb11 is an essential mediator of canonical Delta-Notch signalling
    Sander H Diks
    Deptartment of Cell Biology, University Medical Center Groningen, University of Groningen, A Deusinglaan 1, NL 9713 AV Groningen, The Netherlands
    Nat Cell Biol 10:1190-8. 2008
    ..We conclude that d-Asb11 is a component in the regulation of Delta-Notch signalling, important in fine-tuning the lateral inhibition gradients between DeltaA and Notch through a cell non-autonomous mechanism...