D Denys

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint [25 years antipsychotics: back to the future?]
    D Denys
    Afdeling Psychiatrie, Academisch Medisch Centrum Universiteit van Amsterdam, Amsterdam
    Tijdschr Psychiatr 50:105-9. 2008
  2. pmc Obsessionality & compulsivity: a phenomenology of obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Philos Ethics Humanit Med 6:3. 2011
  3. doi request reprint Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Arch Gen Psychiatry 67:1061-8. 2010
  4. pmc How new is the new philosophy of psychiatry?
    Damiaan Denys
    Department of Psychiatry, AMC, University of Amsterdam, PA, 2 179, PO Box 75867, 1070 AW Amsterdam, The Netherlands
    Philos Ethics Humanit Med 2:22. 2007
  5. ncbi request reprint [Deep brain stimulation in psychiatric disorders]
    D Denys
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Psychiatrie, PA 2 179, Postbus 75 867, 1070 AW Amsterdam
    Ned Tijdschr Geneeskd 152:2330-5. 2008
  6. doi request reprint Deep brain stimulation in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, AMC, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Prog Brain Res 175:419-27. 2009
  7. doi request reprint Smoking cessation and weight loss after chronic deep brain stimulation of the nucleus accumbens: therapeutic and research implications: case report
    Mariska Mantione
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurosurgery 66:E218; discussion E218. 2010
  8. ncbi request reprint A double-blind switch study of paroxetine and venlafaxine in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:37-43. 2004
  9. pmc Deep brain stimulation affects conditioned and unconditioned anxiety in different brain areas
    A Van Dijk
    Department of Psychiatry, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Transl Psychiatry 3:e289. 2013
  10. doi request reprint Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients
    Nienke C C Vulink
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 70:1001-8. 2009

Collaborators

Detail Information

Publications34

  1. ncbi request reprint [25 years antipsychotics: back to the future?]
    D Denys
    Afdeling Psychiatrie, Academisch Medisch Centrum Universiteit van Amsterdam, Amsterdam
    Tijdschr Psychiatr 50:105-9. 2008
    ..Although some patients have undoubtedly benefited from these new atypical antipsychotics, the drugs have not lived up to our expectations...
  2. pmc Obsessionality & compulsivity: a phenomenology of obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Philos Ethics Humanit Med 6:3. 2011
    ..TRANSLATION: This article is translated from Dutch, originally published in [Handbook Obsessive-compulsive disorders, Damiaan Denys, Femke de Geus (Eds.), (2007). De Tijdstroom uitgeverij BV, Utrecht. ISBN13: 9789058980878.]...
  3. doi request reprint Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Arch Gen Psychiatry 67:1061-8. 2010
    ..Even when the best available treatments are applied, approximately 10% of patients remain severely afflicted and run a long-term deteriorating course of OCD...
  4. pmc How new is the new philosophy of psychiatry?
    Damiaan Denys
    Department of Psychiatry, AMC, University of Amsterdam, PA, 2 179, PO Box 75867, 1070 AW Amsterdam, The Netherlands
    Philos Ethics Humanit Med 2:22. 2007
    ..As Jaspers said "Everybody inclined to disregard philosophy will be overwhelmed by philosophy in an unperceived way"...
  5. ncbi request reprint [Deep brain stimulation in psychiatric disorders]
    D Denys
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Psychiatrie, PA 2 179, Postbus 75 867, 1070 AW Amsterdam
    Ned Tijdschr Geneeskd 152:2330-5. 2008
    ..The speed of responses following deep brain stimulation is urging psychiatrists to reconsider basic pathophysiological mechanisms of psychiatric disorders...
  6. doi request reprint Deep brain stimulation in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, AMC, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Prog Brain Res 175:419-27. 2009
    ..The speed of the effect of deep brain stimulation causes fundamental assumptions on the pathophysiology of obsessive-compulsive disorder...
  7. doi request reprint Smoking cessation and weight loss after chronic deep brain stimulation of the nucleus accumbens: therapeutic and research implications: case report
    Mariska Mantione
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurosurgery 66:E218; discussion E218. 2010
    ..In this case report, we describe a patient who quit smoking and lost weight without any effort, and we review the underlying mechanisms of action...
  8. ncbi request reprint A double-blind switch study of paroxetine and venlafaxine in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:37-43. 2004
    ..However, no controlled research has been published yet that prospectively examined the effects of changing SRIs. This article describes the first double-blind switch study of 2 SRIs in patients with OCD...
  9. pmc Deep brain stimulation affects conditioned and unconditioned anxiety in different brain areas
    A Van Dijk
    Department of Psychiatry, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Transl Psychiatry 3:e289. 2013
    ..This suggests that the anxiolytic effects of DBS seen in OCD patients may not be induced by stimulation of the NAc, but rather by the IC. ..
  10. doi request reprint Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients
    Nienke C C Vulink
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 70:1001-8. 2009
    ..To assess the efficacy of quetiapine addition to citalopram in treatment-naive or medication-free obsessive-compulsive disorder (OCD) patients...
  11. ncbi request reprint A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:1040-8. 2004
    ..This study was conducted to evaluate the efficacy and tolerability of quetiapine in addition to an SRI for treatment-refractory patients with OCD...
  12. ncbi request reprint A double blind comparison of venlafaxine and paroxetine in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, University Medical Center B 01 206, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Psychopharmacol 23:568-75. 2003
    ..These results show that venlafaxine was equally effective to paroxetine in treating patients with OCD. Venlafaxine may be a useful therapy for obsessive-compulsive patients, but is not superior to SSRIs...
  13. ncbi request reprint A score for predicting response to pharmacotherapy in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Int Clin Psychopharmacol 18:315-22. 2003
    ..63-0.8), demonstrating a reasonable discriminatory power. This study is the first to present a model that can estimate by the use of prediction rules the probability of treatment response to antidepressants in patients with OCD...
  14. ncbi request reprint Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder
    Damiaan Denys
    Department of Psychiatry, UMC, Rudolf Magnus Institute of Neuroscience, B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Psychoneuroendocrinology 31:355-60. 2006
    ..This study was carried out to investigate whether treatment with paroxetine and venlafaxine modifies the immune function in OCD and whether this modification is related to treatment outcome...
  15. ncbi request reprint Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial
    Damiaan Denys
    Department of Psychiatry, The Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 68:747-53. 2007
    ..The purpose of the present study was to determine whether polymorphisms of the serotonin transporter (5-HTT), 5-HT1B, and 5-HT2A receptor genes affect the efficacy of SRI treatment in OCD...
  16. ncbi request reprint Effects of quetiapine on cognitive functioning in obsessive-compulsive disorder
    Femke de Geus
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 22:77-84. 2007
    ..It is proposed that this failure may be caused by attention difficulties owing to somnolence...
  17. ncbi request reprint Quetiapine addition in obsessive-compulsive disorder: is treatment outcome affected by type and dose of serotonin reuptake inhibitors?
    Damiaan Denys
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 61:412-4. 2007
    ..The purpose of this study was to assess the effect of type and dose of serotonin reuptake inhibitors (SRIs) on treatment outcome in quetiapine addition trials for obsessive-compulsive disorder...
  18. ncbi request reprint Perception of facial expressions in obsessive-compulsive disorder: a dimensional approach
    B Montagne
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Psychiatry 23:26-8. 2008
    ..Results showed that the High Risk Assessment and Checking subtype was more sensitive in perceiving the emotions fear and happiness. This suggests that altered affective processing may underlie the clinical manifestation of OCD...
  19. ncbi request reprint The adequacy of pharmacotherapy in outpatients with obsessive-compulsive disorder
    D Denys
    Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    Int Clin Psychopharmacol 17:109-14. 2002
    ..A large proportion of patients with OCD fail to receive adequate treatment. Many patients were prescribed SRIs at doses below those recommended for the guidelines...
  20. ncbi request reprint Quetiapine addition to serotonin reuptake inhibitor treatment in patients with treatment-refractory obsessive-compulsive disorder: an open-label study
    Damiaan Denys
    Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    J Clin Psychiatry 63:700-3. 2002
    ..The objective of this study was to examine whether addition of the atypical antipsychotic quetiapine to SRIs is useful for patients with OCD who do not respond to SRI monotherapy...
  21. ncbi request reprint A case of venlafaxine-induced inhibition of T-lymphocyte proliferation
    Damiaan Denys
    Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    Psychopharmacology (Berl) 164:432. 2002
  22. doi request reprint Lipopolysaccharide-induced cytokine production in obsessive-compulsive disorder and generalized social anxiety disorder
    Sjoerd Fluitman
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychiatry Res 178:313-6. 2010
    ..This supports the idea of immunological involvement in the pathophysiology of OCD and suggests that GSAD and OCD might be different in immunological respect...
  23. ncbi request reprint Emerging skin-picking behaviour after serotonin reuptake inhibitor-treatment in patients with obsessive-compulsive disorder: possible mechanisms and implications for clinical care
    Damiaan Denys
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    J Psychopharmacol 17:127-9. 2003
    ..Two case reports are presented demonstrating that SSRI-treatment may induce or aggravate pathological skin-picking behaviour. Possible mechanisms of SSRI-induced pathological skin-picking and implications for clinical care are discussed...
  24. ncbi request reprint Prevalence of psychotic disorders in patients with obsessive-compulsive disorder
    Lieuwe De Haan
    Department of Psychiatry, Academic Medical Centre, Amsterdam
    CNS Spectr 14:415-7. 2009
    ..However, the rate of psychosis comorbidity in OCD patients has yet to be systematically evaluated...
  25. ncbi request reprint Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 55:1041-5. 2004
    ..Despite growing evidence for involvement of the dopaminergic system in obsessive-compulsive disorder (OCD), the functional anatomy of the dopaminergic system in the basal ganglia has been investigated sparsely...
  26. ncbi request reprint Decreased TNF-alpha and NK activity in obsessive-compulsive disorder
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychoneuroendocrinology 29:945-52. 2004
    ..This study was carried out to investigate whether obsessive-compulsive disorder is associated with altered activity of the immune system, and whether these changes are related to particular clinical characteristics...
  27. ncbi request reprint New pharmacotherapeutic approaches to obsessive-compulsive disorder
    Martijn Figee
    Department of Psychiatry, Academic Medical Centre, University of Amsterdam, The Netherlands
    CNS Spectr 14:13-23. 2009
    ..Lastly, successful treatment with an SSRI results in both serotonergic and dopaminergic changes, but more research is necessary in order to define the biological characteristics of responders and nonresponders...
  28. ncbi request reprint Symptom dimensions in obsessive-compulsive disorder: factor analysis on a clinician-rated scale and a self-report measure
    Damiaan Denys
    Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands
    Psychopathology 37:181-9. 2004
    ..This means that the use of both clinician-administered and self-report measures is recommended, so that the entire spectrum of symptoms is represented...
  29. ncbi request reprint Use of factor analysis to detect potential phenotypes in obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, University Medical Center, HP B 01 206, PO Box 85500, GA Utrecht 3508, The Netherlands
    Psychiatry Res 128:273-80. 2004
    ..We observed significant differences in sex distribution, age of onset, Y-BOCS scores and familial prevalence of OCD in relation to the symptom dimensions. These findings provide further evidence for distinct clinical phenotypes in OCD...
  30. ncbi request reprint The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence
    Damiaan Denys
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychiatry 65:11-7. 2004
    ..In this review, the preclinical and clinical evidence on the role of dopamine in OCD is summarized...
  31. ncbi request reprint Bupropion for patients with obsessive-compulsive disorder: an open-label, fixed-dose study
    Nienke C C Vulink
    Department of Psychiatry, University Medical Center Utrecht, The Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Clin Psychiatry 66:228-30. 2005
    ..In the present study, we examined the efficacy of bupropion for patients with obsessive-compulsive disorder (OCD)...
  32. ncbi request reprint Sexual pleasure in women with obsessive-compulsive disorder?
    Nienke C C Vulink
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht UMCU, B 01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Affect Disord 91:19-25. 2006
    ..This study compared subjective appreciation of sexuality and sexual functioning between OCD patients and healthy subjects and controlled for the influence of medication or OCD subtypes on sexual functioning and satisfaction...
  33. ncbi request reprint Female hormones affect symptom severity in obsessive-compulsive disorder
    Nienke C C Vulink
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Int Clin Psychopharmacol 21:171-5. 2006
    ..Because reproductive cycle events influence the symptom severity of OCD, the menstrual cycle should be taken into account when assessing the severity of OCD symptoms during pharmacological studies...
  34. ncbi request reprint Spatial working memory in obsessive-compulsive disorder improves with clinical response: A functional MRI study
    Nic J A van der Wee
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 X Utrecht, The Netherlands
    Eur Neuropsychopharmacol 17:16-23. 2007
    ..Our preliminary findings suggests that spatial working memory deficits in OCD and their functional anatomical correlates, as assessed with a spatial n-back task, are, at least to some extent, state dependent...