Research Topics
| Martijn D de KruifSummaryAffiliation: Academic Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Prednisolone dose-dependently influences inflammation and coagulation during human endotoxemiaMartijn D de Kruif
Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 178:1845-51. 2007..These data indicate that prednisolone dose-dependently and differentially influences the systemic activation of different host response pathways during human endotoxemia...- Chlamydia pneumoniae infections in mouse models: relevance for atherosclerosis researchMartijn D de Kruif
Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Cardiovasc Res 65:317-27. 2005..pneumoniae unless the therapy was started early during the acute infection. The results summarized here may help to better understand the results of the clinical antibiotic trials... 
Additional value of procalcitonin for diagnosis of infection in patients with fever at the emergency departmentMartijn D de Kruif
Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
Crit Care Med 38:457-63. 2010..Second, to create a simple scoring rule implementing PCT values. Third, to determine and compare associations of CRP and PCT with clinical outcomes...
Differential gene expression changes in children with severe dengue virus infectionsMartijn D de Kruif
Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
PLoS Negl Trop Dis 2:e215. 2008..This study aimed to define differential immune responses in association with clinical outcomes by gene expression profiling of a selected panel of inflammatory genes in whole blood samples from children with severe dengue infections...- PTX3 predicts severe disease in febrile patients at the emergency departmentMartijn D de Kruif
Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
J Infect 60:122-7. 2010..In order to identify patients warranting critical care as quickly as possible, we investigated the value of PTX3 as a biomarker for disease severity in patients presenting with fever at the emergency department... - The influence of corticosteroids on the release of novel biomarkers in human endotoxemiaMartijn D de Kruif
Center for Experimental and Molecular Medicine, Room G2 132, Academic Medical Center, Meibergdreef 9, 1105 Amsterdam, AZ, The Netherlands
Intensive Care Med 34:518-22. 2008..However, it is not known whether these biomarkers are influenced by sepsis intervention strategies. Therefore we investigated the markers in a model of human endotoxemia intervened by increasing doses of prednisolone... - Effects of prednisolone on the systemic release of mediators of cell-mediated cytotoxicity during human endotoxemiaMartijn D de Kruif
Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
Shock 29:458-61. 2008..This study demonstrates that prednisolone differentially inhibits the systemic release of mediators involved in cell-mediated cytotoxicity in humans in vivo... - Differential dose-dependent effects of prednisolone on shedding of endothelial adhesion molecules during human endotoxemiaLucienne C Lemaire
Center for Experimental and Molecular Medicine, Academic Medical Center, Room G2 132, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Immunol Lett 121:93-6. 2008..Levels of sICAM-1 were not affected by prednisolone. Together, the data suggest that prednisolone differentially and dose-dependently influences the release of soluble endothelial adhesion molecules during human endotoxemia... - Dobutamine does not influence inflammatory pathways during human endotoxemiaLucienne C Lemaire
Department of Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Crit Care Med 34:1365-71. 2006..None of these responses were influenced by dobutamine. CONCLUSIONS: Dobutamine, infused in a clinically relevant dose, does not influence inflammatory and coagulant pathways during human endotoxemia... - Long pentraxin PTX3 is associated with mortality and disease severity in severe LeptospirosisJiri F P Wagenaar
Slotervaart Hospital, Department of Internal Medicine 9B, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
J Infect 58:425-32. 2009..To evaluate the long pentraxin PTX3 in patients with severe leptospirosis and to compare the results with the widely used short pentraxin C-reactive protein and the pro-inflammatory cytokines IL-6 and IL-8... - In vivo lipopolysaccharide exposure of human blood leukocytes induces cross-tolerance to multiple TLR ligandsAlex F de Vos
Center of Infection and Immunity Amsterdam and Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
J Immunol 183:533-42. 2009.... - Infections and endothelial cellsTymen T Keller
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Cardiovasc Res 60:40-8. 2003..Rather than being a unidirectional relationship, the interaction between inflammation and coagulation appears to be significant. In the crosstalk, the endothelium is playing a pivotal role... - Effects on coagulation and fibrinolysis induced by influenza in mice with a reduced capacity to generate activated protein C and a deficiency in plasminogen activator inhibitor type 1Tymen T Keller
Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
Circ Res 99:1261-9. 2006..These findings suggest that influenza leads to a prothrombotic state by coagulation activation. Heparin treatment reduces the influenza induced prothrombotic state... - Elevated plasma levels of the long pentraxin, pentraxin 3, in severe dengue virus infectionsAlbert T A Mairuhu
Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
J Med Virol 76:547-52. 2005..The role of pentraxin 3 in the pathogenesis of dengue and its potential as an early prognostic indicator of disease severity needs further assessment... - The hemostatic balance in HIV-infected patients with and without antiretroviral therapy: partial restoration with antiretroviral therapyEefje Jong
Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
AIDS Patient Care STDS 23:1001-7. 2009.... - Prescription of physical activity is not sufficient to change sedentary behavior and improve glycemic control in type 2 diabetes patientsWilleke Wisse
Department of Internal Medicine, Slotervaarthospital, Amsterdam, The Netherlands
Diabetes Res Clin Pract 88:e10-3. 2010..To assess the impact of personalized exercise prescription on habitual physical activity and glycemic control in sedentary, insulin treated type 2 diabetes patients during a 2-y intervention period... - Plasma levels of pentraxin-3, an acute phase protein, are increased during sickle cell painful crisisErfan Nur
Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
Blood Cells Mol Dis 46:189-94. 2011..The increase of PTX3 levels during painful crisis and their relation to the duration of subsequent hospital stay suggest that PTX3 might serve both as a diagnostic and severity marker of the painful sickle cell crisis... - Streptococcal lung abscesses from a dental focus following tocilizumab: a case reportMartijn D de Kruif
Department of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands
Clin Exp Rheumatol 30:951-3. 2012..Tocilizumab is a novel therapeutic agent targeting interleukin-6. We describe a case of streptococcal lung abscesses from a dental focus after use of tocilizumab for treatment of Takayasu arteritis...