L de Haan

..The third case, an 18-year-old male, illustrates that specialized investigation into high-risk symptoms of psychosis are sometimes needed to reveal frank psychotic symptoms...

..To determine the course of obsessive-compulsive symptoms (OCS) and obsessive-compulsive disorder (OCD) in first-episode schizophrenia and related disorders and their relationship with clinical characteristics...

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..DIPT may be a more important predictor of negative symptoms at outcome than is delay in starting antipsychotic medication alone...

..Given the reluctance of patients to accept treatment, these problems further complicate the initiating of treatment. Mothers emphasize that a more active approach by professional caregivers could reduce treatment delay...

..This paper gives an overview of studies on the association between dopaminergic neurotransmission and the subjective experience of patients with schizophrenia...

..Doses of antipsychotic drugs administered to such individuals often need to be lower than the commonly used levels, as these may induce drowsiness and lack of energy...

..To study the relation between obsessive-compulsive symptoms (OCS) and positive, negative, and depressive symptoms in patients with recent-onset schizophrenic disorders...

..It has been suggested that a low availability of these receptors may increase the risk for addictive behavior...

..The aim of this prospective study was to compare the predictive validity of early improvement of subjective experience and early improvement of rater assessed symptoms on enduring symptomatic remission (ESR) status during 5 years follow...

..However, the rate of psychosis comorbidity in OCD patients has yet to be systematically evaluated...

..Some awareness of mental disorder at onset was related to a shorter duration of untreated psychosis (DUP). Delaying treatment until patients themselves become aware of the need for treatment may enlarge DUP...

..In addition, they sought preliminary evidence on whether subjective experience is better with low-dose olanzapine than with low-dose haloperidol...

..The agreement of these findings with findings from earlier studies underlines the importance of suggesting specific changes in the delivery of care...

..The Y-BOCS showed good internal consistency and interrater reliability in this population; however, findings concerning the divergent validity against depressive and negative symptoms are inconsistent...

..Subjective experience of antipsychotic drugs is relevant for medication compliance and quality of life. There is, however, sparse knowledge about the assessment of subjective experience...

..To determine whether severity of obsessive-compulsive symptoms (OCS) differs during treatment with olanzapine or risperidone and to establish whether duration of antipsychotic treatment is related to severity of OCS...

..The goal of this study is to assess, prospectively, the relative contribution of baseline variables to long-term medication adherence in patients with a first episode of schizophrenia...

..The areas of cognitive functioning assessed include verbal memory and learning, visuospatial working memory, executive function, sustained attention and motor speed...

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..The authors' goal was to study the relationship between subjective experience during treatment with olanzapine or risperidone and dopamine D(2) receptor occupancy in stabilized patients with schizophrenia...

..Hence, we investigated a prospective cohort of UHR subjects comparing whole brain fractional anisotropy (FA) of those later developing psychosis (UHR-P) to those who did not (UHR-NP)...

..However, the disturbed relationship between D₂R BP(ND) and pPRL values suggests DAergic dysfunction at a different level. Further studies on DAergic function in extra-striatal brain regions and under challenged conditions are needed...

..The aim of the present study was to examine whether this association is confounded by gender or other substance use in a large cohort of patients with a non-affective psychotic disorder...

..The present study is the first known to compare implicit and explicit cannabis associations in individuals with and without psychotic disorder...

..To investigate the predictive value of the Strauss and Carpenter Prognostic Scale (SCPS) for transition to a first psychotic episode in subjects clinically at high risk (CHR) of psychosis...

..Neurocognitive abnormalities are prevalent in both first episode schizophrenia patients and in ultra high risk (UHR) patients...

..However, we found important differences between groups of respondents. The results suggest that in psychiatric services great attention should be given to psycho-education and early outpatient intervention...

..The study focused on investigating the relationship between cannabis use and early and high-risk symptoms in subjects at clinical high risk for psychosis...

..The saccadic rate was related to positive UHR symptoms. Our findings indicate that abnormalities in SPEM are already present in UHR patients, prior to a first psychotic episode. These abnormalities occur only in the saccadic system...

..The investigation into the course of ultra high risk (UHR) symptomatology of those patients who eventually do not meet the psychosis-threshold criteria within the 3-year timeframe of the study...

..CONCLUSIONS: Family intervention has helped parents to support their children, thereby diminishing institutional care...

..The presence of 22q11DS represents one of the highest risk factors for the development of schizophrenia. The study of 22q11DS offers a unique opportunity to increase the understanding of the pathogenesis of schizophrenia...

..This review seeks to determine the interventions that were examined in the past decade to improve adherence rates...

..Here, we investigated the effect of COMT Val158Met polymorphism on brain anatomy and cognition in adults with VCFS...

..Identifying reasons for cannabis use and subjective effects in patients with psychotic disorders can provide insight into the functions of cannabis use, and this may lead to targeted interventions...

..503, P=0.048). Unsaturated fatty acids may be necessary for the myelinating activity of oligodendrocytes or for myelin maintenance. These results warrant further investigation...

..Although some patients have undoubtedly benefited from these new atypical antipsychotics, the drugs have not lived up to our expectations...

..The reference lists of included papers were searched to identify other eligible papers. A meta-analysis was performed on a subgroup of studies...

..In order to find the most effective interventions to reduce DUP, it is important to know what factors in these pathways to care contribute to DUP...

..If there is no intervention, severe hepatic damage can develop within three days. Even after a few days have passed it is still advisable to start treating the patient with acetylcysteine...

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..An important question that arises in policy discussions concerning the use of cannabis is whether the possible harmful effects of cannabis are reversible...

..aim To discuss neurobiological and psychosocial developmental factors in adolescence and early adulthood which may contribute to this co-occurrence...

..These complications fall into various categories: metabolic, cardiovascular, neurobiological, haematological, gastro-intestinal and urogenital...