Esther C de Jong

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development
    Hermelijn H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, and Department of Molecular Cell Biology, Free University Medical Center, Amsterdam, The Netherlands
    J Immunol 168:1710-6. 2002
  2. doi request reprint CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation
    Jelle de Wit
    Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 118:6107-14. 2011
  3. ncbi request reprint Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals
    Esther C de Jong
    Department of Cell Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 168:1704-9. 2002
  4. ncbi request reprint Dendritic cell-mediated T cell polarization
    Esther C de Jong
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ, Amsterdam, The Netherlands
    Springer Semin Immunopathol 26:289-307. 2005
  5. pmc Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission
    Fedde Groot
    Dept, of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 3:52. 2006
  6. ncbi request reprint Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
    Hermelijn H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Allergy Clin Immunol 115:1260-7. 2005
  7. ncbi request reprint Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation
    Sander W Tas
    Division of Clinical Immunology and Rheumatology, Academic Medical Center AMC University of Amsterdam, Amsterdam, The Netherlands
    Blood 110:1540-9. 2007
  8. ncbi request reprint Dichotomy between Lactobacillus rhamnosus and Klebsiella pneumoniae on dendritic cell phenotype and function
    Henri Braat
    Academic Medical Center, Department of Experimental Internal Medicine, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    J Mol Med (Berl) 82:197-205. 2004
  9. ncbi request reprint Monocyte-derived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profile
    Huub C Gelderblom
    Department of Gastroenterology and Hepatology, AMC Liver Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Liver Int 27:944-53. 2007
  10. ncbi request reprint Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition
    Fedde Groot
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Blood 108:1957-64. 2006

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development
    Hermelijn H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, and Department of Molecular Cell Biology, Free University Medical Center, Amsterdam, The Netherlands
    J Immunol 168:1710-6. 2002
    ..This mechanism may be operational during viral infections...
  2. doi request reprint CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation
    Jelle de Wit
    Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 118:6107-14. 2011
    ..The present data favor the novel concept that alternative costimulation via CD5, rather than classic costimulation via CD28, primes naive T cells for stable Th17 development through promoting the expression of IL-23R...
  3. ncbi request reprint Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals
    Esther C de Jong
    Department of Cell Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 168:1704-9. 2002
    ..The data suggest that the molecular basis of Th1/Th2 polarization via DCs is unexpectedly diverse and is adapted to the nature of the microbial compounds...
  4. ncbi request reprint Dendritic cell-mediated T cell polarization
    Esther C de Jong
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ, Amsterdam, The Netherlands
    Springer Semin Immunopathol 26:289-307. 2005
    ..This review discusses the way DC adapt the T cell response to the type of pathogen, focusing on the tools that DC use in this management of the T cell response...
  5. pmc Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission
    Fedde Groot
    Dept, of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 3:52. 2006
    ..The TEM cell subset, which can be further divided into effector Th1 and Th2 cells, has been shown to be the prime target for viral replication after HIV-1 infection, and is abundantly present in mucosal tissues...
  6. ncbi request reprint Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
    Hermelijn H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Allergy Clin Immunol 115:1260-7. 2005
    ..On the basis of pathogenic or tissue-specific priming, dendritic cells (DC) acquire different T cell-instructive signals and drive the differentiation of naive T H cells into either T H 1, T H 2, or regulatory effector T cells...
  7. ncbi request reprint Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation
    Sander W Tas
    Division of Clinical Immunology and Rheumatology, Academic Medical Center AMC University of Amsterdam, Amsterdam, The Netherlands
    Blood 110:1540-9. 2007
    ..These findings reveal an important role of the noncanonical NF-kappaB pathway in the regulation of immunity...
  8. ncbi request reprint Dichotomy between Lactobacillus rhamnosus and Klebsiella pneumoniae on dendritic cell phenotype and function
    Henri Braat
    Academic Medical Center, Department of Experimental Internal Medicine, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    J Mol Med (Berl) 82:197-205. 2004
    ..Thus our results strongly support the concept that differential modulation of DC explains the differences in the immune response to various bacterial strains and indicates that K. pneumoniae induces Th1 immune responses via DC...
  9. ncbi request reprint Monocyte-derived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profile
    Huub C Gelderblom
    Department of Gastroenterology and Hepatology, AMC Liver Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Liver Int 27:944-53. 2007
    ..Therefore, we studied the presence of HCV RNA in monocytes and monocyte-derived DCs from chronic HCV patients...
  10. ncbi request reprint Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition
    Fedde Groot
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Blood 108:1957-64. 2006
    ..This study shows that the 2 main types of DCs have opposing roles in HIV-1 infection of T cells...
  11. ncbi request reprint Double-stranded RNA-exposed human keratinocytes promote Th1 responses by inducing a Type-1 polarized phenotype in dendritic cells: role of keratinocyte-derived tumor necrosis factor alpha, type I interferons, and interleukin-18
    M Cristina Lebre
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Invest Dermatol 120:990-7. 2003
    ....
  12. pmc Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN--gp120 interaction
    Fedde Groot
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Virol 79:3009-15. 2005
    ..DC-mediated capture of a bLF-resistant HIV-1 variant that was selected during long-term culturing in T cells could still be blocked by bLF. This underscores the usefulness of bLF as a microbicide drug to prevent HIV-1 transmission...
  13. doi request reprint Cutting edge: virus selectively primes human langerhans cells for CD70 expression promoting CD8+ T cell responses
    Angelic M G van der Aar
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Immunol 187:3488-92. 2011
    ..Whereas LCs ignore bacteria, they are superior to DDCs to initiate effective CD70-mediated CD8(+) T cells in response to virus stimulation...
  14. ncbi request reprint Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells
    Astrid J van Beelen
    Department of Cell Biology and Histology, Academic Medical Centre of the University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Immunity 27:660-9. 2007
    ..Thus, antibacterial Th17-mediated immunity in humans is orchestrated by DCs upon sensing bacterial NOD2-ligand MDP...
  15. doi request reprint Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells
    Angelic M G van der Aar
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Invest Dermatol 133:1240-9. 2013
    ..In conclusion, LCs form a unique DC subset that is adapted at multiple levels for the maintenance of tolerance to bacterial skin flora...
  16. doi request reprint Viral dsRNA-activated human dendritic cells produce IL-27, which selectively promotes cytotoxicity in naive CD8+ T cells
    Rosa De Groot
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Leukoc Biol 92:605-10. 2012
    ..These data support the concept that viral dsRNA-activated human DCs produce IL-27 to act as a specialized procytotoxic, antiviral cytokine in the development of effector CD8(+) T cells...
  17. doi request reprint IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and FcγRIIa in human dendritic cells
    Jeroen den Dunnen
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 120:112-21. 2012
    ..Taken together, these data identified cross-talk between TLRs and FcγRIIa as a novel mechanism by which DCs promote protective effector Th17-cell responses against bacteria...
  18. ncbi request reprint Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9
    Maria C Lebre
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Invest Dermatol 127:331-41. 2007
    ..Altogether, these findings stress an unexpectedly multifaceted role of keratinocytes in innate immunity as evident by their differential, TLR-mediated responses to PAMPs associated with different classes of pathogens...
  19. doi request reprint Aberrant function of peripheral blood myeloid and plasmacytoid dendritic cells in atopic dermatitis patients
    M Cristina Lebre
    Department of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Allergy Clin Immunol 122:969-976.e5. 2008
    ..Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by an initial phase predominated by T(H)2 cytokines that switches into a second, more chronic T(H)1-dominated eczematous phase...
  20. pmc Differential transmission of human immunodeficiency virus type 1 by distinct subsets of effector dendritic cells
    Rogier W Sanders
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Virol 76:7812-21. 2002
    ..The ICAM-1-LFA-1 interaction is known to be important for immunological cross talk between DC and T cells, and our results indicate that this cell-cell contact is exploited by HIV-1 for efficient transmission...
  21. pmc Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1
    Fedde Groot
    Department of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 3:75. 2006
    ..To corroborate the importance of the ICAM-1- LFA-1 interaction, we performed transmission experiments to LFA-1 negative leukocytes from Leukocyte Adhesion Deficiency type 1 (LAD-1) patients...
  22. ncbi request reprint Muramyl dipeptide-induced differential gene expression in NOD2 mutant and wild-type Crohn's disease patient-derived dendritic cells
    Zuzana Zelinkova
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Inflamm Bowel Dis 14:186-94. 2008
    ..To study the mechanism of CD resulting from NOD2 mutations, we analyzed NOD2-dependent whole-genome expression profiles of patient-derived antigen-presenting cells...
  23. ncbi request reprint Differential expression of inflammatory chemokines by Th1- and Th2-cell promoting dendritic cells: a role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation
    M Cristina Lebre
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Immunol Cell Biol 83:525-35. 2005
    ....
  24. doi request reprint Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cells
    Angelic M G van der Aar
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Allergy Clin Immunol 127:1532-40.e7. 2011
    ..A proposed mechanism of VitD3-mediated suppression is priming of dendritic cells (DCs) to induce regulatory T (Treg) cells...
  25. ncbi request reprint Generation of regulatory gut-homing human T lymphocytes using ex vivo interleukin 10 gene transfer
    Catherine Van Montfrans
    Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 123:1877-88. 2002
    ..Ex vivo gene transfer of the interleukin (IL)-10 gene to gut-homing CD4(+) cells may lead to improved long-term management...
  26. ncbi request reprint Different faces of regulatory DCs in homeostasis and immunity
    Hermelijn H Smits
    Departments of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ Amsterdam, The Netherlands
    Trends Immunol 26:123-9. 2005
  27. doi request reprint Intradermally administered TLR4 agonist GLA-SE enhances the capacity of human skin DCs to activate T cells and promotes emigration of Langerhans cells
    Laura P Schneider
    Department of Dermatology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Vaccine 30:4216-24. 2012
    ..Altogether, our data show that GLA-SE has a notable potency to stimulate the function of skin DCs, indicating that GLA-SE may be a good candidate as adjuvant for vaccines administered via the intradermal route...
  28. ncbi request reprint The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells
    Mark J Kwakkenbos
    Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Leukoc Biol 71:854-62. 2002
    ..Different expression patterns and the inability of EMR2 to interact with the CD97 ligand CD55 indicate that the molecular twins EMR2 and CD97 likely have nonredundant functions...
  29. ncbi request reprint Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence
    Jörg Hamann
    Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 33:1365-71. 2003
    ..Thus, EMR4 surprisingly accounts for a genetic difference between humans and primates related to immunity...
  30. ncbi request reprint Interleukin-17 in inflammatory skin disorders
    Astrid J van Beelen
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Curr Opin Allergy Clin Immunol 7:374-81. 2007
    ..The question is addressed as to what extent inflammatory skin diseases are associated with the actions of this newly discovered Th17 cell subset...
  31. pmc Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2
    Sonja I Gringhuis
    Center of Infection and Immunity Amsterdam and Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS Pathog 7:e1001259. 2011
    ..Thus, dectin-1 and dectin-2 control adaptive T(H)-17 immunity to fungi via Malt1-dependent activation of c-Rel...
  32. ncbi request reprint Selective inhibition of NF-kappaB in dendritic cells by the NEMO-binding domain peptide blocks maturation and prevents T cell proliferation and polarization
    Sander W Tas
    Division of Clinical Immunology and Rheumatology, AMC University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 35:1164-74. 2005
    ..Also, these data indicate that the NBD peptide could be used as an elegant tool in DC based immunotherapy for unwanted cellular immune responses...
  33. doi request reprint IL-17 and IL-22 in atopic allergic disease
    Yuri Souwer
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    Curr Opin Immunol 22:821-6. 2010
    ....