Diederik van de Beek

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Validation of a Dutch risk score predicting poor outcome in adults with bacterial meningitis in Vietnam and Malawi
    Ewout S Schut
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 7:e34311. 2012
  2. pmc Genetic variation and cerebrospinal fluid levels of mannose binding lectin in pneumococcal meningitis patients
    Matthijs C Brouwer
    Department of Neurology, Academic Medical Center, Center of Infection and Immunity Amsterdam CINIMA, Amsterdam, The Netherlands
    PLoS ONE 8:e65151. 2013
  3. pmc Community-acquired bacterial meningitis in alcoholic patients
    Martijn Weisfelt
    Department of Neurology, Kennemer Gasthuis, Haarlem, The Netherlands
    PLoS ONE 5:e9102. 2010
  4. pmc Genetic variation in the β2-adrenocepter gene is associated with susceptibility to bacterial meningitis in adults
    Kirsten S Adriani
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e37618. 2012
  5. pmc Intracerebral hemorrhages in adults with community associated bacterial meningitis in adults: should we reconsider anticoagulant therapy?
    Barry B Mook-Kanamori
    Department of Neurology, Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e45271. 2012
  6. pmc Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis
    Madelijn Geldhoff
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    BMC Infect Dis 13:358. 2013
  7. doi request reprint Endocarditis in adults with bacterial meningitis
    Marjolein J Lucas
    Academic Medical Center, Center of Infection and Immunity Amsterdam, Department of Neurology
    Circulation 127:2056-62. 2013
  8. doi request reprint Stroke: long-term effect of infections after stroke
    Diederik van de Beek
    Department of Neurology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Nat Rev Neurol 9:126-7. 2013
  9. doi request reprint Advances in treatment of bacterial meningitis
    Diederik van de Beek
    Department of Neurology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    Lancet 380:1693-702. 2012
  10. pmc Characterization of a pneumococcal meningitis mouse model
    Barry Mook-Kanamori
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    BMC Infect Dis 12:71. 2012

Collaborators

Detail Information

Publications37

  1. pmc Validation of a Dutch risk score predicting poor outcome in adults with bacterial meningitis in Vietnam and Malawi
    Ewout S Schut
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 7:e34311. 2012
    ..70) or in the Malawian cohort (c = 0.68). Our validation study shows that new prognostic models have to be developed for these countries in a sufficiently large series of unselected patients...
  2. pmc Genetic variation and cerebrospinal fluid levels of mannose binding lectin in pneumococcal meningitis patients
    Matthijs C Brouwer
    Department of Neurology, Academic Medical Center, Center of Infection and Immunity Amsterdam CINIMA, Amsterdam, The Netherlands
    PLoS ONE 8:e65151. 2013
    ..33, 99% CI 1.39-3.90). We conclude that MBL2 polymorphisms influence CSF MBL levels and substantially increase the risk of pneumococcal meningitis...
  3. pmc Community-acquired bacterial meningitis in alcoholic patients
    Martijn Weisfelt
    Department of Neurology, Kennemer Gasthuis, Haarlem, The Netherlands
    PLoS ONE 5:e9102. 2010
    ..In the present study we described characteristics in alcoholic patients with bacterial meningitis and delineate the differences with findings in non-alcoholic adults with bacterial meningitis...
  4. pmc Genetic variation in the β2-adrenocepter gene is associated with susceptibility to bacterial meningitis in adults
    Kirsten S Adriani
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e37618. 2012
    ....
  5. pmc Intracerebral hemorrhages in adults with community associated bacterial meningitis in adults: should we reconsider anticoagulant therapy?
    Barry B Mook-Kanamori
    Department of Neurology, Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e45271. 2012
    ..To study the incidence, clinical presentation and outcome of intracranial hemorrhagic complications in adult patients with community associated bacterial meningitis...
  6. pmc Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis
    Madelijn Geldhoff
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    BMC Infect Dis 13:358. 2013
    ..In a murine model of pneumococcal meningitis we examined the pathophysiological roles of two inflammasome proteins, NLRP3 (Nod-like receptor protein-3) and adaptor protein ASC (apoptosis-associated speck-like protein)...
  7. doi request reprint Endocarditis in adults with bacterial meningitis
    Marjolein J Lucas
    Academic Medical Center, Center of Infection and Immunity Amsterdam, Department of Neurology
    Circulation 127:2056-62. 2013
    ..Endocarditis may precede or complicate bacterial meningitis, but the incidence and impact of endocarditis in bacterial meningitis are unknown...
  8. doi request reprint Stroke: long-term effect of infections after stroke
    Diederik van de Beek
    Department of Neurology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Nat Rev Neurol 9:126-7. 2013
    ..Studies are needed to assess treatment strategies to prevent early infection in patients with acute stroke...
  9. doi request reprint Advances in treatment of bacterial meningitis
    Diederik van de Beek
    Department of Neurology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    Lancet 380:1693-702. 2012
    ..We review this challenge, with a focus on strategies to optimise antibiotic efficacy in view of increasingly drug-resistant bacteria, and discuss the role of current and future adjunctive therapies...
  10. pmc Characterization of a pneumococcal meningitis mouse model
    Barry Mook-Kanamori
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    BMC Infect Dis 12:71. 2012
    ..S. pneumoniae is the most common causative agent of meningitis, and is associated with high morbidity and mortality. We aimed to develop an integrated and representative pneumococcal meningitis mouse model resembling the human situation...
  11. pmc Perfusion CT to evaluate the effect of transluminal angioplasty on cerebral perfusion in the treatment of vasospasm after subarachnoid hemorrhage
    Charles B L M Majoie
    Department of Radiology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Neurocrit Care 6:40-4. 2007
    ..We present the use of perfusion computed tomography (PTC) to evaluate the effect of transluminal percutaneous angioplasty in a with SAH and vasospasm-induced ischemia...
  12. pmc Macrophage migration inhibitory factor, infection, the brain, and corticosteroids
    Madelijn Geldhoff
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100DD Amsterdam, The Netherlands
    Crit Care 13:170. 2009
    ..Here, we discuss the role of MIF in infection, the brain, and corticosteroids and conclude that experimental meningitis studies have to determine whether MIF is a potential target for adjunctive therapy in pneumococcal meningitis...
  13. pmc Post-stroke infection: a systematic review and meta-analysis
    Willeke F Westendorp
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    BMC Neurol 11:110. 2011
    ..We performed a systematic review and meta-analysis to estimate the pooled post-stroke infection rate and its effect on outcome...
  14. pmc Attenuated cerebrospinal fluid leukocyte count and sepsis in adults with pneumococcal meningitis: a prospective cohort study
    Martijn Weisfelt
    Department of Neurology, Centre of Infection and Immunity Amsterdam CINIMA, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    BMC Infect Dis 6:149. 2006
    ..Whereas a low CSF WBC indicates the presence of sepsis with early meningitis in patients with meningococcal infections, the relation between CSF WBC and outcome in patients with pneumococcal meningitis is not understood...
  15. pmc Hyperglycemia in bacterial meningitis: a prospective cohort study
    Ewout S Schut
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    BMC Infect Dis 9:57. 2009
    ..Hyperglycemia has been associated with unfavorable outcome in several disorders, but few data are available in bacterial meningitis. We assessed the incidence and significance of hyperglycemia in adults with bacterial meningitis...
  16. pmc Arthritis in adults with community-acquired bacterial meningitis: a prospective cohort study
    Martijn Weisfelt
    Department of Neurology, Centre of Infection and Immunity Amsterdam CINIMA, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    BMC Infect Dis 6:64. 2006
    ..Although the coexistence of bacterial meningitis and arthritis has been noted in several studies, it remains unclear how often both conditions occur simultaneously...
  17. doi request reprint Preventive antibiotics for infections in acute stroke: a systematic review and meta-analysis
    Diederik van de Beek
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    Arch Neurol 66:1076-81. 2009
    ..To provide a systematic overview and meta-analysis of randomized clinical trials evaluating preventive antibiotics in patients with acute stroke...
  18. doi request reprint Corticosteroids for acute adult bacterial meningitis
    D van de Beek
    Department of Neurology, Centre of Infection and Immunity of Amsterdam CINIMA, Academic Medical Centre, University of Amsterdam, P O Box 22700, 1100 Amsterdam, The Netherlands
    Med Mal Infect 39:531-8. 2009
    ..Since prompt use of dexamethasone and appropriate antibiotics improves the prognosis of adults with bacterial meningitis, hospitals will need protocols to include dexamethasone with the initial antibiotic therapy...
  19. doi request reprint Vertebral osteomyelitis complicating pneumococcal meningitis
    M C Brouwer
    Academic Medical Center Department of Neurology, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Neurology 71:612-3. 2008
  20. doi request reprint Streptococcus suis meningitis in the Netherlands
    Diederik van de Beek
    Department of Neurology, Centre of Infection and Immunity Amsterdam CINIMA, Academic Medical Centre, University of Amsterdam, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    J Infect 57:158-61. 2008
    ..Outcome was characterized by severe hearing loss. Physicians should be aware of occupational exposure with S. suis and risk of meningitis associated with this pathogen...
  21. ncbi request reprint Clinical features and prognostic factors in adults with bacterial meningitis
    Diederik van de Beek
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    N Engl J Med 351:1849-59. 2004
    ..We conducted a nationwide study in the Netherlands to determine clinical features and prognostic factors in adults with community-acquired acute bacterial meningitis...
  22. ncbi request reprint Community-acquired bacterial meningitis in adults
    Diederik van de Beek
    Department of Neurology, Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    N Engl J Med 354:44-53. 2006
  23. ncbi request reprint Cognitive impairment in adults with good recovery after bacterial meningitis
    Diederik van de Beek
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    J Infect Dis 186:1047-52. 2002
    ..46 to -0.38). In conclusion, adults surviving pneumococcal meningitis were at significant risk of neuropsychological abnormalities, even if they were clinically well recovered...
  24. ncbi request reprint Drug Insight: adjunctive therapies in adults with bacterial meningitis
    Diederik van de Beek
    Academic Medical Center, Center of Infection and Immunity Amsterdam, University of Amsterdam, The Netherlands
    Nat Clin Pract Neurol 2:504-16. 2006
    ..This review briefly summarizes the pathogenesis and pathophysiology of bacterial meningitis, and focuses on the evidence for and against use of the available adjunctive therapies in clinical practice...
  25. ncbi request reprint Group a streptococcal meningitis in adults: report of 41 cases and a review of the literature
    Diederik van de Beek
    Department of Neurology, Academic Medical Center, and The Netherlands Reference Laboratory for Bacterial Meningitis, Amsterdam, The Netherlands
    Clin Infect Dis 34:e32-6. 2002
    ....
  26. ncbi request reprint Steroids in adults with acute bacterial meningitis: a systematic review
    Diederik van de Beek
    Department of Neurology, Academic Medical Centre, University of Amsterdam, Netherlands
    Lancet Infect Dis 4:139-43. 2004
    ....
  27. ncbi request reprint Antibiotic guidelines and antibiotic use in adult bacterial meningitis in The Netherlands
    Diederik van de Beek
    Department of Neurology, Academic Medical Centre, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    J Antimicrob Chemother 49:661-6. 2002
    ..The microbiological coverage for the patients who were treated in compliance with the guidelines was almost complete (98%)...
  28. doi request reprint Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis
    M C Brouwer
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    Neurology 75:1533-9. 2010
    ..In this nationwide prospective cohort study, we evaluated the implementation of adjunctive dexamethasone therapy in Dutch adults with pneumococcal meningitis...
  29. ncbi request reprint Hyponatraemia in adults with community-acquired bacterial meningitis
    M C Brouwer
    Department of Neurology, The Netherlands Reference Laboratory for Bacterial Meningitis, Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    QJM 100:37-40. 2007
    ..Hyponatraemia in adults with bacterial meningitis has been described as a common complication, but its true prevalence and clinical importance are unknown...
  30. ncbi request reprint Community-acquired Haemophilus influenzae meningitis in adults
    M C Brouwer
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Microbiol Infect 13:439-42. 2007
    ..It was concluded that H. influenzae meningitis in adults is a disease with a rather benign clinical course and a relatively good prognosis compared with pneumococcal meningitis...
  31. doi request reprint Seizures in adults with bacterial meningitis
    E Zoons
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Neurology 70:2109-15. 2008
    ..To evaluate the occurrence and prognostic relevance of seizures in adults with community-acquired bacterial meningitis...
  32. ncbi request reprint Nosocomial bacterial meningitis in adults: a prospective series of 50 cases
    M Weisfelt
    Center of Infection and Immunity Amsterdam, Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    J Hosp Infect 66:71-8. 2007
    ..Underlying conditions, especially a history of neurosurgery or a distant focus of infection, were present in the large majority of patients, and mortality and morbidity rates were high...
  33. ncbi request reprint Dexamethasone treatment in adults with pneumococcal meningitis: risk factors for death
    M Weisfelt
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Centre, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    Eur J Clin Microbiol Infect Dis 25:73-8. 2006
    ..Treatment with adjunctive dexamethasone in adults with pneumococcal meningitis reduces both systemic and neurological complications...
  34. doi request reprint Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis
    E S Schut
    Department of Neurology, Center of Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Neurology 73:1988-95. 2009
    ..To report an unusual clinical course in 6 patients with community-acquired acute bacterial meningitis and to compare clinical features with cases reported in the literature...
  35. pmc Development of antibodies against tetravalent meningococcal polysaccharides in revaccinated complement-deficient patients
    M Drogari-Apiranthitou
    Department of Medical Microbiology, University of Amsterdam, The Netherlands
    Clin Exp Immunol 119:311-6. 2000
    ..Whether revaccination should be required within a period shorter than 7 years is discussed, since two vaccinees developed meningococcal disease to vaccine serogroup Y...
  36. ncbi request reprint A systematic review of Helicobacter pylori eradication therapy--the impact of antimicrobial resistance on eradication rates
    M H Houben
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 13:1047-55. 1999
    ....
  37. pmc Pathogenesis and pathophysiology of pneumococcal meningitis
    Barry B Mook-Kanamori
    Department of Neurology, Center of Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, The Netherlands
    Clin Microbiol Rev 24:557-91. 2011
    ..This review discusses the most recent views on the pathophysiology of pneumococcal meningitis, as well as potential targets for (adjunctive) therapy...