S M Boekholdt

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Validation of a model to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the rotterdam ischemic heart disease and stroke computer simulation (RISC) model
    Bob J H van Kempen
    Department of Epidemiology, Erasmus MC Rotterdam, Dr Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands
    BMC Med 10:158. 2012
  2. ncbi request reprint Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels
    S M Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Genet 69:263-70. 2006
  3. ncbi request reprint Initial thyroid status and cardiovascular risk factors: the EPIC-Norfolk prospective population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 72:404-10. 2010
  4. ncbi request reprint Plasma concentrations of ascorbic acid and C-reactive protein, and risk of future coronary artery disease, in apparently healthy men and women: the EPIC-Norfolk prospective population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Br J Nutr 96:516-22. 2006
  5. ncbi request reprint Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 22:e24-7. 2002
  6. ncbi request reprint Physical activity, C-reactive protein levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands
    Eur J Cardiovasc Prev Rehabil 13:970-6. 2006
  7. ncbi request reprint Molecular variation at the apolipoprotein B gene locus in relation to lipids and cardiovascular disease: a systematic meta-analysis
    S Matthijs Boekholdt
    Department of Cardiology, Room F3 241, Academic Medical Center, PO Box 22660, 1100 DD, Amsterdam, The Netherlands
    Hum Genet 113:417-25. 2003
  8. ncbi request reprint [The endocannabinoid system, overweight, and the CB1-endocannabinoid-receptor antagonist rimonabant]
    S M Boekholdt
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Cardiologie
    Ned Tijdschr Geneeskd 151:2615-9. 2007
  9. ncbi request reprint Arterial thrombosis and the role of thrombophilia
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Semin Thromb Hemost 33:588-96. 2007
  10. ncbi request reprint Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study
    J S Rana
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Intern Med 262:678-89. 2007

Detail Information

Publications56

  1. pmc Validation of a model to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the rotterdam ischemic heart disease and stroke computer simulation (RISC) model
    Bob J H van Kempen
    Department of Epidemiology, Erasmus MC Rotterdam, Dr Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands
    BMC Med 10:158. 2012
    ..We developed a Monte Carlo Markov model designed to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD. Internal, predictive, and external validity of the model have not yet been established...
  2. ncbi request reprint Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels
    S M Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Genet 69:263-70. 2006
    ..Multiple environmental and genetic influences on HDL-C plasma levels still have to be elucidated...
  3. ncbi request reprint Initial thyroid status and cardiovascular risk factors: the EPIC-Norfolk prospective population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 72:404-10. 2010
    ..Thyroid status affects several aspects of cardiovascular risk profile, including lipid levels and blood pressure. Whether thyroid status affects the risk of coronary heart disease (CHD) and all-cause mortality remains controversial...
  4. ncbi request reprint Plasma concentrations of ascorbic acid and C-reactive protein, and risk of future coronary artery disease, in apparently healthy men and women: the EPIC-Norfolk prospective population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Br J Nutr 96:516-22. 2006
    ..These data suggest that the risk reduction associated with higher ascorbic acid plasma concentrations, a marker of fruit and vegetable intake, is independent of classical risk factors and also independent of CRP concentration...
  5. ncbi request reprint Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 22:e24-7. 2002
    ..It was our objective to verify this hypothesis in an independent cohort...
  6. ncbi request reprint Physical activity, C-reactive protein levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands
    Eur J Cardiovasc Prev Rehabil 13:970-6. 2006
    ..Whether this relationship is in part mediated by lower levels of systemic inflammation, as indicated by C-reactive protein concentrations, is unknown...
  7. ncbi request reprint Molecular variation at the apolipoprotein B gene locus in relation to lipids and cardiovascular disease: a systematic meta-analysis
    S Matthijs Boekholdt
    Department of Cardiology, Room F3 241, Academic Medical Center, PO Box 22660, 1100 DD, Amsterdam, The Netherlands
    Hum Genet 113:417-25. 2003
    ..These data suggest that the relationship between apoB levels, hypercholesterolemia and IHD risk cannot have a simple molecular basis in the apoB gene...
  8. ncbi request reprint [The endocannabinoid system, overweight, and the CB1-endocannabinoid-receptor antagonist rimonabant]
    S M Boekholdt
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Cardiologie
    Ned Tijdschr Geneeskd 151:2615-9. 2007
    ..Whether the beneficial effects of rimonabant on weight reduction and cardiovascular risk factors translate into a reduction in cardiovascular morbidity and mortality remains to be established in large phase III trials...
  9. ncbi request reprint Arterial thrombosis and the role of thrombophilia
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Semin Thromb Hemost 33:588-96. 2007
    ..We conclude that thrombophilia screening in unselected patient populations with myocardial infarction or ischemic stroke is not justified...
  10. ncbi request reprint Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study
    J S Rana
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Intern Med 262:678-89. 2007
    ..There is paucity of data on the differential leucocyte count and its relationship with the risk of CHD and CVD...
  11. pmc Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: a prospective case-control analysis nested in the EPIC-Norfolk population study
    A G Holleboom
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Lipid Res 51:416-21. 2010
    ..45, CI: 0.94-2.22, P for linearity = 0.036). In contrast to our studies in carriers of LCAT mutations, the current data show that low LCAT plasma levels are not associated with increased atherosclerosis in the general population...
  12. ncbi request reprint Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia
    Emily S van Aalst-Cohen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Hum Genet 13:1137-42. 2005
    ....
  13. ncbi request reprint IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 24:1503-8. 2004
    ..To study the role of IL-8 in predicting future coronary artery disease (CAD) in apparently healthy men and women...
  14. ncbi request reprint Tissue factor serum levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study
    T T Keller
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Thromb Haemost 4:2391-6. 2006
    ..High levels of circulating TF are found in patients with acute atherothrombotic events. Whether high serum TF levels predict risk of future CAD independent of known risk factors remains unknown...
  15. ncbi request reprint Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study
    Stefan F C Vaessen
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Lipid Res 47:2064-70. 2006
    ..The positive correlation of apoA-V levels with TG levels, negative correlation with LPL levels, and lack of association with CAD risk highlight the need for further human studies to clarify the role of apoA-V...
  16. ncbi request reprint Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects
    S M Boekholdt
    Department of Cardiology, Academic Medical Center, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 111:278-87. 2005
    ..In addition, an interaction has been implicated between this genetic variant and pravastatin treatment, but this has not been confirmed...
  17. ncbi request reprint Fibrinogen plasma levels modify the association between the factor XIII Val34Leu variant and risk of coronary artery disease: the EPIC-Norfolk prospective population study
    S M Boekholdt
    Department of Cardiology and Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Thromb Haemost 4:2204-9. 2006
    ..The factor (F) XIII Val34Leu variant has been implicated in coronary artery disease (CAD). In vitro evidence suggests an interaction between this variant and fibrinogen concentrations in determining thrombus structure...
  18. ncbi request reprint Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke: the EPIC-Norfolk Prospective Population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Med 117:390-7. 2004
    ..To determine whether plasma levels of macrophage migration inhibitory factor, a proinflammatory cytokine involved in atherogenesis, are predictive of myocardial infarction or death from coronary artery disease...
  19. ncbi request reprint C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: the EPIC-Norfolk prospective population study 1993-2003
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 187:415-22. 2006
    ..Measurement of C-reactive protein (CRP) levels has been proposed as a useful marker to improve the prediction of future coronary artery disease (CAD) risk, but this notion has been challenged recently...
  20. ncbi request reprint High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-I: significance for cardiovascular risk: the IDEAL and EPIC-Norfolk studies
    Wim A van der Steeg
    Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    J Am Coll Cardiol 51:634-42. 2008
    ....
  21. ncbi request reprint Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study
    Sabine Pinedo
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Lipid Res 48:139-44. 2007
    ..29) and the adjusted OR was 0.97 (95% CI = 0.68-1.39). In this large prospective study, higher levels of plant sterols, at least in the physiological range, do not appear to be adversely related to CAD in apparently healthy individuals...
  22. ncbi request reprint Serum lipoprotein lipase concentration and risk for future coronary artery disease: the EPIC-Norfolk prospective population study
    Jaap Rip
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 26:637-42. 2006
    ..Recent retrospective studies, however, indicate that LPL concentration can be reliably measured in serum that enabled evaluation of the prospective association between LPL and future CAD...
  23. ncbi request reprint Role of the apolipoprotein B-apolipoprotein A-I ratio in cardiovascular risk assessment: a case-control analysis in EPIC-Norfolk
    Wim A van der Steeg
    Academic Medical Center, Amsterdam, The Netherlands
    Ann Intern Med 146:640-8. 2007
    ..It is not known whether this ratio is better than traditional lipid values for risk assessment and prediction and whether it adds predictive value to the Framingham risk score...
  24. ncbi request reprint Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study
    Karim El Harchaoui
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 49:547-53. 2007
    ..We assessed relations of low-density lipoprotein (LDL) particle number (LDL-P) and LDL particle size as measured by nuclear magnetic resonance spectroscopy with LDL cholesterol (LDL-C) and the risk of future coronary artery disease (CAD)...
  25. ncbi request reprint Role of CETP inhibitors in the treatment of dyslipidemia
    W A van der Steeg
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands
    Curr Opin Lipidol 15:631-6. 2004
    ..In addition, it will underline that therapeutic targeting of the high-density lipoprotein (HDL) metabolism entails more than simply observing changes in cholesterol levels of this lipoprotein...
  26. ncbi request reprint Relationship between in vitro lipopolysaccharide-induced cytokine response in whole blood, angiographic in-stent restenosis, and toll-like receptor 4 gene polymorphisms
    Saskia Z H Rittersma
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Chem 51:516-21. 2005
    ..We evaluated the association between polymorphisms in the Toll-like receptor 4 (TLR4) gene and cytokine response after lipopolysaccharide (LPS) challenge and the development of ISR...
  27. ncbi request reprint Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers
    Nick R Bijsterveld
    Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circulation 106:2550-4. 2002
    ..The aim of this study was to investigate whether recombinant factor VIIa (rFVIIa) could neutralize the anticoagulant effects of subcutaneously administered fondaparinux...
  28. ncbi request reprint Lipids, apolipoproteins, and their ratios in relation to cardiovascular events with statin treatment
    John J P Kastelein
    Academic Medical Center, Department of Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 117:3002-9. 2008
    ....
  29. ncbi request reprint Interaction between a genetic variant of the platelet fibrinogen receptor and fibrinogen levels in determining the risk of cardiovascular events
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Am Heart J 147:181-6. 2004
    ..We investigated whether the effect of this genetic variant of the platelet fibrinogen receptor on the risk of cardiovascular events is affected by fibrinogen plasma levels...
  30. ncbi request reprint Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease
    S Matthijs Boekholdt
    Academic Medical Center, Department of Cardiology, Room F3 241, 1100 DD Amsterdam, The Netherlands
    J Lipid Res 44:1080-93. 2003
    ..05 mmol/l higher HDL levels in 405VV homozygotes than in 405II homozygotes (95% CI = 0.03-0.07, P < 0.0001). The implications of these studies for cardiovascular disease will be addressed...
  31. pmc Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study
    Rakesh S Birjmohun
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 4:e6809. 2009
    ..In order to evaluate the atheroprotective potential of PON1, we assessed the relationships among PON1-genotype, PON1-activity and risk of future coronary artery disease (CAD), in a large prospective case-control study...
  32. pmc Chemokine ligand 2 genetic variants, serum monocyte chemoattractant protein-1 levels, and the risk of coronary artery disease
    Diederik F van Wijk
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 30:1460-6. 2010
    ..In humans, evidence about the association between levels of monocyte chemoattractant protein-1 (MCP-1), its coding gene chemokine (C-C motif) ligand 2 (CCL2), and risk of coronary artery disease (CAD) is contradictory...
  33. ncbi request reprint Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study
    Marijn C Meuwese
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 50:159-65. 2007
    ..We evaluated whether serum myeloperoxidase (MPO) levels are associated with the risk of future development of coronary artery disease (CAD) in apparently healthy individuals...
  34. ncbi request reprint Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT
    Menno Vergeer
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 211:558-64. 2010
    ..We determined whether five tagging single nucleotide polymorphisms (SNP) in LIPG were associated with lipid parameters, the risk of CAD and the risk of DVT...
  35. ncbi request reprint Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women: the prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 110:1418-23. 2004
    ..Evidence exists that the effect of CETP depends on metabolic context, in particular on triglyceride levels...
  36. ncbi request reprint Genetic variation at the phospholipid transfer protein locus affects its activity and high-density lipoprotein size and is a novel marker of cardiovascular disease susceptibility
    Menno Vergeer
    Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Circulation 122:470-7. 2010
    ....
  37. ncbi request reprint Serum levels of mannose-binding lectin and the risk of future coronary artery disease in apparently healthy men and women
    Tymen T Keller
    Academic Medical Center of Amsterdam, Department of Vascular Medicine Room F4 121, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 26:2345-50. 2006
    ..To determine the association between serum levels of mannose-binding lectin (MBL) and the risk of future coronary artery disease (CAD) in apparently healthy men and women...
  38. ncbi request reprint Serum levels of type II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 25:839-46. 2005
    ..To study the prospective relationship between serum levels of type II secretory phospholipase A2 (sPLA2) and the risk of future coronary artery disease (CAD) in apparently healthy men and women...
  39. ncbi request reprint Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD
    Olga W Souverein
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Hum Genet 13:445-51. 2005
    ..Nevertheless, only a small part of variation in TG levels could be explained by the polymorphisms...
  40. ncbi request reprint Genetic variation in coagulation and fibrinolytic proteins and their relation with acute myocardial infarction: a systematic review
    S M Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, Netherlands
    Circulation 104:3063-8. 2001
    ..66, 95% CI 0.44 to 0.99, P=0.04), whereas the PAI-1 4G4G genotype was significantly associated with increased risk (OR 1.20, 95% CI 1.04 to 1.39, P=0.04)...
  41. ncbi request reprint CETP gene variation: relation to lipid parameters and cardiovascular risk
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Curr Opin Lipidol 15:393-8. 2004
    ..Research on naturally occurring variants in the CETP gene has yielded numerous insights that have been relevant for understanding lipoprotein metabolism, and crucial to the development of pharmacological CETP inhibition...
  42. ncbi request reprint Comparison between gradient gel electrophoresis and nuclear magnetic resonance spectroscopy in estimating coronary heart disease risk associated with LDL and HDL particle size
    Benoit J Arsenault
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Clin Chem 56:789-98. 2010
    ..However, whether or not GGE- or NMR-measured LDL or HDL particle size predicts coronary heart disease (CHD) risk to a similar extent is currently unknown...
  43. ncbi request reprint Prolactin levels and the risk of future coronary artery disease in apparently healthy men and women
    Anne Q Reuwer
    Departments of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Circ Cardiovasc Genet 2:389-95. 2009
    ..Because inflammation is considered of crucial importance in the development of atherosclerosis, we aimed to evaluate whether prolactin levels are associated with the occurrence of coronary artery disease (CAD)...
  44. ncbi request reprint Inherited disorders of HDL metabolism and atherosclerosis
    G Kees Hovingh
    Department of Vascular Medicine, Academic Medical Center, AZ Amsterdam, The Netherlands
    Curr Opin Lipidol 16:139-45. 2005
    ..Ultrasound imaging of carotid arteries has provided a tool to assess the risk in hereditary hypo and hyperalphalipoproteinemia. This review gives a comprehensive summary...
  45. ncbi request reprint High-density lipoprotein particle size and concentration and coronary risk
    Karim El Harchaoui
    Academic Medical Center, Amsterdam, The Netherlands
    Ann Intern Med 150:84-93. 2009
    ..Because HDL particles are heterogeneous in size and composition, they may be differentially associated with other cardiovascular risk factors and with cardiovascular risk...
  46. ncbi request reprint Apolipoprotein A-II is inversely associated with risk of future coronary artery disease
    Rakesh S Birjmohun
    Academic Medical Center, Department of Vascular Medicine, 1100 DD, Amsterdam, The Netherlands
    Circulation 116:2029-35. 2007
    ..To study this suggestion more closely, we evaluated how serum levels of apoA-II and apoA-I relate to the risk of future coronary artery disease (CAD) in a large, prospective study...
  47. ncbi request reprint Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events
    S Matthijs Boekholdt
    Leiden University Medical Center, Department of Cardiology C5 P, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
    Circulation 107:2416-21. 2003
    ....
  48. ncbi request reprint Evaluation of the Framingham risk score in the European Prospective Investigation of Cancer-Norfolk cohort: does adding glycated hemoglobin improve the prediction of coronary heart disease events?
    Rebecca K Simmons
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, England
    Arch Intern Med 168:1209-16. 2008
    ..There is a continuous relationship between glycated hemoglobin (HbA(1c)) and coronary heart disease (CHD) risk, even below diagnostic thresholds for diabetes mellitus...
  49. ncbi request reprint Gene polymorphisms and the risk of myocardial infarction--an emerging relation
    Ron J G Peters
    N Engl J Med 347:1963-5. 2002
  50. ncbi request reprint Body fat distribution and risk of coronary heart disease in men and women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk cohort: a population-based prospective study
    Dexter Canoy
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Circulation 116:2933-43. 2007
    ..Body fat distribution has been cross-sectionally associated with atherosclerotic disease risk factors, but the prospective relation with coronary heart disease remains uncertain...
  51. ncbi request reprint Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPIC-Norfolk prospective population study
    Benoit J Arsenault
    Department of Cardiology, Quebec Heart Institute, Hôpital Laval Research Centre, Pavilion Marguerite D Youville, 4th Floor, 2725, Chemin Sainte Foy, Quebec, QC, Canada G1V 4G5
    Eur Heart J 28:2770-7. 2007
    ..To evaluate the association of low-density lipoprotein cholesterol (LDL-C) levels in small and large LDL particles with risk of incident coronary heart disease (CHD)...
  52. ncbi request reprint Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, England, UK
    Circulation 115:450-8. 2007
    ..In the present study, we report 2 separate nested case-control comparisons in 2 different prospective, population-based cohorts, plus an updated meta-analysis of 27 additional prospective studies in general Western populations...
  53. ncbi request reprint Thrombospondin gene polymorphisms and the risk of angiographic coronary in-stent restenosis
    Saskia Z H Rittersma
    Am J Med 116:499-500. 2004
  54. ncbi request reprint Circulating secretory phospholipase A2 activity and risk of incident coronary events in healthy men and women: the EPIC-Norfolk study
    Ziad Mallat
    INSERM U689, Centre de Recherché Cardiovasculaire Lariboisière, Paris, France
    Arterioscler Thromb Vasc Biol 27:1177-83. 2007
    ..To assess the association between secretory phospholipase A2 (sPLA2) activity, which encompasses several types of sPLA2, and cardiovascular disease (CAD) in healthy individuals...
  55. ncbi request reprint Inhibition of lipoprotein-associated phospholipase activity by darapladib: shifting gears in cardiovascular drug development: are antiinflammatory drugs the next frontier?
    S Matthijs Boekholdt
    Circulation 118:1120-2. 2008
  56. ncbi request reprint Cholesteryl ester transfer protein (CETP) inhibition beyond raising high-density lipoprotein cholesterol levels: pathways by which modulation of CETP activity may alter atherogenesis
    Anke H E M Klerkx
    Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 26:706-15. 2006
    ....