Maarten F Bijlsma

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Room G2 105, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cell Signal 19:2596-604. 2007
  2. pmc Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines
    Robert J Lipinski
    Department of Surgery, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA
    BMC Cell Biol 9:49. 2008
  3. doi request reprint Hypoxia induces a hedgehog response mediated by HIF-1alpha
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Cell Mol Med 13:2053-60. 2009
  4. doi request reprint Leukotriene synthesis is required for hedgehog-dependent neurite projection in neuralized embryoid bodies but not for motor neuron differentiation
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Stem Cells 26:1138-45. 2008
  5. pmc Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef, Amsterdam, Netherlands
    PLoS Biol 4:e232. 2006
  6. doi request reprint Endogenous hedgehog expression contributes to myocardial ischemia-reperfusion-induced injury
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands
    Exp Biol Med (Maywood) 233:989-96. 2008
  7. ncbi request reprint The Urokinase Receptor (uPAR) Facilitates Clearance of Borrelia burgdorferi
    Joppe W R Hovius
    Center for Experimental and Molecular Medicine CEMM, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
    PLoS Pathog 5:e1000447. 2009
  8. ncbi request reprint Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation
    Keren S Borensztajn
    Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Exp Cell Res 313:2622-33. 2007
  9. ncbi request reprint Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation
    Sjoukje H Slofstra
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibregdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood 110:3176-82. 2007
  10. ncbi request reprint Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer
    Lois W Brüggemann
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cancer Biol Ther 10:79-88. 2010

Detail Information

Publications19

  1. ncbi request reprint Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Room G2 105, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cell Signal 19:2596-604. 2007
    ....
  2. pmc Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines
    Robert J Lipinski
    Department of Surgery, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA
    BMC Cell Biol 9:49. 2008
    ..We previously characterized the individual and cooperative roles of the Gli proteins in Hh target gene regulation using a battery of primary embryonic fibroblasts from Gli null mice...
  3. doi request reprint Hypoxia induces a hedgehog response mediated by HIF-1alpha
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Cell Mol Med 13:2053-60. 2009
    ..In conclusion, we have established that hypoxia is translated into a hedgehog response through HIF-1alpha and this mechanism is likely to be responsible for the hedgehog response observed in various ischaemia models...
  4. doi request reprint Leukotriene synthesis is required for hedgehog-dependent neurite projection in neuralized embryoid bodies but not for motor neuron differentiation
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Stem Cells 26:1138-45. 2008
    ..These data establish a function for the previously described arachidonic acid-dependent Hh pathway in a developmentally relevant model system...
  5. pmc Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef, Amsterdam, Netherlands
    PLoS Biol 4:e232. 2006
    ....
  6. doi request reprint Endogenous hedgehog expression contributes to myocardial ischemia-reperfusion-induced injury
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands
    Exp Biol Med (Maywood) 233:989-96. 2008
    ..Thus, Hh seems to exert a dualistic action in cardiac ischemia in which high exogenous levels are able to foster tissue repair and endogenous Hh seems to be deleterious...
  7. ncbi request reprint The Urokinase Receptor (uPAR) Facilitates Clearance of Borrelia burgdorferi
    Joppe W R Hovius
    Center for Experimental and Molecular Medicine CEMM, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
    PLoS Pathog 5:e1000447. 2009
    ..In conclusion, in B. burgdorferi infection, uPAR is required for phagocytosis and adequate eradication of the spirochete from the heart by a mechanism that is independent of binding of uPAR to uPA or its role in the fibrinolytic system...
  8. ncbi request reprint Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation
    Keren S Borensztajn
    Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Exp Cell Res 313:2622-33. 2007
    ..We thus provide evidence that beyond its role in blood coagulation, FXa plays a key role in cellular processes in which Bim is the central player in determining cell survival...
  9. ncbi request reprint Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation
    Sjoukje H Slofstra
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibregdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood 110:3176-82. 2007
    ..These results uncover an important role for PAR-4 in the Shwartzman reaction and suggest that inhibition of PAR-4 signaling in neutrophils could be protective in systemic inflammation and DIC...
  10. ncbi request reprint Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer
    Lois W Brüggemann
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cancer Biol Ther 10:79-88. 2010
    ..However, in in vivo models vitamin D3 was not found to be effective against tumor cell growth...
  11. pmc The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi
    Joppe W R Hovius
    Center for Experimental and Molecular Medicine CEMM, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
    PLoS Pathog 5:e1000447. 2009
    ..In conclusion, in B. burgdorferi infection, uPAR is required for phagocytosis and adequate eradication of the spirochete from the heart by a mechanism that is independent of binding of uPAR to uPA or its role in the fibrinolytic system...
  12. ncbi request reprint Hedgehog: an unusual signal transducer
    Maarten F Bijlsma
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Bioessays 26:387-94. 2004
    ..These atypical features make Hedgehog physiology unique in biology and may explain why this field has attracted such significant attention...
  13. ncbi request reprint Hedgehog morphogen in cardiovascular disease
    Maarten F Bijlsma
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 114:1985-91. 2006
    ..In light of the recent discovery of Hh transport by insect lipophorin, we also hypothesize a role for low-density lipoprotein (LDL) in mammalian Hh transport, creating a surprising role for LDL in cardiovascular disease...
  14. ncbi request reprint Hedgehog turns lipoproteins into Janus-faced particles
    Maarten F Bijlsma
    Academic Medical Center, Laboratory of Experimental Internal Medicine, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Trends Cardiovasc Med 16:217-20. 2006
    ..No longer would LDL merely be bad news for the progression of atherosclerotic plaques, as it also conveys a revascularization and tissue salvage signal in the form of hedgehog...
  15. ncbi request reprint Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
    Wouter J de Jonge
    Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Nat Immunol 6:844-51. 2005
    ..We conclude that the vagal anti-inflammatory pathway acts by alpha7 subunit-mediated Jak2-STAT3 activation...
  16. doi request reprint Coagulation factor Xa inhibits cancer cell migration via protease-activated receptor-1 activation
    Keren Borensztajn
    Department of Cell Biology, University of Groningen, Groningen, The Netherlands
    Thromb Res 124:219-25. 2009
    ..These results suggest that, beyond its role in blood coagulation, FXa plays a key role in cancer cell migration. They also shed light on an unexpected role of PAR-1, which appears to be a Janus-like receptor in cancer cell biology...
  17. pmc Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma
    Helene Damhofer
    Laboratory for Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands Electronic address
    Mol Oncol 7:1031-42. 2013
    ..In addition, the study has yielded several candidates that are interesting therapeutic targets for a disease for which treatment options are still inadequate. ..
  18. pmc Dichotomy in Hedgehog signaling between human healthy vessel and atherosclerotic plaques
    Karla C S Queiroz
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Mol Med 18:1122-7. 2012
    ....
  19. ncbi request reprint A dual role for 7-dehydrocholesterol reductase in regulating Hedgehog signalling?
    Maarten F Bijlsma
    Development 133:3951; author reply 3952-3. 2006