Dominique Baeten

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. doi request reprint The cartilage protein melanoma inhibitory activity contributes to inflammatory arthritis
    Nataliya Yeremenko
    Department of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Rheumatology (Oxford) 53:438-47. 2014
  2. doi request reprint Undifferentiated spondyloarthritis vs ankylosing spondylitis and psoriatic arthritis: a real-life prospective cohort study of clinical presentation and response to treatment
    Jacqueline E Paramarta
    Academic Medical Center University of Amsterdam, Department of Clinical Immunology and Rheumatology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Rheumatology (Oxford) 52:1873-8. 2013
  3. doi request reprint Altered BANK1 expression is not associated with humoral autoimmunity in chronic joint inflammation
    Tineke Cantaert
    Division of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Rheumatology (Oxford) 52:252-60. 2013
  4. pmc Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis
    Christian Barthel
    Clinic for Immunology and Rheumatology, Hannover Medical School MHH, Carl Neuberg Strasse 1, Hannover 30625, Germany
    Arthritis Res Ther 11:R82. 2009
  5. pmc Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment
    Lisa Gm van Baarsen
    Department of Pathology, VU University Medical Center, De Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands
    Arthritis Res Ther 12:R11. 2010
  6. pmc Distinct synovial immunopathology in Behçet disease and psoriatic arthritis
    Juan D Canete
    Arthritis Unit, Department of Rheumatology, Hospital Clinic de Barcelona and IDIBAPS, Villaroel 170, Barcelona 08036, Spain
    Arthritis Res Ther 11:R17. 2009
  7. pmc IL-17 in spondyloarthritis: is the T-party over?
    Nataliya Yeremenko
    Arthritis Res Ther 13:115. 2011
  8. doi request reprint Spondylarthritis in the absence of B lymphocytes
    Dominique Baeten
    Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 58:730-3. 2008
  9. pmc Synovial inflammation does not change in the absence of effective treatment: implications for the use of synovial histopathology as biomarker in early phase clinical trials in rheumatoid arthritis
    D Baeten
    Clinical Immunology and Rheumatology, Academic Medical Centre University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Ann Rheum Dis 65:990-7. 2006
  10. doi request reprint Use of TNF blockers and other targeted therapies in rare refractory immune-mediated inflammatory diseases: evidence-based or rational?
    Dominique Baeten
    Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Ann Rheum Dis 69:2067-73. 2010

Detail Information

Publications72

  1. doi request reprint The cartilage protein melanoma inhibitory activity contributes to inflammatory arthritis
    Nataliya Yeremenko
    Department of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Rheumatology (Oxford) 53:438-47. 2014
    ..Conclusion. These data support a role for MIA as an autoantigen during arthritis development. Whether MIA can influence the balance of pathogenic vs regulatory responses in human RA remains to be investigated. ..
  2. doi request reprint Undifferentiated spondyloarthritis vs ankylosing spondylitis and psoriatic arthritis: a real-life prospective cohort study of clinical presentation and response to treatment
    Jacqueline E Paramarta
    Academic Medical Center University of Amsterdam, Department of Clinical Immunology and Rheumatology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Rheumatology (Oxford) 52:1873-8. 2013
    ..This study aimed to investigate whether, despite a different phenotypic presentation, patients with undifferentiated SpA (uSpA) have similar disease activity and response to treatment to those with AS and PsA...
  3. doi request reprint Altered BANK1 expression is not associated with humoral autoimmunity in chronic joint inflammation
    Tineke Cantaert
    Division of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Rheumatology (Oxford) 52:252-60. 2013
    ....
  4. pmc Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis
    Christian Barthel
    Clinic for Immunology and Rheumatology, Hannover Medical School MHH, Carl Neuberg Strasse 1, Hannover 30625, Germany
    Arthritis Res Ther 11:R82. 2009
    ..We previously described the presence of nerve growth factor receptors in the inflamed synovial compartment. Here we investigated the presence of the corresponding nerve growth factors, with special focus on nerve growth factor (NGF)...
  5. pmc Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment
    Lisa Gm van Baarsen
    Department of Pathology, VU University Medical Center, De Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands
    Arthritis Res Ther 12:R11. 2010
    ..Therefore, we determined the effect of TNF blockade in rheumatoid arthritis (RA) on the type I IFN response gene activity in relation to clinical response...
  6. pmc Distinct synovial immunopathology in Behçet disease and psoriatic arthritis
    Juan D Canete
    Arthritis Unit, Department of Rheumatology, Hospital Clinic de Barcelona and IDIBAPS, Villaroel 170, Barcelona 08036, Spain
    Arthritis Res Ther 11:R17. 2009
    ..The aim of the study was to investigate synovial immunopathology differences between early Behçet disease (BD) and psoriatic arthritis (PsA)...
  7. pmc IL-17 in spondyloarthritis: is the T-party over?
    Nataliya Yeremenko
    Arthritis Res Ther 13:115. 2011
    ..Understanding molecular mechanisms behind these early innate immune responses will be the key to designing rational therapies targeting these important inflammatory pathways...
  8. doi request reprint Spondylarthritis in the absence of B lymphocytes
    Dominique Baeten
    Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 58:730-3. 2008
    ....
  9. pmc Synovial inflammation does not change in the absence of effective treatment: implications for the use of synovial histopathology as biomarker in early phase clinical trials in rheumatoid arthritis
    D Baeten
    Clinical Immunology and Rheumatology, Academic Medical Centre University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Ann Rheum Dis 65:990-7. 2006
    ..To determine the impact on synovial histopathology of changes in clinical disease activity in the absence of effective treatment...
  10. doi request reprint Use of TNF blockers and other targeted therapies in rare refractory immune-mediated inflammatory diseases: evidence-based or rational?
    Dominique Baeten
    Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Ann Rheum Dis 69:2067-73. 2010
    ....
  11. doi request reprint The relationship between synovial lymphocyte aggregates and the clinical response to infliximab in rheumatoid arthritis: a prospective study
    Ruth Klaasen
    University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 60:3217-24. 2009
    ....
  12. doi request reprint Absence of a classically activated macrophage cytokine signature in peripheral spondylarthritis, including psoriatic arthritis
    Bernard Vandooren
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 60:966-75. 2009
    ..The purpose of this study was to assess whether this differential infiltration with macrophage subsets was associated with a different local inflammatory milieu in SpA as compared with rheumatoid arthritis (RA)...
  13. doi request reprint Disease-specific and inflammation-independent stromal alterations in spondylarthritis synovitis
    Nataliya Yeremenko
    Department of Clinical Immunology and Rheumatology, Academic Medical Center and University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 65:174-85. 2013
    ..Therefore, we aimed to identify novel and unsuspected disease-specific pathways in SpA by a systematic and unbiased synovial gene expression analysis...
  14. doi request reprint Anti-TNF treatment blocks the induction of T cell-dependent humoral responses
    Gabriela Franco Salinas
    Department of Clinical Immunology and Rheumatology, Academic Medical Centre University of Amsterdam, Amsterdam, The Netherlands
    Ann Rheum Dis 72:1037-43. 2013
    ....
  15. doi request reprint The value of rheumatoid factor and anti-citrullinated protein antibodies as predictors of response to infliximab in rheumatoid arthritis: an exploratory study
    Ruth Klaasen
    Department of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Rheumatology (Oxford) 50:1487-93. 2011
    ..We investigated the relationship between the presence and levels of different RF and ACPA isotypes and the response to TNF blockade in an exploratory study...
  16. doi request reprint Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation
    Bernard Vandooren
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 58:3051-62. 2008
    ..Cadherin 11 expressed on fibroblast-like synoviocytes (FLS) plays a key role in normal synovial architecture. The purpose of this study was to examine the expression of cadherin 11 in human synovitis...
  17. doi request reprint Analysis of apoptosis in peripheral blood and synovial tissue very early after initiation of infliximab treatment in rheumatoid arthritis patients
    Carla A Wijbrandts
    Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 58:3330-9. 2008
    ..This study was undertaken to investigate whether infliximab induces apoptosis within the first 24 hours after infusion...
  18. doi request reprint Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis
    Troy Noordenbos
    Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 64:99-109. 2012
    ..Recent observations have indicated a marked synovial mast cell infiltration in psoriatic SpA. We therefore undertook the present study to investigate the potential contribution of mast cells to synovial inflammation in SpA...
  19. doi request reprint The abundant synovial expression of the RANK/RANKL/Osteoprotegerin system in peripheral spondylarthritis is partially disconnected from inflammation
    Bernard Vandooren
    Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 58:718-29. 2008
    ..To assess the potential role of this system in the distinct bone phenotype, we studied the synovial expression of these mediators in SpA and RA peripheral synovitis...
  20. doi request reprint Synovial lymphoid neogenesis does not define a specific clinical rheumatoid arthritis phenotype
    Rogier M Thurlings
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 58:1582-9. 2008
    ..To investigate the relationship between lymphoid neogenesis in the synovium of patients with rheumatoid arthritis (RA) and characteristics of inflammation and disease severity...
  21. ncbi request reprint Pathogenesis of spondyloarthritis: insights from synovial membrane studies
    Leen De Rycke
    Division of Clinical Immunology and Rheumatology, F4 148, Academic Medical Center University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Curr Rheumatol Rep 8:275-82. 2006
    ..Therefore, we propose that an exaggerated response of the innate immune system in genetically susceptible patients rather than a classic, lymphocyte-mediated autoimmune process is involved in the pathogenesis of SpA...
  22. doi request reprint Pathogenesis of spondyloarthritis: autoimmune or autoinflammatory?
    Carmen Ambarus
    Department of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Curr Opin Rheumatol 24:351-8. 2012
    ..Spondyloarthritis (SpA) is a chronic immune-mediated inflammatory disease of unknown origin. Here we aim to review whether SpA is driven by T-cell and/or B-cell autoreactivity or by abnormal innate immune responses...
  23. doi request reprint In vitro spontaneous osteoclastogenesis of human peripheral blood mononuclear cells is not crucially dependent on T lymphocytes
    Bernard Vandooren
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 60:1020-5. 2009
    ..In vitro spontaneous osteoclastogenesis from peripheral blood mononuclear cells (PBMCs) is increased in diseases with excessive bone loss. The purpose of this study was to reassess the role of T lymphocytes in this process...
  24. doi request reprint Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trial
    Clarissa E Vergunst
    Academic Medical Center, and University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 58:1931-9. 2008
    ..Blocking CCR2 prevents CCL2-mediated chemotaxis in vitro and modulates arthritis in animal models of RA. In this study we examined the effects of CCR2 blockade on synovial inflammation in RA...
  25. doi request reprint Presence and role of anti-citrullinated protein antibodies in experimental arthritis models
    Tineke Cantaert
    Academic Medical Center and University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 65:939-48. 2013
    ....
  26. doi request reprint Alterations of the synovial T cell repertoire in anti-citrullinated protein antibody-positive rheumatoid arthritis
    Tineke Cantaert
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 60:1944-56. 2009
    ..The purpose of this study was to investigate this hypothesis by systematic histologic and molecular analyses of synovial T cells in ACPA+ versus ACPA- RA patients...
  27. ncbi request reprint Synovial and mucosal immunopathology in spondyloarthritis
    Bernard Vandooren
    Clinical Immunology and Rheumatology, University of Amsterdam, Amsterdam, The Netherlands
    Adv Exp Med Biol 649:71-84. 2009
    ..Here, we will review the immunopathology of these different disease manifestations and relate them to clinical applications as well as emerging pathogenic concepts...
  28. doi request reprint Peripheral joint inflammation in early onset spondyloarthritis is not specifically related to enthesitis
    Jacqueline E Paramarta
    Department of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Ann Rheum Dis 73:735-40. 2014
    ..Therefore, the current study aimed to reassess enthesitis versus synovitis in peripheral arthritis by a combined imaging and histopathological study in early untreated disease...
  29. doi request reprint Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis
    Sarah Krausz
    Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
    Ann Rheum Dis 71:1402-10. 2012
    ....
  30. ncbi request reprint A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis
    Jasper J Haringman
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 54:2387-92. 2006
    ..The objective of this study was to evaluate the effects of human anti-CCL2/MCP-1 monoclonal antibody (ABN912) treatment in patients with rheumatoid arthritis (RA)...
  31. doi request reprint The role of B lymphocytes in the progression from autoimmunity to autoimmune disease
    Gabriela Franco Salinas
    Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, The Netherlands
    Clin Immunol 146:34-45. 2013
    ....
  32. ncbi request reprint B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis
    Tineke Cantaert
    Clinical Immunology and Rheumatology, Department of Experimental Immunology, Academic Medical Center University of Amsterdam, The Netherlands
    J Immunol 181:785-94. 2008
    ..Therefore, we conclude that synovial lymphoid neogenesis is not a major determinant of these rheumatoid arthritis-specific autoantibody responses...
  33. ncbi request reprint Citrullinated proteins in rheumatoid arthritis: crucial...but not sufficient!
    Tineke Cantaert
    University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 54:3381-9. 2006
  34. pmc Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance
    Tineke Cantaert
    Academic Medical Center University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Arthritis Res Ther 12:219. 2010
    ..Finally, we discuss the clinical relevance of this proposed cross-regulation for biological therapies such as type I IFN or anti-TNFα treatment...
  35. pmc Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis
    J J Haringman
    Division of Clinical Immunology and Rheumatology, F4 218, Academic Medical Centre University of Amsterdam, Meibergdreef 9, NL 1105 AZ Amsterdam, The Netherlands
    Ann Rheum Dis 64:834-8. 2005
    ..Previous work identified synovial sublining macrophage numbers as a potential biomarker for clinical efficacy in rheumatoid arthritis...
  36. doi request reprint TNF blockade abrogates the induction of T cell-dependent humoral responses in an allotransplantation model
    Gabriela Francosalinas
    Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    J Leukoc Biol 90:367-75. 2011
    ..Taken together, these data indicate that TNF blockade abrogates the induction of TD humoral responses and accordingly, may have a beneficial effect in antibody-mediated inflammatory pathologies...
  37. pmc Synovial Tissue Response to Treatment with TNF Blockers in Peripheral Spondyloarthritis
    Jacqueline E Paramarta
    Department of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Open Rheumatol J 5:127-32. 2011
    ..Moreover, detailed cellular and molecular analysis of synovial features allows to identify synovial biomarkers of clinical response to therapeutic interventions which can be used in future early phase clinical trials in SpA...
  38. doi request reprint Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial
    Dominique Baeten
    Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    Lancet 382:1705-13. 2013
    ..We assessed the efficacy and safety of the anti-IL-17A monoclonal antibody secukinumab in treating patients with active ankylosing spondylitis...
  39. doi request reprint 'MRI-tis' in the early diagnosis of axial SpA: issues and limitations
    Leen De Rycke
    Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Nat Rev Rheumatol 6:666-9. 2010
    ..Prospective, longitudinal studies are needed to validate the utility of this new imaging modality for the diagnosis of axial SpA...
  40. doi request reprint Melanoma inhibitory activity, a biomarker related to chondrocyte anabolism, is reversibly suppressed by proinflammatory cytokines in rheumatoid arthritis
    B Vandooren
    Academic Medical Center University of Amsterdam, The Netherlands
    Ann Rheum Dis 68:1044-50. 2009
    ..In mice, melanoma inhibitory activity (MIA) is a chondrocyte-specific molecule with similar regulation to collagen type II. As MIA is a small secreted protein, its value as cartilage biomarker in human inflammatory arthritis was assessed...
  41. pmc Exposure to nuclear antigens contributes to the induction of humoral autoimmunity during tumour necrosis factor alpha blockade
    T Cantaert
    Academic Medical Center University of Amsterdam, The Netherlands
    Ann Rheum Dis 68:1022-9. 2009
    ..This study assessed whether similar mechanisms contribute to break peripheral B-cell tolerance in humans by studying the induction of antinuclear antibodies by tumour necrosis factor blockade in spondyloarthritis...
  42. ncbi request reprint Differential expression and response to anti-TNFalpha treatment of infiltrating versus resident tissue macrophage subsets in autoimmune arthritis
    Leen De Rycke
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    J Pathol 206:17-27. 2005
    ....
  43. ncbi request reprint Dynamic T cell receptor clonotype changes in synovial tissue of patients with early rheumatoid arthritis: effects of treatment with cyclosporin A (Neoral)
    Ann Vanderborght
    Biomedisch Onderzoeksinstituut DWI, Limburgs Universitair Centrum, Diepenbeek, Belgium
    J Rheumatol 29:416-26. 2002
    ....
  44. ncbi request reprint Macrophages expressing the scavenger receptor CD163: a link between immune alterations of the gut and synovial inflammation in spondyloarthropathy
    Dominique Baeten
    Department of Rheumatology, OK121B, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
    J Pathol 196:343-50. 2002
    ..The correlation with inflammatory parameters, the expression of HLA-DR, the production of TNFalpha but not IL-10, and the reduction by anti-TNFalpha therapy support a role for CD163+ macrophages in the synovial inflammation in SpA...
  45. ncbi request reprint Localization of MHC class II/human cartilage glycoprotein-39 complexes in synovia of rheumatoid arthritis patients using complex-specific monoclonal antibodies
    Peter G A Steenbakkers
    Department of Pharmacology, N V Organon, Oss, The Netherlands
    J Immunol 170:5719-27. 2003
    ..These data support a role of HC gp-39 in the local autoimmune response that leads to chronic inflammation and joint destruction...
  46. ncbi request reprint Identification of synovial biomarkers of response to experimental treatment in early-phase clinical trials in spondylarthritis
    Elli Kruithof
    Ghent University Hospital, Ghent, Belgium
    Arthritis Rheum 54:1795-804. 2006
    ..To identify biomarkers for effective treatment in early-phase clinical trials of spondylarthritis (SpA), by analyzing which synovial features can be reliably identified in patients with SpA...
  47. ncbi request reprint Synovial tissue analysis in clinical trials
    Barry Bresnihan
    Department of Rheumatology, St Vincent s University Hospital, Dublin, Ireland
    J Rheumatol 32:2481-4. 2005
    ..This special interest group is working on establishing the evidence to have this endpoint meet the OMERACT filter criteria...
  48. ncbi request reprint Immunomodulatory effects of etanercept on peripheral joint synovitis in the spondylarthropathies
    Elli Kruithof
    Ghent University Hospital, Ghent, Belgium
    Arthritis Rheum 52:3898-909. 2005
    ....
  49. ncbi request reprint Tumor necrosis factor alpha blockade treatment down-modulates the increased systemic and local expression of Toll-like receptor 2 and Toll-like receptor 4 in spondylarthropathy
    Leen De Rycke
    Ghent University Hospital, Ghent, Belgium
    Arthritis Rheum 52:2146-58. 2005
    ....
  50. pmc Synovial histopathology of psoriatic arthritis, both oligo- and polyarticular, resembles spondyloarthropathy more than it does rheumatoid arthritis
    Elli Kruithof
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Arthritis Res Ther 7:R569-80. 2005
    ....
  51. pmc Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy
    Dominique Baeten
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Arthritis Res Ther 7:R359-69. 2005
    ..These data support a prominent role for innate immune cells in SpA synovitis and warrant further evaluation of synovial histopathology as a surrogate marker in early-phase therapeutic trials in SpA...
  52. ncbi request reprint Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor alpha blockade in spondylarthropathy
    Bernard Vandooren
    Ghent University Hospital, Ghent, Belgium
    Arthritis Rheum 50:2942-53. 2004
    ..To investigate the role of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in spondylarthropathy (SpA) synovitis...
  53. ncbi request reprint Diagnostic classification of spondylarthropathy and rheumatoid arthritis by synovial histopathology: a prospective study in 154 consecutive patients
    Dominique Baeten
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Arthritis Rheum 50:2931-41. 2004
    ....
  54. ncbi request reprint Detection of major histocompatibility complex/human cartilage gp-39 complexes in rheumatoid arthritis synovitis as a specific and independent histologic marker
    Dominique Baeten
    Ghent University Hospital, Ghent, Belgium
    Arthritis Rheum 50:444-51. 2004
    ..The aim of the present study was to analyze whether presentation of the immunodominant epitope of HC gp-39 by shared epitope-positive synovial dendritic cells is a specific event in the development of chronic synovial inflammation in RA...
  55. doi request reprint Increased cortisol relative to adrenocorticotropic hormone predicts improvement during anti-tumor necrosis factor therapy in rheumatoid arthritis
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 58:976-84. 2008
    ..We undertook this study to investigate the predictive value of hypothalamic-pituitary-adrenal (HPA) axis hormones for clinical improvement during anti-TNF therapy...
  56. ncbi request reprint Distinct synovial immunopathologic characteristics of juvenile-onset spondylarthritis and other forms of juvenile idiopathic arthritis
    Elli Kruithof
    Ghent University Hospital, Ghent, Belgium
    Arthritis Rheum 54:2594-604. 2006
    ..To characterize the synovial immunopathologic features of juvenile-onset spondylarthritis (SpA) in relation to adult SpA and other forms of juvenile idiopathic arthritis (JIA)...
  57. pmc Ectopic lymphoid neogenesis in psoriatic arthritis
    Juan D Canete
    Servicio de Reumatologia, Hospital 12 de Octubre, 28041 Madrid, Spain
    Ann Rheum Dis 66:720-6. 2007
    ..This process involves the expression of specific homing chemokines and the development of high endothelial venules (HEV)...
  58. ncbi request reprint Immune linkages between inflammatory bowel disease and spondyloarthropathies
    Dominique Baeten
    Department of Rheumatology, Ghent University Hospital, Belgium
    Curr Opin Rheumatol 14:342-7. 2002
    ....
  59. ncbi request reprint Infliximab in patients who have spondyloarthropathy: clinical efficacy, safety, and biological immunomodulation
    Filip De Keyser
    Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Rheum Dis Clin North Am 29:463-79. 2003
    ....
  60. ncbi request reprint Serum levels of matrix metalloproteinase 3 and macrophage colony-stimulating factor 1 correlate with disease activity in ankylosing spondylitis
    Chunhua Yang
    University of California Los Angeles, USA
    Arthritis Rheum 51:691-9. 2004
    ..To assess the usefulness of measuring serum matrix metalloproteinase 3 (MMP-3) and macrophage colony-stimulating factor (M-CSF) in patients with ankylosing spondylitis (AS)...
  61. ncbi request reprint Structure-modifying capacity of anti-tumour necrosis factor-alpha therapy in ankylosing spondylitis
    Filip De Keyser
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Drugs 64:2793-811. 2004
    ..However, despite these concerns, anti-TNFalpha therapy represents a major therapeutic advancement in the treatment of AS...
  62. ncbi request reprint Fibrin deimination in synovial tissue is not specific for rheumatoid arthritis but commonly occurs during synovitides
    Sabine Chapuy-Regaud
    Laboratory of Epidermis Differentiation and Rheumatoid Autoimmunity, Unité Mixte de Recherche 5165 Centre National de la Recherche Scientifique Toulouse III University, Institut Federatif de Recherche 30, Toulouse, France
    J Immunol 174:5057-64. 2005
    ..Therefore, fibrin deimination in the ST is a general phenomenon associated to any synovitis, which does not necessarily induce a B autoimmune response with production of AhFibA...
  63. pmc Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance
    Sophie Brouard
    Institut National de la Sante et de la Recherche Medicale, U643, Centre Hospitalier Universitaire de Nantes, Institut de Transplantation et de Recherche en Transplantation, and Université de Nantes, Faculte de Medicine, F 44000 Nantes, France
    Proc Natl Acad Sci U S A 104:15448-53. 2007
    ..Further validation of this tool for safe IS minimization in prospective clinical trials is warranted...
  64. ncbi request reprint Infliximab, but not etanercept, induces IgM anti-double-stranded DNA autoantibodies as main antinuclear reactivity: biologic and clinical implications in autoimmune arthritis
    Leen De Rycke
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Arthritis Rheum 52:2192-201. 2005
    ..To analyze the clinical and biologic correlates of autoantibody induction during longer-term tumor necrosis factor alpha (TNFalpha) blockade with either the monoclonal antibody infliximab or the soluble receptor etanercept...
  65. ncbi request reprint Effect of infliximab treatment on T cell cytokine responses in spondylarthropathy: comment on the article by Zou et al
    Dominique Baeten
    Arthritis Rheum 50:1015-6; author reply 1017. 2004
  66. ncbi request reprint B cell clonal expansion and somatic hypermutation of Ig variable heavy chain genes in the synovial membrane of patients with osteoarthritis
    Reng Rong Da
    Department of Neurology, University of California Irvine, Irvine, CA 92697, USA
    J Immunol 178:557-65. 2007
    ..These data demonstrate the presence in inflamed knee OA synovium of clonally expanded, Ag-driven B cells that may contribute to the development or progression of the disease...
  67. ncbi request reprint Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity
    Leen De Rycke
    Ghent University Hospital, Belgium
    Arthritis Rheum 52:2323-30. 2005
    ....
  68. pmc Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice
    Estelle Bettelli
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 116:2393-402. 2006
    ..Thus, CNS antigen-specific T and B cells cooperate to induce a distinct clinicopathologic EAE pattern that closely replicates human Devic disease...
  69. ncbi request reprint Association of CD163+ macrophages and local production of soluble CD163 with decreased lymphocyte activation in spondylarthropathy synovitis
    Dominique Baeten
    Department of Rheumatology, 0K12IB, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Arthritis Rheum 50:1611-23. 2004
    ..Since CD163+ macrophages are selectively increased in spondylarthropathy (SpA) synovitis, we investigated the role of CD163+ macrophages in synovial inflammation...
  70. ncbi request reprint The histopathology of spondyloarthropathy
    Dominique Baeten
    Department of Rheumatology, Ghent University Hospital, Belgium
    Curr Mol Med 4:1-12. 2004
    ....
  71. ncbi request reprint Gut inflammation and spondyloarthropathies
    Filip De Keyser
    Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, Ghent B 9000, Belgium
    Curr Rheumatol Rep 4:525-32. 2002
    ..The recent introduction and positioning of anti-tumor necrosis factor-alpha therapy in patients with ankylosing spondylitis and other types of SpA is, in large part, based on this concept...
  72. ncbi request reprint Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor alpha (infliximab) versus placebo in active spondylarthropathy
    Filip Van den Bosch
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Arthritis Rheum 46:755-65. 2002
    ..To confirm in a placebo-controlled trial the safety and efficacy profile of infliximab in short-term treatment of patients with active spondylarthropathy (SpA)...