E Aronica

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi Overexpression of the human major vault protein in gangliogliomas
    Eleonora Aronica
    Department of Neuro Pathology, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 44:1166-75. 2003
  2. ncbi Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 45:441-51. 2004
  3. ncbi Differential expression of major histocompatibility complex class I in developmental glioneuronal lesions
    Avanita S Prabowo
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands
    J Neuroinflammation 10:12. 2013
  4. ncbi Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 β
    Emanuele Zurolo
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, AZ 1105, The Netherlands
    J Neuroinflammation 9:280. 2012
  5. ncbi Cerebral expression of drug transporters in epilepsy
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Adv Drug Deliv Rev 64:919-29. 2012
  6. ncbi Astrocyte immune responses in epilepsy
    Eleonora Aronica
    Department of Neuro Pathology, Academisch Medisch Centrum, Amsterdam, The Netherlands
    Glia 60:1258-68. 2012
  7. ncbi Cellular distribution of vascular endothelial growth factor A (VEGFA) and B (VEGFB) and VEGF receptors 1 and 2 in focal cortical dysplasia type IIB
    Karin Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Acta Neuropathol 115:683-96. 2008
  8. ncbi Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Neurosci 31:1100-7. 2010
  9. ncbi Expression and cellular distribution of high- and low-affinity neurotrophin receptors in malformations of cortical development
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Acta Neuropathol 108:422-34. 2004
  10. ncbi Gene expression profile analysis of epilepsy-associated gangliogliomas
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Neuroscience 151:272-92. 2008

Detail Information

Publications110 found, 100 shown here

  1. ncbi Overexpression of the human major vault protein in gangliogliomas
    Eleonora Aronica
    Department of Neuro Pathology, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 44:1166-75. 2003
    ..We investigated the expression and cellular localization of MVP in gangliogliomas (GGs), which are increasingly recognized causes of chronic pharmacoresistant epilepsy...
  2. ncbi Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 45:441-51. 2004
    ....
  3. ncbi Differential expression of major histocompatibility complex class I in developmental glioneuronal lesions
    Avanita S Prabowo
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands
    J Neuroinflammation 10:12. 2013
    ..abstract:..
  4. ncbi Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 β
    Emanuele Zurolo
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, AZ 1105, The Netherlands
    J Neuroinflammation 9:280. 2012
    ..abstract:..
  5. ncbi Cerebral expression of drug transporters in epilepsy
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Adv Drug Deliv Rev 64:919-29. 2012
    ..Knowledge of the cerebral expression patterns of drug transporters in normal and epileptogenic brain will provide relevant information to guide strategies attempting to overcome drug resistance by targeting specific transporters...
  6. ncbi Astrocyte immune responses in epilepsy
    Eleonora Aronica
    Department of Neuro Pathology, Academisch Medisch Centrum, Amsterdam, The Netherlands
    Glia 60:1258-68. 2012
    ....
  7. ncbi Cellular distribution of vascular endothelial growth factor A (VEGFA) and B (VEGFB) and VEGF receptors 1 and 2 in focal cortical dysplasia type IIB
    Karin Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Acta Neuropathol 115:683-96. 2008
    ..In addition, the expression of VEGFA and its receptors in glial cells within the dysplastic cortex indicates that VEGF-mediated signaling could contribute to astroglial activation and associated inflammatory reactions...
  8. ncbi Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Neurosci 31:1100-7. 2010
    ....
  9. ncbi Expression and cellular distribution of high- and low-affinity neurotrophin receptors in malformations of cortical development
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Acta Neuropathol 108:422-34. 2004
    ..Further research is necessary to investigate how activation of these specific receptors could contribute to the development and the epileptogenicity of these developmental disorders...
  10. ncbi Gene expression profile analysis of epilepsy-associated gangliogliomas
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Neuroscience 151:272-92. 2008
    ..Furthermore, they indicate possible targets that may be investigated in order to dissect the mechanisms of epileptogenesis and possibly counteract the epileptogenic process in these developmental lesions...
  11. ncbi Activation of metabotropic glutamate receptor 3 enhances interleukin (IL)-1beta-stimulated release of IL-6 in cultured human astrocytes
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Neuroscience 130:927-33. 2005
    ....
  12. ncbi Interleukin-1 beta down-regulates the expression of metabotropic glutamate receptor 5 in cultured human astrocytes
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9 1105 AZ Amsterdam, The Netherlands
    J Neuroimmunol 160:188-94. 2005
    ..Thus, interleukin 1beta may represent an additional pathway through which mGluR5 expression and function can be modulated in astrocytes under different pathological conditions associated with an inflammatory response...
  13. ncbi Congenital disorder of glycosylation type Ia: a clinicopathological report of a newborn infant with cerebellar pathology
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Acta Neuropathol 109:433-42. 2005
    ..The data proved useful in determining the underlying disease process associated with a defective N-glycosylation pathway...
  14. ncbi Distribution, characterization and clinical significance of microglia in glioneuronal tumours from patients with chronic intractable epilepsy
    E Aronica
    Department of Neuro Pathology, Academic Medical Centre, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Neuropathol Appl Neurobiol 31:280-91. 2005
    ....
  15. ncbi Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 46:849-57. 2005
    ..This study investigated the expression and cellular distribution of BCRP in human control and epileptic brain, including a large number of both neoplastic and nonneoplastic specimens from patients with chronic pharmacoresistant epilepsy...
  16. ncbi Gene expression profile in temporal lobe epilepsy
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Neuroscientist 13:100-8. 2007
    ....
  17. ncbi Inhibitory networks in epilepsy-associated gangliogliomas and in the perilesional epileptic cortex
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Epilepsy Res 74:33-44. 2007
    ....
  18. ncbi Differential expression patterns of chloride transporters, Na+-K+-2Cl--cotransporter and K+-Cl--cotransporter, in epilepsy-associated malformations of cortical development
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Neuroscience 145:185-96. 2007
    ....
  19. ncbi Inflammation in epilepsy: clinical observations
    Eleonora Aronica
    Department of Neuro Pathology, University of Amsterdam and Epilepsy Institute, The Netherlands
    Epilepsia 52:26-32. 2011
    ....
  20. ncbi Expression and cell distribution of group I and group II metabotropic glutamate receptor subtypes in taylor-type focal cortical dysplasia
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 44:785-95. 2003
    ..Because recent studies indicate that metabotropic glutamate receptor subtypes (mGluRs) play a role in epileptogenesis, we investigated the expression and cellular distribution pattern of mGluRs in FCD specimens...
  21. ncbi Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Neurosci 17:2106-18. 2003
    ....
  22. ncbi Expression of brain-derived neurotrophic factor and tyrosine kinase B receptor proteins in glioneuronal tumors from patients with intractable epilepsy: colocalization with N-methyl-D-aspartic acid receptor
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Acta Neuropathol 101:383-92. 2001
    ..In addition, since these neurons contain both NMDAR1 and NMDAR2A/B subunits, the BDNF-TrkB pathway may also contribute through a modulation of glutamatergic transmission to the intrinsic epileptogenicity of glioneuronal tumors...
  23. ncbi Expression of connexin 43 and connexin 32 gap-junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Acta Neuropathol 101:449-59. 2001
    ..The high expression of connexin proteins in low-grade tumors and in the peritumoral reactive astrocytes suggests that they could contribute to tumor-related seizures...
  24. ncbi Ionotropic and metabotropic glutamate receptor protein expression in glioneuronal tumours from patients with intractable epilepsy
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropathol Appl Neurobiol 27:223-37. 2001
    ....
  25. ncbi Immunohistochemical localization of group I and II metabotropic glutamate receptors in control and amyotrophic lateral sclerosis human spinal cord: upregulation in reactive astrocytes
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Neuroscience 105:509-20. 2001
    ..Upregulation of mGluRs in reactive astrocytes may represent a critical mechanism for modulation of glial function and changes in glial-neuronal communication in the course of neurodegenerative diseases...
  26. ncbi Glioneuronal tumors and medically intractable epilepsy: a clinical study with long-term follow-up of seizure outcome after surgery
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Epilepsy Res 43:179-91. 2001
    ..01). Our results indicate that a prompt diagnosis, relatively soon after seizure onset, followed by complete resection of glioneuronal tumors provides the best chance for curing epilepsy and preventing their malignant transformation...
  27. ncbi Expression and localization of voltage dependent potassium channel Kv4.2 in epilepsy associated focal lesions
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurobiol Dis 36:81-95. 2009
    ....
  28. ncbi Ontogenetic modifications of neuronal excitability during brain maturation: developmental changes of neurotransmitter receptors
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Epilepsia 52:3-5. 2011
    ..We will also briefly discuss recent evidence on the involvement of the endocannabinoid signaling in the regulation of neuronal excitability during early brain development....
  29. ncbi Expression and regulation of voltage-gated sodium channel beta1 subunit protein in human gliosis-associated pathologies
    Eleonora Aronica
    Department of Neuro Pathology, H2, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Acta Neuropathol 105:515-23. 2003
    ..These findings demonstrate that the expression of NaCh beta1 subunit protein in astrocytes is plastic, and indicate a novel mechanism for modulation of glial function in gliosis-associated pathologies...
  30. ncbi Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 Amsterdam, The Netherlands
    Neuroscience 118:417-29. 2003
    ....
  31. ncbi Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 52:1645-55. 2011
    ..We hypothesized that dysregulation of ADK is an ubiquitous pathologic hallmark of TLE...
  32. ncbi Cystatin C, a cysteine protease inhibitor, is persistently up-regulated in neurons and glia in a rat model for mesial temporal lobe epilepsy
    E Aronica
    Department of (Neuro)-Pathology, Academic Medical Centre, University of Amsterdam, The Netherlands
    Eur J Neurosci 14:1485-91. 2001
    ....
  33. ncbi Complement activation in experimental and human temporal lobe epilepsy
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Neurobiol Dis 26:497-511. 2007
    ..The persistence of complement activation could contribute to a sustained inflammatory response and could destabilize neuronal networks involved...
  34. ncbi Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies
    A M Iyer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuroscience 167:929-45. 2010
    ....
  35. ncbi Immunohistochemical characterization of the out-of frame splice variants GFAP Delta164/Deltaexon 6 in focal lesions associated with chronic epilepsy
    K Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Epilepsy Res 90:99-109. 2010
    ..Thus, the possible role of this subpopulation of astrocytes in epilepsy is likely minor, compared to astrocytes expressing other GFAP isoforms...
  36. ncbi Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and somatostatin-immunoreactive neurons
    J A Gorter
    Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Neurosci 13:657-69. 2001
    ....
  37. ncbi Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex
    K Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Epilepsy Res 78:7-21. 2008
    ..Our findings demonstrate a persistent and complex activation of inflammatory pathways in cortical tubers and SGCT...
  38. ncbi A neuropathological study of two autopsy cases of syndromic hemimegalencephaly
    K Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropathol Appl Neurobiol 33:455-70. 2007
    ....
  39. ncbi Expression patterns of Group III metabotropic glutamate receptors mGluR4 and mGluR8 in multiple sclerosis lesions
    J J G Geurts
    MS Research Center, VU Medical Center, Amsterdam, The Netherlands
    J Neuroimmunol 158:182-90. 2005
    ..Our results suggest a role for these receptor subtypes in the inflammatory response in MS that involves both astrocytes and cells of the microglia/macrophage lineage...
  40. ncbi Induction of neonatal sodium channel II and III alpha-isoform mRNAs in neurons and microglia after status epilepticus in the rat hippocampus
    E Aronica
    Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Neurosci 13:1261-6. 2001
    ....
  41. ncbi Cellular localization of metabotropic glutamate receptors in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex
    K Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Neuroscience 156:203-15. 2008
    ..Individual mGluR subtypes may represent potential pharmacological targets for the treatment of the neurological manifestations associated with TSC brain lesions...
  42. ncbi Innate and adaptive immunity in amyotrophic lateral sclerosis: evidence of complement activation
    M Sta
    Department of Genome Analysis, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
    Neurobiol Dis 42:211-20. 2011
    ..We propose a complement-driven immune response which may contribute to the progression of the inflammation and ultimately lead to even more motor neuron injury...
  43. ncbi Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy
    L Holtman
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Epilepsy Res 84:56-66. 2009
    ....
  44. ncbi Evidence of activated microglia in focal cortical dysplasia
    K Boer
    Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Neuroimmunol 173:188-95. 2006
    ....
  45. ncbi CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies
    E Zurolo
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Neuroscience 170:28-41. 2010
    ....
  46. ncbi Expression of Id proteins increases in astrocytes in the hippocampus of epileptic rats
    E Aronica
    Department of (Neuro) Pathology H2, Academic Medical Center, Meibergdreef 9, University of Amsterdam, 1105 AZ Amsterdam; The Netherlands
    Neuroreport 12:2461-5. 2001
    ..Three months after SE when rats experience spontaneous seizures, Id expression had returned to control levels. These results support a role of the Id gene family in regulating astrocyte reactivity in epileptic tissue...
  47. ncbi Sodium channel beta1-subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Section of Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 16:360-4. 2002
    ....
  48. ncbi Complement protein 6 deficiency in PVG/c rats does not lead to neuroprotection against seizure induced cell death
    L Holtman
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    Neuroscience 188:109-16. 2011
    ..Whether complement components upstream of MAC play a crucial role in neuronal death and/or epileptogenesis needs to be further investigated...
  49. ncbi Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue
    M Casula
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Neuroscience 179:233-43. 2011
    ..In this context, future studies, using animal models, will be important to achieve a better understanding of these signaling pathways in ALS in view of the development of new therapeutic strategies...
  50. ncbi Glutamate transporters alterations in the reorganizing dentate gyrus are associated with progressive seizure activity in chronic epileptic rats
    Jan A Gorter
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM, Amsterdam, The Netherlands
    J Comp Neurol 442:365-77. 2002
    ..Considering the steady growth of reorganizing mossy fibers in the iml, the absence of a glutamate reuptake mechanism in this region could contribute to progression of spontaneous seizure activity, which occurs with a similar time course...
  51. ncbi Immunohistochemical localization of vascular endothelial growth factor receptors-1, -2 and -3 in human spinal cord: altered expression in amyotrophic lateral sclerosis
    W G M Spliet
    Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropathol Appl Neurobiol 30:351-9. 2004
    ..Moreover, the altered expression observed in ALS supports a role for these receptors in the complex reactive processes that are associated with the progression of spinal cord damage...
  52. ncbi Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats
    E A van Vliet
    Epilepsy Institute of The Netherlands, Heemstede, The Netherlands
    J Pharmacol Exp Ther 322:141-7. 2007
    ..These findings show that overexpression of P-gp at the blood-brain barrier of specific limbic brain regions causes a decrease of local PHT levels in the rat brain...
  53. ncbi Increased expression of connective tissue growth factor in amyotrophic lateral sclerosis human spinal cord
    Wim G M Spliet
    Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Acta Neuropathol (Berl) 106:449-57. 2003
    ..However, the altered CTGF expression observed in neurons might represent an additional mechanism involved in motor neuron dysfunction and changes in glial-neuronal communication in the course of the neurodegenerative process...
  54. ncbi Increased expression of ferritin, an iron-storage protein, in specific regions of the parahippocampal cortex of epileptic rats
    Jan A Gorter
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 46:1371-9. 2005
    ..In this study we used ferritin as indicator for disturbed iron homeostasis to acquire insight into whether this could play a role in the pathogenesis of temporal lobe epilepsy...
  55. ncbi Expression and distribution of id helix-loop-helix proteins in human astrocytic tumors
    Dmitri A A Vandeputte
    Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Glia 38:329-38. 2002
    ..The evidence also supports the involvement of the Id gene family in tumor angiogenesis, a process that critically influences the malignant behavior of glial tumors...
  56. ncbi Expression patterns of AMOG in developing human cortex and malformations of cortical development
    K Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Epilepsy Res 91:84-93. 2010
    ..Whether dysfunction of AMOG might influence the ionic and osmotic regulation, contributing to neuronal hyperexcitability, deserves further investigation...
  57. ncbi Differential distribution of group I metabotropic glutamate receptors in developing human cortex
    Karin Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Brain Res 1324:24-33. 2010
    ..These findings show a differential expression pattern of group I mGluR subtypes, suggesting a role for both receptors in the early stages of corticogenesis with, however, a different contribution to human cortical developmental events...
  58. ncbi Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias
    Anand Iyer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 51:1763-73. 2010
    ..In the present study we examined the innate and adaptive immune responses in focal cortical dysplasia (FCD) with different histopathologic and pathogenetic features...
  59. ncbi Localization of mGluR5, GABAB, GABAA, and cannabinoid receptors on the vago-vagal reflex pathway responsible for transient lower esophageal sphincter relaxation in humans: an immunohistochemical study
    W O Rohof
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    Neurogastroenterol Motil 24:383-e173. 2012
    ..However, the distribution of these receptors in the neural pathway underlying the triggering of TLESRs has not been evaluated in humans...
  60. ncbi Concomitant CNS pathology in a patient with amyotropic lateral sclerosis following poliomyelitis in childhood
    M Casula
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Clin Neuropathol 30:111-7. 2011
    ....
  61. ncbi Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma
    M de Groot
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 77:532-9. 2011
    ..To correlate SV2A expression in surgically removed tumor and peritumoral tissue of glioma patients with epilepsy with the clinical response to levetiracetam in a prospective cohort...
  62. ncbi Extension of the clinical spectrum of Danon disease
    A J van der Kooi
    Department of Neurology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam
    Neurology 70:1358-9. 2008
  63. ncbi A case of neonatal dural sinus malformation: clinical symptoms, imaging and neuropathological investigations
    T R de Haan
    Department of Paediatrics, Division of Neonatology, Academic Medical Centre, Meibergdreef 9, 1100 DD Amsterdam, The Netherlands
    Eur J Paediatr Neurol 12:41-5. 2008
    ..The diagnosis was confirmed with autopsy. We discuss the clinical presentation, imaging and neuropathological results and relate our findings to embryological data and the existing literature...
  64. ncbi Specific human astrocyte subtype revealed by affinity purified GFAP antibody; unpurified serum cross-reacts with neurofilament-L in Alzheimer
    Jinte Middeldorp
    Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    PLoS ONE 4:e7663. 2009
    ..g., along the subventricular zone, in the hippocampus, in the striatum and in the spinal cord of controls, Alzheimer, and Parkinson patients. The presence of a specific GFAP-isoform suggests a specialized function of these astrocytes...
  65. ncbi Calcium extrusion protein expression in the hippocampal formation of chronic epileptic rats after kainate-induced status epilepticus
    Susan O M Ketelaars
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 45:1189-201. 2004
    ..We investigated whether the expression of these calcium-extrusion proteins is altered in the course of epileptogenesis...
  66. ncbi Induction of sodium channel Na(x) (SCN7A) expression in rat and human hippocampus in temporal lobe epilepsy
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 51:1791-800. 2010
    ..Herein we investigated the expression and cellular distribution of SCN7A mRNA and protein in normal and epileptic rat and human hippocampus...
  67. ncbi Astrocytes produce interferon-alpha and CXCL10, but not IL-6 or CXCL8, in Aicardi-Goutières syndrome
    Jane T van Heteren
    Emma Children s Hospital, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Glia 56:568-78. 2008
    ..The lack of the inflammatory cytokines IL-6 and CXCL8 in AGS suggest that the neuroinflammatory reaction in this disease is distinct from viral disease...
  68. ncbi Expression patterns of synaptic vesicle protein 2A in focal cortical dysplasia and TSC-cortical tubers
    Sjoukje T Toering
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Epilepsia 50:1409-18. 2009
    ..The aim of the study was to define the expression and cell-specific distribution of SV2A in developmental focal lesions associated with medically intractable epilepsy...
  69. ncbi Pontocerebellar hypoplasia type 2: a neuropathological update
    Peter G Barth
    Department of Neuropathology, Academic Medical Centre, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Acta Neuropathol 114:373-86. 2007
    ..Immunohistochemical evaluation of the endoplasmic reticulum stress response is negative. We conclude that the neuropathological findings in PCH-2 are sufficiently specific to enable an unequivocal diagnosis based on neuropathology...
  70. ncbi Rhabdomyolysis in pontocerebellar hypoplasia type 2 (PCH-2)
    Peter G Barth
    Department of Paediatric Neurology, Room G8 211, Emma Children s Hospital Academic Medical Centre, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Neuromuscul Disord 18:52-8. 2008
    ..Random serum creatine kinase values in six other PCH-2 patients without clinical signs of neuromuscular involvement were increased in four. Collected data provide preliminary evidence of a subclinical myopathy associated with PCH-2...
  71. ncbi Decreased cortical inhibition and yet cerebellar pathology in 'familial cortical myoclonic tremor with epilepsy'
    Anne Fleur van Rootselaar
    Department of Neurology and Clinical Neurophysiology, University of Amsterdam, Amsterdam, The Netherlands
    Mov Disord 22:2378-85. 2007
    ..Alternatively, decreased cortical inhibition may be caused by dysfunction of the cerebello-thalamo-cortical loop as a result of primary cerebellar pathology...
  72. ncbi Altered expression patterns of group I and II metabotropic glutamate receptors in multiple sclerosis
    J J G Geurts
    Department of Radiology, Division of Neuropathology, Vrije Universiteit Medical Center, Meibergdreef 9, 91105 AZ Amsterdam, The Netherlands
    Brain 126:1755-66. 2003
    ....
  73. ncbi Dynamic changes of proteases and protease inhibitors revealed by microarray analysis in CA3 and entorhinal cortex during epileptogenesis in the rat
    Jan A Gorter
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan, Amsterdam, The Netherlands
    Epilepsia 48:53-64. 2007
    ..The fact that several proteolytic genes were still activated in the chronic epileptic phase makes them interesting candidates to modify and slow down seizure progression...
  74. ncbi Pi3K-mTOR signaling and AMOG expression in epilepsy-associated glioneuronal tumors
    Karin Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Brain Pathol 20:234-44. 2010
    ..The strong expression of AMOG within the precursor cells of GG may represent an additional marker for the diagnostic evaluation of these glioneuronal lesions...
  75. ncbi Familial cortical tremor with epilepsy and cerebellar pathological findings
    Anne-Fleur van Rootselaar
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Mov Disord 19:213-7. 2004
    ..Pathological investigation showed cerebellar degeneration and somal sprouting and loss of dendritic tree in Purkinje cells. Striking similarities were found in diseases caused by channelopathies such as spinocerebellar ataxia subtype 6...
  76. ncbi Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Epilepsia 44:647-58. 2003
    ....
  77. ncbi GAP-43 mRNA and protein expression in the hippocampal and parahippocampal region during the course of epileptogenesis in rats
    Else A Tolner
    Swammerdam Institute of Life Sciences, Section of Neurobiology, University of Amsterdam, Graduate School of Neurosciences Amsterdam, 1098 SM, Amsterdam, The Netherlands
    Eur J Neurosci 17:2369-80. 2003
    ..Whether reorganization of fibers has occurred in this region after SE needs to be investigated with tools other than GAP-43...
  78. ncbi Progression of temporal lobe epilepsy in the rat is associated with immunocytochemical changes in inhibitory interneurons in specific regions of the hippocampal formation
    Erwin A van Vliet
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Exp Neurol 187:367-79. 2004
    ....
  79. ncbi Cerebral necrosis after 25Gy radiotherapy in childhood followed 28 years later by 54Gy radiotherapy
    Radboud W Koot
    Department of Neurosurgery, Academic Medical Center, University of Amsterdam, The Netherlands
    Clin Neurol Neurosurg 109:607-12. 2007
    ..Patients undergoing repeat radiotherapy therefore need to be followed life-long for potential late radiation toxicity...
  80. ncbi Co-expression of cyclin D1 and phosphorylated ribosomal S6 proteins in hemimegalencephaly
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Acta Neuropathol 114:287-93. 2007
    ..PTEN, TSC1, or TSC2 gene mutations were not detected suggesting that sporadic HMEG is distinct from HMEG associated with Proteus syndrome or tuberous sclerosis complex...
  81. ncbi GFAPdelta in radial glia and subventricular zone progenitors in the developing human cortex
    Jinte Middeldorp
    Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Development 137:313-21. 2010
    ..Furthermore, we provide evidence that GFAPdelta can distinguish resting astrocytes from proliferating SVZ progenitors...
  82. ncbi Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy
    Jan A Gorter
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM, Amsterdam, The Netherlands
    J Neurosci 26:11083-110. 2006
    ..Especially genes related to the immune response, such as complement factors, interleukins, and genes related to prostaglandin synthesis and coagulation pathway may be interesting targets...
  83. ncbi Doublecortin-like (DCL) expression in focal cortical dysplasia and cortical tubers
    Karin Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 50:2629-37. 2009
    ..The aim of our study was to define the expression and cell-specific distribution of doublecortin-like (DCL), a protein critically involved in neuronal division and radial migration during early corticogenesis, in both FCD and TSC...
  84. ncbi Clinicopathological and immunohistochemical findings in an autopsy case of tuberous sclerosis complex
    Karin Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropathology 28:577-90. 2008
    ..Autopsy findings confirm the complexity of the brain abnormalities encountered in TSC patients and proved useful in clarifying certain aspects of the pathogenesis, epileptogenesis and pharmacoresistance of TSC lesions...
  85. ncbi Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment
    Dannis G van Vuurden
    Department of Pediatric Oncology Hematology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 4:e5953. 2009
    ..This commonly results in Na(+) and Ca(2+)-permeability and thereby in excitotoxic cell death of the surrounding neurons. Here we investigated how the GBM cells themselves survive in a glutamate-rich environment...
  86. ncbi Gene expression analysis of tuberous sclerosis complex cortical tubers reveals increased expression of adhesion and inflammatory factors
    Karin Boer
    Department of Neuro Pathology, Academic Medical Center, Amsterdam, The Netherlands
    Brain Pathol 20:704-19. 2010
    ..Changes in gene expression yield insights into new candidate genes that may contribute to tuber formation or seizure onset, representing new targets for potential therapeutic development...
  87. ncbi Long-lasting increased excitability differs in dentate gyrus vs. CA1 in freely moving chronic epileptic rats after electrically induced status epilepticus
    Jan A Gorter
    Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    Hippocampus 12:311-24. 2002
    ..These observed changes indicate a lasting increased excitability in CA1 and DG networks that could play a role in the recurrence of spontaneous seizures...
  88. ncbi Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development
    Emanuele Zurolo
    Department of Neuro Pathology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Brain 134:1015-32. 2011
    ..Our findings provide novel evidence of intrinsic activation of these pro-inflammatory signalling pathways in focal malformations of cortical development, which could contribute to the high epileptogenicity of these developmental lesions...
  89. ncbi Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients
    Paul J Lucassen
    Centre for Neuroscience, Swammerdam Institute of Life Sciences, University of Amsterdam, P O box 94214, 1090 GE Amsterdam, The Netherlands
    Neuropharmacology 58:940-9. 2010
    ..Whether the reduction is a cause or consequence of depression awaits to be determined...
  90. ncbi Expression and cellular distribution of major vault protein: a putative marker for pharmacoresistance in a rat model for temporal lobe epilepsy
    Erwin A van Vliet
    Stichting Epilepsie Instellingen Nederland, Heemstede, The Netherlands
    Epilepsia 45:1506-16. 2004
    ..CONCLUSIONS: MVP expression is upregulated in chronic epileptic rats and may contribute to the development of pharmacoresistance...
  91. ncbi Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance
    Massimo Rizzi
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
    J Neurosci 22:5833-9. 2002
    ..P-gp alterations significantly affect antiepileptic drugs concentrations in the brain, suggesting that seizure-induced mdr mRNA expression contributes to MDR in epilepsy...
  92. ncbi Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    Teresa Ravizza
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Neurobiol Dis 29:142-60. 2008
    ..These data show that specific inflammatory pathways are chronically activated during epileptogenesis and they persist in chronic epileptic tissue, suggesting they may contribute to the etiopathogenesis of TLE...
  93. ncbi Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats
    Erwin A van Vliet
    Epilepsy Institute of The Netherlands (SEIN, Heemstede, The Netherlands
    Epilepsia 47:672-80. 2006
    ....
  94. ncbi Targeted gene expression analysis in hemimegalencephaly: activation of beta-catenin signaling
    Jia Yu
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Brain Pathol 15:179-86. 2005
    ..Enhanced cyclin D1 and c-myc transcription likely reflects increased transcriptionally active beta-catenin due to decreased Ser33/Ser37/Thr41 phospho-beta-catenin and suggests activation of the Wnt-1/beta-catenin cascade in HMEG...
  95. ncbi Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats
    Erwin A van Vliet
    Epilepsy Institute of the Netherlands SEIN, Heemstede, The Netherlands
    Epilepsia 46:1569-80. 2005
    ..In the present study, we investigated the expression of different multidrug transporters during epileptogenesis in the rat. In addition, we determined whether these transporters affected phenytoin (PHT) distribution in the brain...
  96. ncbi GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) "phasic" receptors
    Eleonora Palma
    Dipartimento di Fisiologia Umana e Farmacologia Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma Sapienza, Piazzale A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 104:20944-8. 2007
    ..Our findings point to the rundown of GABA(A) receptors as a hallmark of TLE and suggest that modulating tonic and phasic mTLE GABA(A) receptor activity may represent a useful therapeutic approach to the disease...
  97. ncbi Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain
    Andrea Caricasole
    Siena Biotech, 53100 Siena, Italy
    J Neurosci 24:6021-7. 2004
    ..We conclude that induction of DKK1 contributes to the pathological cascade triggered by beta-amyloid and is critically involved in the process of tau phosphorylation...
  98. ncbi Upregulation of neuronal nitric oxide synthase in in vitro stellate astrocytes and in vivo reactive astrocytes after electrically induced status epilepticus
    Maria Vincenza Catania
    Institute of Neurological Sciences, National Research Council, Section of Catania, Vl Regina Margherita 6, 95125 Catania, Italy
    Neurochem Res 28:607-15. 2003
    ..Thus, nNOS upregulation occurs in both in vitro stellate and in vivo reactive astrocytes, suggesting a possible involvement of glial nNOS in neurological diseases characterized by reactive gliosis...
  99. ncbi Electrocorticography discharge patterns in patients with a cavernous hemangioma and pharmacoresistent epilepsy
    Cyrille H Ferrier
    Department of Clinical Neurophysiology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    J Neurosurg 107:495-503. 2007
    ..Because cavernomas, another congenital abnormality, are also associated with pharmacoresistant epilepsy, the authors wondered whether they exhibit discharge patterns similar to those occurring in NDLs...
  100. ncbi Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats
    Erwin van Vliet
    Stichting Epilepsie Instellingen Nederland, Achterweg 5, 2103 SW Heemstede, The Netherlands
    Epilepsy Res 60:203-13. 2004
    ..These findings show that both mdr1a and mdr1b are induced by SE, although the increase in mdr1b isoform was more persistent. More importantly, increased P-gp expression is still present in chronic epileptic rats...
  101. ncbi Altered expression of neurotransmitter-receptor subunit and uptake site mRNAs in hemimegalencephaly
    Marianna Baybis
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 45:1517-24. 2004
    ..CONCLUSIONS: Selective alterations occur in distinct neurotransmitter-receptor and -uptake sites in HMEG. Differential expression of neurotransmitter-receptor and -uptake sites in HMEG may contribute to epileptogenesis in HMEG...