Derk Amsen

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. pmc Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
    Derk Amsen
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:89-99. 2007
  2. doi request reprint The different faces of Notch in T-helper-cell differentiation
    Derk Amsen
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Rev Immunol 9:116-24. 2009
  3. ncbi request reprint Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
    Derk Amsen
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 117:515-26. 2004
  4. pmc Notch controls the magnitude of T helper cell responses by promoting cellular longevity
    Christina Helbig
    Department of Cell Biology and Histology, Academic Medical Center, 1105AZ Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 109:9041-6. 2012
  5. pmc How are T(H)1 and T(H)2 effector cells made?
    Derk Amsen
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Curr Opin Immunol 21:153-60. 2009
  6. doi request reprint Decisions on the road to memory
    Derk Amsen
    Department of Hematopoiesis, Sanquin Sanquin Research at CLB and Landsteiner Laboratory, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands
    Adv Exp Med Biol 785:107-20. 2013
  7. doi request reprint The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1
    Julien J Karrich
    Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, Amsterdam, The Netherlands
    Blood 119:5191-200. 2012
  8. doi request reprint Co-ordination of incoming and outgoing traffic in antigen-presenting cells by pattern recognition receptors and T cells
    Priyanka Nair
    Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Traffic 12:1669-76. 2011

Collaborators

Detail Information

Publications8

  1. pmc Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
    Derk Amsen
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:89-99. 2007
    ..Moreover, absence of GATA-3 turned Notch from a Th2 inducer into a powerful inducer of Th1 differentiation. Therefore, Gata3 is a critical element determining inductive Th2 differentiation and limiting Th1 differentiation by Notch...
  2. doi request reprint The different faces of Notch in T-helper-cell differentiation
    Derk Amsen
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Rev Immunol 9:116-24. 2009
    ..In this Review, we discuss recent findings that help to reconcile this discrepancy and highlight the accumulating evidence for the role of Notch in T-cell-mediated diseases...
  3. ncbi request reprint Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
    Derk Amsen
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 117:515-26. 2004
    ..Notch directs Th2 differentiation by inducing GATA3 and by directly regulating il4 gene transcription through RBPJkappa sites in a 3' enhancer...
  4. pmc Notch controls the magnitude of T helper cell responses by promoting cellular longevity
    Christina Helbig
    Department of Cell Biology and Histology, Academic Medical Center, 1105AZ Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 109:9041-6. 2012
    ..Our findings, therefore, show that Notch controls the magnitude of CD4(+) T-cell responses by promoting cellular longevity...
  5. pmc How are T(H)1 and T(H)2 effector cells made?
    Derk Amsen
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Curr Opin Immunol 21:153-60. 2009
    ..Together, these mechanisms ensure stable inheritance of the differentiated fate in the numerous progeny of the original naïve CD4(+) T cells...
  6. doi request reprint Decisions on the road to memory
    Derk Amsen
    Department of Hematopoiesis, Sanquin Sanquin Research at CLB and Landsteiner Laboratory, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands
    Adv Exp Med Biol 785:107-20. 2013
    ..As the mechanisms determining generation of immunological memory are unraveled, opportunities will emerge for the improvement of vaccination strategies...
  7. doi request reprint The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1
    Julien J Karrich
    Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, Amsterdam, The Netherlands
    Blood 119:5191-200. 2012
    ..In search for Spi-B target genes, we identified the antiapoptotic gene Bcl2-A1 as a specific and direct target gene, thereby consolidating the critical role of Spi-B in cell survival...
  8. doi request reprint Co-ordination of incoming and outgoing traffic in antigen-presenting cells by pattern recognition receptors and T cells
    Priyanka Nair
    Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Traffic 12:1669-76. 2011
    ....