Amantha Thathiah

Summary

Publications

  1. doi The role of G protein-coupled receptors in the pathology of Alzheimer's disease
    Amantha Thathiah
    Department for Molecular and Developmental Genetics, Flanders Institute for Biotechnology VIB, Leuven, Belgium
    Nat Rev Neurosci 12:73-87. 2011
  2. doi β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease
    Amantha Thathiah
    Vlaams Instituut voor Biotechnologie Center for the Biology of Disease, Leuven, Belgium
    Nat Med 19:43-9. 2013
  3. pmc Alteration of the microRNA network during the progression of Alzheimer's disease
    Pierre Lau
    VIB Center for the Biology of Disease, Leuven, Belgium Center for Human Genetics, Leuven Institute for Neurodegenerative Disorders LIND University Hospitals Leuven, and University of Leuven, O and N4, Herestraat, Leuven, Belgium
    EMBO Mol Med 5:1613-34. 2013
  4. pmc Regulation of amyloid precursor protein processing by serotonin signaling
    Anna A Pimenova
    KU Leuven Center for Human Genetics and Leuven research Institute for Neuroscience and Disease LIND, Leuven, Belgium VIB Center for the Biology of disease, Leuven, Belgium
    PLoS ONE 9:e87014. 2014
  5. ncbi G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease
    Amantha Thathiah
    Molecular and Developmental Genetics, VIB, Leuven, Belgium
    Sci Signal 2:re8. 2009

Collaborators

Detail Information

Publications5

  1. doi The role of G protein-coupled receptors in the pathology of Alzheimer's disease
    Amantha Thathiah
    Department for Molecular and Developmental Genetics, Flanders Institute for Biotechnology VIB, Leuven, Belgium
    Nat Rev Neurosci 12:73-87. 2011
    ..Additionally, amyloid-β has been shown to perturb GPCR function. Emerging insights into the mechanistic link between GPCRs and AD highlight the potential of this class of receptors as a therapeutic target for AD...
  2. doi β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease
    Amantha Thathiah
    Vlaams Instituut voor Biotechnologie Center for the Biology of Disease, Leuven, Belgium
    Nat Med 19:43-9. 2013
    ..Collectively, these studies identify β-arrestin 2 as a new therapeutic target for reducing amyloid pathology and GPCR dysfunction in Alzheimer's disease...
  3. pmc Alteration of the microRNA network during the progression of Alzheimer's disease
    Pierre Lau
    VIB Center for the Biology of Disease, Leuven, Belgium Center for Human Genetics, Leuven Institute for Neurodegenerative Disorders LIND University Hospitals Leuven, and University of Leuven, O and N4, Herestraat, Leuven, Belgium
    EMBO Mol Med 5:1613-34. 2013
    ..We provide evidence that miR-132-3p may contribute to disease progression through aberrant regulation of mRNA targets in the Tau network. The transcription factor (TF) FOXO1a appears to be a key target of miR-132-3p in this pathway. ..
  4. pmc Regulation of amyloid precursor protein processing by serotonin signaling
    Anna A Pimenova
    KU Leuven Center for Human Genetics and Leuven research Institute for Neuroscience and Disease LIND, Leuven, Belgium VIB Center for the Biology of disease, Leuven, Belgium
    PLoS ONE 9:e87014. 2014
    ..Our findings provide a novel route to explore the treatment of AD through 5-HT4 receptor-induced α-secretase activation. ..
  5. ncbi G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease
    Amantha Thathiah
    Molecular and Developmental Genetics, VIB, Leuven, Belgium
    Sci Signal 2:re8. 2009
    ....