Neuropsychiatric non-motor aspects of Parkinson's diseaseB R Thanvi
Department of Integrated Medicine, Leicester General Hospital, University Hospitals of Leicester NHS Trust, UK
Postgrad Med J 79:561-5. 2003
..Pathogenesis of these aspects is not fully understood, though there has been a significant increase in the knowledge in recent years. Management of these aspects involves a multidisciplinary approach...
Cannabis and stroke: is there a link?B R Thanvi
South Warwickshire General Hospital, Lakin Road, Warwick CV34 5BW, UK
Postgrad Med J 85:80-3. 2009
..Presuming that cannabis may cause stroke, potential pathophysiologic mechanisms are not known. In this paper, we shall review the literature linking cannabis use and stroke and possible mechanisms supporting this link...
- Early neurological deterioration in acute ischaemic stroke: predictors, mechanisms and management
B Thanvi
Southwarwickshire Hospital, Warwick, UK
Postgrad Med J 84:412-7. 2008
..END has potentially serious consequences on the short term (morbidity and death) and long term (recovery from stroke) outcomes for the patient. Therefore, attempts to prevent and treat END should be made promptly and aggressively...
- Haemorrhagic transformation in acute ischaemic stroke following thrombolysis therapy: classification, pathogenesis and risk factors
B R Thanvi
Southwarwickshire Hospital, Lakin Road, Warwick CV345BW, UK
Postgrad Med J 84:361-7. 2008
..The knowledge of these factors may help in improving patient selection for thrombolytic therapy...
- Complete occlusion of extracranial internal carotid artery: clinical features, pathophysiology, diagnosis and management
Bhomraj Thanvi
Department of Integrated Medicine, Glenfield General Hospital, University Hospitals of Leicester NHS Trust, Leicester LE3 9QP, UK
Postgrad Med J 83:95-9. 2007
..With advances in the measurement of cerebral haemodynamics, it may be possible to identify high-risk patients who could benefit from the bypass surgery...
Sporadic cerebral amyloid angiopathy--an important cause of cerebral haemorrhage in older peopleBhomraj Thanvi
Leicester General Hospital, Medicine for the Care of Older People, Leicester, UK
Age Ageing 35:565-71. 2006
..Currently, there is no specific treatment available for CAA. Recent advances in the immunopathology and pathogenesis of CAA are expected to help in developing specific anti-amyloid therapy...
- Essential tremor-the most common movement disorder in older people
Bhomraj Thanvi
Leicester General Hospital, Medicine for the Elderly, Leicester, UK
Age Ageing 35:344-9. 2006
..Current therapy (drugs and neurosurgery) has significant limitations in older people. A better understanding of its pathophysiology in the future will help in developing more effective therapy, including neuroprotective strategies...
- Psychosis in Parkinson's disease
B R Thanvi
Department of Medicine for Older People, Leicester General Hospital, University Hospitals of Leicester NHS Trust, Leicester LE5 4PW, UK
Postgrad Med J 81:644-6. 2005
..Some of the newer atypical antipsychotics are effective against psychosis with no significant worsening of PD. Psychosis in PD is associated with poor quality of life for patients and the carers...
- Freezing of gait in older people: associated conditions, clinical aspects, assessment and treatment
Bhomraj Thanvi
South Warwickshire General Hospital, Lakin Road, Warwick CV34 5BW, UK
Postgrad Med J 86:472-7. 2010
..FOG is a strong risk factor for falls and adversely affects the quality of life of patients and carers. A multidisciplinary team approach is essential for optimum management...
- Acceptability of oesophagogastroduodenoscopy without intravenous sedation: patients' versus endoscopist's perception with special reference to older patients
B R Thanvi
Department of Medicine for the Elderly, Leicester General Hospital, University Hospitals of Leicester NHS Trust, UK
Postgrad Med J 79:650-1. 2003
..Older patients are said to tolerate it better than younger patients. However, patients' perception of the discomfort for the unsedated OGD has not been well studied...
- Long term motor complications of levodopa: clinical features, mechanisms, and management strategies
B R Thanvi
Department of Integrated Medicine, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Infirmary Squire, Leicester LE1 5WW, UK
Postgrad Med J 80:452-8. 2004
..Current management of motor complications is less than satisfactory. With better understanding of the pathogenetic mechanisms, it is hoped that future therapeutic strategies will provide a safer and targeted treatment...
- Update on myasthenia gravis
B R Thanvi
Department of Integrated Medicine, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK
Postgrad Med J 80:690-700. 2004
..In this article the current knowledge of the various aspects of myasthenia gravis are outlined...
- Vascular parkinsonism--an important cause of parkinsonism in older people
Bhomraj Thanvi
Leicester Royal Infirmary, Medicine for the Care of Older People, Leicester, UK
Age Ageing 34:114-9. 2005
..However, recent studies have shown a beneficial effect of L-dopa in a subset of patients. Despite great advances in overall understanding of the disease, there are several gaps in our knowledge...
- Carotid and vertebral artery dissection syndromes
B Thanvi
Department of Integrated Medicine, Leicester General Hospital, Gwendolen Road, University Hospitals of Leicester NHS Trust, Leicester LE5 4PW, UK
Postgrad Med J 81:383-8. 2005
..The prognosis of extracranial CAD is generally much better than that of the intracranial CAD. Recurrences are rare in CAD...
- Levodopa-induced dyskinesia in Parkinson's disease: clinical features, pathogenesis, prevention and treatment
Bhomraj Thanvi
Department of Integrated Medicine, Leicester General Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK
Postgrad Med J 83:384-8. 2007
..LID can adversely affect the quality of life and increase the cost of healthcare...
- Malignant middle cerebral artery (MCA) infarction: pathophysiology, diagnosis and management
Sean D Treadwell
Consultant Stroke Physician, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester LE5 4PW, UK
Postgrad Med J 86:235-42. 2010
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- Inclusion body myositis: an underdiagnosed myopathy of older people
Sunil K Munshi
Department of Medicine for the Elderly, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK
Age Ageing 35:91-4. 2006
..Sometimes, the diagnosis is missed because of the slow progression of the disease and a lack of suspicion on the part of physicians. The following case report and literature review will explore many of these issues...
- Paraneoplastic limbic encephalitis--case report and review of literature
Sunil K Munshi
Department of Cerebrovascular Medicine and Medicine for the Elderly, Leicester General Hospital, University Hospital of Leicester, Gwendolen Road, Leicester LE5 4PW, UK
Age Ageing 34:190-3. 2005
..A diagnosis of paraneoplastic limbic encephalitis should be considered in the differential diagnosis of unexplained dementias and appropriate investigations performed to diagnose the condition...
