Mahendra Kumar Thakur

Summary

Publications

  1. ncbi request reprint Estradiol regulates APP mRNA alternative splicing in the mice brain cortex
    M K Thakur
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Neurosci Lett 381:154-7. 2005
  2. ncbi request reprint Aging of brain: role of estrogen
    M K Thakur
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Neurochem Res 31:1389-98. 2006
  3. ncbi request reprint Age and sex dependent alteration in presenilin expression in mouse cerebral cortex
    Mahendra Kumar Thakur
    Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India
    Cell Mol Neurobiol 27:1059-67. 2007
  4. ncbi request reprint In the cerebral cortex of female and male mice, amyloid precursor protein (APP) promoter methylation is higher in females and differentially regulated by sex steroids
    S T Mani
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Brain Res 1067:43-7. 2006
  5. doi request reprint Role of CREB signaling in aging brain
    Vijay Paramanik
    Biochemistry and Molecular Biology Laboratory, Centre of Advanced Study, Department of Zoology, Banaras Hindu University, Varanasi, India Email
    Arch Ital Biol 151:1461. 2013
  6. ncbi request reprint 17Beta-estradiol modulates age-dependent binding of 40 kDa nuclear protein to androgen receptor promoter in mouse cerebral cortex
    Mahendra K Thakur
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Biogerontology 8:575-82. 2007
  7. ncbi request reprint Transcription of estrogen receptor alpha and beta in mouse cerebral cortex: effect of age, sex, 17beta-estradiol and testosterone
    M K Thakur
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Neurochem Int 50:314-21. 2007
  8. doi request reprint Interaction of estrogen receptor alpha transactivation domain with MTA1 decreases in old mouse brain
    M K Thakur
    Department of Zoology, Banaras Hindu University, Varanasi, India
    J Mol Neurosci 37:269-73. 2009
  9. doi request reprint Binding of estrogen receptor alpha promoter to nuclear proteins of mouse cerebral cortex: effect of age, sex, and gonadal steroids
    M K Thakur
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 221005, India
    Biogerontology 9:467-78. 2008
  10. doi request reprint Role of steroid hormone coregulators in health and disease
    M K Thakur
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    Horm Res 71:194-200. 2009

Collaborators

  • Sarika Singh
  • Swati Ghosh
  • Vijay Paramanik
  • Soumi Ghosh
  • R C Kumar
  • P K Sharma
  • S T Mani
  • Thamil Mani Sivanandam
  • A Asaithambi
  • S Mukherjee

Detail Information

Publications30

  1. ncbi request reprint Estradiol regulates APP mRNA alternative splicing in the mice brain cortex
    M K Thakur
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Neurosci Lett 381:154-7. 2005
    ..Thus these results show that the level of APP695 mRNA changes with age and estradiol may play a key role in the development of Alzheimer's disease by modulating the level of APP mRNA isoforms...
  2. ncbi request reprint Aging of brain: role of estrogen
    M K Thakur
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Neurochem Res 31:1389-98. 2006
    ..In the present paper, we review the effects of aging on brain structure and function, and estrogen action and signaling during brain aging. The findings suggest key role of estrogen in the maintenance of brain functions during aging...
  3. ncbi request reprint Age and sex dependent alteration in presenilin expression in mouse cerebral cortex
    Mahendra Kumar Thakur
    Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India
    Cell Mol Neurobiol 27:1059-67. 2007
    ..Taken together, these findings show age and sex dependent alteration in PS expression, which in turn may influence the signal transduction pathways and consequently brain functions...
  4. ncbi request reprint In the cerebral cortex of female and male mice, amyloid precursor protein (APP) promoter methylation is higher in females and differentially regulated by sex steroids
    S T Mani
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Brain Res 1067:43-7. 2006
    ....
  5. doi request reprint Role of CREB signaling in aging brain
    Vijay Paramanik
    Biochemistry and Molecular Biology Laboratory, Centre of Advanced Study, Department of Zoology, Banaras Hindu University, Varanasi, India Email
    Arch Ital Biol 151:1461. 2013
    ..Such understanding of CREB signaling through ER may help to design therapeutic strategies for age related cognitive deficits and neurodegenerative disorders. ..
  6. ncbi request reprint 17Beta-estradiol modulates age-dependent binding of 40 kDa nuclear protein to androgen receptor promoter in mouse cerebral cortex
    Mahendra K Thakur
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Biogerontology 8:575-82. 2007
    ..Further characterization of this protein may help to explore the intricate mechanism that underlies the transcriptional regulation of androgen responsive genes during aging...
  7. ncbi request reprint Transcription of estrogen receptor alpha and beta in mouse cerebral cortex: effect of age, sex, 17beta-estradiol and testosterone
    M K Thakur
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Neurochem Int 50:314-21. 2007
    ....
  8. doi request reprint Interaction of estrogen receptor alpha transactivation domain with MTA1 decreases in old mouse brain
    M K Thakur
    Department of Zoology, Banaras Hindu University, Varanasi, India
    J Mol Neurosci 37:269-73. 2009
    ..Altogether these findings suggest that age-dependent decrease in the expression of MTA1 and its interaction with ERalpha-TAD may influence the estrogen-mediated signaling pathway during aging of mouse brain...
  9. doi request reprint Binding of estrogen receptor alpha promoter to nuclear proteins of mouse cerebral cortex: effect of age, sex, and gonadal steroids
    M K Thakur
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 221005, India
    Biogerontology 9:467-78. 2008
    ..Thus, these findings demonstrate differential binding of nuclear proteins to mouse ERalpha promoter which may account for different functions of estrogen in the brain...
  10. doi request reprint Role of steroid hormone coregulators in health and disease
    M K Thakur
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    Horm Res 71:194-200. 2009
    ..Furthermore, the possible therapeutic approach has been discussed for the treatment of steroid-related diseases, which will be of future interest in the field of medical sciences...
  11. doi request reprint GST-tagged mouse estrogen receptor alpha-transactivation domain fusion protein is specifically degraded during its over-expression in E. coli and purification
    M K Thakur
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    Mol Biol Rep 37:1335-40. 2010
    ..Such specific degradation of GST-tagged mouse ERalpha-TAD during its overproduction in E. coli and purification indicates the induction of specific protease and suggests the modification of expression system...
  12. ncbi request reprint Mild stress and healthy aging: applying hormesis in aging research and interventions
    Mahendra K Thakur
    Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Curr Aging Sci 1:144. 2008
    ..Thus the book is worth reading by not only biogerontologists but by all those who are interested in understanding the hormetic approach for healthy aging...
  13. doi request reprint Expression of Trk A and Src and their interaction with ERβ ligand binding domain show age and sex dependent alteration in mouse brain
    M K Thakur
    Biochemistry and Molecular Biology Laboratory, Centre of Advanced Study, Department of Zoology, Banaras Hindu University, Varanasi, 221 005, India
    Neurochem Res 37:448-53. 2012
    ..These findings suggest the implication of Trk A and Src in ERβ mediated brain functions and related disorders during aging...
  14. ncbi request reprint PS2 protein expression is upregulated by sex steroids in the cerebral cortex of aging mice
    Soumi Ghosh
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Neurochem Int 52:363-7. 2008
    ..Thus these results demonstrate up-regulation of PS2 protein expression by sex steroids, which in turn may influence PS2 associated brain functions...
  15. pmc Estrogen receptor β and its domains interact with casein kinase 2, phosphokinase C, and N-myristoylation sites of mitochondrial and nuclear proteins in mouse brain
    Vijay Paramanik
    Biochemistry and Molecular Biology Laboratory, Centre of Advanced Study, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Biol Chem 287:22305-16. 2012
    ....
  16. ncbi request reprint Overproduction of mouse estrogen receptor alpha-ligand binding domain decreases bacterial growth
    Swati Ghosh
    Biochemistry and Molecular Biology Laboratory, Center of Advanced Study in Zoology, Banaras Hindu University, Varanasi, 221005, India
    Mol Biol Rep 35:589-94. 2008
    ..The overproduction of mouse ERalpha-LBD, as reflected by total protein content and expression pattern, resulted in the decrease of bacterial growth...
  17. ncbi request reprint PS1 expression is downregulated by gonadal steroids in adult mouse brain
    Soumi Ghosh
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Neurochem Res 33:365-9. 2008
    ..Such sex-dependent regulation of PS1 expression during aging by gonadal steroids might account for the PS-related brain functions...
  18. doi request reprint Interaction of estrogen receptor-alpha ligand binding domain with nuclear proteins of aging mouse brain
    Swati Ghosh
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    J Neurosci Res 87:2591-600. 2009
    ..Thus we report the identification and interaction of five nuclear proteins with mERalpha-LBD, indicating their role in estrogen signaling and brain functions during aging...
  19. ncbi request reprint Sex steroids reduce DNaseI accessibility of androgen receptor promoter in adult male mice brain
    R C Kumar
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University Varanasi, Uttar Pradesh 221 005, India
    Brain Res Mol Brain Res 131:1-7. 2004
    ..Thus, these findings suggest that the chromatin conformation of AR promoter varies with age and sex and its accessibility to DNaseI is reduced by testosterone and estradiol in the brain cortex of adult male mice...
  20. doi request reprint Age-dependent decrease in the interaction of beta-tubulin with estrogen receptor alpha transactivation domain in mouse brain
    Swati Ghosh
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Neurosci Lett 464:218-21. 2009
    ..However, the expression of beta-tubulin showed no significant change with age and sex. Such age and sex dependent alteration in the interaction of beta-tubulin might account for the estrogen-mediated brain functions during aging...
  21. doi request reprint Interaction of estrogen receptor-alpha transactivation domain with nuclear proteins of mouse brain: p68 RNA helicase shows age- and sex-specific change
    Swati Ghosh
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    J Neurosci Res 87:1323-8. 2009
    ..Such age- and sex-specific interaction of p68 suggests its implication in ERalpha-mediated brain functions during aging...
  22. ncbi request reprint Expression of 112-kDa estrogen receptor in mouse brain cortex and its autoregulation with age
    A Asaithambi
    Biochemistry and Molecular Biology Laboratory, Banaras Hindu University, Varanasi, India
    Biochem Biophys Res Commun 231:683-5. 1997
    ..Our results provide evidence for the expression of a novel form of ER in mouse brain cortex and its regulation by sex steroid hormones in age-specific manner...
  23. ncbi request reprint Expression of estrogen receptor (ER) alpha and beta in mouse cerebral cortex: effect of age, sex and gonadal steroids
    P K Sharma
    Biochemistry and Molecular Biology Laboratory, Centre of Advanced Study in Zoology, Banaras Hindu University, Varanasi 221005, India
    Neurobiol Aging 27:880-7. 2006
    ..Thus, these findings showed that the expression of ERalpha and ERbeta protein is differentially influenced by age, sex and gonadal steroids in the mouse cerebral cortex, suggesting differences in ER-mediated brain functions...
  24. ncbi request reprint Androgen receptor mRNA is inversely regulated by testosterone and estradiol in adult mouse brain
    R C Kumar
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Neurobiol Aging 25:925-33. 2004
    ..Such regulation of AR expression might influence androgen action during aging of the mice brain...
  25. ncbi request reprint Sex-specific alterations in chromatin conformation of the brain of aging mouse
    M K Thakur
    Biochemistry and Molecular Biology Laboratory, Centre of Advanced Study in Zoology, Banaras Hindu University, Varanasi, India
    Mol Biol Rep 26:239-47. 1999
    ..Such sex- and age-dependent conformation of chromatin may attribute to differential expression of genes in the mouse brain...
  26. doi request reprint Age-dependent expression of apolipoprotein E in mouse cerebral cortex
    Sarika Singh
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 221005, India
    J Mol Neurosci 43:251-6. 2011
    ..This indicates that during normal aging, apoE level is maintained in old similar to adult and suggests involvement of other factors in maintaining apoE-mediated brain functions in old...
  27. ncbi request reprint Estrogen receptor alpha expression in mice kidney shows sex differences during aging
    P K Sharma
    Biochemistry and Molecular Biology Laboratory, Center of Advanced Study in Zoology, Banaras Hindu University, Varanasi 221005, India
    Biogerontology 5:375-81. 2004
    ..However, unlike uterus, neither ERbeta mRNA nor protein could be detected in the kidney of adult or old mice. Thus the present data reveal that the expression of ERalpha in mice kidney shows sex differences during aging...
  28. ncbi request reprint Amplification of exons 4 and 5 of androgen receptor gene by testosterone in aged female mouse brain cortex
    M K Thakur
    Biochemistry and Molecular Biology Laboratory, Centre of Advanced Study in Zoology, Banaras Hindu University, Varanasi 221 005, India
    Biogerontology 1:329-34. 2000
    ..Thus our results suggest that the in vivo induction of mouse AR gene amplification by testosterone is tissue- and age-specific, and might contribute to the progress of genetic instability in the brain of aged female mice...
  29. ncbi request reprint Age- and sex-related expression of norbin in the brain cortex of mice
    S T Mani
    Biochemistry and Molecular Biology Laboratory, Centre of Advanced Study in Zoology, Banaras Hindu University, 221 005, Varanasi, India
    Neurosci Lett 308:57-9. 2001
    ..However, Western blotting revealed that the protein increased in male but decreased in female with advancing age. These findings suggest that norbin is involved in brain function which is dependent on age and sex...
  30. doi request reprint Traumatic brain injury: a risk factor for Alzheimer's disease
    Thamil Mani Sivanandam
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Neurosci Biobehav Rev 36:1376-81. 2012
    ..This review focuses on AD related genes which are expressed during TBI and its relevance to progression of the disease. Such understanding will help to diagnose the risk of TBI patients to develop AD and design therapeutic interventions...