Nicholas J White

Summary

Affiliation: Mahidol University
Country: Thailand

Publications

  1. pmc Microsatellite genotyping of Plasmodium vivax infections and their relapses in pregnant and non-pregnant patients on the Thai-Myanmar border
    Supinya Thanapongpichat
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 12:275. 2013
  2. pmc A clinicopathological correlation of the expression of the angiopoietin-Tie-2 receptor pathway in the brain of adults with Plasmodium falciparum malaria
    Panote Prapansilp
    Nuffield Department of Medicine, Oxford University, Oxford, UK
    Malar J 12:50. 2013
  3. pmc A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan
    Richard M Hoglund
    Unit for Pharmacokinetics and Drug Metabolism, Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden
    Malar J 11:398. 2012
  4. pmc Temporal trends in severe malaria in Chittagong, Bangladesh
    Richard James Maude
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 11:323. 2012
  5. pmc Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda
    Joel Tarning
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Malar J 11:293. 2012
  6. pmc The anaemia of Plasmodium vivax malaria
    Nicholas M Douglas
    Global Health Division, Menzies School of Health Research, PO Box 41096, Casuarina, NT 0811, Australia
    Malar J 11:135. 2012
  7. pmc Pharmaceutical development and optimization of azithromycin suppository for paediatric use
    Tina Kauss
    Univ Bordeaux, EA 4575 Analytical and Pharmaceutical Developments Applied to Neglected Diseases and Counterfeits, Bordeaux, France
    Int J Pharm 441:218-26. 2013
  8. pmc Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria
    Kris M Jamsen
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
    Malar J 11:143. 2012
  9. pmc Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator
    Jennifer A Flegg
    WorldWide Anti malarial Resistance Network WWARN and Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK
    Malar J 10:339. 2011
  10. pmc What is the optimal therapy for patients with H5N1 influenza?
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 6:e1000091. 2009

Collaborators

Detail Information

Publications87

  1. pmc Microsatellite genotyping of Plasmodium vivax infections and their relapses in pregnant and non-pregnant patients on the Thai-Myanmar border
    Supinya Thanapongpichat
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 12:275. 2013
    ..The aim of the study was to assess whether there were any differences between the parasites found in pregnant and non-pregnant patients, and/or between the admission infections and recurrent episodes during follow-up...
  2. pmc A clinicopathological correlation of the expression of the angiopoietin-Tie-2 receptor pathway in the brain of adults with Plasmodium falciparum malaria
    Panote Prapansilp
    Nuffield Department of Medicine, Oxford University, Oxford, UK
    Malar J 12:50. 2013
    ....
  3. pmc A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan
    Richard M Hoglund
    Unit for Pharmacokinetics and Drug Metabolism, Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden
    Malar J 11:398. 2012
    ..The aim of this study was to investigate the population pharmacokinetics of piperaquine in pregnant and non-pregnant Sudanese women with uncomplicated Plasmodium falciparum malaria...
  4. pmc Temporal trends in severe malaria in Chittagong, Bangladesh
    Richard James Maude
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 11:323. 2012
    ..Chittagong Medical College Hospital (CMCH) is the major tertiary referral hospital for severe malaria in Chittagong Division...
  5. pmc Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda
    Joel Tarning
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Malar J 11:293. 2012
    ..The objective of this study was to evaluate the population pharmacokinetic properties of artemether and its active metabolite dihydroartemisinin in pregnant women with uncomplicated P. falciparum malaria in Uganda...
  6. pmc The anaemia of Plasmodium vivax malaria
    Nicholas M Douglas
    Global Health Division, Menzies School of Health Research, PO Box 41096, Casuarina, NT 0811, Australia
    Malar J 11:135. 2012
    ..Anaemia can be averted by early and effective anti-malarial treatment...
  7. pmc Pharmaceutical development and optimization of azithromycin suppository for paediatric use
    Tina Kauss
    Univ Bordeaux, EA 4575 Analytical and Pharmaceutical Developments Applied to Neglected Diseases and Counterfeits, Bordeaux, France
    Int J Pharm 441:218-26. 2013
    ..This product has potential both as a classical antibiotic and as a product for use in severely ill children in rural areas. Industrial partners for further development are being sought...
  8. pmc Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria
    Kris M Jamsen
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
    Malar J 11:143. 2012
    ....
  9. pmc Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator
    Jennifer A Flegg
    WorldWide Anti malarial Resistance Network WWARN and Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK
    Malar J 10:339. 2011
    ..This lag complicates the clearance estimation, introduces observer subjectivity, and may influence the accuracy and consistency of reported results...
  10. pmc What is the optimal therapy for patients with H5N1 influenza?
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 6:e1000091. 2009
    ..These issues may also apply to therapy of patients hospitalized with severe disease due to novel swine-origin influenza A (H1N1) virus infection...
  11. pmc Central venous catheter use in severe malaria: time to reconsider the World Health Organization guidelines?
    Josh Hanson
    Department of Medicine, Cairns Base Hospital, Queensland, Australia
    Malar J 10:342. 2011
    ..However there are few data from clinical trials to support this recommendation...
  12. pmc Laboratory prediction of the requirement for renal replacement in acute falciparum malaria
    Josh Hanson
    Cairns Base Hospital, Australia
    Malar J 10:217. 2011
    ..Even when RRT is available, delaying its initiation may increase mortality. Earlier identification of patients who will need RRT may improve outcomes...
  13. pmc Coma in fatal adult human malaria is not caused by cerebral oedema
    Isabelle M Medana
    Nuffield Department of Clinical Laboratory Sciences, The John Radcliffe Hospital, University of Oxford, Oxford, UK
    Malar J 10:267. 2011
    ....
  14. pmc Modelling malaria elimination on the internet
    Richard J Maude
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 10:191. 2011
    ..There is thus an urgent need for user-friendly and accessible models purpose-designed in collaboration with policymakers to answer pertinent questions arising from the field...
  15. pmc Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria
    Kris M Jamsen
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
    Malar J 10:181. 2011
    ..In this work optimal design methods were used to determine sampling designs for typical future population PK studies of dihydroartemisinin, the principal biologically active metabolite of oral artesunate...
  16. pmc The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership
    Catherine Lacaze
    Ellipse Pharmaceuticals, Pessac, France
    Malar J 10:142. 2011
    ....
  17. pmc Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
    Kiattawee Choowongkomon
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Phayathai, Bangkok 10400, Thailand
    Malar J 9:65. 2010
    ....
  18. pmc Access to artemisinin combination therapy for malaria in remote areas of Cambodia
    Shunmay Yeung
    Health Policy Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Malar J 7:96. 2008
    ....
  19. pmc World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs
    Ric N Price
    International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    Malar J 6:119. 2007
    ..This resource will help guide rational drug policies that optimize antimalarial drug use, in the hope that the emergence and spread of resistance to new drugs can be, if not prevented, at least delayed...
  20. pmc Towards optimal design of anti-malarial pharmacokinetic studies
    Julie A Simpson
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, Melbourne, Victoria, Australia
    Malar J 8:189. 2009
    ....
  21. pmc Erythropoietin and its receptors in the brainstem of adults with fatal falciparum malaria
    Isabelle M Medana
    Nuffield Department of Clinical Laboratory Sciences, The John Radcliffe Hospital, University of Oxford, Oxford, UK
    Malar J 8:261. 2009
    ....
  22. pmc A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of Thailand
    Robert Hutagalung
    Shoklo Malaria Research Unit, Mae Sod, Tak Province, Thailand
    Malar J 4:46. 2005
    ..The trial presented here was conducted to monitor the efficacy of the six-dose regimen of artemether-lumefantrine (ALN) in an area of multi-drug resistance, along the Thai-Myanmar border...
  23. pmc Dihydroartemisinin-piperaquine versus chloroquine to treat vivax malaria in Afghanistan: an open randomized, non-inferiority, trial
    Ghulam Rahim Awab
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 9:105. 2010
    ..Chloroquine resistance in P. vivax is emerging in Asia. Therapeutic responses across Afghanistan have not been evaluated in detail...
  24. pmc Cost of increasing access to artemisinin combination therapy: the Cambodian experience
    Shunmay Yeung
    Health Policy Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Malar J 7:84. 2008
    ..However, in order to ensure that ACTs are correctly used and are accessible to the poor and remote communities who need them, specific interventions will be necessary and the additional costs need to be considered...
  25. pmc Implementation of a reference standard and proficiency testing programme by the World Wide Antimalarial Resistance Network (WWARN)
    Chris Lourens
    WorldWide Antimalarial Resistance Network WWARN, Oxford, UK
    Malar J 9:375. 2010
    ..This requires the establishment of an external quality assurance process to assure results that can be compared. This paper describes this process...
  26. pmc Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription
    Sachel Mok
    School of Biological Sciences, Nanyang Technological University, Singapore
    BMC Genomics 12:391. 2011
    ..To identify key features associated with the delayed parasite clearance phenotype, we employed DNA microarrays to profile the physiological gene expression pattern of the resistant isolates...
  27. pmc Protein-based signatures of functional evolution in Plasmodium falciparum
    Kate B Gardner
    Wellcome Trust Mahidol University Oxford Tropical Medicine Research Unit MORU, 420 6 Rajwithi Road, Bangkok, 10400 Thailand
    BMC Evol Biol 11:257. 2011
    ..The potential for these regions of protein sequence to undergo high levels of genetic drift provides a fundamental challenge to attempts to identify the molecular basis of adaptive change in malaria parasites...
  28. pmc Limited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from Thailand
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 49:4393-5. 2005
    ..Mutations of Pvdhps and Pvdhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance...
  29. pmc Artemether bioavailability after oral or intramuscular administration in uncomplicated falciparum malaria
    Kamolrat Silamut
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 47:3795-8. 2003
    ..5 to 3.0 h) than after intramuscular administration (median, 8 h; range, 4 to 24 h) (P=0.001). Intramuscular artemether is absorbed very slowly in patients with acute malaria...
  30. pmc Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 52:2657-9. 2008
    ..02). Five coding mutations in pvmdr1, independent of gene amplification, were also found...
  31. doi request reprint In vivo parasitological measures of artemisinin susceptibility
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    J Infect Dis 201:570-9. 2010
    ....
  32. ncbi request reprint Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, and Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 190:1773-82. 2004
    ..This raised the possibility that the efficacy of the current coformulation may not be optimal in the treatment of multidrug-resistant falciparum malaria...
  33. pmc Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 2:e204. 2005
    ..P. falciparum releases a specific histidine-rich protein (PfHRP2) into plasma. Quantitative measurement of plasma PfHRP2 concentrations may reflect the total parasite biomass in falciparum malaria...
  34. pmc Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 7:249. 2008
    ..The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity...
  35. ncbi request reprint Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 195:927-33. 2007
    ..Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection. It has been assumed that parasites causing relapse would be a subset of the parasites that caused the primary infection...
  36. pmc Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:253. 2009
    ..The importance of anti-malarial treatment dosing has been underappreciated. Treatment recommendations are often for the lowest doses that produce "satisfactory" results...
  37. ncbi request reprint The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria
    Paul N Newton
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Eur J Clin Pharmacol 62:1003-9. 2006
    ..The choice of doses used has been empirical. To inform dosage recommendations we assessed the pharmacokinetics of intravenous artesunate after the first dose...
  38. ncbi request reprint Risk factors for recurrent melioidosis in northeast Thailand
    Direk Limmathurotsakul
    Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand
    Clin Infect Dis 43:979-86. 2006
    ..A recent study revealed that 25% of patients with recurrence had reinfection rather than a relapse resulting from a failure to cure. The aim of this study was to reevaluate these 2 patient groups to define their individual risk factors...
  39. pmc Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria
    Paul N Newton
    Mae Sot, Tak and Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 49:1622-5. 2005
    ..The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal...
  40. ncbi request reprint Prospective evaluation of a rapid immunochromogenic cassette test for the diagnosis of melioidosis in northeast Thailand
    Allen C Cheng
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok, 10400, Thailand
    Trans R Soc Trop Med Hyg 100:64-7. 2006
    ..Low sensitivity and specificity of clinical rules is consistent with the protean manifestations of melioidosis and clinical difficulty in identifying patients with melioidosis...
  41. pmc Genetic analysis of the dihydrofolate reductase-thymidylate synthase gene from geographically diverse isolates of Plasmodium malariae
    Naowarat Tanomsing
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 51:3523-30. 2007
    ..Five isolates with the wild-type DHFR could be assayed for drug susceptibility in vitro and were found to be sensitive to pyrimethamine (mean 50% inhibitory concentration, 2.24 ng/ml [95% confidence interval, 0.4 to 3.1])...
  42. pmc Exploring the contribution of candidate genes to artemisinin resistance in Plasmodium falciparum
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 54:2886-92. 2010
    ..Artemisinin resistance in western Cambodia is not linked to candidate genes, as was suggested by earlier studies...
  43. ncbi request reprint Artesunate-dapsone-proguanil treatment of falciparum malaria: genotypic determinants of therapeutic response
    Sivicha Krudsood
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 99:142-9. 2005
    ..The addition of artesunate considerably augments the antimalarial activity of the biguanide-dapsone combination, but this is insufficient for infections with parasites carrying the highly antifol-resistant Pfdhfr I164L mutation...
  44. ncbi request reprint Randomized comparison of artesunate and quinine in the treatment of severe falciparum malaria
    Paul N Newton
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 37:7-16. 2003
    ..03). Artesunate is at least as effective as quinine in the treatment of adults with severe malaria. Larger trials are required to determine whether mortality is reduced among patients treated with artesunate...
  45. pmc Artemisinin resistance in Plasmodium falciparum malaria
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    N Engl J Med 361:455-67. 2009
    ..There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance...
  46. pmc Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies
    Wirichada Pongtavornpinyo
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 7:229. 2008
    ..Formulating an appropriate dynamic data-driven model is a powerful predictive tool for exploring the impact of these strategies quantitatively...
  47. doi request reprint A simple score to predict the outcome of severe malaria in adults
    Josh Hanson
    Mahidol University, Bangkok, Thailand
    Clin Infect Dis 50:679-85. 2010
    ..However, ICU facilities are limited in the resource-poor settings where most malaria occurs. Identification of patients at greater risk of complications may facilitate their triage and resource allocation...
  48. pmc Transmission-blocking activities of quinine, primaquine, and artesunate
    Kesinee Chotivanich
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 50:1927-30. 2006
    ..Artesunate both prevents the maturation of immature P. falciparum gametocytes and reduces the transmission potential of mature gametocytes. Both of these effects may contribute to reducing malaria transmission...
  49. pmc A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand
    Janjira Thaipadungpanit
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 1:e56. 2007
    ..A sustained outbreak of leptospirosis occurred in northeast Thailand between 1999 and 2003, the basis for which was unknown...
  50. ncbi request reprint In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand
    Kesinee Chotivanich
    Faculty of Tropical Medicine, and Department of Pathobiology, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 70:395-7. 2004
    ..5 ng/mL. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine...
  51. doi request reprint Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria
    Sue Jean Lee
    Mahidol Oxford Tropical Medicine Research Unit, MORU, Mahidol University, Bangkok, Thailand
    Eur J Clin Pharmacol 64:987-92. 2008
    ..We compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria...
  52. pmc In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up
    Kasia Stepniewska
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 48:4271-80. 2004
    ..94) or if the entomological inoculation rate was known. In the assessment of drug efficacy against falciparum malaria, 28 days should be the minimum period of follow-up...
  53. pmc A simple scoring system to differentiate between relapse and re-infection in patients with recurrent melioidosis
    Direk Limmathurotsakul
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 2:e327. 2008
    ..Distinguishing between the two is important but requires bacterial genotyping. The aim of this study was to develop a simple scoring system to distinguish re-infection from relapse...
  54. pmc Plasmodium falciparum pfmdr1 amplification, mefloquine resistance, and parasite fitness
    Piyanuch Preechapornkul
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 53:1509-15. 2009
    ..pfmdr1 gene amplification in P. falciparum is a frequent event and confers mefloquine resistance. Parasites with multiple copies of the pfmdr1 gene have decreased survival fitness in the absence of drug pressure...
  55. pmc Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approach
    Kasia Stepniewska
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Malar J 6:4. 2007
    ..If isolates cannot be stored for re-testing, more accurate estimations of the degree of resistance can be obtained using a Bayesian approach to data analysis which is described here...
  56. pmc The first Plasmodium vivax relapses of life are usually genetically homologous
    Mallika Imwong
    Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 205:680-3. 2012
    ..02). The first P. vivax relapses of life are usually genetically homologous, whereas relapse in adults may result from activation of heterologous latent hypnozoites acquired from previous inoculations...
  57. ncbi request reprint Trimethoprim/sulfamethoxazole resistance in clinical isolates of Burkholderia pseudomallei
    Vanaporn Wuthiekanun
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Antimicrob Chemother 55:1029-31. 2005
    ..Antimicrobial susceptibility testing using the disc diffusion method is commonly used in melioidosis-endemic areas, but may overestimate resistance to trimethoprim/sulfamethoxazole...
  58. pmc Modulating effects of plasma containing anti-malarial antibodies on in vitro anti-malarial drug susceptibility in Plasmodium falciparum
    Preeyaporn Monatrakul
    Department of Clinical Tropical Medicine, Mahidol University, 420 6 Rajvithi, Bangkok, Thailand
    Malar J 9:326. 2010
    ..This study characterized the effects of 'immune' plasma to Plasmodium falciparumon the in vitro susceptibility of P. falciparum to anti-malarial drugs...
  59. ncbi request reprint Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations
    Paul N Newton
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 100:184-6. 2006
    ..Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria...
  60. ncbi request reprint Two randomized controlled trials of ceftazidime alone versus ceftazidime in combination with trimethoprim-sulfamethoxazole for the treatment of severe melioidosis
    Wirongrong Chierakul
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 41:1105-13. 2005
    ..It is not known whether TMP-SMX provides an additional benefit...
  61. pmc Activities of artesunate and primaquine against asexual- and sexual-stage parasites in falciparum malaria
    Sasithon Pukrittayakamee
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 48:1329-34. 2004
    ..038). These results suggest that artesunate predominantly inhibits gametocyte development whereas primaquine accelerates gametocyte clearance in P. falciparum malaria...
  62. pmc The spectrum of retinopathy in adults with Plasmodium falciparum malaria
    Richard J Maude
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trans R Soc Trop Med Hyg 103:665-71. 2009
    ..Portable retinal photography has potential as a valuable tool to study malarial retinopathy...
  63. ncbi request reprint Short report: disease severity and outcome of melioidosis in HIV coinfected individuals
    Wirongrong Chierakul
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 73:1165-6. 2005
    ..Coinfection was detected in only 8 of 524 (1.5%) adults with melioidosis in northeast Thailand. Clinical presentation and acute outcome were similar in HIV-positive and HIV-negative patients...
  64. pmc The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia
    Richard J Maude
    Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok 10400, Thailand
    Malar J 8:31. 2009
    ..The use of such an approach to investigate the likely effectiveness of different containment measures with the ultimate aim of eliminating artemisinin-resistant malaria is described...
  65. pmc Spurious amplification of a Plasmodium vivax small-subunit RNA gene by use of primers currently used to detect P. knowlesi
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Clin Microbiol 47:4173-5. 2009
    ..vivax genomic DNA. A nested primer set that targets one of the P. knowlesi small-subunit rRNA genes was validated for specificity and for sensitivity of detection of <10 parasite genomes...
  66. pmc Accurate and sensitive detection of Plasmodium species in humans by use of the dihydrofolate reductase-thymidylate synthase linker region
    Naowarat Tanomsing
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Clin Microbiol 48:3735-7. 2010
    ..This provides highly sensitive specific detection and identification of the five parasite species that infect humans...
  67. pmc Circulating red cell-derived microparticles in human malaria
    Duangdao Nantakomol
    Department of Clinical Microscopy, Faculty of Allied Health Science, Chulalongkorn University, Bangkok, Thailand
    J Infect Dis 203:700-6. 2011
    ..Hemin and parasite products induced RMP production in URBCs, which was inhibited by N-acetylcysteine, suggesting heme-mediated oxidative stress as a pathway for the generation of RMPs...
  68. pmc Role and significance of quantitative urine cultures in diagnosis of melioidosis
    Direk Limmathurotsakul
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    J Clin Microbiol 43:2274-6. 2005
    ..The presence of B. pseudomallei in urine during systemic infection is associated with a poor prognosis...
  69. pmc Intrahost modeling of artemisinin resistance in Plasmodium falciparum
    Sompob Saralamba
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok 10400, Thailand
    Proc Natl Acad Sci U S A 108:397-402. 2011
    ..This result supports the hypothesis that artemisinin resistance mainly reflects reduced ring-stage susceptibility and predicts that doubling the frequency of dosing will accelerate clearance of artemisinin-resistant parasites...
  70. pmc A comparison of two short-course primaquine regimens for the treatment and radical cure of Plasmodium vivax malaria in Thailand
    Sasithon Pukrittayakamee
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 82:542-7. 2010
    ..A 1 week course of primaquine 60 mg daily is an effective treatment of vivax malaria in this region...
  71. ncbi request reprint The role and significance of sputum cultures in the diagnosis of melioidosis
    Diana Huis In 't Veld
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 73:657-61. 2005
    ..The presence of B. pseudomallei in the sputum of patients with melioidosis is associated with a poorer prognosis...
  72. ncbi request reprint Baseline correlation and comparative kinetics of cerebrospinal fluid colony-forming unit counts and antigen titers in cryptococcal meningitis
    Annemarie E Brouwer
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 192:681-4. 2005
    ..5 dilutions. In individual patients, there was no correlation between the rate of decline in CSF cryptococcal colony-forming unit counts and that in CSF cryptococcal antigen titers...
  73. ncbi request reprint Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy
    Mathieu Nacher
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 97:273-6. 2003
    ..vivax malaria. In P. vivax-endemic areas, systematic iron and folate supplementation confers both benefit and risk in pregnancy...
  74. ncbi request reprint Stage-dependent production and release of histidine-rich protein 2 by Plasmodium falciparum
    Varunee Desakorn
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 99:517-24. 2005
    ..This assessment of the stage-dependent release of PfHRP2 is an essential prerequisite for future studies aimed at estimating the total patient parasite mass from the peripheral blood PfHRP2 concentration...
  75. doi request reprint Quantification of dihydroartemisinin, artesunate and artemisinin in human blood: overcoming the technical challenge of protecting the peroxide bridge
    Niklas Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Bioanalysis 3:1613-24. 2011
    ..Quantification of artemisinin (ARN) and its derivatives in whole blood has hitherto been thought impossible...
  76. pmc Serological evidence for increased human exposure to Burkholderia pseudomallei following the tsunami in southern Thailand
    Vanaporn Wuthiekanun
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Clin Microbiol 44:239-40. 2006
    ..The findings were suggestive of increased recent exposure in both tsunami survivors and uninjured bystanders. Survivors of the Thailand tsunami may be at increased risk of melioidosis...
  77. pmc Spatio-temporal patterns of malaria infection in Bhutan: a country embarking on malaria elimination
    Kinley Wangdi
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 10:89. 2011
    ..Poisson regression was performed to study the trend of malaria incidences at district level from 1994 to 2008. Spatial Empirical Bayesian smoothing was deployed to identify clusters of malaria at the sub-district level from 2004 to 2008...
  78. doi request reprint The relationship between age and the manifestations of and mortality associated with severe malaria
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 47:151-7. 2008
    ..The reported case-fatality rate associated with severe malaria varies widely. Whether age is an independent risk factor is uncertain...
  79. ncbi request reprint Rapid diagnosis of scrub typhus in rural Thailand using polymerase chain reaction
    Piengchan Sonthayanon
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 75:1099-102. 2006
    ..PCR using primers to amplify a fragment of the 56-kd gene had a sensitivity and specificity of 29.0% and 99.2%, respectively. PCR has a high specificity but low sensitivity for the rapid diagnosis of scrub typhus in this endemic setting...
  80. pmc Novel point mutations in the dihydrofolate reductase gene of Plasmodium vivax: evidence for sequential selection by drug pressure
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, National Science and Technology Development Agency, Bangkok, Thailand
    Antimicrob Agents Chemother 47:1514-21. 2003
    ..Highly mutated genes carry the S-->T rather than the S-->N mutation at residue 117. Mutations at residues 57 and 61 then occur, followed by a fifth mutation at residue 13...
  81. ncbi request reprint Effects of malaria heme products on red blood cell deformability
    Forradee Nuchsongsin
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 77:617-22. 2007
    ..The findings suggest novel approaches to the treatment of potentially lethal malaria...
  82. doi request reprint A liquid chromatographic-tandem mass spectrometric method for determination of artemether and its metabolite dihydroartemisinin in human plasma
    Warunee Hanpithakpong
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Bioanalysis 1:37-46. 2009
    ..Quantification of artemether and its metabolite dihydroartemisinin in biological matrices has traditionally been difficult, with sensitivity being an issue...
  83. ncbi request reprint Unidentified acids of strong prognostic significance in severe malaria
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Crit Care Med 32:1683-8. 2004
    ....
  84. pmc Quantification of the anti-influenza drug zanamivir in plasma using high-throughput HILIC-MS/MS
    Niklas Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Bioanalysis 3:157-65. 2011
    ..parenteral zanamivir is a promising drug for the treatment of severe influenza. However, quantification of this polar drug in biological matrices has traditionally been difficult and the methods developed have been relatively insensitive...
  85. pmc Genetic diversity of Plasmodium vivax in Kolkata, India
    Jung Ryong Kim
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 5:71. 2006
    ..There has been limited information on the genotypic polymorphism of P. vivax in this malaria endemic area. Three highly polymorphic and single copy genes were selected for a study of genetic diversity in Kolkata strains...
  86. pmc Cost-effectiveness of parenteral artesunate for treating children with severe malaria in sub-Saharan Africa
    Yoel Lubell
    Faculty of Tropical Medicine, Mahidol University, 420 6 Ratchawithi Road, Bangkok, 10400, Thailand
    Bull World Health Organ 89:504-12. 2011
    ..To explore the cost-effectiveness of parenteral artesunate for the treatment of severe malaria in children and its potential impact on hospital budgets...
  87. pmc Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea
    Kesinee Chotivanich
    Faculty of Tropical Medicine, and Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 80:902-4. 2009
    ..5, P = 0.01). Compared with P. vivax in Thailand, P. vivax in the Republic of Korea was more sensitive to quinine and mefloquine, but equally sensitive to chloroquine and artesunate...