N White

Summary

Affiliation: Mahidol University
Country: Thailand

Publications

  1. ncbi request reprint Why is it that antimalarial drug treatments do not always work?
    N J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Ann Trop Med Parasitol 92:449-58. 1998
  2. doi request reprint Simplified antimalarial therapeutic monitoring: using the day-7 drug level?
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Trends Parasitol 24:159-63. 2008
  3. ncbi request reprint Chloroquine versus sulfadoxine-pyrimethamine for treatment of Plasmodium falciparum malaria in Savannakhet Province, Lao People's Democratic Republic: an assessment of national antimalarial drug recommendations
    Mayfong Mayxay
    Department of Medicine, Faculty of Medical Science, National University of Laos, Savannakhet, Lao People s Democratic Republic
    Clin Infect Dis 37:1021-8. 2003
  4. ncbi request reprint Melioidosis
    N J White
    Faculty of Tropical Medicine, Mahidol University, 10400, Bangkok, Thailand
    Lancet 361:1715-22. 2003
  5. pmc The de novo selection of drug-resistant malaria parasites
    N J White
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Proc Biol Sci 270:545-54. 2003
  6. ncbi request reprint The assessment of antimalarial drug efficacy
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, 10400, Bangkok, Thailand
    Trends Parasitol 18:458-64. 2002
  7. ncbi request reprint Ex-vivo short-term culture and developmental assessment of Plasmodium vivax
    K Chotivanich
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trans R Soc Trop Med Hyg 95:677-80. 2001
  8. ncbi request reprint Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine
    N J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Pharmacokinet 37:105-25. 1999
  9. pmc Antimalarial drug resistance and combination chemotherapy
    N White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Philos Trans R Soc Lond B Biol Sci 354:739-49. 1999
  10. ncbi request reprint The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria
    Paul N Newton
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Eur J Clin Pharmacol 62:1003-9. 2006

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint Why is it that antimalarial drug treatments do not always work?
    N J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Ann Trop Med Parasitol 92:449-58. 1998
    ..How parasites persist despite apparently adequate antimalarial treatment remains unresolved...
  2. doi request reprint Simplified antimalarial therapeutic monitoring: using the day-7 drug level?
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Trends Parasitol 24:159-63. 2008
    ..Measurement of the day-7 drug level should be considered as a routine part of antimalarial drug trials...
  3. ncbi request reprint Chloroquine versus sulfadoxine-pyrimethamine for treatment of Plasmodium falciparum malaria in Savannakhet Province, Lao People's Democratic Republic: an assessment of national antimalarial drug recommendations
    Mayfong Mayxay
    Department of Medicine, Faculty of Medical Science, National University of Laos, Savannakhet, Lao People s Democratic Republic
    Clin Infect Dis 37:1021-8. 2003
    ..Gametocytemia after antimalarial treatment was associated with receipt of sulfadoxine-pyrimethamine therapy and with treatment failure (P=.009). The efficacy of both chloroquine and sulfadoxine-pyrimethamine in Laos is unsatisfactory...
  4. ncbi request reprint Melioidosis
    N J White
    Faculty of Tropical Medicine, Mahidol University, 10400, Bangkok, Thailand
    Lancet 361:1715-22. 2003
    ..With improvements in health care and diagnostic microbiology in endemic areas of Asia, and increased travel, melioidosis will probably be recognised increasingly during the next decade...
  5. pmc The de novo selection of drug-resistant malaria parasites
    N J White
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Proc Biol Sci 270:545-54. 2003
    ..Artemisinin derivative combinations are particularly effective. Ensuring adequate treatment of the relatively few heavily infected patients would slow the emergence of resistance...
  6. ncbi request reprint The assessment of antimalarial drug efficacy
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, 10400, Bangkok, Thailand
    Trends Parasitol 18:458-64. 2002
    ..A relapse cannot be distinguished confidently from a recrudescence. Host immunity is a major contributor to the therapeutic response, and can make failing drugs appear effective...
  7. ncbi request reprint Ex-vivo short-term culture and developmental assessment of Plasmodium vivax
    K Chotivanich
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trans R Soc Trop Med Hyg 95:677-80. 2001
    ..This simple method of culturing P. vivax ex vivo is suitable for antimalarial susceptibility and immunoparasitology studies...
  8. ncbi request reprint Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine
    N J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Pharmacokinet 37:105-25. 1999
    ..Characterisation of these pharmacokinetic-pharmacodynamic relationships provided the basis for dosage optimisation, an approach that could be applied to other antimalarial drugs...
  9. pmc Antimalarial drug resistance and combination chemotherapy
    N White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Philos Trans R Soc Lond B Biol Sci 354:739-49. 1999
    ..There are good arguments for no longer using antimalarial drugs alone in treatment, and instead always using a combination with artemisinin or one of its derivatives...
  10. ncbi request reprint The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria
    Paul N Newton
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Eur J Clin Pharmacol 62:1003-9. 2006
    ..The choice of doses used has been empirical. To inform dosage recommendations we assessed the pharmacokinetics of intravenous artesunate after the first dose...
  11. pmc Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria
    Paul N Newton
    Mae Sot, Tak and Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 49:1622-5. 2005
    ..The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal...
  12. pmc Limited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from Thailand
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 49:4393-5. 2005
    ..Mutations of Pvdhps and Pvdhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance...
  13. pmc Dihydroartemisinin-piperaquine versus chloroquine to treat vivax malaria in Afghanistan: an open randomized, non-inferiority, trial
    Ghulam Rahim Awab
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 9:105. 2010
    ..Chloroquine resistance in P. vivax is emerging in Asia. Therapeutic responses across Afghanistan have not been evaluated in detail...
  14. pmc Artemether bioavailability after oral or intramuscular administration in uncomplicated falciparum malaria
    Kamolrat Silamut
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 47:3795-8. 2003
    ..5 to 3.0 h) than after intramuscular administration (median, 8 h; range, 4 to 24 h) (P=0.001). Intramuscular artemether is absorbed very slowly in patients with acute malaria...
  15. ncbi request reprint A randomized comparison of oral chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in Laos
    Mayfong Mayxay
    Department of Medicine, Faculty of Medical Science, National University of Laos, Laos
    Trans R Soc Trop Med Hyg 97:343-4. 2003
    ..The proportion of patients with treatment failure was high (CQ = 78%, RIII 46%; SP = 36%, RIII 15%). The treatment policy for uncomplicated P. falciparum malaria in Laos needs to be reviewed urgently...
  16. ncbi request reprint Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 195:927-33. 2007
    ..Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection. It has been assumed that parasites causing relapse would be a subset of the parasites that caused the primary infection...
  17. ncbi request reprint Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, and Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 190:1773-82. 2004
    ..This raised the possibility that the efficacy of the current coformulation may not be optimal in the treatment of multidrug-resistant falciparum malaria...
  18. ncbi request reprint Risk factors for recurrent melioidosis in northeast Thailand
    Direk Limmathurotsakul
    Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand
    Clin Infect Dis 43:979-86. 2006
    ..A recent study revealed that 25% of patients with recurrence had reinfection rather than a relapse resulting from a failure to cure. The aim of this study was to reevaluate these 2 patient groups to define their individual risk factors...
  19. pmc Artemisinin resistance in Plasmodium falciparum malaria
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    N Engl J Med 361:455-67. 2009
    ..There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance...
  20. pmc Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 7:249. 2008
    ..The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity...
  21. doi request reprint Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria
    Sue Jean Lee
    Mahidol Oxford Tropical Medicine Research Unit, MORU, Mahidol University, Bangkok, Thailand
    Eur J Clin Pharmacol 64:987-92. 2008
    ..We compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria...
  22. pmc Activities of artesunate and primaquine against asexual- and sexual-stage parasites in falciparum malaria
    Sasithon Pukrittayakamee
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 48:1329-34. 2004
    ..038). These results suggest that artesunate predominantly inhibits gametocyte development whereas primaquine accelerates gametocyte clearance in P. falciparum malaria...
  23. ncbi request reprint Artesunate-dapsone-proguanil treatment of falciparum malaria: genotypic determinants of therapeutic response
    Sivicha Krudsood
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 99:142-9. 2005
    ..The addition of artesunate considerably augments the antimalarial activity of the biguanide-dapsone combination, but this is insufficient for infections with parasites carrying the highly antifol-resistant Pfdhfr I164L mutation...
  24. ncbi request reprint Optimising operational use of artesunate-mefloquine: a randomised comparison of four treatment regimens
    Frank Smithuis
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok, 10400 Thailand
    Trans R Soc Trop Med Hyg 98:182-92. 2004
    ..Active measures to ensure absorption and improve adherence will be necessary to realise this advantage operationally...
  25. pmc A comparison of two short-course primaquine regimens for the treatment and radical cure of Plasmodium vivax malaria in Thailand
    Sasithon Pukrittayakamee
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 82:542-7. 2010
    ..A 1 week course of primaquine 60 mg daily is an effective treatment of vivax malaria in this region...
  26. pmc Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies
    Wirichada Pongtavornpinyo
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 7:229. 2008
    ..Formulating an appropriate dynamic data-driven model is a powerful predictive tool for exploring the impact of these strategies quantitatively...
  27. ncbi request reprint An open, randomized, controlled trial of penicillin, doxycycline, and cefotaxime for patients with severe leptospirosis
    Yupin Suputtamongkol
    Department of Medicine, Faculty of Medicine at Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 39:1417-24. 2004
    ..Although leptospirosis generally is susceptible to antibiotics, there is no consensus regarding the optimal treatment for severe leptospirosis...
  28. pmc In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up
    Kasia Stepniewska
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 48:4271-80. 2004
    ..94) or if the entomological inoculation rate was known. In the assessment of drug efficacy against falciparum malaria, 28 days should be the minimum period of follow-up...
  29. ncbi request reprint Pharmacokinetic and pharmacodynamic assessment of co-amoxiclav in the treatment of melioidosis
    Wirongrong Chierakul
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Antimicrob Chemother 58:1215-20. 2006
    ..We conducted a prospective pharmacokinetic study of oral co-amoxiclav in patients with melioidosis to determine the optimal dosage and dosing interval in this potentially fatal infection...
  30. ncbi request reprint Short report: disease severity and outcome of melioidosis in HIV coinfected individuals
    Wirongrong Chierakul
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 73:1165-6. 2005
    ..Coinfection was detected in only 8 of 524 (1.5%) adults with melioidosis in northeast Thailand. Clinical presentation and acute outcome were similar in HIV-positive and HIV-negative patients...
  31. pmc Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approach
    Kasia Stepniewska
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Malar J 6:4. 2007
    ..If isolates cannot be stored for re-testing, more accurate estimations of the degree of resistance can be obtained using a Bayesian approach to data analysis which is described here...
  32. doi request reprint Activation of the coagulation cascade in patients with leptospirosis
    Wirongrong Chierakul
    Department of Clinical Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 46:254-60. 2008
    ..The aim of this study was to evaluate coagulation factors and the presence of DIC in patients with leptospirosis in northeast Thailand...
  33. pmc Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 52:2657-9. 2008
    ..02). Five coding mutations in pvmdr1, independent of gene amplification, were also found...
  34. pmc A simple scoring system to differentiate between relapse and re-infection in patients with recurrent melioidosis
    Direk Limmathurotsakul
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 2:e327. 2008
    ..Distinguishing between the two is important but requires bacterial genotyping. The aim of this study was to develop a simple scoring system to distinguish re-infection from relapse...
  35. doi request reprint In vivo parasitological measures of artemisinin susceptibility
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    J Infect Dis 201:570-9. 2010
    ....
  36. pmc The role of anti-malarial drugs in eliminating malaria
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 7:S8. 2008
    ..More evidence is needed on the safety of primaquine when administered without screening for G6PD deficiency to inform individual and mass treatment approaches in the context of malaria elimination programmes...
  37. pmc N-acetylcysteine as adjunctive treatment in severe malaria: a randomized, double-blinded placebo-controlled clinical trial
    Prakaykaew Charunwatthana
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Crit Care Med 37:516-22. 2009
    ..It has been suggested that the antioxidant N-acetylcysteine (NAC) may be beneficial in treatment. We studied the efficacy and safety of parenteral NAC as an adjunct to artesunate treatment of severe falciparum malaria...
  38. pmc Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:253. 2009
    ..The importance of anti-malarial treatment dosing has been underappreciated. Treatment recommendations are often for the lowest doses that produce "satisfactory" results...
  39. ncbi request reprint Randomized comparison of artesunate and quinine in the treatment of severe falciparum malaria
    Paul N Newton
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 37:7-16. 2003
    ..03). Artesunate is at least as effective as quinine in the treatment of adults with severe malaria. Larger trials are required to determine whether mortality is reduced among patients treated with artesunate...
  40. ncbi request reprint The effects of quinine and chloroquine antimalarial treatments in the first trimester of pregnancy
    Rose McGready
    Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand
    Trans R Soc Trop Med Hyg 96:180-4. 2002
    ..These results suggest that therapeutic doses of quinine and chloroquine are safe to use in the first trimester of pregnancy...
  41. ncbi request reprint In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand
    Kesinee Chotivanich
    Faculty of Tropical Medicine, and Department of Pathobiology, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 70:395-7. 2004
    ..5 ng/mL. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine...
  42. pmc Clinical trial of oral artesunate with or without high-dose primaquine for the treatment of vivax malaria in Thailand
    Udomsak Silachamroon
    Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 69:14-8. 2003
    ..The combination of five days of artesunate and 14 days of primaquine is a highly effective and generally well-tolerated treatment regimen for vivax malaria in Thailand...
  43. pmc Antimalarial drug resistance
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Clin Invest 113:1084-92. 2004
    ..Artemisinin-derivative combinations are particularly effective, since they act rapidly and are well tolerated and highly effective. Widespread use of these drugs could roll back malaria...
  44. pmc Oral artesunate dose-response relationship in acute falciparum malaria
    Brian J Angus
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 46:778-82. 2002
    ..6 mg/kg of body weight. These results imply that there is no reduction in PCTs with the use of single doses of artesunate higher than 2 mg/kg, and this therefore reflects the average lower limit of the maximally effective dose...
  45. pmc Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria
    Paul N Newton
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 46:1125-7. 2002
    ..The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate...
  46. ncbi request reprint Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices
    Shunmay Yeung
    Wellcome Trust Mahidol University Oxford Tropical Medicine Research Program, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 71:179-86. 2004
    ....
  47. pmc Transmission-blocking activities of quinine, primaquine, and artesunate
    Kesinee Chotivanich
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 50:1927-30. 2006
    ..Artesunate both prevents the maturation of immature P. falciparum gametocytes and reduces the transmission potential of mature gametocytes. Both of these effects may contribute to reducing malaria transmission...
  48. pmc Modelling malaria control
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 3:e111. 2006
  49. pmc The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia
    Richard J Maude
    Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok 10400, Thailand
    Malar J 8:31. 2009
    ..The use of such an approach to investigate the likely effectiveness of different containment measures with the ultimate aim of eliminating artemisinin-resistant malaria is described...
  50. ncbi request reprint Short communication: An assessment of the use of malaria rapid tests by village health volunteers in rural Laos
    Mayfong Mayxay
    Faculty of Medical Science, National University of Laos, Vientiane, Lao People s Democratic Republic
    Trop Med Int Health 9:325-9. 2004
    ..2). Previously untrained Lao VHVs performed malaria rapid tests reliably with high sensitivity and specificity after minimal training...
  51. ncbi request reprint Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations
    Paul N Newton
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 100:184-6. 2006
    ..Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria...
  52. pmc Plasmodium falciparum-based bioassay for measurement of artemisinin derivatives in plasma or serum
    Paktiya Teja-Isavadharm
    Armed Forces Research Institute of Medical Sciences Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 48:954-60. 2004
    ....
  53. ncbi request reprint Malaria--time to act
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    N Engl J Med 355:1956-7. 2006
  54. ncbi request reprint Central role of the spleen in malaria parasite clearance
    Kesinee Chotivanich
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 185:1538-41. 2002
    ..Current criteria for high-grade antimalarial drug resistance that are based on changes in parasitemia are not appropriate for asplenic patients...
  55. pmc Population pharmacokinetics of artesunate and amodiaquine in African children
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:200. 2009
    ..The aim of this study was to evaluate the PK properties of a newly developed and registered fixed dose combination (FDC) of artesunate and amodiaquine...
  56. pmc How antimalarial drug resistance affects post-treatment prophylaxis
    Nicholas J White
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Malar J 7:9. 2008
    ..More information is needed on PTP following intermittent preventive treatments, and on the relationship between the duration of PTP and immunity, so that policy recommendations can have a firmer evidence base...
  57. ncbi request reprint Assessment of the neurotoxicity of oral dihydroartemisinin in mice
    Apichart Nontprasert
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 96:99-101. 2002
    ..These data indicate that once and twice daily oral administration of artemether, artesunate and dihydroartemisinin is relatively safe when compared to intramuscular administration of the oil-based compounds...
  58. pmc Optimization of culture of Leptospira from humans with leptospirosis
    Vanaporn Wuthiekanun
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    J Clin Microbiol 45:1363-5. 2007
    ....
  59. ncbi request reprint Effects of different antimalarial drugs on gametocyte carriage in P. vivax malaria
    Sasithon Pukrittayakamee
    Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 79:378-84. 2008
    ..4% versus 14.1%, P = 0.002). Sexual stage activities corresponded with asexual stage activity for all tested regimens. Treatment with potent antimalarial drugs reduces the transmission potential of P. vivax...
  60. ncbi request reprint Levamisole inhibits sequestration of infected red blood cells in patients with falciparum malaria
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand
    J Infect Dis 196:460-6. 2007
    ..Binding to CD36, the major vascular receptor, is stabilized through dephosphorylation of CD36 by an alkaline phosphatase. This is inhibited by the alkaline phosphatase-inhibitor levamisole, resulting in decreased cytoadhesion...
  61. pmc Novel point mutations in the dihydrofolate reductase gene of Plasmodium vivax: evidence for sequential selection by drug pressure
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, National Science and Technology Development Agency, Bangkok, Thailand
    Antimicrob Agents Chemother 47:1514-21. 2003
    ..Highly mutated genes carry the S-->T rather than the S-->N mutation at residue 117. Mutations at residues 57 and 61 then occur, followed by a fifth mutation at residue 13...
  62. pmc Intermittent presumptive treatment for malaria
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 2:e3. 2005
  63. pmc Evaluation of immunoglobulin M (IgM) and IgG rapid cassette test kits for diagnosis of melioidosis in an area of endemicity
    Vanaporn Wuthiekanun
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok, 10400 Thailand
    J Clin Microbiol 42:3435-7. 2004
    ..This kit represents an improvement over IHA for the diagnosis of melioidosis an area of endemicity although, as with other serological tests, it has reduced diagnostic utility in a population with high background seropositivity...
  64. ncbi request reprint Host vascular endothelial growth factor is trophic for Plasmodium falciparum-infected red blood cells
    Navakanit Sachanonta
    Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Asian Pac J Allergy Immunol 26:37-45. 2008
    ..We conclude that P. falciparum iRBC can bind host VEGF-R on the erythrocyte membrane and accumulate host VEGF within the parasitophorous vacuole, which may have a trophic effect on parasite growth...
  65. pmc Spurious amplification of a Plasmodium vivax small-subunit RNA gene by use of primers currently used to detect P. knowlesi
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Clin Microbiol 47:4173-5. 2009
    ..vivax genomic DNA. A nested primer set that targets one of the P. knowlesi small-subunit rRNA genes was validated for specificity and for sensitivity of detection of <10 parasite genomes...
  66. ncbi request reprint Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancy
    Mathieu Nacher
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 97:273-6. 2003
    ..vivax malaria. In P. vivax-endemic areas, systematic iron and folate supplementation confers both benefit and risk in pregnancy...
  67. ncbi request reprint Neuropathologic toxicity of artemisinin derivatives in a mouse model
    Apichart Nontprasert
    Department of Clinical Tropical Medicine and Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 67:423-9. 2002
    ..Thus clinical assessment was a sensitive measure of neurotoxicity. There may be a reversible component to artemether neurotoxicity...
  68. ncbi request reprint Mixed-species malaria infections in humans
    Mayfong Mayxay
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Trends Parasitol 20:233-40. 2004
  69. ncbi request reprint Combined molecular and clinical assessment of Plasmodium falciparum antimalarial drug resistance in the Lao People's Democratic Republic (Laos)
    Mayfong Mayxay
    Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao People Democratic Republic
    Am J Trop Med Hyg 77:36-43. 2007
    ..These findings suggest that chloroquine and sulfadoxine-pyrimethamine are no longer viable therapy in this country...
  70. ncbi request reprint Artemisinin-based combination treatment of falciparum malaria
    Francois Nosten
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Am J Trop Med Hyg 77:181-92. 2007
    ....
  71. pmc The evolution of drug-resistant malaria: the role of drug elimination half-life
    Ian M Hastings
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Philos Trans R Soc Lond B Biol Sci 357:505-19. 2002
    ..The model is also applicable to the evolution of antibiotic resistance in bacteria: in particular, the need for these models to incorporate drug pharmacokinetics to avoid potentially large errors in their predictions...
  72. ncbi request reprint A selective sweep driven by pyrimethamine treatment in southeast asian malaria parasites
    Shalini Nair
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Mol Biol Evol 20:1526-36. 2003
    ....
  73. ncbi request reprint Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial
    Tinh Hien Tran
    Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    Lancet 363:18-22. 2004
    ..There is general acceptance that to combat resistance, combinations of antimalarial drugs that include an artemisinin derivative should be used, and, if possible, these should be formulated in a single tablet...
  74. doi request reprint Increased gametocytemia after treatment: an early parasitological indicator of emerging sulfadoxine-pyrimethamine resistance in falciparum malaria
    Karen I Barnes
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    J Infect Dis 197:1605-13. 2008
    ..Although malaria treatment aims primarily to eliminate the asexual blood stages that cause illness, reducing the carriage of gametocytes is critical for limiting malaria transmission and the spread of resistance...
  75. ncbi request reprint A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Clin Infect Dis 41:425-32. 2005
    ..The current regimen involves 4 doses given over 3 days. Simplification of the dose regimen should facilitate treatment adherence and thereby increase effectiveness...
  76. ncbi request reprint Diagnosis and management of malaria by rural community health providers in the Lao People's Democratic Republic (Laos)
    Mayfong Mayxay
    Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao PDR
    Trop Med Int Health 12:540-6. 2007
    ..This study strongly suggests that further training of Lao rural health providers in malaria diagnosis and management is needed to improve the quality of health services in areas remote from district hospitals...
  77. pmc Open-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline, and chloramphenicol compared with trimethoprim-sulfamethoxazole and doxycycline for maintenance therapy of melioidosis
    Wipada Chaowagul
    Medical Department, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand
    Antimicrob Agents Chemother 49:4020-5. 2005
    ..7-fold increase of relapse or death. A combination of TMP-SMX and doxycycline is as effective as and better tolerated than the conventional four-drug regimen for the oral treatment phase of melioidosis...
  78. ncbi request reprint Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil
    Michele van Vugt
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Clin Infect Dis 35:1498-504. 2002
    ..014). Artesunate-atovaquone-proguanil is a highly effective and well-tolerated treatment for multidrug-resistant falciparum malaria...
  79. ncbi request reprint Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei
    Steven P Larosa
    Division of Infectious Disease, Rhode Island Hospital, Gerry House 113, 593 Eddy Street, and Infectious Diseases and Microbiologic Divisions of Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Int J Infect Dis 10:25-31. 2006
    ..Excessive release of these cytokines may lead to endothelial injury, depletion of naturally occurring endothelial modulators, microvascular thrombosis, organ failure, and death...
  80. ncbi request reprint Artemisinin-based combinations
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
    Curr Opin Infect Dis 18:531-6. 2005
    ..Artemisinin-based combination treatments have been the mainstay of treatment for falciparum malaria in Southeast Asia for more than 10 years and are now increasingly recommended as first-line treatment throughout the rest of the world...
  81. ncbi request reprint Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
    Ric N Price
    Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, London, UK
    Lancet 364:438-47. 2004
    ..A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are not known...
  82. pmc Effect of artemether-lumefantrine policy and improved vector control on malaria burden in KwaZulu-Natal, South Africa
    Karen I Barnes
    Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa
    PLoS Med 2:e330. 2005
    ..Malaria is diagnosed definitively and treatment is provided free of charge in reasonably accessible public-sector health-care facilities...
  83. pmc A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of Thailand
    Robert Hutagalung
    Shoklo Malaria Research Unit, Mae Sod, Tak Province, Thailand
    Malar J 4:46. 2005
    ..The trial presented here was conducted to monitor the efficacy of the six-dose regimen of artemether-lumefantrine (ALN) in an area of multi-drug resistance, along the Thai-Myanmar border...
  84. ncbi request reprint Short report: no evidence of cardiotoxicity of atovaquone-proguanil alone or in combination with artesunate
    Ravindra K Gupta
    Department of Infection, St Thomas Hospital, London, United Kingdom
    Am J Trop Med Hyg 73:267-8. 2005
    ..We conclude that atovaquone-proguanil shows no evidence of cardiotoxicity either alone or when combined with artesunate...
  85. ncbi request reprint A randomized comparison of artesunate-atovaquone-proguanil versus quinine in treatment for uncomplicated falciparum malaria during pregnancy
    Rose McGready
    Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
    J Infect Dis 192:846-53. 2005
    ..There is no safe, practical, and effective treatment for pregnant women infected with multidrug-resistant Plasmodium falciparum...
  86. ncbi request reprint Population biology and antimalarial resistance: The transmission of antimalarial drug resistance in Plasmodium falciparum
    Karen I Barnes
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town 7925, South Africa
    Acta Trop 94:230-40. 2005
    ..Artemisinin-based combination therapies are the only antimalarials currently available which rapidly reduce both asexual and gametocyte stages of the P. falciparum lifecycle...
  87. ncbi request reprint Artesunate-atovaquone-proguanil rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report
    Rose McGready
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Trans R Soc Trop Med Hyg 97:592-4. 2003
    ..falciparum malaria...
  88. ncbi request reprint Comparison of chloroquine, sulfadoxine/pyrimethamine, mefloquine and mefloquine-artesunate for the treatment of falciparum malaria in Kachin State, North Myanmar
    Frank Smithuis
    Medecins Sans Frontieres Holland, Yangon, Myanmar
    Trop Med Int Health 9:1184-90. 2004
    ..Mefloquine treatment is much more effective, but three day combination regimens with artesunate will be needed for optimum efficacy and protection against resistance...
  89. ncbi request reprint Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria
    Ric N Price
    Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Clin Infect Dis 42:1570-7. 2006
    ..Our study examined the relative contributions of host, pharmacokinetic, and parasitological factors in determining the therapeutic response to artemether-lumefantrine (AL)...
  90. ncbi request reprint Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison
    Frank Smithuis
    Medecins Sans Frontieres Holland, Yangon, Myanmar
    Lancet 367:2075-85. 2006
    ....
  91. ncbi request reprint Thiamin deficiency and uncomplicated falciparum malaria in Laos
    Mayfong Mayxay
    Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Trop Med Int Health 12:363-9. 2007
    ..We therefore estimated the frequency of biochemical thiamin deficiency in patients presenting with uncomplicated falciparum malaria in southern Laos...
  92. ncbi request reprint Chloroquine prophylaxis against vivax malaria in pregnancy: a randomized, double-blind, placebo-controlled trial
    Leopoldo Villegas
    Shoklo Malaria Research Unit, Mae SotThailand
    Trop Med Int Health 12:209-18. 2007
    ..To assess the safety of chloroquine (CQ) as prophylaxis against Plasmodium vivax infection during pregnancy...
  93. ncbi request reprint Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Trop Med Int Health 12:201-8. 2007
    ..If the fixed antimalarial drug combination artemether-lumefantrine (AL) could be given once daily, this should improve adherence and thus effectiveness and lower the risk of selecting for resistance...
  94. ncbi request reprint How much fat is necessary to optimize lumefantrine oral bioavailability?
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Trop Med Int Health 12:195-200. 2007
    ..The aim of this study was to describe the dose-response relationship between coadministration of fat and relative lumefantrine bioavailability, in order to determine the minimum amount of fat necessary to optimize absorption...
  95. ncbi request reprint In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos)
    Mayfong Mayxay
    Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao PDR
    Am J Trop Med Hyg 76:245-50. 2007
    ..P. falciparum in Laos is multi-drug resistant; antimalarial immunity resulting from the use of ineffective chloroquine before 2005 probably contributes significantly to the therapeutic responses in clinical trials...
  96. ncbi request reprint Sulfadoxine-pyrimethamine pharmacokinetics in malaria: pediatric dosing implications
    Karen I Barnes
    Division of Clinical Pharmacology and Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa
    Clin Pharmacol Ther 80:582-96. 2006
    ..Despite decades of widespread use, there are few data to inform dose recommendations...
  97. ncbi request reprint An open label randomized comparison of mefloquine-artesunate as separate tablets vs. a new co-formulated combination for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Tak, Thailand
    Trop Med Int Health 11:1653-60. 2006
    ..A new fixed combination of mefloquine plus artesunate has been developed. This was compared with the conventional regimen of separate tablets for the treatment of uncomplicated multidrug-resistant falciparum malaria...
  98. ncbi request reprint The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria
    Rose McGready
    Shoklo Malaria Research Unit, P O Box 46, Mae Sot, Tak, Thailand
    Eur J Clin Pharmacol 62:1021-31. 2006
    ..To determine the pharmacokinetic properties of artemether and lumefantrine (AL) in pregnant women with recrudescent uncomplicated multi-drug resistant falciparum malaria...
  99. ncbi request reprint The effects of Plasmodium falciparum and P. vivax infections on placental histopathology in an area of low malaria transmission
    Rose McGready
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Am J Trop Med Hyg 70:398-407. 2004
    ..These findings emphasize the importance of treating malaria in pregnancy promptly with effective antimalarial drugs...
  100. pmc Population pharmacokinetic assessment of a new regimen of mefloquine used in combination treatment of uncomplicated falciparum malaria
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, P O Box 46, Mae Sot, Tak 63110, Thailand
    Antimicrob Agents Chemother 50:2281-5. 2006
    ..This new regimen is well tolerated and results in an equivalent therapeutic response...
  101. ncbi request reprint Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic Republic
    Mayfong Mayxay
    Wellcome Trust Mahosot Hospital, Oxford Tropical Medicine Research Collaboration, Vientiane, Lao PDR
    Clin Infect Dis 39:1139-47. 2004
    ....