N J White

Summary

Affiliation: Mahidol University
Country: Thailand

Publications

  1. pmc New medicines for tropical diseases in pregnancy: catch-22
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 5:e133. 2008
  2. pmc Population pharmacokinetics of artesunate and amodiaquine in African children
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:200. 2009
  3. doi request reprint Mass primaquine treatment to eliminate vivax malaria: lessons from the past
    Anatoly Kondrashin
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 13:51. 2014
  4. doi request reprint Malaria
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford, UK Electronic address
    Lancet 383:723-35. 2014
  5. doi request reprint Entomological determinants of insecticide-treated bed net effectiveness in Western Myanmar
    Frank M Smithuis
    Mahidol Oxford Tropical Medicine Research Unit MORU, Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420 6 Rajvithi Rd, Ratchathewi District, Bangkok 10400, Thailand
    Malar J 12:364. 2013
  6. pmc The effect of insecticide-treated bed nets on the incidence and prevalence of malaria in children in an area of unstable seasonal transmission in western Myanmar
    Frank M Smithuis
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420 6 Rajvithi Rd, Ratchathewi District, Bangkok 10400, Thailand
    Malar J 12:363. 2013
  7. pmc Prognostic indicators in adults hospitalized with falciparum malaria in Western Thailand
    Paul N Newton
    Lao Oxford Mahosot Hospital Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Malar J 12:229. 2013
  8. pmc Prevalence of antifolate resistance mutations in Plasmodium falciparum isolates in Afghanistan
    Ghulam R Awab
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Bangkok, Thailand
    Malar J 12:96. 2013
  9. pmc Efficacy of artemether-lumefantrine, the nationally-recommended artemisinin combination for the treatment of uncomplicated falciparum malaria, in southern Laos
    Mayfong Mayxay
    Wellcome Trust Mahosot Hospital Oxford University Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao PDR
    Malar J 11:184. 2012
  10. pmc In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam
    Tran Tinh Hien
    Wellcome Trust Major Overseas Programme MOP, Oxford University Clinical Research Unit OUCRU, Ho Chi Minh City, Vietnam
    Malar J 11:355. 2012

Detail Information

Publications194 found, 100 shown here

  1. pmc New medicines for tropical diseases in pregnancy: catch-22
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 5:e133. 2008
  2. pmc Population pharmacokinetics of artesunate and amodiaquine in African children
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:200. 2009
    ..The aim of this study was to evaluate the PK properties of a newly developed and registered fixed dose combination (FDC) of artesunate and amodiaquine...
  3. doi request reprint Mass primaquine treatment to eliminate vivax malaria: lessons from the past
    Anatoly Kondrashin
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 13:51. 2014
    ....
  4. doi request reprint Malaria
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford, UK Electronic address
    Lancet 383:723-35. 2014
    ..We review the epidemiology, clinical features, pathology, prevention, and treatment of malaria. ..
  5. doi request reprint Entomological determinants of insecticide-treated bed net effectiveness in Western Myanmar
    Frank M Smithuis
    Mahidol Oxford Tropical Medicine Research Unit MORU, Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420 6 Rajvithi Rd, Ratchathewi District, Bangkok 10400, Thailand
    Malar J 12:364. 2013
    ..A coincident entomological investigation measured malaria vector abundance and biting behaviour and the human population sleeping habits, factors relevant to ITN effectiveness...
  6. pmc The effect of insecticide-treated bed nets on the incidence and prevalence of malaria in children in an area of unstable seasonal transmission in western Myanmar
    Frank M Smithuis
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420 6 Rajvithi Rd, Ratchathewi District, Bangkok 10400, Thailand
    Malar J 12:363. 2013
    ..This study's objective was to evaluate the malaria protective efficacy of village-wide usage of ITN in Western Myanmar and estimate the cost-effectiveness of ITN compared with extending early diagnosis and treatment services...
  7. pmc Prognostic indicators in adults hospitalized with falciparum malaria in Western Thailand
    Paul N Newton
    Lao Oxford Mahosot Hospital Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Malar J 12:229. 2013
    ..Severe malaria remains a major cause of death and morbidity amongst adults in the Asiatic tropics...
  8. pmc Prevalence of antifolate resistance mutations in Plasmodium falciparum isolates in Afghanistan
    Ghulam R Awab
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Bangkok, Thailand
    Malar J 12:96. 2013
    ..Molecular studies provide a sensitive means to investigate the current state of drug susceptibility to the SP component, and can also provide information on the likely efficacy of other potential forms of artemisinin-combination therapy...
  9. pmc Efficacy of artemether-lumefantrine, the nationally-recommended artemisinin combination for the treatment of uncomplicated falciparum malaria, in southern Laos
    Mayfong Mayxay
    Wellcome Trust Mahosot Hospital Oxford University Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Lao PDR
    Malar J 11:184. 2012
    ..With evidence of resistance to artemisinin derivatives in adjacent Cambodia, there has been a concern as to AL efficacy. Monitoring of AL efficacy would help the Lao Government to make decisions on appropriate malaria treatment...
  10. pmc In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam
    Tran Tinh Hien
    Wellcome Trust Major Overseas Programme MOP, Oxford University Clinical Research Unit OUCRU, Ho Chi Minh City, Vietnam
    Malar J 11:355. 2012
    ..Therefore, there is an urgent need to investigate whether there is any evidence of a change in the parasitological response to the artemisinin derivatives in Vietnam...
  11. pmc Primaquine radical cure of Plasmodium vivax: a critical review of the literature
    George K John
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Malar J 11:280. 2012
    ..Despite this its clinical efficacy is poorly characterized resulting in a lack of consensus over the optimal regimen for the radical cure of Plasmodium vivax...
  12. pmc Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria
    Thiranut Ramutton
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 11:276. 2012
    ..The Pfhrp2 gene is highly polymorphic, with deletion of the entire gene reported in both laboratory and field isolates. These issues potentially confound the interpretation of PFHRP2 measurements...
  13. pmc Lethal malaria: Marchiafava and Bignami were right
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 208:192-8. 2013
    ..Since then, several alternative hypotheses have been proposed. These formed the basis for adjunctive interventions, which have either been ineffective or harmful. Recent evidence strongly suggests that Marchiafava and Bignami were right...
  14. doi request reprint Primaquine to prevent transmission of falciparum malaria
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet Infect Dis 13:175-81. 2013
    ..50-0.75 mg base per kg), which would be safer, might still be very effective...
  15. doi request reprint Relapse
    Nicholas J White
    Mahidol Oxford Research Unit, Mahidol University, Bangkok, Thailand
    Adv Parasitol 80:113-50. 2012
    ..Long-latency P. vivax phenotypes may be more widespread and more prevalent than currently thought. These observations have important implications for the assessment of radical treatment efficacy and for malaria control and elimination...
  16. pmc Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 11:418. 2012
    ..25 mg base/kg) would be safer and equally effective. This lower dose could be deployed together with ACTs without G6PD testing wherever use of a specific gametocytocide is indicated...
  17. pmc The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum
    Kesinee Chotivanich
    MORU, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Malar J 11:177. 2012
    ..In this study, the consequences of lipidaemia on anti-malarial drug efficacy were assessed in vitro...
  18. pmc A review of mixed malaria species infections in anopheline mosquitoes
    Mallika Imwong
    Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 10:253. 2011
    ..To determine whether mixed species infections in humans are derived from mainly from simultaneous or separate mosquito inoculations the literature on malaria species infection in wild captured anopheline mosquitoes was reviewed...
  19. pmc Spatio-temporal patterns of malaria infection in Bhutan: a country embarking on malaria elimination
    Kinley Wangdi
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 10:89. 2011
    ..Poisson regression was performed to study the trend of malaria incidences at district level from 1994 to 2008. Spatial Empirical Bayesian smoothing was deployed to identify clusters of malaria at the sub-district level from 2004 to 2008...
  20. pmc The role of simple mathematical models in malaria elimination strategy design
    Lisa J White
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Malar J 8:212. 2009
    ..However, in many malaria countries reliable data are not available and policy must be formed based on information like an estimate of the average parasite prevalence...
  21. pmc Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies
    Wirichada Pongtavornpinyo
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 7:229. 2008
    ..Formulating an appropriate dynamic data-driven model is a powerful predictive tool for exploring the impact of these strategies quantitatively...
  22. pmc The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria
    Sue J Lee
    Mahidol Oxford Tropical Medicine Research Unit MORU, Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420 6 Ratchawithi Rd, Ratchathewi District, Bangkok 10400, Thailand
    Malar J 7:149. 2008
    ..Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other...
  23. pmc Modulating effects of plasma containing anti-malarial antibodies on in vitro anti-malarial drug susceptibility in Plasmodium falciparum
    Preeyaporn Monatrakul
    Department of Clinical Tropical Medicine, Mahidol University, 420 6 Rajvithi, Bangkok, Thailand
    Malar J 9:326. 2010
    ..This study characterized the effects of 'immune' plasma to Plasmodium falciparumon the in vitro susceptibility of P. falciparum to anti-malarial drugs...
  24. pmc World Antimalarial Resistance Network (WARN) IV: clinical pharmacology
    Karen I Barnes
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
    Malar J 6:122. 2007
    ....
  25. pmc Development of temporal modelling for forecasting and prediction of malaria infections using time-series and ARIMAX analyses: a case study in endemic districts of Bhutan
    Kinley Wangdi
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 9:251. 2010
    ..To strengthen the country's prevention and control measures, this study was carried out to develop forecasting and prediction models of malaria incidence in the endemic districts of Bhutan using time series and ARIMAX...
  26. pmc Randomized controlled trial of artesunate or artemether in Vietnamese adults with severe falciparum malaria
    Nguyen H Phu
    Hospital for Tropical Diseases, 190 Ham Tu, Quan 5, Ho Chi Minh City, Vietnam
    Malar J 9:97. 2010
    ..These two artemisinin derivatives had not been compared in a randomized trial...
  27. pmc Some considerations in the design and interpretation of antimalarial drug trials in uncomplicated falciparum malaria
    Kasia Stepniewska
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Malar J 5:127. 2006
    ....
  28. pmc Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approach
    Kasia Stepniewska
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Malar J 6:4. 2007
    ..If isolates cannot be stored for re-testing, more accurate estimations of the degree of resistance can be obtained using a Bayesian approach to data analysis which is described here...
  29. pmc Thrombocytopaenia in pregnant women with malaria on the Thai-Burmese border
    Saw Oo Tan
    Shoklo Malaria Research Unit, PO Box 46 Mae Sot, Tak, 63110, Thailand
    Malar J 7:209. 2008
    ..Examined here is thrombocytopaenia in pregnant women infected with Plasmodium falciparum or Plasmodium vivax in a low transmission area on the north-western border of Thailand...
  30. pmc Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 4:20. 2005
    ..P. vivax resistance to drugs has more recently emerged and monitoring the situation would be helped, as for P. falciparum, by molecular methods that can be used to characterize parasites in field studies and drug efficacy trials...
  31. pmc Genetic diversity of Plasmodium vivax in Kolkata, India
    Jung Ryong Kim
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 5:71. 2006
    ..There has been limited information on the genotypic polymorphism of P. vivax in this malaria endemic area. Three highly polymorphic and single copy genes were selected for a study of genetic diversity in Kolkata strains...
  32. pmc Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trial
    Frank Smithuis
    Medecins Sans Frontieres Holland, Yangon, Myanmar
    Lancet Infect Dis 10:673-81. 2010
    ..We aimed to compare effectiveness of four fixed-dose ACTs and a loose tablet combination of artesunate and mefloquine, and assess the addition of a single gametocytocidal dose of primaquine...
  33. pmc Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
    Arjen M Dondorp
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 376:1647-57. 2010
    ..We compared parenteral treatment with either artesunate or quinine in African children with severe malaria...
  34. pmc The murine cerebral malaria phenomenon
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trends Parasitol 26:11-5. 2010
    ..The value of the mouse model in identifying pathological processes or therapeutic interventions in human cerebral malaria is questionable...
  35. ncbi request reprint Sharing malarias
    N J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Lancet 363:1006. 2004
  36. pmc Antimalarial drug resistance
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Clin Invest 113:1084-92. 2004
    ..Artemisinin-derivative combinations are particularly effective, since they act rapidly and are well tolerated and highly effective. Widespread use of these drugs could roll back malaria...
  37. pmc Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:253. 2009
    ..The importance of anti-malarial treatment dosing has been underappreciated. Treatment recommendations are often for the lowest doses that produce "satisfactory" results...
  38. pmc The role of anti-malarial drugs in eliminating malaria
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 7:S8. 2008
    ..More evidence is needed on the safety of primaquine when administered without screening for G6PD deficiency to inform individual and mass treatment approaches in the context of malaria elimination programmes...
  39. pmc How antimalarial drug resistance affects post-treatment prophylaxis
    Nicholas J White
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Malar J 7:9. 2008
    ..More information is needed on PTP following intermittent preventive treatments, and on the relationship between the duration of PTP and immunity, so that policy recommendations can have a firmer evidence base...
  40. pmc Modelling malaria control
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 3:e111. 2006
  41. pmc The parasite clearance curve
    N J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 10:278. 2011
    ..The factors affecting parasite clearance are reviewed. Methods of presentation and the approaches to analysis are discussed...
  42. ncbi request reprint Cardiotoxicity of antimalarial drugs
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet Infect Dis 7:549-58. 2007
    ..At currently recommended doses, other antimalarial drugs do not have clinically significant cardiac effects. More information on amodiaquine, primaquine, and the newer structurally related compounds is needed...
  43. pmc Determinants of relapse periodicity in Plasmodium vivax malaria
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    Malar J 10:297. 2011
    ..Long-latency P. vivax phenotypes may be more widespread and more prevalent than currently thought. These observations have important implications for the assessment of radical treatment efficacy and for malaria control and elimination...
  44. doi request reprint Plasmodium knowlesi: the fifth human malaria parasite
    N J White
    Department of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 46:172-3. 2008
  45. doi request reprint Qinghaosu (artemisinin): the price of success
    N J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Science 320:330-4. 2008
    ..A global subsidy would make these drugs more affordable and available. ACTs are central to current malaria elimination initiatives, but there are concerns that tolerance to artemisinins may be emerging in Cambodia...
  46. pmc Intermittent presumptive treatment for malaria
    Nicholas J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 2:e3. 2005
  47. ncbi request reprint Fake antimalarials in Southeast Asia are a major impediment to malaria control: multinational cross-sectional survey on the prevalence of fake antimalarials
    A M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trop Med Int Health 9:1241-6. 2004
    ..To assess the prevalence of counterfeit antimalarial drugs in Southeast (SE) Asia...
  48. pmc Pharmacokinetics of high-dose oseltamivir in healthy volunteers
    Y Wattanagoon
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 53:945-52. 2009
    ..Probenecid coadministration may allow considerable dose saving for oseltamivir, but more information on OC penetration into respiratory secretions is needed to devise appropriate dose regimens...
  49. ncbi request reprint Antimalarial drugs reduce cytoadherence and rosetting Plasmodium falciparum
    R Udomsangpetch
    Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    J Infect Dis 173:691-8. 1996
    ..These results suggest that artemisinin derivatives are more effective than quinine in preventing pathologic processes in parasitized erythrocytes that contribute to microvascular obstruction in severe malaria...
  50. pmc Quantification of artemisinin in human plasma using liquid chromatography coupled to tandem mass spectrometry
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Pharm Biomed Anal 49:768-73. 2009
    ..The limit of detection was 0.257 ng/mL for artemisinin and the calibration range was 1.03-762 ng/mL using 50 microL plasma. The method was free from matrix effects as demonstrated both graphically and quantitatively...
  51. ncbi request reprint Comparison of imipenem and ceftazidime as therapy for severe melioidosis
    A J Simpson
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 29:381-7. 1999
    ..011). Both treatments were well tolerated. Imipenem is a safe and effective treatment for acute severe melioidosis and may be considered an alternative to ceftazidime...
  52. pmc Pharmacokinetic determinants of the window of selection for antimalarial drug resistance
    K Stepniewska
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 52:1589-96. 2008
    ..The windows were examined for the currently available antimalarials. Drugs with elimination half-lives of less than 1 day, such as the artemisinins and quinine, do not select for resistance during the elimination phase...
  53. ncbi request reprint Use of artemisinin derivatives for the control of malaria
    F Nosten
    Faculty of Tropical Medicine, Madihol University, Bangkok, Thailand
    Med Trop (Mars) 58:45-9. 1998
    ..Similar trends were observed in Vietnam where artemisinin is widely used. Combination therapies that include an artemisinin derivative could have a major role in the control of malaria and the spread of drug resistance...
  54. ncbi request reprint A comparison of the in vivo kinetics of Plasmodium falciparum ring-infected erythrocyte surface antigen-positive and -negative erythrocytes
    P N Newton
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Blood 98:450-7. 2001
    ..017) after treatment with an artemisinin derivative than after treatment with quinine. Parasitization of red cells leads to changes in the erythrocyte that shorten their survival even if the parasite is removed subsequently...
  55. ncbi request reprint A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria
    P N Newton
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trans R Soc Trop Med Hyg 95:519-23. 2001
    ..There is no benefit evident from combining parenteral administration of these 2 antimalarial drugs in the acute phase of treatment...
  56. ncbi request reprint Validation and application of a liquid chromatographic-mass spectrometric method for determination of artesunate in pharmaceutical samples
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Pharm Biomed Anal 45:149-53. 2007
    ..3 (70:30, v/v) at a flow rate of 1 mL/min. The assay was implemented for the analysis of artesunate for injection purchased from Guilin Pharmaceutical Company in China...
  57. pmc A comparison of oral artesunate and artemether antimalarial bioactivities in acute falciparum malaria
    Y Suputtamongkol
    Department of Medicine, Siriraj Hospital, Bangkok, Thailand
    Br J Clin Pharmacol 52:655-61. 2001
    ..CONCLUSIONS: The oral antimalarial bioavailability following artemether was significantly lower than that after artesunate. Artemether oral antimalarial bioavailability is reduced in acute malaria...
  58. pmc Limited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from Thailand
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 49:4393-5. 2005
    ..Mutations of Pvdhps and Pvdhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance...
  59. doi request reprint Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Chromatogr B Analyt Technol Biomed Life Sci 876:54-60. 2008
    ..These various pitfalls have undoubtedly contributed to the large inter-subject variation in plasma concentration profiles and derived pharmacokinetic parameters for these important antimalarial drugs...
  60. ncbi request reprint Oral quinine pharmacokinetics and dietary salt intake
    P Newton
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Eur J Clin Pharmacol 57:111-3. 2001
    ..5 (4.3-10.2) h] than after a low-salt diet [10.0 (7.6-14.8) h] (P = 0.04). CONCLUSION: Dietary salt does not affect the relative oral bioavailability of quinine sulphate...
  61. ncbi request reprint Comparative bioavailability of oral, rectal, and intramuscular artemether in healthy subjects: use of simultaneous measurement by high performance liquid chromatography and bioassay
    P Teja Isavadharm
    Department of Immunology and Parasitology, US Army Medical Component, Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
    Br J Clin Pharmacol 42:599-604. 1996
    ..Further studies are needed to determine whether i.r. artemether would be an effective treatment of severe malaria in the rural tropics in situations where oral or parenteral administration is not possible...
  62. ncbi request reprint Contribution of humoral immunity to the therapeutic response in falciparum malaria
    M Mayxay
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 65:918-23. 2001
    ..7 [0.1-3.5] versus 2.6 [0.1-12.1]; P < 0.001). These results suggest that antimalarial antibodies may play an important supportive role in the therapeutic response to antimalarial drugs during acute falciparum malaria...
  63. ncbi request reprint Safety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancy
    R McGready
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 65:285-9. 2001
    ..The results suggest that the risk of DEET accumulating in the fetus is low and that DEET is safe to use in later pregnancy...
  64. pmc Quinine pharmacokinetic-pharmacodynamic relationships in uncomplicated falciparum malaria
    S Pukrittayakamee
    Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 47:3458-63. 2003
    ..4 microg/ml and an MIC of 0.7 microg/ml for uncomplicated falciparum malaria in Thailand. To ensure a cure, the minimum parasiticidal concentration must be exceeded during four asexual cycles (>6 days)...
  65. ncbi request reprint Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine
    N J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Pharmacokinet 37:105-25. 1999
    ..Characterisation of these pharmacokinetic-pharmacodynamic relationships provided the basis for dosage optimisation, an approach that could be applied to other antimalarial drugs...
  66. pmc Artemether bioavailability after oral or intramuscular administration in uncomplicated falciparum malaria
    Kamolrat Silamut
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 47:3795-8. 2003
    ..5 to 3.0 h) than after intramuscular administration (median, 8 h; range, 4 to 24 h) (P=0.001). Intramuscular artemether is absorbed very slowly in patients with acute malaria...
  67. ncbi request reprint A new approach to evaluate regression models during validation of bioanalytical assays
    T Singtoroj
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Pharm Biomed Anal 41:219-27. 2006
    ..The results showed that log-log transformation without weighting was the simplest model to fit the calibration data and ensure good predictability for this data set...
  68. ncbi request reprint Prognostic value of cytokine concentrations (tumor necrosis factor-alpha, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis
    A J Simpson
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Infect Dis 181:621-5. 2000
    ..Therefore, APACHE II scores and either IL-6 or IL-10 concentration may be the most reliable parameters for stratification of patients in future studies of severe gram-negative sepsis...
  69. ncbi request reprint Persistence of Plasmodium falciparum HRP-2 in successfully treated acute falciparum malaria
    M Mayxay
    Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 95:179-82. 2001
    ..The PfHRP-2 dipstick test provides a useful indicator of recent severe malaria, but does not predict the therapeutic response...
  70. ncbi request reprint Assessment of the neurotoxicity of parenteral artemisinin derivatives in mice
    A Nontprasert
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 59:519-22. 1998
    ..At this dose the relative risk (95% confidence interval) for death or disability was 5.3 (2.6-11.2) for artemether recipients. Intramuscular artemether is significantly more neurotoxic than intramuscular artesunate in this murine model...
  71. ncbi request reprint Comparison of artemether and chloroquine for severe malaria in Gambian children
    N J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 339:317-21. 1992
    ..Artemether is a well tolerated and rapidly effective parenteral treatment for severe malaria in children, and would be especially valuable in areas with chloroquine-resistant P falciparum...
  72. doi request reprint Development and validation of a high-throughput zwitterionic hydrophilic interaction liquid chromatography solid-phase extraction-liquid chromatography-tandem mass spectrometry method for determination of the anti-influenza drug peramivir in plasma
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Chromatogr A 1215:145-51. 2008
    ..Validation of over-curve samples ensured that it would be possible with dilution if samples went outside the calibration range...
  73. ncbi request reprint Ex-vivo short-term culture and developmental assessment of Plasmodium vivax
    K Chotivanich
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trans R Soc Trop Med Hyg 95:677-80. 2001
    ..This simple method of culturing P. vivax ex vivo is suitable for antimalarial susceptibility and immunoparasitology studies...
  74. ncbi request reprint Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, and Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 190:1773-82. 2004
    ..This raised the possibility that the efficacy of the current coformulation may not be optimal in the treatment of multidrug-resistant falciparum malaria...
  75. pmc In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up
    Kasia Stepniewska
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 48:4271-80. 2004
    ..94) or if the entomological inoculation rate was known. In the assessment of drug efficacy against falciparum malaria, 28 days should be the minimum period of follow-up...
  76. ncbi request reprint Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 195:927-33. 2007
    ..Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection. It has been assumed that parasites causing relapse would be a subset of the parasites that caused the primary infection...
  77. ncbi request reprint Efficacy and safety of dihydroartemisinin-piperaquine
    H Y Myint
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 101:858-66. 2007
    ..The dosing regimen has been simplified from four doses to once daily over 3 days. More information on efficacy in Africa, and more pharmacokinetic and efficacy data in children are needed...
  78. pmc Association of genetic mutations in Plasmodium vivax dhfr with resistance to sulfadoxine-pyrimethamine: geographical and clinical correlates
    M Imwong
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 45:3122-7. 2001
    ..01). The three mutations at the pvdhfr codons for residues 57, 58, and 117 are associated with high levels of S-P resistance in P. vivax. These mutations presumably arose from selection pressure...
  79. pmc Population pharmacokinetics of intramuscular artesunate in African children with severe malaria: implications for a practical dosing regimen
    I C E Hendriksen
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Pharmacol Ther 93:443-50. 2013
    ..001), resulting in lower ARS and DHA exposure levels in smaller children. An adapted dosing regimen including a practical dosing table per weight band is proposed for young children based on the pharmacokinetic model...
  80. doi request reprint A liquid chromatographic-tandem mass spectrometric method for determination of artesunate and its metabolite dihydroartemisinin in human plasma
    W Hanpithakpong
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Chromatogr B Analyt Technol Biomed Life Sci 876:61-8. 2008
    ..The method was free from matrix effects as demonstrated both graphically and quantitatively...
  81. pmc Optimizing the culture of Plasmodium falciparum in hollow fiber bioreactors
    P Preechapornkul
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 41:761-9. 2010
    ..The system opens new possibilities for the study of in vitro drug sensitivity under conditions mimicking in vivo pharmacokinetics, and the selection of anti-malarial drug resistance and associated parasite biological and genomic changes...
  82. doi request reprint Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of piperaquine in plasma stable isotope labeled internal standard does not always compensate for matrix effects
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Chromatogr B Analyt Technol Biomed Life Sci 862:227-36. 2008
    ..It was found that this could lead to an underestimation of the true concentration with 50% despite the use of a deuterated internal standard...
  83. ncbi request reprint Intrarectal artemisinin derivatives
    F Nosten
    Faculty of Tropical Medicine, Madihol University, Bangkok, Thailand
    Med Trop (Mars) 58:63-4. 1998
    ..Preliminary studies have shown that artemisinin and its derivatives artesunate and artemether are effective when given intrarectally. More studies are needed to establish the optimum regimen...
  84. ncbi request reprint Artemisinin antimalarials in pregnancy: a prospective treatment study of 539 episodes of multidrug-resistant Plasmodium falciparum
    R McGready
    Shoklo Malaria Research Unit, Mae Sot, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 33:2009-16. 2001
    ..These results are reassuring, but further information about the safety of these valuable antimalarials in pregnancy is needed...
  85. ncbi request reprint Delaying antimalarial drug resistance with combination chemotherapy
    N J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Parassitologia 41:301-8. 1999
    ..This suggests that antimalarial drugs should not be used alone in treatment, but always in combination, as in the treatment of tuberculosis or HIV, and that the combination should include artemisinin or one of its derivatives...
  86. ncbi request reprint Rosetting characteristics of uninfected erythrocytes from healthy individuals and malaria patients
    K T Chotivanich
    Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Ann Trop Med Parasitol 92:45-56. 1998
    ..Similar effects were observed with uninfected rbc from patients with severe malaria after treatment with artesunate but not after quinine. The mechanisms underlying this potentially beneficial effect on rbc adherence are not known...
  87. ncbi request reprint Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated, falciparum malaria in Thailand
    P Wilairatana
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Thailand
    Ann Trop Med Parasitol 91:125-32. 1997
    ..The results demonstrate that short-course treatment with dapsone plus either proguanil or chlorproguanil is ineffective for the treatment of falciparum malaria in Thailand...
  88. ncbi request reprint The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria
    Paul N Newton
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Eur J Clin Pharmacol 62:1003-9. 2006
    ..The choice of doses used has been empirical. To inform dosage recommendations we assessed the pharmacokinetics of intravenous artesunate after the first dose...
  89. pmc Dihydroartemisinin-piperaquine versus chloroquine to treat vivax malaria in Afghanistan: an open randomized, non-inferiority, trial
    Ghulam Rahim Awab
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 9:105. 2010
    ..Chloroquine resistance in P. vivax is emerging in Asia. Therapeutic responses across Afghanistan have not been evaluated in detail...
  90. pmc Clinical trial of oral artesunate with or without high-dose primaquine for the treatment of vivax malaria in Thailand
    Udomsak Silachamroon
    Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 69:14-8. 2003
    ..The combination of five days of artesunate and 14 days of primaquine is a highly effective and generally well-tolerated treatment regimen for vivax malaria in Thailand...
  91. ncbi request reprint High throughput assay for the determination of lumefantrine in plasma
    A Annerberg
    Wellcome Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Chromatogr B Analyt Technol Biomed Life Sci 822:330-3. 2005
    ..The use of 96-well plate format and short chromatographic run has increased the daily sample throughput four times. The assay is particularly suitable for large therapeutic drug monitoring studies using day 7 sampling...
  92. ncbi request reprint Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of oseltamivir and its metabolite oseltamivir carboxylate in plasma, saliva and urine
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Chromatogr B Analyt Technol Biomed Life Sci 859:74-83. 2007
    ..The suppression did not affect the quantification of OP...
  93. ncbi request reprint Development and validation of a solid-phase extraction-liquid chromatographic method for determination of amoxicillin in plasma
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Ther Drug Monit 27:503-8. 2005
    ..050 microg/mL and 0.025 microg/mL, respectively, for 100 microL plasma. Long-term storage stability studies of amoxicillin in plasma indicate that a temperature of -80 degrees C is necessary to prevent degradation of amoxicillin...
  94. ncbi request reprint Qinghaosu in combinations
    N J White
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Med Trop (Mars) 58:85-8. 1998
    ..Those drugs with a particularly vulnerable profile, in which a single or double point mutation confers high level resistance, should not be deployed alone and should always be combined with an artemisinin derivative...
  95. ncbi request reprint Serum bactericidal and inhibitory titres in the management of melioidosis
    A J Simpson
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    J Antimicrob Chemother 45:123-7. 2000
    ..Pre-dose titres correlated with renal function; renal function was the most important predictor of mortality. Determination of serum inhibitory or bactericidal titres is unhelpful in the management of severe melioidosis...
  96. ncbi request reprint Studies of the neurotoxicity of oral artemisinin derivatives in mice
    A Nontprasert
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 62:409-12. 2000
    ....
  97. ncbi request reprint Artesunate-dapsone-proguanil treatment of falciparum malaria: genotypic determinants of therapeutic response
    Sivicha Krudsood
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 99:142-9. 2005
    ..The addition of artesunate considerably augments the antimalarial activity of the biguanide-dapsone combination, but this is insufficient for infections with parasites carrying the highly antifol-resistant Pfdhfr I164L mutation...
  98. ncbi request reprint Optimising operational use of artesunate-mefloquine: a randomised comparison of four treatment regimens
    Frank Smithuis
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok, 10400 Thailand
    Trans R Soc Trop Med Hyg 98:182-92. 2004
    ..Active measures to ensure absorption and improve adherence will be necessary to realise this advantage operationally...
  99. pmc Activities of artesunate and primaquine against asexual- and sexual-stage parasites in falciparum malaria
    Sasithon Pukrittayakamee
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 48:1329-34. 2004
    ..038). These results suggest that artesunate predominantly inhibits gametocyte development whereas primaquine accelerates gametocyte clearance in P. falciparum malaria...
  100. pmc Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria
    Paul N Newton
    Mae Sot, Tak and Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 49:1622-5. 2005
    ..The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal...
  101. ncbi request reprint Central role of the spleen in malaria parasite clearance
    Kesinee Chotivanich
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Infect Dis 185:1538-41. 2002
    ..Current criteria for high-grade antimalarial drug resistance that are based on changes in parasitemia are not appropriate for asplenic patients...