Research Topics
| Joel TarningSummaryAffiliation: Mahidol University Location: Bangkok, Thailand Summary: Pharmacometric research Publications
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Detail Information
Publications
Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malariaJoel Tarning
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Antimicrob Agents Chemother 53:3837-46. 2009..In conclusion, altered pharmacokinetic properties of lumefantrine contribute to the high rates of failure of artemether-lumefantrine treatment in later pregnancy. Dose optimization is urgently needed...- Towards optimal design of anti-malarial pharmacokinetic studiesJulie A Simpson
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, Melbourne, Victoria, Australia
Malar J 8:189. 2009.... - Orally formulated artemisinin in healthy fasting Vietnamese male subjects: a randomized, four-sequence, open-label, pharmacokinetic crossover studyTran Tinh Hien
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Clin Ther 33:644-54. 2011..Artemisinin and piperaquine have recently been proven to be prospective candidates for combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria... - Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether-lumefantrineShabana Ali
Department of Pharmacology and Therapeutics, Army Medical College, National University of Sciences and Technology NUST, Islamabad, Pakistan
Malar J 9:275. 2010..The aim of this study was to evaluate the pharmacokinetics of artemether and its active metabolite, dihydroartemisinin, in healthy Pakistani volunteers... - Intrahost modeling of artemisinin resistance in Plasmodium falciparumSompob Saralamba
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok 10400, Thailand
Proc Natl Acad Sci U S A 108:397-402. 2011..This result supports the hypothesis that artemisinin resistance mainly reflects reduced ring-stage susceptibility and predicts that doubling the frequency of dosing will accelerate clearance of artemisinin-resistant parasites... - Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malariaElizabeth A Ashley
Shoklo Malaria Research Unit, Mae Sot, Thailand
Eur J Clin Pharmacol 66:705-12. 2010..The aim of this study was to describe the relationship between piperaquine concentrations measured in capillary blood, venous blood and venous plasma... - Pitfalls in estimating piperaquine eliminationJoel Tarning
Department of Pharmacology, , Sweden
Antimicrob Agents Chemother 49:5127-8. 2005..This result illustrates the importance of extended sampling duration and sensitive assay methodologies in characterizing the disposition of slowly eliminated antimalarial drugs... - Artemisinin resistance in Plasmodium falciparum malariaArjen M Dondorp
Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
N Engl J Med 361:455-67. 2009..There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance... - Quantification of artemisinin in human plasma using liquid chromatography coupled to tandem mass spectrometryN Lindegardh
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
J Pharm Biomed Anal 49:768-73. 2009..The limit of detection was 0.257 ng/mL for artemisinin and the calibration range was 1.03-762 ng/mL using 50 microL plasma. The method was free from matrix effects as demonstrated both graphically and quantitatively... - Does artesunate prolong the electrocardiograph QT interval in patients with severe malaria?Richard J Maude
Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
Am J Trop Med Hyg 80:126-32. 2009..No effect was observed on the JTc or PR interval, QRS width, blood pressure, or heart rate. Intravenous artesunate does not have significant cardiovascular effects in patients with severe falciparum malaria... 
Development and validation of an automated solid phase extraction and liquid chromatographic method for the determination of piperaquine in urineJ Tarning
Department of Pharmacology, Sahlgrenska Academy, , Sweden
J Pharm Biomed Anal 41:213-8. 2006..0%, 5.2% and 9.8% at 5000, 500 and 50 ng/mL, respectively. The lower limit of quantification (LLOQ) was set to 3 ng/mL using 1 mL of urine, which could be lowered to 0.33 ng/mL when using 9 mL of urine and an increased injection volume...- A new approach to evaluate regression models during validation of bioanalytical assaysT Singtoroj
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
J Pharm Biomed Anal 41:219-27. 2006..The results showed that log-log transformation without weighting was the simplest model to fit the calibration data and ensure good predictability for this data set... - Characterization of human urinary metabolites of the antimalarial piperaquineJ Tarning
Department of Pharmacology, , , Sweden
Drug Metab Dispos 34:2011-9. 2006..Assuming formation rate-limiting kinetics, this would support recent findings that the terminal elimination half-life of PQ has been underestimated previously... - Pharmacokinetics and metabolism of the antimalarial piperaquine after intravenous and oral single doses to the ratJ Tarning
Department of Pharmacology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
J Pharm Sci 97:3400-10. 2008..The similarity with results in humans indicates the rat to be a suitable species for nonclinical in vivo piperaquine studies... - Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in ThailandJ Tarning
Department of Pharmacology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Antimicrob Agents Chemother 52:1052-61. 2008..Our data lend further support to a simplified once-daily treatment regimen to improve treatment adherence and efficacy and indicate that weight-adjusted piperaquine doses in children may need to be higher than in adults... 
Quantification of the antimalarial piperaquine in plasmaJoel Tarning
Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
Trans R Soc Trop Med Hyg 102:409-11. 2008..Five of these allow for quantification of piperaquine in plasma and are discussed in this paper...- Pharmacokinetics of high-dose oseltamivir in healthy volunteersY Wattanagoon
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Antimicrob Agents Chemother 53:945-52. 2009..Probenecid coadministration may allow considerable dose saving for oseltamivir, but more information on OC penetration into respiratory secretions is needed to devise appropriate dose regimens... - Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malariaKris M Jamsen
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
Malar J 11:143. 2012.... - Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malariaKris M Jamsen
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
Malar J 10:181. 2011..In this work optimal design methods were used to determine sampling designs for typical future population PK studies of dihydroartemisinin, the principal biologically active metabolite of oral artesunate... - Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax malaria during and after pregnancyJoel Tarning
Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
Antimicrob Agents Chemother 56:5764-73. 2012..2% to 7.4% at day 35. In conclusion, pregnancy did not have a clinically relevant impact on the pharmacokinetic properties of amodiaquine or desethylamodiaquine. No dose adjustments are required in pregnancy... - A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in SudanRichard M Hoglund
Unit for Pharmacokinetics and Drug Metabolism, Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden
Malar J 11:398. 2012..The aim of this study was to investigate the population pharmacokinetics of piperaquine in pregnant and non-pregnant Sudanese women with uncomplicated Plasmodium falciparum malaria... - Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in UgandaJoel Tarning
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
Malar J 11:293. 2012..The objective of this study was to evaluate the population pharmacokinetic properties of artemether and its active metabolite dihydroartemisinin in pregnant women with uncomplicated P. falciparum malaria in Uganda... - Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malariaJ Tarning
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Clin Pharmacol Ther 91:497-505. 2012..025) but had significantly lower day 7 piperaquine concentrations (P = 0.024) and total piperaquine exposures (P = 0.021), suggesting that an increased dose regimen for young children should be evaluated... - Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated malariaJoel Tarning
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Antimicrob Agents Chemother 56:1997-2007. 2012..The clinical impact of these pharmacokinetic findings in pregnant women with uncomplicated malaria needs to be evaluated in larger series...