Joel Tarning

Summary

Affiliation: Mahidol University
Location: Bangkok, Thailand
Summary:
Pharmacometric research

Publications

  1. pmc Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria
    Joel Tarning
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 53:3837-46. 2009
  2. pmc Towards optimal design of anti-malarial pharmacokinetic studies
    Julie A Simpson
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, Melbourne, Victoria, Australia
    Malar J 8:189. 2009
  3. pmc Orally formulated artemisinin in healthy fasting Vietnamese male subjects: a randomized, four-sequence, open-label, pharmacokinetic crossover study
    Tran Tinh Hien
    Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Clin Ther 33:644-54. 2011
  4. pmc Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether-lumefantrine
    Shabana Ali
    Department of Pharmacology and Therapeutics, Army Medical College, National University of Sciences and Technology NUST, Islamabad, Pakistan
    Malar J 9:275. 2010
  5. pmc Intrahost modeling of artemisinin resistance in Plasmodium falciparum
    Sompob Saralamba
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok 10400, Thailand
    Proc Natl Acad Sci U S A 108:397-402. 2011
  6. pmc Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Eur J Clin Pharmacol 66:705-12. 2010
  7. pmc Pitfalls in estimating piperaquine elimination
    Joel Tarning
    Department of Pharmacology, Goteborg University, Sweden
    Antimicrob Agents Chemother 49:5127-8. 2005
  8. pmc Artemisinin resistance in Plasmodium falciparum malaria
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    N Engl J Med 361:455-67. 2009
  9. pmc Quantification of artemisinin in human plasma using liquid chromatography coupled to tandem mass spectrometry
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Pharm Biomed Anal 49:768-73. 2009
  10. pmc Does artesunate prolong the electrocardiograph QT interval in patients with severe malaria?
    Richard J Maude
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    Am J Trop Med Hyg 80:126-32. 2009

Collaborators

Detail Information

Publications25

  1. pmc Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria
    Joel Tarning
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 53:3837-46. 2009
    ..In conclusion, altered pharmacokinetic properties of lumefantrine contribute to the high rates of failure of artemether-lumefantrine treatment in later pregnancy. Dose optimization is urgently needed...
  2. pmc Towards optimal design of anti-malarial pharmacokinetic studies
    Julie A Simpson
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, Melbourne, Victoria, Australia
    Malar J 8:189. 2009
    ....
  3. pmc Orally formulated artemisinin in healthy fasting Vietnamese male subjects: a randomized, four-sequence, open-label, pharmacokinetic crossover study
    Tran Tinh Hien
    Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Clin Ther 33:644-54. 2011
    ..Artemisinin and piperaquine have recently been proven to be prospective candidates for combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria...
  4. pmc Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether-lumefantrine
    Shabana Ali
    Department of Pharmacology and Therapeutics, Army Medical College, National University of Sciences and Technology NUST, Islamabad, Pakistan
    Malar J 9:275. 2010
    ..The aim of this study was to evaluate the pharmacokinetics of artemether and its active metabolite, dihydroartemisinin, in healthy Pakistani volunteers...
  5. pmc Intrahost modeling of artemisinin resistance in Plasmodium falciparum
    Sompob Saralamba
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok 10400, Thailand
    Proc Natl Acad Sci U S A 108:397-402. 2011
    ..This result supports the hypothesis that artemisinin resistance mainly reflects reduced ring-stage susceptibility and predicts that doubling the frequency of dosing will accelerate clearance of artemisinin-resistant parasites...
  6. pmc Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Eur J Clin Pharmacol 66:705-12. 2010
    ..The aim of this study was to describe the relationship between piperaquine concentrations measured in capillary blood, venous blood and venous plasma...
  7. pmc Pitfalls in estimating piperaquine elimination
    Joel Tarning
    Department of Pharmacology, Goteborg University, Sweden
    Antimicrob Agents Chemother 49:5127-8. 2005
    ..This result illustrates the importance of extended sampling duration and sensitive assay methodologies in characterizing the disposition of slowly eliminated antimalarial drugs...
  8. pmc Artemisinin resistance in Plasmodium falciparum malaria
    Arjen M Dondorp
    Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    N Engl J Med 361:455-67. 2009
    ..There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance...
  9. pmc Quantification of artemisinin in human plasma using liquid chromatography coupled to tandem mass spectrometry
    N Lindegardh
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Pharm Biomed Anal 49:768-73. 2009
    ..The limit of detection was 0.257 ng/mL for artemisinin and the calibration range was 1.03-762 ng/mL using 50 microL plasma. The method was free from matrix effects as demonstrated both graphically and quantitatively...
  10. pmc Does artesunate prolong the electrocardiograph QT interval in patients with severe malaria?
    Richard J Maude
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
    Am J Trop Med Hyg 80:126-32. 2009
    ..No effect was observed on the JTc or PR interval, QRS width, blood pressure, or heart rate. Intravenous artesunate does not have significant cardiovascular effects in patients with severe falciparum malaria...
  11. ncbi request reprint Development and validation of an automated solid phase extraction and liquid chromatographic method for the determination of piperaquine in urine
    J Tarning
    Department of Pharmacology, Sahlgrenska Academy, Goteborg, Sweden
    J Pharm Biomed Anal 41:213-8. 2006
    ..0%, 5.2% and 9.8% at 5000, 500 and 50 ng/mL, respectively. The lower limit of quantification (LLOQ) was set to 3 ng/mL using 1 mL of urine, which could be lowered to 0.33 ng/mL when using 9 mL of urine and an increased injection volume...
  12. ncbi request reprint A new approach to evaluate regression models during validation of bioanalytical assays
    T Singtoroj
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Pharm Biomed Anal 41:219-27. 2006
    ..The results showed that log-log transformation without weighting was the simplest model to fit the calibration data and ensure good predictability for this data set...
  13. ncbi request reprint Characterization of human urinary metabolites of the antimalarial piperaquine
    J Tarning
    Department of Pharmacology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Drug Metab Dispos 34:2011-9. 2006
    ..Assuming formation rate-limiting kinetics, this would support recent findings that the terminal elimination half-life of PQ has been underestimated previously...
  14. ncbi request reprint Pharmacokinetics and metabolism of the antimalarial piperaquine after intravenous and oral single doses to the rat
    J Tarning
    Department of Pharmacology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Pharm Sci 97:3400-10. 2008
    ..The similarity with results in humans indicates the rat to be a suitable species for nonclinical in vivo piperaquine studies...
  15. pmc Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand
    J Tarning
    Department of Pharmacology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Antimicrob Agents Chemother 52:1052-61. 2008
    ..Our data lend further support to a simplified once-daily treatment regimen to improve treatment adherence and efficacy and indicate that weight-adjusted piperaquine doses in children may need to be higher than in adults...
  16. doi request reprint Quantification of the antimalarial piperaquine in plasma
    Joel Tarning
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 102:409-11. 2008
    ..Five of these allow for quantification of piperaquine in plasma and are discussed in this paper...
  17. pmc Pharmacokinetics of high-dose oseltamivir in healthy volunteers
    Y Wattanagoon
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 53:945-52. 2009
    ..Probenecid coadministration may allow considerable dose saving for oseltamivir, but more information on OC penetration into respiratory secretions is needed to devise appropriate dose regimens...
  18. pmc Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults
    Pauline Byakika-Kibwika
    Infectious Diseases Institute, Makerere University, PO Box 22418, Kampala, Uganda
    Malar J 11:132. 2012
    ..The aim of this study was to assess the pharmacokinetics and pharmacodynamics of intravenous artesunate in Ugandan adults with severe malaria...
  19. pmc Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria
    Kris M Jamsen
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
    Malar J 11:143. 2012
    ....
  20. pmc Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria
    Kris M Jamsen
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
    Malar J 10:181. 2011
    ..In this work optimal design methods were used to determine sampling designs for typical future population PK studies of dihydroartemisinin, the principal biologically active metabolite of oral artesunate...
  21. pmc Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda
    Joel Tarning
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Malar J 11:293. 2012
    ..The objective of this study was to evaluate the population pharmacokinetic properties of artemether and its active metabolite dihydroartemisinin in pregnant women with uncomplicated P. falciparum malaria in Uganda...
  22. pmc A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan
    Richard M Hoglund
    Unit for Pharmacokinetics and Drug Metabolism, Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden
    Malar J 11:398. 2012
    ..The aim of this study was to investigate the population pharmacokinetics of piperaquine in pregnant and non-pregnant Sudanese women with uncomplicated Plasmodium falciparum malaria...
  23. pmc Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax malaria during and after pregnancy
    Joel Tarning
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 56:5764-73. 2012
    ..2% to 7.4% at day 35. In conclusion, pregnancy did not have a clinically relevant impact on the pharmacokinetic properties of amodiaquine or desethylamodiaquine. No dose adjustments are required in pregnancy...
  24. pmc Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria
    J Tarning
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Pharmacol Ther 91:497-505. 2012
    ..025) but had significantly lower day 7 piperaquine concentrations (P = 0.024) and total piperaquine exposures (P = 0.021), suggesting that an increased dose regimen for young children should be evaluated...
  25. pmc Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated malaria
    Joel Tarning
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 56:1997-2007. 2012
    ..The clinical impact of these pharmacokinetic findings in pregnant women with uncomplicated malaria needs to be evaluated in larger series...