Sharon J Peacock

Summary

Affiliation: Mahidol University
Country: Thailand

Publications

  1. pmc Clinical diagnosis and geographic distribution of leptospirosis, Thailand
    Vanaporn Wuthiekanun
    Mahidol University, Bangkok, Thailand
    Emerg Infect Dis 13:124-6. 2007
  2. pmc Management of accidental laboratory exposure to Burkholderia pseudomallei and B. mallei
    Sharon J Peacock
    Mahidol University, Bangkok, Thailand
    Emerg Infect Dis 14:e2. 2008
  3. pmc Genetic diversity and microevolution of Burkholderia pseudomallei in the environment
    Narisara Chantratita
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 2:e182. 2008
  4. pmc A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand
    Janjira Thaipadungpanit
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 1:e56. 2007
  5. pmc The core and accessory genomes of Burkholderia pseudomallei: implications for human melioidosis
    Siew Hoon Sim
    Defense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Republic of Singapore
    PLoS Pathog 4:e1000178. 2008
  6. pmc Emergence of community-associated methicillin-resistant Staphylococcus aureus associated with pediatric infection in Cambodia
    Kheng Chheng
    Angkor Hospital for Children, Siem Reap, Kingdom of Cambodia
    PLoS ONE 4:e6630. 2009
  7. pmc Burkholderia pseudomallei Is Genetically Diverse in Agricultural Land in Northeast Thailand
    Vanaporn Wuthiekanun
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 3:e496. 2009
  8. pmc Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates
    Bernice Meng Qi Sim
    Genome Institute of Singapore, 60 Biopolis Street, 138672 Singapore
    Genome Biol 11:R89. 2010
  9. pmc Genomic islands from five strains of Burkholderia pseudomallei
    Apichai Tuanyok
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    BMC Genomics 9:566. 2008
  10. pmc Comparison of Ashdown's medium, Burkholderia cepacia medium, and Burkholderia pseudomallei selective agar for clinical isolation of Burkholderia pseudomallei
    Sharon J Peacock
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Clin Microbiol 43:5359-61. 2005

Detail Information

Publications118 found, 100 shown here

  1. pmc Clinical diagnosis and geographic distribution of leptospirosis, Thailand
    Vanaporn Wuthiekanun
    Mahidol University, Bangkok, Thailand
    Emerg Infect Dis 13:124-6. 2007
    ..Accuracy of clinical diagnosis varied from 0% to 50% between the provinces and was highest during the rainy season. Most confirmed cases occurred in the north and northeast regions of the country...
  2. pmc Management of accidental laboratory exposure to Burkholderia pseudomallei and B. mallei
    Sharon J Peacock
    Mahidol University, Bangkok, Thailand
    Emerg Infect Dis 14:e2. 2008
    ..pseudomallei. The overall mortality rate of infected persons is 50% in northeast Thailand (35% in children) and 19% in Australia...
  3. pmc Genetic diversity and microevolution of Burkholderia pseudomallei in the environment
    Narisara Chantratita
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 2:e182. 2008
    ..The soil dwelling Gram-negative pathogen Burkholderia pseudomallei is the cause of melioidosis. The diversity and population structure of this organism in the environment is poorly defined...
  4. pmc A dominant clone of Leptospira interrogans associated with an outbreak of human leptospirosis in Thailand
    Janjira Thaipadungpanit
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 1:e56. 2007
    ..A sustained outbreak of leptospirosis occurred in northeast Thailand between 1999 and 2003, the basis for which was unknown...
  5. pmc The core and accessory genomes of Burkholderia pseudomallei: implications for human melioidosis
    Siew Hoon Sim
    Defense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Republic of Singapore
    PLoS Pathog 4:e1000178. 2008
    ..Our results suggest that the Bp accessory genome is likely to play an important role in microbial adaptation and virulence...
  6. pmc Emergence of community-associated methicillin-resistant Staphylococcus aureus associated with pediatric infection in Cambodia
    Kheng Chheng
    Angkor Hospital for Children, Siem Reap, Kingdom of Cambodia
    PLoS ONE 4:e6630. 2009
    ..One explanation for this difference is that resource poor countries lack the diagnostic microbiology facilities necessary to detect the presence of CA-MRSA carriage and infection...
  7. pmc Burkholderia pseudomallei Is Genetically Diverse in Agricultural Land in Northeast Thailand
    Vanaporn Wuthiekanun
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 3:e496. 2009
    ..pseudomallei exists despite the effects of flooding and the physical and chemical processes associated with farming. These findings form an important baseline for future studies of environmental B. pseudomallei...
  8. pmc Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates
    Bernice Meng Qi Sim
    Genome Institute of Singapore, 60 Biopolis Street, 138672 Singapore
    Genome Biol 11:R89. 2010
    ..To study B. thailandensis genomic variation, we profiled 50 isolates using a pan-genome microarray comprising genomic elements from 28 Burkholderia strains and species...
  9. pmc Genomic islands from five strains of Burkholderia pseudomallei
    Apichai Tuanyok
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    BMC Genomics 9:566. 2008
    ..The purpose of this study was to examine the role of genomic islands (GIs) as sources of genomic diversity in this species...
  10. pmc Comparison of Ashdown's medium, Burkholderia cepacia medium, and Burkholderia pseudomallei selective agar for clinical isolation of Burkholderia pseudomallei
    Sharon J Peacock
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    J Clin Microbiol 43:5359-61. 2005
    ..pseudomallei from 155 clinical specimens that proved positive for this organism. The sensitivity of each was equivalent; the selectivity of BPSA was lower than that of Ashdown's or B. cepacia medium...
  11. ncbi request reprint Public health impact of establishing the cause of bacterial infections in rural Asia
    Sharon J Peacock
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trans R Soc Trop Med Hyg 102:5-6. 2008
    ..These factors have major implications for empirical therapy of fever. Initiatives are urgently needed to strengthen the infrastructure of microbiology in rural Asia...
  12. pmc Determinants of acquisition and carriage of Staphylococcus aureus in infancy
    Sharon J Peacock
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Clin Microbiol 41:5718-25. 2003
    ..S. aureus carriage in infants is likely to be determined by a combination of host, environmental, and bacterial factors, but bacterial interference does not appear to be an ultimate determinant of carrier status...
  13. ncbi request reprint Melioidosis
    Sharon J Peacock
    Wellcome Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Curr Opin Infect Dis 19:421-8. 2006
    ..A brief summary of studies relating to genomics and genotyping, immunology and pathogenesis is provided...
  14. pmc Burkholderia pseudomallei genome plasticity associated with genomic island variation
    Sarinna Tumapa
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    BMC Genomics 9:190. 2008
    ..pseudomallei isolates, little is known about the extent of variation between related strains or their association with disease or environmental survival...
  15. pmc Nonrandom distribution of Burkholderia pseudomallei clones in relation to geographical location and virulence
    Mongkol Vesaratchavest
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand, and Churchill Hospital, Oxford, UK
    J Clin Microbiol 44:2553-7. 2006
    ..This analysis reveals strong genetic differentiation on the basis of geographical isolation and a significant differentiation on the basis of virulence potential...
  16. ncbi request reprint Prospective evaluation of a rapid immunochromogenic cassette test for the diagnosis of melioidosis in northeast Thailand
    Allen C Cheng
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok, 10400, Thailand
    Trans R Soc Trop Med Hyg 100:64-7. 2006
    ..Low sensitivity and specificity of clinical rules is consistent with the protean manifestations of melioidosis and clinical difficulty in identifying patients with melioidosis...
  17. ncbi request reprint Risk factors for recurrent melioidosis in northeast Thailand
    Direk Limmathurotsakul
    Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand
    Clin Infect Dis 43:979-86. 2006
    ..A recent study revealed that 25% of patients with recurrence had reinfection rather than a relapse resulting from a failure to cure. The aim of this study was to reevaluate these 2 patient groups to define their individual risk factors...
  18. pmc Rapid isolation and susceptibility testing of Leptospira spp. using a new solid medium, LVW agar
    Vanaporn Wuthiekanun
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 57:297-302. 2013
    ..The use of LVW agar, which enables rapid growth, isolation of single colonies, and simple antimicrobial susceptibility testing for Leptospira spp., provides an opportunity for new areas of fundamental and applied research...
  19. pmc Loop-mediated isothermal amplification method targeting the TTS1 gene cluster for detection of Burkholderia pseudomallei and diagnosis of melioidosis
    Narisara Chantratita
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    J Clin Microbiol 46:568-73. 2008
    ..The PCR and LAMP assays evaluated here are not sufficiently sensitive to replace culture in our clinical setting...
  20. pmc A simple scoring system to differentiate between relapse and re-infection in patients with recurrent melioidosis
    Direk Limmathurotsakul
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 2:e327. 2008
    ..Distinguishing between the two is important but requires bacterial genotyping. The aim of this study was to develop a simple scoring system to distinguish re-infection from relapse...
  21. pmc Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis
    Rachaneeporn Tiyawisutsri
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    BMC Microbiol 7:19. 2007
    ..Genomic and epidemiological studies have shown that B. mallei is a recently emerged, host restricted clone of B. pseudomallei...
  22. pmc High rates of homologous recombination in the mite endosymbiont and opportunistic human pathogen Orientia tsutsugamushi
    Piengchan Sonthayanon
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 4:e752. 2010
    ....
  23. pmc Association of high Orientia tsutsugamushi DNA loads with disease of greater severity in adults with scrub typhus
    Piengchan Sonthayanon
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Clin Microbiol 47:430-4. 2009
    ..7] versus 281 [5.2] copies/ml; P < 0.001). This study has demonstrated a relationship between bacterial load and disease severity in adults with scrub typhus...
  24. pmc Recurrent melioidosis in patients in northeast Thailand is frequently due to reinfection rather than relapse
    Bina Maharjan
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    J Clin Microbiol 43:6032-4. 2005
    ..This finding has important implications for the clinical management of melioidosis patients and for antibiotic treatment studies that use recurrent disease as a marker for treatment failure...
  25. pmc Emergence of pediatric melioidosis in Siem Reap, Cambodia
    Yos Pagnarith
    Angkor Hospital for Children, Siem Reap, Cambodia
    Am J Trop Med Hyg 82:1106-12. 2010
    ..Our findings indicate the need for heightened awareness of melioidosis in Cambodia, and they have led us to review microbiology procedures and antimicrobial prescribing of suspected and confirmed cases...
  26. pmc Burkholderia pseudomallei antibodies in children, Cambodia
    Vanaporn Wuthiekanun
    Mahidol University, Bangkok, Thailand
    Emerg Infect Dis 14:301-3. 2008
    ..This organism was isolated from 30% of rice paddies in the surrounding vicinity. Despite the lack of reported indigenous cases, melioidosis is likely to occur in Cambodia...
  27. pmc Serological evidence for increased human exposure to Burkholderia pseudomallei following the tsunami in southern Thailand
    Vanaporn Wuthiekanun
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Clin Microbiol 44:239-40. 2006
    ..The findings were suggestive of increased recent exposure in both tsunami survivors and uninjured bystanders. Survivors of the Thailand tsunami may be at increased risk of melioidosis...
  28. pmc Molecular confirmation of co-infection by pathogenic Leptospira spp. and Orientia tsutsugamushi in patients with acute febrile illness in Thailand
    Piengchan Sonthayanon
    Department of Molecular Tropical Medicine and Genetics, Department of Clinical Tropical Medicine, Mahidol Oxford Tropical Medicine Research Unit, Department of Tropical Hygiene, and Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand WHO FAO OIE Collaborating Centre for Reference and Research on Leptospirosis, Western Pacific Region, Communicable Disease Unit, Queensland Health Forensic and Scientific Services, Brisbane, Queensland, Australia Center for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Am J Trop Med Hyg 89:797-9. 2013
    ..We conclude that dual infection occurs, but that serologic tests may overestimate the frequency of co-infections...
  29. pmc Fool's gold: Why imperfect reference tests are undermining the evaluation of novel diagnostics: a reevaluation of 5 diagnostic tests for leptospirosis
    Direk Limmathurotsakul
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 55:322-31. 2012
    ..We hypothesized that our reference standard was imperfect and used statistical modeling to investigate this hypothesis...
  30. pmc Molecular detection and speciation of pathogenic Leptospira spp. in blood from patients with culture-negative leptospirosis
    Siriphan Boonsilp
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    BMC Infect Dis 11:338. 2011
    ..Leptospira spp. are fastidious bacteria, and we hypothesized that a false-negative culture result may represent infection with a distinct bacterial subset that fail to grow in standard culture medium...
  31. pmc Simultaneous infection with more than one strain of Burkholderia pseudomallei is uncommon in human melioidosis
    Direk Limmathurotsakul
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Clin Microbiol 45:3830-2. 2007
    ..Genotyping of 2,058 bacterial colonies isolated from 215 samples taken from 133 patients demonstrated that mixed infection is uncommon (2/133 cases [1.5%; 95% confidence interval, 0.2 to 5.3%])...
  32. doi request reprint Genetic typing of the 56-kDa type-specific antigen gene of contemporary Orientia tsutsugamushi isolates causing human scrub typhus at two sites in north-eastern and western Thailand
    Stuart D Blacksell
    Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    FEMS Immunol Med Microbiol 52:335-42. 2008
    ..80, Fisher's exact). Within this diversity there were also examples of isolates with identical 56-kDa genotypes that were cultured from patients from the same geographical areas...
  33. pmc Biological relevance of colony morphology and phenotypic switching by Burkholderia pseudomallei
    Narisara Chantratita
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    J Bacteriol 189:807-17. 2007
    ..These findings have major implications for therapeutics and vaccine development...
  34. pmc Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia
    Emma K Nickerson
    Mahidol Oxford Tropical Medicine Research Unit, and Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 84:313-7. 2011
    ..The study findings have important implications for healthcare in a setting where diagnostic microbiology and access to antimicrobial drugs with efficacy against MRSA are limited...
  35. pmc Optimization of culture of Leptospira from humans with leptospirosis
    Vanaporn Wuthiekanun
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    J Clin Microbiol 45:1363-5. 2007
    ....
  36. pmc Accuracy of enzyme-linked immunosorbent assay using crude and purified antigens for serodiagnosis of melioidosis
    Narisara Chantratita
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Vaccine Immunol 14:110-3. 2007
    ..pseudomallei antigen (sensitivity, 81%; specificity, 70%), an improvement over the indirect hemagglutination assay (sensitivity, 73%; specificity, 64%)...
  37. pmc Rapid detection of Burkholderia pseudomallei in blood cultures using a monoclonal antibody-based immunofluorescent assay
    Narisara Chantratita
    Department of Microbiology and Immunology, Mahidol Oxford Tropical Medicine Research Unit, and Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Department of Clinical Pathology, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Am J Trop Med Hyg 89:971-2. 2013
    ..pseudomallei (specificity = 100%). The Mab-IFA could be a valuable supplementary tool for rapid detection. We recommend the use of the Mab-IFA to test blood cultures that flag positive in regions where melioidosis is endemic...
  38. pmc Proteomic analysis of colony morphology variants of Burkholderia pseudomallei defines a role for the arginine deiminase system in bacterial survival
    Narisara Chantratita
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Proteomics 75:1031-42. 2012
    ..1. These data provide novel insights into proteomic alterations that occur during the complex process of morphotype switching, and lend support to the idea that this is associated with a fitness advantage in vivo...
  39. pmc Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast Thailand
    Vanaporn Wuthiekanun
    Mahidol Oxford Tropical Medicine Research Unit, Department of Microbiology and Immunology, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 55:5388-91. 2011
    ..Resistance to carbapenem drugs was not detected. These findings support the current prescribing recommendations for melioidosis...
  40. pmc Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis
    Direk Limmathurotsakul
    Department of Tropical Hygiene, Department of Microbiology and Immunology and Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithee Road, Bangkok, Thailand
    Am J Trop Med Hyg 84:858-61. 2011
    ..However, repeat cultures of respiratory secretions, urine, throat swabs, or pus/surface swabs provide no prognostic information. This finding highlights the need for follow-up blood cultures in patients with melioidosis...
  41. pmc Accuracy of loop-mediated isothermal amplification for diagnosis of human leptospirosis in Thailand
    Piengchan Sonthayanon
    Department of Clinical Tropical Medicine, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, 420 6 Rajvithi Road, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 84:614-20. 2011
    ..84.6, 95% CI = 69.5-94.1). The rrs LAMP can provide an admission diagnosis in approximately half of patients with leptospirosis, but its clinical utility is reduced by a lower specificity...
  42. ncbi request reprint Quantitation of B. Pseudomallei in clinical samples
    Vanaporn Wuthiekanun
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 77:812-3. 2007
    ..1, 1.5 x 10(4), 1.1 x 10(5), and 1.1 x 10(7) CFU/mL in these sample types, respectively. This provides important insights into the likely feasibility of future studies such as expression microarray analysis using clinical material...
  43. pmc Evaluation of immunoglobulin M (IgM) and IgG rapid cassette test kits for diagnosis of melioidosis in an area of endemicity
    Vanaporn Wuthiekanun
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok, 10400 Thailand
    J Clin Microbiol 42:3435-7. 2004
    ..This kit represents an improvement over IHA for the diagnosis of melioidosis an area of endemicity although, as with other serological tests, it has reduced diagnostic utility in a population with high background seropositivity...
  44. pmc Rapid immunofluorescence microscopy for diagnosis of melioidosis
    Vanaporn Wuthiekanun
    Faculty of Tropical Medicine, Wellcome Trust Oxford University Mahidol University Tropical Medicine Research Program, Bangkok, Thailand
    Clin Diagn Lab Immunol 12:555-6. 2005
    ..The sensitivities of both IF tests were 66%, and the specificities were 99.5 and 99.4%, respectively...
  45. ncbi request reprint Pulsed-field gel electrophoresis as a discriminatory typing technique for the biothreat agent burkholderia mallei
    Narisara Chantratita
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 74:345-7. 2006
    ..We demonstrated good resolution by PFGE together with clustering of some geographically related isolates, and confirmed previous observations that B. mallei is clonal as defined by MLST...
  46. pmc Antibodies from patients with melioidosis recognize Burkholderia mallei but not Burkholderia thailandensis antigens in the indirect hemagglutination assay
    Rachaneeporn Tiyawisutsri
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Clin Microbiol 43:4872-4. 2005
    ..pseudomallei, B. mallei, and B. thailandensis antigens. We demonstrate a lack of cross-reactivity between B. pseudomallei and B. thailandensis but marked cross-reactivity between B. pseudomallei and B. mallei...
  47. pmc Detection of Burkholderia pseudomallei in soil within the Lao People's Democratic Republic
    Vanaporn Wuthiekanun
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok, 10400 Thailand
    J Clin Microbiol 43:923-4. 2005
    ..In this study, 36% of 110 soil samples in northern Lao PDR were positive for B. pseudomallei, providing further evidence for the presence of melioidosis in this country...
  48. pmc Prevalence of melioidosis in patients with suspected pulmonary tuberculosis and sputum smear negative for acid-fast bacilli in northeast Thailand
    Pornpan Suntornsut
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Department of Medicine, Udon Thani Hospital, Udon Thani, Thailand Department of Medical Technology, Udon Thani Hospital, Udon Thani, Thailand Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom Department of Medicine, Cambridge University, Addenbrooke s Hospital, Cambridge, United Kingdom Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 89:983-5. 2013
    ..5%; 95% confidence interval [CI] 0.5-7.3%). We propose that in melioidosis-endemic areas, residual sputum from AFB testing should be routinely cultured for B. pseudomallei...
  49. ncbi request reprint Two randomized controlled trials of ceftazidime alone versus ceftazidime in combination with trimethoprim-sulfamethoxazole for the treatment of severe melioidosis
    Wirongrong Chierakul
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 41:1105-13. 2005
    ..It is not known whether TMP-SMX provides an additional benefit...
  50. pmc Diagnostic accuracy of real-time PCR assays targeting 16S rRNA and lipL32 genes for human leptospirosis in Thailand: a case-control study
    Janjira Thaipadungpanit
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS ONE 6:e16236. 2011
    ..Here, we compare the diagnostic sensitivity and specificity of two real-time PCR assays targeting rrs or lipL32 for the diagnosis of leptospirosis in northeast Thailand...
  51. pmc Role and significance of quantitative urine cultures in diagnosis of melioidosis
    Direk Limmathurotsakul
    Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    J Clin Microbiol 43:2274-6. 2005
    ..The presence of B. pseudomallei in urine during systemic infection is associated with a poor prognosis...
  52. doi request reprint Staphylococcus aureus disease and drug resistance in resource-limited countries in south and east Asia
    Emma K Nickerson
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet Infect Dis 9:130-5. 2009
    ..An initiative is needed to raise the profile of S aureus disease in developing countries, and to define a programme of research to find practical solutions to the health-care challenges posed by this important global pathogen...
  53. pmc Staphylococcus aureus bacteraemia in a tropical setting: patient outcome and impact of antibiotic resistance
    Emma K Nickerson
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    PLoS ONE 4:e4308. 2009
    ..Most information on invasive Staphylococcus aureus infections comes from temperate countries. There are considerable knowledge gaps in epidemiology, treatment, drug resistance and outcome of invasive S. aureus infection in the tropics...
  54. pmc Burkholderia pseudomallei is spatially distributed in soil in northeast Thailand
    Direk Limmathurotsakul
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 4:e694. 2010
    ..The aim of this study was to evaluate spatial distribution of B. pseudomallei in soil and consider the implications of this for soil sampling strategies...
  55. doi request reprint Activation of the coagulation cascade in patients with leptospirosis
    Wirongrong Chierakul
    Department of Clinical Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 46:254-60. 2008
    ..The aim of this study was to evaluate coagulation factors and the presence of DIC in patients with leptospirosis in northeast Thailand...
  56. pmc Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei
    Narisara Chantratita
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Proc Natl Acad Sci U S A 108:17165-70. 2011
    ..The mechanism described here represents an explanation for ceftazidime treatment failure, and may be a frequent but undetected resistance event...
  57. ncbi request reprint Development of antibodies to Burkholderia pseudomallei during childhood in melioidosis-endemic northeast Thailand
    Vanaporn Wuthiekanun
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 74:1074-5. 2006
    ..There was a sharp rise in detectable antibodies from birth to 4 years followed by reactivity in approximately 60-70% of children thereafter...
  58. pmc Leptospira species in floodwater during the 2011 floods in the Bangkok Metropolitan Region, Thailand
    Janjira Thaipadungpanit
    Mahidol Oxford Tropical Medicine Research Unit and Departments of Microbiology and Immunology, Tropical Hygiene, and Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Am J Trop Med Hyg 89:794-6. 2013
    ..This study provides baseline information on environmental Leptospira in Bangkok together with a set of laboratory tests that could be readily deployed in the event of future flooding...
  59. ncbi request reprint Trimethoprim/sulfamethoxazole resistance in clinical isolates of Burkholderia pseudomallei
    Vanaporn Wuthiekanun
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Antimicrob Chemother 55:1029-31. 2005
    ..Antimicrobial susceptibility testing using the disc diffusion method is commonly used in melioidosis-endemic areas, but may overestimate resistance to trimethoprim/sulfamethoxazole...
  60. pmc Monoclonal antibody-based immunofluorescence microscopy for the rapid identification of Burkholderia pseudomallei in clinical specimens
    Sarunporn Tandhavanant
    Department of Microbiology and Immunology, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 89:165-8. 2013
    ..The diagnostic sensitivity and specificity of the Mab-IFA was comparable to the Pab-IFA (48.4% versus 45.3% for sensitivity, and 99.8% versus 98.8% for specificity). We have incorporated the Mab-IFA into our routine practice...
  61. pmc A single multilocus sequence typing (MLST) scheme for seven pathogenic Leptospira species
    Siriphan Boonsilp
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 7:e1954. 2013
    ..interrogans and L. kirschneri. Our aim was to broaden the utility of this scheme to incorporate a total of seven pathogenic species...
  62. pmc Melioidosis vaccines: a systematic review and appraisal of the potential to exploit biodefense vaccines for public health purposes
    Sharon J Peacock
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 6:e1488. 2012
    ..Here, we discuss target populations for vaccination, consider the cost-benefit of different vaccination strategies and review potential vaccine candidates...
  63. pmc Accuracy of a commercial IgM ELISA for the diagnosis of human leptospirosis in Thailand
    Varunee Desakorn
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 86:524-7. 2012
    ..This was 20 Panbio units, which gave a sensitivity and specificity of 76.1% and 82.6%, respectively, on paired sera. We conclude that using either cutoff value, the accuracy of IgM ELISA is limited in our setting...
  64. ncbi request reprint Prospective clinical evaluation of the accuracy of 16S rRNA real-time PCR assay for the diagnosis of melioidosis
    Narisara Chantratita
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 77:814-7. 2007
    ..4 CFU/ml (0.2-13.5 CFU/ml); this may explain the low sensitivity of PCR for this specimen. The PCR assay described here is not sufficiently sensitive to replace culture in our clinical setting...
  65. ncbi request reprint Short report: disease severity and outcome of melioidosis in HIV coinfected individuals
    Wirongrong Chierakul
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 73:1165-6. 2005
    ..Coinfection was detected in only 8 of 524 (1.5%) adults with melioidosis in northeast Thailand. Clinical presentation and acute outcome were similar in HIV-positive and HIV-negative patients...
  66. ncbi request reprint The role and significance of sputum cultures in the diagnosis of melioidosis
    Diana Huis In 't Veld
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 73:657-61. 2005
    ..The presence of B. pseudomallei in the sputum of patients with melioidosis is associated with a poorer prognosis...
  67. pmc Accuracy of Burkholderia pseudomallei identification using the API 20NE system and a latex agglutination test
    Premjit Amornchai
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Clin Microbiol 45:3774-6. 2007
    ..mallei and 98 B. thailandensis isolates were not correctly identified. A latex agglutination test was positive for 796/800 (99.5%) B. pseudomallei isolates and negative for 120 other oxidase-positive gram-negative bacilli...
  68. pmc Common TLR1 Genetic Variation Is Not Associated with Death from Melioidosis, a Common Cause of Sepsis in Rural Thailand
    Narisara Chantratita
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS ONE 9:e83285. 2014
    ..Our findings highlight the need for additional studies of TLR1 and other innate immune genetic modulators of the inflammatory host response and determinants of sepsis in southeast Asian populations. ..
  69. pmc Prospective observational study of the frequency and features of intra-abdominal abscesses in patients with melioidosis in northeast Thailand
    Rapeephan R Maude
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Rajthevi, Bangkok, Thailand
    Trans R Soc Trop Med Hyg 106:629-31. 2012
    ..The mortality rate at 4 weeks post-discharge was lower in patients who were abscess-positive vs abscess-negative (10%, 8/77 vs 20%, 31/153)...
  70. pmc Effectiveness of a simplified method for isolation of Burkholderia pseudomallei from soil
    Direk Limmathurotsakul
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Appl Environ Microbiol 78:876-7. 2012
    ..We describe a simple method for detecting B. pseudomallei using direct culture of soil in enrichment broth. This gives a rate of positivity comparable to that obtained with a standard method but is cheaper and labor saving...
  71. doi request reprint Melioidosis: a clinical overview
    Direk Limmathurotsakul
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Br Med Bull 99:125-39. 2011
    ..Melioidosis, an infection caused by the environmental Gram-negative bacillus Burkholderia pseudomallei, has emerged as an important cause of morbidity and mortality in Southeast Asia and northern Australia...
  72. ncbi request reprint Short report: Melioidosis in Myanmar: forgotten but not gone?
    Vanaporn Wuthiekanun
    The Wellcome Trust Mahidol University Oxford Tropical Medicine Research Program, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 75:945-6. 2006
    ..Antibodies were detectable by indirect hemagglutination assay (IHA) in 757 (78%) of 968 adults, of whom 69 (7%) had an IHA titer > or =1:160...
  73. pmc Increasing incidence of human melioidosis in Northeast Thailand
    Direk Limmathurotsakul
    Department of Tropical Hygiene and Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 82:1113-7. 2010
    ..63 per 100,000 people (95% CI = 7.33-10.11), the third most common cause of death from infectious diseases in northeast Thailand after human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) and tuberculosis...
  74. ncbi request reprint Serological and blood culture investigations of Nepalese fever patients
    Stuart D Blacksell
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trans R Soc Trop Med Hyg 101:686-90. 2007
    ..Many patients demonstrated static IgM antibody results between paired serum collections, suggesting recent rather than acutely active infections...
  75. ncbi request reprint Patient and sample-related factors that effect the success of in vitro isolation of Orientia tsutsugamushi
    Rungnapa Luksameetanasan
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 38:91-6. 2007
    ..This study demonstrates that O. tsutsugamushi can often be isolated in vitro from the blood of scrub typhus patients when transported at ambient tropical temperatures for many days...
  76. ncbi request reprint Variable presentation of neurological melioidosis in Northeast Thailand
    Direk Limmathurotsakul
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 77:118-20. 2007
    ..The appropriate duration and choice of parenteral and oral antimicrobial therapy for neurologic melioidosis are also discussed...
  77. pmc Enzyme-linked immunosorbent assay for the diagnosis of melioidosis: better than we thought
    Direk Limmathurotsakul
    Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 52:1024-8. 2011
    ..The new cutoff was unbiased towards misclassification caused by an imperfect gold standard and resulted in an increase in both sensitivity (from 66.4% to 80.2%) and specificity (82.1% and 95.0%)...
  78. pmc Prevalence and sequence diversity of a factor required for actin-based motility in natural populations of Burkholderia species
    Chayada Sitthidet
    Department of Immunology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Pran Nok Road, Bangkoknoi, Bangkok 10700, Thailand
    J Clin Microbiol 46:2418-22. 2008
    ..A geographically restricted subset of B. pseudomallei isolates harbored a B. mallei-like bimA allele (12.1%), confounding a differential diagnostic test based on amplification of species-specific bimA regions...
  79. ncbi request reprint Patterns of organ involvement in recurrent melioidosis
    Direk Limmathurotsakul
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 81:335-7. 2009
    ..Evaluation of 140 patients with recurrence showed that similar patterns of disease occurred during the first and second episode, independent of whether this was caused by relapse or re-infection...
  80. pmc Factors predicting and reducing mortality in patients with invasive Staphylococcus aureus disease in a developing country
    Emma K Nickerson
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    PLoS ONE 4:e6512. 2009
    ..The factors determining mortality in developing countries have not been identified...
  81. pmc Effect of colony morphology variation of Burkholderia pseudomallei on intracellular survival and resistance to antimicrobial environments in human macrophages in vitro
    Sarunporn Tandhavanant
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    BMC Microbiol 10:303. 2010
    ..Isogenic colony morphology types II and III were generated from 5 parental type I B. pseudomallei isolates using nutritional limitation. Survival of types II and III were compared with type I for all assays...
  82. ncbi request reprint Melioidosis in 6 tsunami survivors in southern Thailand
    Wirongrong Chierakul
    Department of Clinical Tropical Medicine, Wellcome TrustMahidol UniversityOxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 41:982-90. 2005
    ..All 6 cases were associated with aspiration, and 4 were also associated with laceration...
  83. pmc Survival of Burkholderia pseudomallei in distilled water for 16 years
    Apinya Pumpuang
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Trans R Soc Trop Med Hyg 105:598-600. 2011
    ..Pulsed-field gel electrophoresis analysis of AvrII DNA restriction fragments revealed six different but related banding patterns, which may represent genomic rearrangement...
  84. pmc Defining the true sensitivity of culture for the diagnosis of melioidosis using Bayesian latent class models
    Direk Limmathurotsakul
    Department of Tropical Hygiene, Mahidol University, Bangkok, Thailand
    PLoS ONE 5:e12485. 2010
    ....
  85. pmc Virulent combinations of adhesin and toxin genes in natural populations of Staphylococcus aureus
    Sharon J Peacock
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, United Kingdom
    Infect Immun 70:4987-96. 2002
    ..Our findings also suggested that allelic variants of a polymorphic locus can make different contributions to the disease process, further study of which is likely to expand our understanding of staphylococcal disease pathogenesis...
  86. ncbi request reprint Molecular typing of Leptospira spp. based on putative O-antigen polymerase gene (wzy), the benefit over 16S rRNA gene sequence
    Piyada Wangroongsarb
    Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    FEMS Microbiol Lett 271:170-9. 2007
    ....
  87. pmc Diagnostic and treatment difficulties of pyelonephritis in pregnancy in resource-limited settings
    Rose McGready
    Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
    Am J Trop Med Hyg 83:1322-9. 2010
    ..Diagnostic innovation in microbiology that permits affordable access is a high priority for resource-poor settings...
  88. pmc Randomized soil survey of the distribution of Burkholderia pseudomallei in rice fields in Laos
    Sayaphet Rattanavong
    Institut de la Francophonie pour la M├ędecine Tropicale, BP 9519, Vientiane, Lao People s Democratic Republic
    Appl Environ Microbiol 77:532-6. 2011
    ..Further studies are needed to investigate potential climatic, soil, and biological determinants of this heterogeneity...
  89. pmc Enhanced determination of Streptococcus pneumoniae serotypes associated with invasive disease in Laos by using a real-time polymerase chain reaction serotyping assay with cerebrospinal fluid
    Catrin E Moore
    Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Laos
    Am J Trop Med Hyg 83:451-7. 2010
    ..Although the sample size is small, these data suggest that the PCV-7 vaccine may have relatively low efficacy in Laos. Further studies are urgently needed to guide pneumococcal vaccine policy in Laos...
  90. ncbi request reprint Rapid diagnosis of scrub typhus in rural Thailand using polymerase chain reaction
    Piengchan Sonthayanon
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 75:1099-102. 2006
    ..PCR using primers to amplify a fragment of the 56-kd gene had a sensitivity and specificity of 29.0% and 99.2%, respectively. PCR has a high specificity but low sensitivity for the rapid diagnosis of scrub typhus in this endemic setting...
  91. pmc Functional blocking of Staphylococcus aureus adhesins following growth in ex vivo media
    Ruth C Massey
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Infect Immun 70:5339-45. 2002
    ..These findings have important implications for future studies of S. aureus adhesins...
  92. ncbi request reprint Antibiotic-resistant sub-populations of the pathogenic bacterium Staphylococcus aureus confer population-wide resistance
    Ruth C Massey
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Level 4, John Radcliffe Hospital, UK
    Curr Biol 12:R686-7. 2002
  93. ncbi request reprint Management of melioidosis
    Vanaporn Wuthiekanun
    Mahidol University, Faculty of Tropical Medicine, Bangkok, Thailand
    Expert Rev Anti Infect Ther 4:445-55. 2006
    ..Future studies aim to address whether meropenem is superior to ceftazidime during parenteral therapy, and whether doxycycline is a necessary component of oral treatment...
  94. ncbi request reprint Pharmacokinetic and pharmacodynamic assessment of co-amoxiclav in the treatment of melioidosis
    Wirongrong Chierakul
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    J Antimicrob Chemother 58:1215-20. 2006
    ..We conducted a prospective pharmacokinetic study of oral co-amoxiclav in patients with melioidosis to determine the optimal dosage and dosing interval in this potentially fatal infection...
  95. ncbi request reprint Characterization of novel LPXTG-containing proteins of Staphylococcus aureus identified from genome sequences
    Fiona M Roche
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Microbiology 149:643-54. 2003
    ..Several IgG samples purified from patients recovering from S. aureus infections had higher titres against Sas proteins than control IgG, suggesting that expression occurred during infection in some patients...
  96. pmc Open-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline, and chloramphenicol compared with trimethoprim-sulfamethoxazole and doxycycline for maintenance therapy of melioidosis
    Wipada Chaowagul
    Medical Department, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand
    Antimicrob Agents Chemother 49:4020-5. 2005
    ..7-fold increase of relapse or death. A combination of TMP-SMX and doxycycline is as effective as and better tolerated than the conventional four-drug regimen for the oral treatment phase of melioidosis...
  97. pmc How clonal is Staphylococcus aureus?
    Edward J Feil
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom
    J Bacteriol 185:3307-16. 2003
    ....
  98. pmc Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 101:9786-91. 2004
    ....
  99. pmc Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei
    Matthew T G Holden
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Proc Natl Acad Sci U S A 101:14240-5. 2004
    ..mallei. We propose that variable horizontal gene acquisition by B. pseudomallei is an important feature of recent genetic evolution and that this has resulted in a genetically diverse pathogenic species...
  100. ncbi request reprint Risk factors for hematogenous complications of intravascular catheter-associated Staphylococcus aureus bacteremia
    Vance G Fowler
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 40:695-703. 2005
    ..The role of both host and pathogen characteristics in hematogenous seeding following Staphylococcus aureus bacteremia is incompletely understood...